Patents Assigned to Cassella
  • Patent number: 5424293
    Abstract: Phenylimidazolidine derivatives of the general formula I ##STR1## in which, for example, Y denotes --CH.sub.2 --CH.sub.2 --CO--r denotes 0 to 3Z denotes oxygenW denotes hydroxylR.sup.1 denotes --NH--C(.dbd.NH)--NH.sub.2R, R.sup.2, R.sup.3 denote hydrogenR.sup.4 denotes --CO--NHR.sup.5,where --NH--R.sup.5 represents an .alpha.-amino acid radical, have useful pharmacological properties such as inhibition of platelet aggregation and osteoclast binding to the bone surfaces.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: June 13, 1995
    Assignee: Cassella AG
    Inventors: Gerhard Zoller, Bernd Jablonka, Melitta Just, Otmar Klingler, Gerhard Breipohl, Jochen Knolle, Wolfgang Konig
  • Patent number: 5424479
    Abstract: The invention relates to a preparation process for aromatic methyl methoxycarboxylates by reaction of aromatic hydroxycarboxylic acids in the form of a mixture with the methoxycarboxylic acids with dimethyl sulphate in water.
    Type: Grant
    Filed: August 23, 1994
    Date of Patent: June 13, 1995
    Assignee: Cassella AG
    Inventors: Rolf Muller, Thomas Wessel
  • Patent number: 5424326
    Abstract: The present invention relates to phenyl-1,2,5-oxadiazolecarboxamide-2-oxides of the general formula I ##STR1## in which one of the radicals R.sup.1 and R.sup.2 represents ##STR2## and the other represents ##STR3## and R.sup.3 and R.sup.4 are defined as indicated in claim 1, to processes for their preparation and to their use for the treatment of disorders of the cardiovascular system, including angina pectoris and erectile dysfunctions.
    Type: Grant
    Filed: May 25, 1993
    Date of Patent: June 13, 1995
    Assignee: Cassella Aktiengesellschaft
    Inventors: Karl Schonafinger, Helmut Bohn
  • Patent number: 5414128
    Abstract: The present invention relates to a process for the preparation of compounds of the general formula I ##STR1## by reaction of compounds of the general formula II ##STR2## with amines of the general formula III ##STR3## wherein R.sup.1 and R.sup.2 independently of one another denote hydrogen, (C.sub.1 -C.sub.4)-alkyl, C.sub.1 -C.sub.4)-hydroxyalkyl or (C.sub.5 -C.sub.6)-cycloalkyl, or, together with the nitrogen atom carrying them, form (C.sub.4 -C.sub.6)-heterocyclyl and R.sup.3 and R.sup.4 independently of one another denote hydrogen, (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-hydroxyalkyl, (C.sub.1 -C.sub.2)-alkylcarbonyl or tosyl.
    Type: Grant
    Filed: December 3, 1992
    Date of Patent: May 9, 1995
    Assignee: Cassella AG
    Inventors: Willi Steckelberg, Rolf Muller, Peter Koch
  • Patent number: 5412150
    Abstract: The present invention relates to a process for the preparation of methyl 5-bromo-6-methoxy-1-naphthoate by brominating methyl 6-methoxy-1-naphthoate with bromine, in which between 0.5 and 0.6 mol of bromine (Br.sub.2) are employed per mole of methyl 6-methoxy-1-naphthoate and the bromination is carried out in the presence of an oxidant.
    Type: Grant
    Filed: May 23, 1994
    Date of Patent: May 2, 1995
    Assignee: Cassella AG
    Inventor: Thomas Wessel
  • Patent number: 5399570
    Abstract: Aspartic acid derivatives of the formula ##STR1## in which X denotes, for example, ##STR2## and R denotes, for example, cyclohexylamino, have useful pharmacological properties.
    Type: Grant
    Filed: March 25, 1993
    Date of Patent: March 21, 1995
    Assignee: Cassella Aktiengesellschaft
    Inventors: Otmar Klingler, Gerhard Zoller, Melitta Just, Bernd Jablonka
  • Patent number: 5399569
    Abstract: The present invention relates to 3-(cis-2,6-dimethylpiperidino)sydnone imine salts of the general formula I ##STR1## in which X denotes H.sub.2 PO.sub.4 or ##STR2## processes for their preparation and their use.
