Patents Assigned to Catholic Healthcare West
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Publication number: 20110312894Abstract: The present invention relates to methods of diagnosing, treating and prognosing mental disorders, such as Alzheimer's Disease. In one embodiment, the present invention provides a method of treating Alzheimer's Disease by inhibiting dysfunctional signaling of ?7 nAChRs in the medial septum region of an individual.Type: ApplicationFiled: January 28, 2010Publication date: December 22, 2011Applicant: CATHOLIC HEALTHCARE WESTInventor: Jie Wu
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Publication number: 20110312011Abstract: The present invention relates to methods of diagnosing samples as well as various microfluidic, microcentrifuge and microfilter devices. In one embodiment, the present invention provides a method of diagnosing neurodegenerative diseases using mitochondrial and/or platelet samples. In another embodiment, the present invention provides a microfluidic device that selectively captures and analyzes a desired amount of target biological particle.Type: ApplicationFiled: March 2, 2010Publication date: December 22, 2011Applicant: CATHOLIC HEALTHCARE WESTInventor: Jonathan E. Valla
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Patent number: 8022702Abstract: A system and method are provided herein for designing and transmitting RF pulses which cause a reduced off-resonance magnetization transfer saturation. An RF pulse shape may be optimized according to a set of Bloch solutions defining a desired magnetization profile. An RF pulse may be transmitted according to this optimized shape according to a k-space trajectory which traverses a high amplitude portion of the RF pulse more times than one or more low amplitude portions. In addition, a generally alternating slice select gradient may be applied during transmission of the RF pulse.Type: GrantFiled: November 17, 2009Date of Patent: September 20, 2011Assignee: Catholic Healthcare West, California Nonprofit Public Benefit CorporationInventor: James Grant Pipe
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Patent number: 8010181Abstract: The present invention concerns a system for utilizing radio frequency signals to dynamically determine the location of a medical device throughout a procedure and to improve navigation of the medical device. For these purposes, a plurality of RF receivers are mounted at operative locations in the operating room and operate on the same clock signal. The system also utilizes a diagnostic medical image such as an MRI, and overlays the position feedback signal on the image. This allows, for example, a surgeon to pick a desired spot on the diagnostic image, and then cause a robotic arm driven device to be moved to that particular spot inside the human body.Type: GrantFiled: February 16, 2007Date of Patent: August 30, 2011Assignee: Catholic Healthcare WestInventors: David W. Smith, Regina DeSanctis-Smith, Alan M. Pitt, Nicholas Theodore, Neil Crawford
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Publication number: 20110101887Abstract: A method and apparatus are provided for viewing a subject. The method includes the steps of providing a predetermined visual contrast among image details of the subject and maintaining the visual contrast for a predetermined time period of less than 100 milliseconds.Type: ApplicationFiled: April 14, 2009Publication date: May 5, 2011Applicant: Catholic Healthcare WestInventor: Stephen L. Macknik
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Publication number: 20110092775Abstract: For minimally invasive surgical applications, an expandable surgical retractor is inserted in a surgical corridor and expanded to a desired size and shape. Cooling allows the retractor to maintain the expanded characteristic. Following surgery, the retractor can be removed in a manner that minimizes bleeding and tissue damage.Type: ApplicationFiled: December 15, 2010Publication date: April 21, 2011Applicant: Catholic Healthcare West,Inventors: Vivek R. Deshmukh, Neil R. Crawford
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Publication number: 20110091574Abstract: Methods of treating adenocarcinoma cells such as NSCLC cells are disclosed that depend upon the level of functionally active LKB1 expressed in the cancer cells being treated. In one embodiment, the cancer cells express functionally active LKB1 and the method comprises contacting those cells with a LKB1-stimulating amount of a COX-2-specific inhibitor in combination with an inhibiting amount of a specific inhibitor of mTOR. In another embodiment, the cancer cells express about 25 percent or less of the normal, functional LKB1 expressed by non-transformed cells of the same type are contacted with a growth inhibiting amount of an agent that inhibits cellular metabolism and induces energetic stress.Type: ApplicationFiled: February 13, 2009Publication date: April 21, 2011Applicant: Catholic Healthcare WestInventors: Landon J. Inge, Keith D. Coon
