Patents Assigned to Catholic Healthcare West
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Publication number: 20090177252Abstract: Disclosed herein are methods, systems, and apparatus for treating a medical condition of a patient, involving detecting a physiological cycle or cycles of the patient and applying an electrical signal to a portion of the patient's vagus nerve through an electrode at a selected point in the physiological cycle(s). The physiological cycle can be the cardiac and/or respiratory cycle. The selected point can be a point in the cardiac cycle correlated with increased afferent conduction on the vagus nerve, such as a point from about 10 msec to about 800 msec after an R-wave of the patient's ECG, optionally during inspiration by the patient. The selected point can be a point in the cardiac cycle when said applying increases heart rate variability, such as a point from about 10 msec to about 800 msec after an R-wave of the patient's ECG, optionally during expiration by the patient.Type: ApplicationFiled: March 10, 2009Publication date: July 9, 2009Applicant: Catholic Healthcare West (d/b/a St. Joseph's Hospital and Medical Center)Inventor: Arthur D. Craig
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Publication number: 20090171405Abstract: An implanted electrical signal generator delivers a novel exogenous electrical signal to a vagus nerve of a patient. The vagus nerve conducts action potentials originating in the heart and lungs to various structures of the brain, thereby eliciting a vagal evoked potential in those structures. The exogenous electrical signal simulates and/or augments the endogenous afferent activity originating from the heart and/or lungs of the patient, thereby enhancing the vagal evoked potential in the various structures of the brain. The exogenous electrical signal includes a series of electrical pulses organized or patterned into a series of microbursts including 2 to 20 pulses each. No pulses are sent between the microbursts. Each of the microbursts may be synchronized with the QRS wave portion of an ECG. The enhanced vagal evoked potential in the various structures of the brain may be used to treat various medical conditions including epilepsy and depression.Type: ApplicationFiled: March 10, 2009Publication date: July 2, 2009Applicant: Catholic Healthcare West (d/b/a St. Joseph's Hospital and Medical Center)Inventor: Arthur D. Craig
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Patent number: 7550293Abstract: A chimeric nAChR receptor subunit polypeptide having a substitution of at least about 15% of the native amino acid sequence of the subunit in the area of the C-terminal cytoplasmic domain is provided, as well as polynucleotides encoding the polypeptide. Vectors, host cells, and related methods for evaluating compounds are also provided.Type: GrantFiled: January 18, 2005Date of Patent: June 23, 2009Assignees: Targacept, Inc., Catholic Healthcare WestInventors: Merouane Bencherif, Ronald J. Lukas
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Publication number: 20090105202Abstract: The disclosure provides androsterone derivatives. The derivatives of the disclosure are useful in the treatment of androgen- and estrogen-associated diseases and disorders, including breast cancer.Type: ApplicationFiled: October 18, 2006Publication date: April 23, 2009Applicants: CALIFORNIA PACIFIC MEDICAL CENTER, CATHOLIC HEALTHCARE WESTInventor: Li-Xi Yang
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Publication number: 20080215181Abstract: A method and system for performing invasive procedures includes a surgical robot which is controlled by a guidance system that uses time of flight calculations from RF transmitters embedded in the robot, surgical instrument, and patient anatomy. Sensors around the room detect RF transmissions emitted by the RF transmitters and drive the robot according to a preprogrammed trajectory entered into the guidance system.Type: ApplicationFiled: August 27, 2007Publication date: September 4, 2008Applicant: Catholic Healthcare West (d/b/a St. Joseph's Hospital and Medical Center)Inventors: DAVID W. SMITH, Regina DeSanctis-Smith, Alan M. Pitt, Nicholas Theodore, Neil Crawford
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Publication number: 20080154389Abstract: A method and system for performing invasive procedures includes a surgical robot which is controlled by a guidance system that uses time of flight calculations from RF transmitters embedded in the robot, surgical instrument, and patient anatomy. Sensors around the room detect RF transmissions emitted by the RF transmitters and drive the robot according to a preprogrammed trajectory entered into the guidance system.Type: ApplicationFiled: August 13, 2007Publication date: June 26, 2008Applicant: Catholic Healthcare West (d/b/a St. Joseph's Hospital and Medical Center)Inventors: David W. Smith, Regina DeSanctis-Smith, Alan M. Pitt, Nicholas Theodore, Neil R. Crawford
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Patent number: 7342114Abstract: 4-O esters of podophyllotoxin and 4?-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4?-demethylepipodophyllotoxin. The compounds are useful for treating cancer.Type: GrantFiled: July 1, 2003Date of Patent: March 11, 2008Assignees: California Pacific Medical Center, Catholic Healthcare West, DBA St. Mary's Medical CenterInventor: Li-Xi Yang
