Patents Assigned to Carlo Erba
  • Patent number: 4089896
    Abstract: Optically active 8,12-diisoprostanoic acids and derivatives, processes for making same, pharmaceutical compositions containing same, and intermediates for producing same are disclosed. The acids include, for instance, 5c,13t-11.alpha.,15S-dihydroxy-9-oxo-8,12-diisoprostadienoic acid. The compounds of the present invention can be used in the same uses as the natural prostaglandins, including the treatment of asthma, parturition to facilitate child bearing labor and as abortion agents.
    Type: Grant
    Filed: December 15, 1972
    Date of Patent: May 16, 1978
    Assignee: Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Gianfederico Doria, Pietro Gaio
  • Patent number: 4083953
    Abstract: A pharmaceutical composition, and method of treating allergic conditions therewith, is disclosed, wherein said composition contains a 5:6-benzo-.gamma.-pyrone derivative, such as, for instance, 6-carboxy-2'-isopropoxy-flavone.The composition may be used to treat various allergic conditions, including bronchial asthma, allergic rhinitis, hay fever, urticaria and dermatosis.
    Type: Grant
    Filed: October 27, 1976
    Date of Patent: April 11, 1978
    Assignee: Carlo Erba, S.p.A.
    Inventors: Gianfederico Doria, Pier Nicola Giraldi, Francesco Lauria, Maria Luisa Corno, Piero Sberze, Marcello Tibolla
  • Patent number: 4078072
    Abstract: Novel N-tricyclic derivatives of azetidine are disclosed of the general formula: ##STR1## WHERE A is a --CH.sub.2 --S-- or --S--CH.sub.2 -- group, the remaining substituents being defined in the specification. Illustrative is the compound 1-[11-(6,11-dihydro-dibenzo [b,e] thiopinyl)]-3-methylamino-azetidine. The compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: March 7, 1978
    Assignee: Carlo Erba S.p.A.
    Inventors: Piero Melloni, Arturo Della Torre, Francesco Lauria, Norina Passerini, Alessandro Rossi, Raffaele Tommasini
  • Patent number: 4078073
    Abstract: Novel N-tricyclic derivatives of azetidine of the formula: ##STR1## wherein A is a --CH.sub.2 --O-- or an --O--CH.sub.2 group, and the remaining substituents being defined in the specification are disclosed. An illustrative compound is 1-[11-(6,11-dihydro-dibenzo [b,e] oxepinyl)]-3-methylamino-azetidine. The compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: March 7, 1978
    Assignee: Carlo Erba S.p.A.
    Inventors: Piero Melloni, Arturo Della Torre, Francesco Lauria, Norina Passerini, Alessandro Rossi, Raffaele Tommasini
  • Patent number: 4065467
    Abstract: Substituted 6-carboxy flavones are disclosed, such as, for instance, 6-carboxy-2'-isopropoxy-flavone. Such flavone derivatives possess anti-allergic activity, decrease airway resistance and increase pulmonary compliance. In addition, the compounds possess anti-ulcer activity.
    Type: Grant
    Filed: February 23, 1976
    Date of Patent: December 27, 1977
    Assignee: Carlo Erba, S. p. A.
    Inventors: Gianfederico Doria, PierNicola Giraldi, Francesco Lauria, Maria Luisa Corno, Piero Sberze, Marcello Tibolla
  • Patent number: 4051245
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 are hydrogen, C.sub.1-6 alkyl or alkoxy, at least one of R.sup.1, R.sup.2 and R.sup.3 is other than hydrogen, R.sup.4 is carboxy, carbalkoxy or a carboxamide group, or a pharmaceutically acceptable salt when R.sup.4 is carboxy are disclosed.
    Type: Grant
    Filed: October 15, 1976
    Date of Patent: September 27, 1977
    Assignee: Carlo Erba, S.p.A.
    Inventors: Vittorio Ambrogi, Willy Logemann, Marc'Antonio Parenti, Raffaele Tommasini
  • Patent number: 4041064
    Abstract: 16S and 16R methyl 13, 14 dehydro PGE.sub.2 compounds have been prepared.
    Type: Grant
    Filed: July 29, 1975
    Date of Patent: August 9, 1977
    Assignee: Carlo-Erba S.p.A.
