Abstract: An imaging apparatus and method are provided. The probe for an imaging apparatus includes a manually manipulable proximal portion; a straight distal portion with a distal tip for locating at a site to define an observational field; and a curved portion between the proximal portion and the distal portion. The imaging method includes the steps of locating a distal tip of an imaging probe at a site to define an observational field; irradiating the observational field from the distal tip; and collecting a return signal at the distal tip; wherein the probe comprises a manually manipulable proximal portion. The apparatus and method provided herein are useful for various applications including but not limited to endomicroscopy and other microsurgical procedures performed under optical stereoscopic magnified visualization, such as neurosurgery, ENT/facial surgery and spinal surgery.

Abstract: An operating microscope has a main objective (1) that extends along an objective plane and is penetrated by a binocular main observer beam path and a binocular co-observer beam path. The binocular main observer beam path has two main observation pupils (3a, 3b) in the objective plane with centers on a first straight line (7). The binocular co-observer beam path has two co-observation pupils (5a, 5b) in the objective plane with centers on a second straight line (9). The first and second straight lines (7, 9) intersect. The co-observer beam path can be displaced with respect to the main observer beam path so that the angle between the second and first straight line (9, 7) changes. The center point (6) between the co-observation pupils (5a, 5b) in the objective plane displaces when there is a change in the angle between the second and first imagined straight lines (9, 7).

Abstract: A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.

Abstract: The invention relates to an optical measuring system comprising a wave front sensor for characterizing a shape of a wave front of measuring light and an imaging lens, wherein the imaging lens comprises a first optical assembly and a second optical assembly for imaging an object region in an entrance region of the wave front sensor. A distance between the object region and the first optical assembly is larger than a focal length of the first optical assembly. Furthermore, the optical measuring system can comprise an optical microscopy system and optionally an OCT system for carrying out different optical examination methods at the same time.

Abstract: A method of visualizing objects using an optical system including an OCT system configured to obtain OCT data from voxels within a first volume having a first lateral extent includes obtaining position data indicative of a position of a predetermined portion of a movable instrument relative to the optical system and determining a first set of voxels from the voxels of the first volume based on the determined position such that at least 80% of the first set of voxels is located within a second volume having a second lateral extent with a size at least half the size of the first lateral extent. The method also includes obtaining OCT data of the first set of voxels, visualizing a representation of the OCT data of the first set of voxels, and repeating the steps of the method at a first repetition rate higher than 5 times per second.

Abstract: A method of detecting a brain tumor includes administering indocyanine green to a living body; exposing brain tissue in the living body; irradiating the exposed brain tissue with excitation light of indocyanine green; obtaining an image based on fluorescence of the excited indocyanine green in the brain tissue, wherein the image is obtained using an endomicroscope; and identifying portions of the brain tissue corresponding to the brain tumor based on the image.

Abstract: A microscope system is for sequential observation of different fluorescent dyes that are accumulated in a tissue in an object plane. An illumination system and an observation system have at least two operating states. In one operating state, illumination radiation has a spectrum that includes an excitation band of a first fluorescent dye and is partly free from an excitation band of another fluorescent dye. In one operating state of the observation system, observation radiation guided in the first observation optical path has a spectrum in sections of the first observation optical path, which includes a first fluorescence band of the first fluorescent dye, while in another operating state observation radiation has a spectrum in at least some sections which is partly free from the first fluorescence band. A controller is configured to selectively switch the illumination system and the observation system into the first and second operating states.

Abstract: Imaging systems are provided allowing examination of different object regions spaced apart in a depth direction by visual microscopy and by optical coherence tomography. An axial field of view and a lateral resolution is varied depending on which object region is examined by the imaging system. The proposed imaging systems are in particular applicable for thorough examination of the human eye.

Abstract: An ophthalmic surgical microscope (100) has a microscope main objective (101) and a viewing beam path (105) which passes through the microscope main objective (101) for visualizing an object region. The ophthalmic surgical microscope (100) includes an OCT-system (140) for recording images of the object region (108). The OCT-system (140) includes an OCT-scanning beam (142) which is guided via a scan mirror arrangement (146) to the object region (108). An optic element (147) is provided between the scan mirror arrangement (146) and the microscope main objective (101). This optic element (147) bundles the OCT-scanning radiation exiting from the scan mirror arrangement (146) and transfers the same into a beam path which passes through the microscope main objective (101). Alternatively or in addition, the ophthalmic surgical microscope (100) includes an ophthalmoscopic magnifier lens (132) which can be pivoted into and out of the viewing beam path (105) and the OCT-scanning beam (142).

Abstract: A method for establishing the refraction of an eye (9) by means of a refractometer (3) is provided, in which the current visual axis (S) of the eye (9) is established before establishing the refraction, the refractometer (3) is aligned with respect to the visual axis (S) of the eye (9) and the refraction is established after the alignment. The visual axis (S) of the eye (9) is established on the basis of the position of a Purkinje image of at least one light source (41, 50) used to illuminate the eye and a relationship between the position of the Purkinje image and the visual axis (S).