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Patent number: 7336073Abstract: The present invention is directed to a method of MR imaging whereby a k-space blade extending through a center of k-space from a subject in motion is acquired. A high-pass convolution of the k-space blade with a reference k-space blade is then determined and converted to a ? function. In-plane motion of the subject during data acquisition of the k-space is then determined from the ? function.Type: GrantFiled: November 14, 2006Date of Patent: February 26, 2008Assignees: General Electric Company, Catholic Healthcare West, California Nonprofit Public Benefit CorporationInventors: Sarah K. Patch, Michael R. Hartley, James Grant Pipe
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Publication number: 20070238985Abstract: The present invention concerns a system for utilizing radio frequency signals to dynamically determine the location of a medical device throughout a procedure and to improve navigation of the medical device. For these purposes, a plurality of RF receivers are mounted at operative locations in the operating room and operate on the same clock signal. The system also utilizes a diagnostic medical image such as an MRI, and overlays the position feedback signal on the image. This allows, for example, a surgeon to pick a desired spot on the diagnostic image, and then cause a robotic arm driven device to be moved to that particular spot inside the human body.Type: ApplicationFiled: February 16, 2007Publication date: October 11, 2007Applicant: Catholic Healthcare West (d/b/a St. Joseph's Hospital and Medical Center)Inventors: David Smith, Regina DeSanctis-Smith, Alan Pitt, Nicholas Theodore, Neil Crawford
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Publication number: 20070233193Abstract: Disclosed herein are methods, systems, and apparatus for treating a medical condition in a patient using an implantable medical device by applying an electrical signal characterized by having a number of pulses per microburst, an interpulse interval, a microburst duration, and an interburst period to a portion of a cranial nerve of said patient, wherein at least one of the number of pulses per microburst, the interpulse interval, the microburst duration, or the interburst period is selected to enhance cranial nerve evoked potentials.Type: ApplicationFiled: March 29, 2007Publication date: October 4, 2007Applicant: Catholic Healthcare West (d/b/a St. Joseph's Hospital and medical Center)Inventor: Arthur D. Craig
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Publication number: 20070233194Abstract: Disclosed herein are methods, systems, and apparatus for treating a medical condition of a patient, involving detecting a physiological cycle or cycles of the patient and applying an electrical signal to a portion of the patient's vagus nerve through an electrode at a selected point in the physiological cycle(s). The physiological cycle can be the cardiac and/or respiratory cycle. The selected point can be a point in the cardiac cycle correlated with increased afferent conduction on the vagus nerve, such as a point from about 10 msec to about 800 msec after an R-wave of the patient's ECG, optionally during inspiration by the patient. The selected point can be a point in the cardiac cycle when said applying increases heart rate variability, such as a point from about 10 msec to about 800 msec after an R-wave of the patient's ECG, optionally during expiration by the patient.Type: ApplicationFiled: March 29, 2007Publication date: October 4, 2007Applicant: Catholic Healthcare West (d/b/a St. Joseph's Hospital and Medical Center)Inventor: Arthur D. Craig
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Publication number: 20070233192Abstract: An implanted electrical signal generator delivers a novel exogenous electrical signal to a vagus nerve of a patient. The vagus nerve conducts action potentials originating in the heart and lungs to various structures of the brain, thereby eliciting a vagal evoked potential in those structures. The exogenous electrical signal simulates and/or augments the endogenous afferent activity originating from the heart and/or lungs of the patient, thereby enhancing the vagal evoked potential in the various structures of the brain. The exogenous electrical signal includes a series of electrical pulses organized or patterned into a series of microbursts including 2 to 20 pulses each. No pulses are sent between the microbursts. Each of the microbursts may be synchronized with the QRS wave portion of an ECG. The enhanced vagal evoked potential in the various structures of the brain may be used to treat various medical conditions including epilepsy and depression.Type: ApplicationFiled: March 29, 2007Publication date: October 4, 2007Applicant: Catholic Healthcare West (d/b/a St. Joseph's Hospital and Medical Center)Inventor: Arthur D. Craig
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Patent number: 7182088Abstract: An arm immobilizer comprises a closeable sleeve of a compressible material which can be placed around the patient's arm above and below the elbow joint with an opening on the inside of the arm positioned to give access to an intravenous site. One or more stays running the length of the immobilizer prevent excessive flexure movement at the elbow, while the compressible foam permits smaller movements that will not dislodge or impede the operation of the intravenous site and attached tube.Type: GrantFiled: December 17, 2003Date of Patent: February 27, 2007Assignee: Catholic Healthcare WestInventor: Karen E. Jenkins