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Patent number: 7879913Abstract: A method for decreasing nicotine and other substance use in humans is disclosed. Iptakalim hydrochloride (IPT) is a novel nicotine acetylcholine receptor (nAChR) blocker. According to the disclosed method, IPT is used to block human ?4?2-nAChR function. Specifically, IPT exhibits a selective blockade of ?4 subunit-containing human nAChR subtypes. According to the disclosed method, IPT is thus used to block the major nicotine targets in the brain, the ?4?2-nAChRs natively expressed in midbrain (VTA) DA system, the brain reward center, and in turn to reduce the nicotine-induced reward signals, namely dopamine level increase in nucleus accumbens. Therefore, IPT is capable of servicing as a nAChR antagonist agent and thus is a novel treatment for decreasing nicotine dependence in humans.Type: GrantFiled: June 28, 2005Date of Patent: February 1, 2011Assignee: Catholic Healthcare WestInventor: Jie Wu
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Patent number: 7875602Abstract: Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.Type: GrantFiled: May 30, 2006Date of Patent: January 25, 2011Assignees: Sutter West Bay Hospitals, Catholic Healthcare WestInventor: Li-Xi Yang
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Patent number: 7872475Abstract: A system and method are provided herein for designing and transmitting RF pulses which cause a reduced off-resonance magnetization transfer saturation. An RF pulse shape may be optimized according to a set of Bloch solutions defining a desired magnetization profile. An RF pulse may be transmitted according to this optimized shape according to a k-space trajectory which traverses a high amplitude portion of the RF pulse more times than one or more low amplitude portions. In addition, a generally alternating slice select gradient may be applied during transmission of the RF pulse.Type: GrantFiled: November 17, 2009Date of Patent: January 18, 2011Assignee: Catholic Healthcare West, California Nonprofit Public Benefit CorporationInventor: James Grant Pipe
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Patent number: 7857452Abstract: A method and apparatus are provided for identifying the covert foci of attention of a person when viewing an image or series of images. The method includes the steps of presenting the person with an image having a plurality of visual elements, measuring eye movements of the subject with respect to those images, and based upon the measured eye movements triangulating and determining the level of covert attentional interest that the person has in the various visual elements.Type: GrantFiled: August 27, 2008Date of Patent: December 28, 2010Assignee: Catholic Healthcare WestInventors: Susana Martinez-Conde, Stephen L. Macknik, Jorge Otero-Millan
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Publication number: 20100277693Abstract: A method and apparatus are provided for characterizing square wave jerks in the eye movements of a person, which may provide a powerful tool in the differential diagnosis of oculomotor and neurological disease. The method includes the steps of a) providing a sequence of saccades, b) identifying pairs of consecutive saccades of the sequence, c) determining whether each saccade of each identified pair is opposite the direction of the other saccade and, if not, then discarding the pair, d) determining whether a magnitude of each saccade of each identified pair is comparable and, if not, then discarding the pair, e) determining whether the pair of saccades of each identified pair are temporally related by a predetermined time period and, if not, then discarding the pair and f) collecting any remaining pairs of saccades as square wave jerks.Type: ApplicationFiled: October 31, 2008Publication date: November 4, 2010Applicant: CATHOLIC HEALTHCARE WESTInventors: Susana Martinez-Conde, Stephen L. Macknik, Xoana Troncoso, Jorge Otero-Millan
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Publication number: 20100217336Abstract: A system for planning a spine surgery, comprising a haptic interface capable of providing force feedback to the user and a computer adapted to simulate a surgical procedure by responding to inputs from the haptic interface and outputting haptic feedback to the haptic interface is provided. The system further comprising a rapid prototyping unit including a unit that is adapted to create models of the anatomical region where the surgical procedure will be performed in its current unoperated condition and in the predicted postoperative condition. Further the rapid prototyping unit is adapted to create a three dimensional guide to be used in the surgical procedure as well as suggest revisions to the surgical procedure. The system further comprises a computer that simulates loading of the spine and planned implanted hardware using finite element software.Type: ApplicationFiled: February 26, 2009Publication date: August 26, 2010Applicant: Catholic Healthcare West (CHW)Inventors: Neil R. Crawford, Nicholas Theodore, Seungwon Baek, Anna G.U. Sawa