    Inventors: Carmelo Gandolfi, Gianfederico Doria, Renato Pellegata, Maria M. Usardi
  • Patent number: 4035392
    Abstract: Lactone and laclol intermediates for prosten-ynoic acids have been prepared.
    Type: Grant
    Filed: February 5, 1975
    Date of Patent: July 12, 1977
    Assignee: Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Gianfederico Doria, Pietro Gaio
  • Patent number: 4035415
    Abstract: Omega-nor-cycloalkyl-13,14-dehydro-prostaglandin compounds, specifically 13,14-dehydro-17-cyclohexyl-20,19,18-trinor-PGF.sub.2.sub..alpha., having selective luteolytic, abortifacient and labor-inducing activity and extremely low untoward gastrointestinal effects are disclosed.
    Type: Grant
    Filed: August 8, 1975
    Date of Patent: July 12, 1977
    Assignee: Carlo Erba, S.p.A.
    Inventors: Carmelo Gandolfi, Renato Pellegata, Roberto Ceserani, Maria M. Usardi
  • Patent number: 4035414
    Abstract: 8,12-DISO-14-CHLORO PGE.sub.2 and PGF.sub.2 and 8,12-diso-prosten-ynoic acids have been prepared.
    Type: Grant
    Filed: November 13, 1975
    Date of Patent: July 12, 1977
    Assignee: Carlo Erba S.P.A.
    Inventors: Carmelo Gandolfi, Gianfederico Doria, Pietro Gaio
  • Patent number: 4021477
    Abstract: 14-Chloro PG.sub.2 compounds have been prepared.
    Type: Grant
    Filed: November 13, 1975
    Date of Patent: May 3, 1977
    Assignee: Carlo-Erba S.p.A.
    Inventors: Carmelo Gandolfi, Gianfederico Doria, Pietro Gaio
  • Patent number: 4010274
    Abstract: Composition and method for the prevention and treatment of syndromes caused by platelet-aggregation disorders wherein the active ingredient is a compound of the formula: ##STR1## wherein R is H or C.sub.1 -C.sub.4 alkyl and R.sub.1 is H, C.sub.1 -C.sub.4 alkyl or ##STR2## wherein n is 1 or 2, and R.sub.2 and R.sub.3 are H or C.sub.1 -C.sub.4 alkyl, or salts thereof.
    Type: Grant
    Filed: October 16, 1975
    Date of Patent: March 1, 1977
    Assignee: Carlo Erba
    Inventors: Pier Nicola Giraldi, Giuliano Nannini, Giovanni Riasoli, Anna Spelta, Aurelio Contone
  • Patent number: 4002750
    Abstract: Compounds of the formula (I) ##STR1## are disclosed, wherein at least one of R.sup.1, R.sup.2 and R.sup.3 is C.sub.1.sub.-6 alkyl and the others are hydrogen atoms; R.sup.4 is hydroxy or C.sub.1.sub.-6 alkoxy, or a salt of the compound wherein R.sup.4 is hydroxy with a pharmaceutically acceptable base. A typical compound is, for example, 2-carboxy-5-methylpyrazine 4-oxide.These compounds exhibit hypoglycaomic and hypolipaomic activity.
    Type: Grant
    Filed: May 19, 1975
    Date of Patent: January 11, 1977
    Assignee: Carlo Erba S.p.A.
    Inventors: Vittorio Ambrogi, Willy Logemann, Marc Antonio Parenti, Raffaele Tommasini
  • Patent number: 4001424
    Abstract: 1-Oxo-1H-naphtho [ 2,1-b] pyran derivatives, such as, for instance, 1-oxo-3-(N-methyl-N-ethyl) amino-1H-naphtho [2,1-b] pyran, are disclosed, as well as pharmaceutical compositions containing same and the method of treating depression by administering such compositions.These compounds are active on the central nervous system, and therefore function as antidepressive agents.
    Type: Grant
    Filed: March 12, 1976
    Date of Patent: January 4, 1977
    Assignee: Carlo Erba S.p.A.
    Inventors: Norina Passerini, Aldo Ermili, Giorgio Roma, Alessandro Balbi, Mauro Mazzei
  • Patent number: 3935254
    Abstract: 14-Chloro and 13-14 dehydro PG.sub.2 analogues have been prepared.
    Type: Grant
    Filed: March 30, 1973
    Date of Patent: January 27, 1976
    Assignee: Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Gianfederico Doria, Pietro Gaio