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Patent number: 7176684Abstract: The present invention is directed to a method of MR imaging whereby a k-space blade extending through a center of k-space from a subject in motion is acquired. A high-pass convolution of the k-space blade with a reference k-space blade is then determined and converted to a ? function. In-plane motion of the subject during data acquisition of the k-space is then determined from the ? function.Type: GrantFiled: June 29, 2005Date of Patent: February 13, 2007Assignees: General Electric Company, Catholic Healthcare West, California Nonprofit Public Benefit Corporation, d/ba St. Joseph's Hospital and Medical CenterInventors: Sarah K. Patch, Michael R. Hartley, James G. Pipe
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Patent number: 7030609Abstract: The present invention provides a system and method of MR imaging particularly applicable with fast spin echo protocols. Odd and even echoes are used to create separate blades or strips in k-space. Preferably, each blade extends through the center of k-space. The blades are incrementally rotated about the center of k-space with each echo train until a full set of k-space data is acquired. After a phase correction, each odd and even blade is combined into a single k-space data set that is used for image reconstruction.Type: GrantFiled: January 26, 2005Date of Patent: April 18, 2006Assignee: Catholic Healthcare West, California Nonprofit Benefit CorporationInventor: James G. Pipe
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Patent number: 6933302Abstract: (20) esters of camptothecin analogs are provided. The compounds are (20) esters of an aminoalkanoic acid or an imidoalkanoic acid and homocamptothecin, which is optionally substituted at the 7, 9, 10, 11, and 12 positions of the homocamptothecin ring. The compounds are useful for treating cancer.Type: GrantFiled: June 3, 2003Date of Patent: August 23, 2005Assignees: California Pacific Medical Center, Catholic Healthcare WestInventor: Li-Xi Yang
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Patent number: 6882148Abstract: The present invention provides a system and method of MR imaging particularly applicable with fast spin echo protocols. Odd and even echoes are used to create separate blades or strips in k-space. Preferably, each blade extends through the center of k-space. The blades are incrementally rotated about the center of k-space with each echo train until a full set of k-space data is acquired. After a phase correction, each odd and even blade is combined into a single k-space data set that is used for image reconstruction.Type: GrantFiled: August 1, 2003Date of Patent: April 19, 2005Assignees: Catholic Healthcare West, California Nonprofit Public Benefit CorporationInventor: James G. Pipe
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Patent number: 6855720Abstract: (20S) esters of camptothecin analogs are provided. The compounds are (20S) esters of an aminoalkanoic acid or an imidoalkanoic acid and camptothecin, which is optionally substituted at the 7, 9, 10, 11, and 12 positions of the camptothecin ring. The compounds are useful for treating cancer.Type: GrantFiled: June 14, 2002Date of Patent: February 15, 2005Assignees: California Pacific Medical Center, Catholic Healthcare WestInventor: Li-Xi Yang
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Patent number: 6853189Abstract: A process and system to implement such a process is configured to determine diffusion properties within a region-of-interest. A metric or index of diffusion is determined from individual diffusion values corresponding to diffusion along, multiple diffusion directions relative to average diffusion at a related voxel or pair of voxels. The invention may be implemented to determine shared diffusion anisotropy between two voxels. Based on a value of a diffusion index or metric, the present invention provides an efficient and tensor-free technique of determining if diffusion in neighboring voxels is anisotropic and if the diffusion is oriented in the same direction within each voxel. The present invention may be used to rapidly determine fractional anisotropy in a single voxel or used to filter diffusion weighted imaging data. The present invention may also be used to color-code diffusion data such that diffusion and tract orientation are readily identifiable in a reconstructed image.Type: GrantFiled: September 29, 2003Date of Patent: February 8, 2005Assignee: Catholic Healthcare West, California Nonprofit Public Benefit CorporationInventor: James G. Pipe
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Patent number: RE39707Abstract: (20S) esters of camptothecin analogs are provided. The compounds are (20S) esters of an oxyalkanoic acid and camptothecin, which is are optionally substituted at the 7, 9, 10, 11, and 12 positions of the camptothecin ring. The compounds are useful for treating cancer.Type: GrantFiled: January 16, 2003Date of Patent: June 26, 2007Assignees: Catholic Healthcare West, California Pacific Medical CenterInventors: Li-Xi Yang, Xiando Pan, Huijan Wang