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Publication number: 20100217154Abstract: An automated blood draw system operates in conjunction with an arterial or venous line. The aspiration mechanism allows the rate of aspiration, volume of aspirate, and the time interval of aspiration to be predetermined. Blood can be collected in sequential collection vials for subsequent analysis of a given laboratory parameter, or delivered directly to integrated analysis devices. While a predetermined volume of aspirate can be wasted, excessive aspiration is prevented by monitoring waste obtained in a collection receptacle. A flush system maintains the patency of the line without contamination of the specimen.Type: ApplicationFiled: February 26, 2009Publication date: August 26, 2010Applicant: Catholic Healthcare West (d/b/a) St. Joseph's Hospital and Medical CenterInventors: Vivek R. Deshmukh, Neil R. Crawford
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Publication number: 20100063563Abstract: Disclosed herein are methods, systems, and apparatus for treating a medical condition in a patient using an implantable medical device by applying an electrical signal characterized by having a number of pulses per microburst, an interpulse interval, a microburst duration, and an interburst period to a portion of a cranial nerve of said patient, wherein at least one of the number of pulses per microburst, the interpulse interval, the microburst duration, or the interburst period is selected to enhance cranial nerve evoked potentials.Type: ApplicationFiled: March 10, 2009Publication date: March 11, 2010Applicant: Catholic Healthcare West (d/b/a St.Joseph's Hospital and Medical Center)Inventor: Arthur D. Craig
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Publication number: 20100039617Abstract: A method and apparatus are provided for identifying the covert foci of attention of a person when viewing an image or series of images. The method includes the steps of presenting the person with an image having a plurality of visual elements, measuring eye movements of the subject with respect to those images, and based upon the measured eye movements triangulating and determining the level of covert attentional interest that the person has in the various visual elements.Type: ApplicationFiled: August 27, 2008Publication date: February 18, 2010Applicant: Catholic Healthcare West (d/b/a) Joseph's Hospital and Medical CenterInventors: Susana Martinez-Conde, Stephen L. Macknik, Jorge Otero-Millan
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Publication number: 20100037373Abstract: A method and apparatus are provided for processing light from a light source. The method includes the steps of measuring a predetermined set of characteristics of the light source and detecting flicker when the predetermined set of characteristics exceed a corresponding flicker fusion threshold value.Type: ApplicationFiled: October 18, 2007Publication date: February 18, 2010Applicant: Catholic Healthcare WestInventor: Stephen L. Macknik
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Publication number: 20100036275Abstract: An improved apparatus and method of using an EEG net to obtain electroencephalographic measurements from a patient in an emergent or urgent care setting. The net is comprised of a headpiece with a plurality of straps and recording ports formed therein. A recording head of an electrode is associated with each recording port and is pre-incorporated into the net. Transmitting wires are associated with each electrode head and have common terminating points. The terminus of each wire is hard wired into a connecting device that can be directly mated to a receiving console or remotely transmit wirelessly the electrode signals.Type: ApplicationFiled: March 27, 2008Publication date: February 11, 2010Applicant: Catholic Healthcare West (d/b/a St. Joseph's Hospi tal and Medical Center)Inventor: Brian Alkire
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Patent number: 7635977Abstract: A system and method are provided herein for designing and transmitting RF pulses which cause a reduced off-resonance magnetization transfer saturation. An RF pulse shape may be optimized according to a set of Bloch solutions defining a desired magnetization profile. An RF pulse may be transmitted according to this optimized shape according to a k-space trajectory which traverses a high amplitude portion of the RF pulse more times than one or more low amplitude portions. In addition, a generally alternating slice select gradient may be applied during transmission of the RF pulse.Type: GrantFiled: April 3, 2007Date of Patent: December 22, 2009Assignee: Catholic Healthcare West, California Nonprofit Public Benefit CorporationInventor: James Grant Pipe
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Patent number: 7605262Abstract: 4-O esters of podophyllotoxin and 4?-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4?-demethylepipodophyllotoxin. The compounds are useful for treating cancer.Type: GrantFiled: January 18, 2008Date of Patent: October 20, 2009Assignees: Sutter West Bay Hospitals, Catholic Healthcare WestInventor: Li-Xi Yang