Abstract: An article for use in an OCT method, the article comprising a solid substrate and nanoparticles dispersed in or on the substrate in at least one light transmissive portion of the article such that the nanoparticles result in an increased extinction of the light transmissive portion along a transmission direction of the light transmissive portion compared to the substrate being free of nanoparticles. The extinction of the light transmissive portion along the transmission direction is less than 6, wherein the extinction is defined as a negative decadic logarithm of a ratio of an intensity of light which is transmitted through the light transmissive portion to an intensity of light which is incident on the light transmissive portion, wherein the light is in at least one of a visible and a near infrared wavelength range.

Abstract: A method of generating a representation of an OCT data set includes obtaining the OCT data set, representing a plurality of tuples, each of which comprises values of three spatial coordinates and a value of a scattering intensity, obtaining a color image data set representing a plurality of tuples, each of which comprises values of two spatial coordinates and a color value, and generating an image data set, representing a plurality of tuples, each of which comprises values of three spatial coordinates and a color value. Generating the image data set is performed depending on an analysis of the OCT data set and an analysis of the color image data set.

Abstract: The invention relates to a device for reducing pressure variations in a fluid flowing in an aspiration branch of a surgical system, which pressure variations are generated by a pump that delivers in a non-continuous manner in the active operating state, with a diffuser arrangement which is arranged, in the aspiration branch, upstream of the pump in the direction of flow of the fluid. The invention also relates to a surgical system, in particular an ophthalmic microsurgical system for lens surgery.

Abstract: Imaging systems and methods are provided herein. An imaging system for imaging a surgical site, may include a macroscopic visualization system; and an imaging apparatus with a probe, the imaging apparatus being adapted to image the observational field and generate second image data; wherein the system is operable to control the macroscopic visualization system and the imaging apparatus to image the site and the observational field respectively at substantially the same time, and to associate the first image data and the second image data. Imaging methods provided herein may include the steps of: imaging the site with a macroscopic visualization system and generating first image data; imaging at substantially the same time an observational field with an imaging apparatus and generating second image data; and associating the first image data and the second image data.

Abstract: Frequency domain optical coherence tomography (FD-OCT) systems and methods are provided. Thereby, a first measurement and a second measurement is performed, wherein in the first measurement an object region is illuminated by measuring light having a spectrum with a first spectral width and in the second measurement the object region is illuminated with measuring light having a spectrum with a second spectral width, wherein the first spectral width is at least 10% greater than the second spectral width. Further, during the first measurement intensities of spectral ranges of light having interacted with the object and being superimposed with reference light are detected, wherein a width of these spectral ranges is greater than a corresponding width during the second measurement. Thus, switching an axial field of view of structural information of the object across a depth direction is enabled upon minimizing radiation damage at the object.

Abstract: A microscopy system and method are provided allowing observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof. A representation of a periphery line of the coherent portion may be generated, and depths profile data may be obtained only from the coherent portion. An illuminating light beam for exciting the fluorescence may be modulated for improving a contrast of fluorescent images.

Abstract: A microscope or stereomicroscope for representing an object that can be placed on an object plane of the stereomicroscope provides at least one pair of optical paths and comprises at least one deflection element with a reflecting surface and a representation system containing several optical elements. The optical elements include a plurality of lenses. In addition, the optical elements are configured in such a way that pupil planes of the optical representation paths intersect the reflecting surface of the deflection element or are located at a distance from said reflecting surface less than 1.5 times the diameter of one of the reflecting surfaces along the optical representation paths on the closest lens of the plurality of lenses. An alternative embodiment provides a stereomicroscope with a particularly compact construction, in which at least one pair of optical representation paths is reflected on a first, second, third, and fourth reflecting surface.

Abstract: A surgical microscope (100) has a viewing beam path for main viewing and a secondary beam path (106) for viewing by another person. The surgical microscope (100) has a microscope main objective (101) through which the viewing beam path for main viewing and the viewing beam path (106) for secondary viewing pass. The surgical microscope (100) includes an OCT-system (120) for examining an object region. The OCT-system (120) includes an OCT-scanning beam (123) which is guided through the microscope main objective (101). In the viewing beam path (106) for secondary viewing, an in-coupling element (150) is provided to couple the OCT-scanning beam (123) into the viewing beam path (106) for secondary viewing and to guide the same through the microscope main objective (101) to the object region (108).

Abstract: A surgical microscopy system comprises microscopy optics for generating an image of an eye under surgery. A pattern generator generates a pattern to be superimposed with the image. An eye-tracker is provided for tracking a position of the superimposed pattern with respect to the image in case of a movement of the eye. The superimposed pattern comprises pattern elements that are equally distributed on first and second circles of different sizes, in order to give assistance when placing a suture during a corneal transplant. The superimposed pattern may also provide an assistance for orientating a toric intra-ocular lens.

Abstract: A surgical microscopy system comprises microscopy optics for generating an image of an eye under surgery. A pattern generator generates a pattern to be superimposed with the image. An eye-tracker is provided for tracking a position of the superimposed pattern with respect to the image in case of a movement of the eye. The superimposed pattern comprises pattern elements that are equally distributed on first and second circles of different sizes, in order to give assistance when placing a suture during a corneal transplant. The superimposed pattern may also provide an assistance for orientating a toric intra-ocular lens.