    Type: Grant
    Filed: May 10, 1993
    Date of Patent: March 21, 1995
    Assignee: Cassella AG
    Inventors: Karl Schonafinger, Eckard Kujath, Dieter Voegele
  • Patent number: 5397796
    Abstract: The present invention relates to 2,4-dioxoimidazolidine compounds of the formula I ##STR1## a process for their preparation and their use as inhibitors of platelet aggregation, metastasis of carcinoma cells and osteoclast binding to the bone surfaces.
    Type: Grant
    Filed: April 12, 1993
    Date of Patent: March 14, 1995
    Assignee: Cassella AG
    Inventors: Gerhard Zoller, Wolfgang Konig, Jochen Knolle, Melitta Just, Bernd Jablonka
  • Patent number: 5393894
    Abstract: The present invention relates to a process for the preparation of N-ethylcarbazole by reaction of carbazole or N-ethoxycarbonylcarbazole with diethyl carbonate.
    Type: Grant
    Filed: July 15, 1994
    Date of Patent: February 28, 1995
    Assignee: Cassella Aktiengesellschaft
    Inventors: Johannes Becherer, Peter Koch
  • Patent number: 5389614
    Abstract: The invention relates to compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Y have the meanings indicated in Claim 1, to processes for their preparation and their use as active pharmacological substances.
    Type: Grant
    Filed: August 4, 1992
    Date of Patent: February 14, 1995
    Assignee: Cassella AG
    Inventors: Wolfgang Konig, Gerhard Zoller, Melitta Just, Bernd Jablonka
  • Patent number: 5389655
    Abstract: The present invention relates to phenylfuroxans of the general formula I ##STR1## in which one of the radicals R.sup.1 and R.sup.2 represents phenyl and the other represents ##STR2## where R.sup.3, R.sup.4 and n are defined as indicated in claim 1, processes for their preparation and their use.
    Type: Grant
    Filed: May 20, 1993
    Date of Patent: February 14, 1995
    Assignee: Cassella AG
    Inventors: Karl Schonafinger, Helmut Bohn
  • Patent number: 5387716
    Abstract: The present invention relates to compounds of the general formula I ##STR1## wherein R.sup.1 denotes formyl or (C.sub.1 -C.sub.3)-alkylcarbonyl,R.sup.2 denotes the group CH.sub.2 --CH(A)--B, wherein A represents hydroxyl and B represents hydrogen or methyl, or A represents hydrogen and B represents hydroxymethyl, or the group COO--CH(X)--CH.sub.2 --D, wherein X represents hydrogen or methyl and D represents chlorine or bromine, or X represents hydrogen and D represents chloromethyl or bromomethyl, andR.sup.3 denotes (C.sub.1 -C.sub.4)-alkyl,processes for their preparation and their use.
    Type: Grant
    Filed: May 3, 1994
    Date of Patent: February 7, 1995
    Assignee: Cassella Aktiengesellschaft
    Inventors: Willi Steckelberg, Peter Koch
  • Patent number: 5383961
    Abstract: The black water-soluble sulphur dyes of the formula ##STR1## in which, for example, F is the dye chromophore of C.I. Leuco Sulphur Black 1,R.sup.1 if hydrogen, alkyl,M.sym. is an alkali metal cation andn is such a large number that the dye contains 5 to 20% by weight of COO.sup..crclbar. groups are, inter alia, outstandingly suitable for producing recording fluids.
    Type: Grant
    Filed: September 30, 1993
    Date of Patent: January 24, 1995
    Assignee: Cassella AG
    Inventors: Wolfgang Bauer, Gert Nagl, Willi Steckelberg, Josef Ritter, Wilhelm Mauelshagen
  • Patent number: 5382585
    Abstract: The present invention relates to pyrimidofuroxans of the general formula I ##STR1## in which A denotes ##STR2## where in each case the nitrogen atom is bonded via the C-4 and the carbon atom via the C-3 of the furoxan ring and the R radicals are defined as indicated in Claim 1, processes for their preparation and their use for the control and prevention of disorders of the cardiovascular system, in particular for the control and prevention of angina pectoris, and for the treatment of erectile dysfunctions.
