Abstract: Optically active 8,12-diisoprostanoic acids and derivatives, processes for making same, pharmaceutical compositions containing same, and intermediates for producing same are disclosed. The acids include, for instance, 5c,13t-11.alpha.,15S-dihydroxy-9-oxo-8,12-diisoprostadienoic acid. The compounds of the present invention can be used in the same uses as the natural prostaglandins, including the treatment of asthma, parturition to facilitate child bearing labor and as abortion agents.
Type:
Grant
Filed:
December 15, 1972
Date of Patent:
May 16, 1978
Assignee:
Carlo Erba S.p.A.
Inventors:
Carmelo Gandolfi, Gianfederico Doria, Pietro Gaio
Abstract: A pharmaceutical composition, and method of treating allergic conditions therewith, is disclosed, wherein said composition contains a 5:6-benzo-.gamma.-pyrone derivative, such as, for instance, 6-carboxy-2'-isopropoxy-flavone.The composition may be used to treat various allergic conditions, including bronchial asthma, allergic rhinitis, hay fever, urticaria and dermatosis.
Type:
Grant
Filed:
October 27, 1976
Date of Patent:
April 11, 1978
Assignee:
Carlo Erba, S.p.A.
Inventors:
Gianfederico Doria, Pier Nicola Giraldi, Francesco Lauria, Maria Luisa Corno, Piero Sberze, Marcello Tibolla
Abstract: Novel N-tricyclic derivatives of azetidine are disclosed of the general formula: ##STR1## WHERE A is a --CH.sub.2 --S-- or --S--CH.sub.2 -- group, the remaining substituents being defined in the specification. Illustrative is the compound 1-[11-(6,11-dihydro-dibenzo [b,e] thiopinyl)]-3-methylamino-azetidine. The compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities.
Type:
Grant
Filed:
November 2, 1976
Date of Patent:
March 7, 1978
Assignee:
Carlo Erba S.p.A.
Inventors:
Piero Melloni, Arturo Della Torre, Francesco Lauria, Norina Passerini, Alessandro Rossi, Raffaele Tommasini
Abstract: Novel N-tricyclic derivatives of azetidine of the formula: ##STR1## wherein A is a --CH.sub.2 --O-- or an --O--CH.sub.2 group, and the remaining substituents being defined in the specification are disclosed. An illustrative compound is 1-[11-(6,11-dihydro-dibenzo [b,e] oxepinyl)]-3-methylamino-azetidine. The compounds are useful for their anti-depressant, anti-convulsant and anxiolytic activities.
Type:
Grant
Filed:
November 2, 1976
Date of Patent:
March 7, 1978
Assignee:
Carlo Erba S.p.A.
Inventors:
Piero Melloni, Arturo Della Torre, Francesco Lauria, Norina Passerini, Alessandro Rossi, Raffaele Tommasini
Abstract: Substituted 6-carboxy flavones are disclosed, such as, for instance, 6-carboxy-2'-isopropoxy-flavone. Such flavone derivatives possess anti-allergic activity, decrease airway resistance and increase pulmonary compliance. In addition, the compounds possess anti-ulcer activity.
Type:
Grant
Filed:
February 23, 1976
Date of Patent:
December 27, 1977
Assignee:
Carlo Erba, S. p. A.
Inventors:
Gianfederico Doria, PierNicola Giraldi, Francesco Lauria, Maria Luisa Corno, Piero Sberze, Marcello Tibolla
Abstract: Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 are hydrogen, C.sub.1-6 alkyl or alkoxy, at least one of R.sup.1, R.sup.2 and R.sup.3 is other than hydrogen, R.sup.4 is carboxy, carbalkoxy or a carboxamide group, or a pharmaceutically acceptable salt when R.sup.4 is carboxy are disclosed.
Abstract: Omega-nor-cycloalkyl-13,14-dehydro-prostaglandin compounds, specifically 13,14-dehydro-17-cyclohexyl-20,19,18-trinor-PGF.sub.2.sub..alpha., having selective luteolytic, abortifacient and labor-inducing activity and extremely low untoward gastrointestinal effects are disclosed.
Type:
Grant
Filed:
August 8, 1975
Date of Patent:
July 12, 1977
Assignee:
Carlo Erba, S.p.A.
Inventors:
Carmelo Gandolfi, Renato Pellegata, Roberto Ceserani, Maria M. Usardi
Abstract: Composition and method for the prevention and treatment of syndromes caused by platelet-aggregation disorders wherein the active ingredient is a compound of the formula: ##STR1## wherein R is H or C.sub.1 -C.sub.4 alkyl and R.sub.1 is H, C.sub.1 -C.sub.4 alkyl or ##STR2## wherein n is 1 or 2, and R.sub.2 and R.sub.3 are H or C.sub.1 -C.sub.4 alkyl, or salts thereof.
Type:
Grant
Filed:
October 16, 1975
Date of Patent:
March 1, 1977
Assignee:
Carlo Erba
Inventors:
Pier Nicola Giraldi, Giuliano Nannini, Giovanni Riasoli, Anna Spelta, Aurelio Contone
Abstract: Compounds of the formula (I) ##STR1## are disclosed, wherein at least one of R.sup.1, R.sup.2 and R.sup.3 is C.sub.1.sub.-6 alkyl and the others are hydrogen atoms; R.sup.4 is hydroxy or C.sub.1.sub.-6 alkoxy, or a salt of the compound wherein R.sup.4 is hydroxy with a pharmaceutically acceptable base. A typical compound is, for example, 2-carboxy-5-methylpyrazine 4-oxide.These compounds exhibit hypoglycaomic and hypolipaomic activity.
Type:
Grant
Filed:
May 19, 1975
Date of Patent:
January 11, 1977
Assignee:
Carlo Erba S.p.A.
Inventors:
Vittorio Ambrogi, Willy Logemann, Marc Antonio Parenti, Raffaele Tommasini
Abstract: 1-Oxo-1H-naphtho [ 2,1-b] pyran derivatives, such as, for instance, 1-oxo-3-(N-methyl-N-ethyl) amino-1H-naphtho [2,1-b] pyran, are disclosed, as well as pharmaceutical compositions containing same and the method of treating depression by administering such compositions.These compounds are active on the central nervous system, and therefore function as antidepressive agents.