    Type: Grant
    Filed: May 25, 1993
    Date of Patent: January 17, 1995
    Assignee: Cassella AG
    Inventors: Joachim Brendel, Karl Schonafinger, Helmut Bohn
  • Patent number: 5374302
    Abstract: The water-insoluble dyes of the formula I ##STR1## in which, for example, F is the dye chromophore of C.I. Leuco Sulphur Black 1,R is hydrogen, alkyl,M.sup..sym. is a quaternary ammonium cation or phosphonium cation in which the sum of carbon atoms in the hydrophobic radicals present is at least 6, andn is such a large number that the dye I contains 5 to 20% by weight of --COO.sup..crclbar. groups,are suitable in particular for producing recording fluids.
    Type: Grant
    Filed: October 6, 1993
    Date of Patent: December 20, 1994
    Assignee: Cassella AG
    Inventors: Wolfgang Bauer, Willi Steckelberg, Josef Ritter, Wilhelm Mauelshagen
  • Patent number: 5374640
    Abstract: The present invention relates to pyridyl-1,2,5-oxadiazolcarboxamide-2-oxides of the general formula I ##STR1## in which one of the radicals R.sup.1 and R.sup.2 represents pyridyl and the other represents ##STR2## and R.sup.3 and R.sup.4 are defined as indicated in claim 1, processes for their preparation and their use.
    Type: Grant
    Filed: May 25, 1993
    Date of Patent: December 20, 1994
    Assignee: Cassella Aktiengesellschaft
    Inventors: Karl Schonafinger, Helmut Bohn
  • Patent number: 5368637
    Abstract: The water-insoluble sulphur dyes of the general formula I ##STR1## in which F is a dye chromophore of, for example, C.I. Sulphur Black 1 and R.sup.1 to R.sup.4 and n are as defined in Claim 1, are suitable in particular for producing recording fluids.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: November 29, 1994
    Assignee: Cassella AG
    Inventors: Wolfgang Bauer, Willi Steckelberg, Josef Ritter, Wilhelm Mauelshagen
  • Patent number: 5360812
    Abstract: The present invention relates to fused 1,2,5-oxadiazole-2-oxides of the general formula I ##STR1## in which A denotes ##STR2## and X, Y, Z as well as R.sup.1, R.sup.2, R.sup.3 and n are defined as indicated in Claim 1, to processes for their preparation and to their use for the control and prevention of disorders of the cardiovascular system, in particular for the control and prevention of angina pectoris, and for the treatment of erectile dysfunctions.
    Type: Grant
    Filed: May 25, 1993
    Date of Patent: November 1, 1994
    Assignee: Cassella Aktiengesellschaft
    Inventors: Joachim Brendel, Karl Schonafinger, Helmut Bohn
  • Patent number: 5347019
    Abstract: 4-(2-Aminophenylthio)naphthalic anhydride derivatives are obtained in good yields and purities by reaction of 2-aminothiophenolates with 4-chloro- or 4-bromonaphthalic anhydrides having a particle size of at most 50 .mu.m.
    Type: Grant
    Filed: May 18, 1993
    Date of Patent: September 13, 1994
    Assignee: Cassella AG
    Inventors: Wolfgang Bauer, Wassilis Koumbouris
  • Patent number: 5331059
    Abstract: The present invention relates to a hydrophilic, highly swellable hydrogel based on (co)polymerized hydrophilic monomers or based on graft (co)polymers, characterized in that it has been surface-modified by means of a mixture ofA) one or more diglycidyl phosphonates andB) one or more other reactive compounds which are capable of reacting with the functional groups in the polymer, to a process for the preparation thereof, to the use thereof, and to diglycidyl phosphonate-containing crosslinking agent mixtures.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: July 19, 1994
    Assignee: Cassella Aktiengesellschaft
    Inventors: Friedrich Engelhardt, Rudiger Funk, Ulrich Riegel, Gerlinde Ebert, Hanss-Jerg Kleiner