Abstract: A blood vessel model simulation apparatus for conducting a test or a simulation surgery on a blood vessel model, including: a blood vessel model mounting unit on which a blood vessel model is mounted to allow a blood-mimicking liquid flow; a blood-mimicking liquid tank unit that is integrally attached to the blood vessel model mounting unit and stores a blood-mimicking liquid which is to be supplied to the blood vessel model mounted on the blood vessel model mounting unit; a pump unit that circulates the blood-mimicking liquid stored in the blood-mimicking liquid tank unit via the blood vessel model; and a pump control unit that controls drive of the pump unit. The units are configured to be integrally coupled to each other such that the blood vessel model simulation apparatus has a reduction in size and weight to be mobile.

Abstract: The present invention relates to a composition for preventing or treating transplantation rejection or a transplantation rejection disease, comprising a novel compound and a calcineurin inhibitor. A co-administration of the present invention 1) reduces the activity of pathogenic Th1 cells or Th17 cells, 2) increases the activity of Treg cells, 3) has an inhibitory effect against side effects, such as tissue damage, occurring in the sole administration thereof, 4) inhibits various pathogenic pathways, 5) inhibits the cell death of inflammatory cells, and 6) increases the activity of mitochondria, in an in vivo or in vitro allogenic model, a transplantation rejection disease model, a skin transplantation model, and a liver-transplanted patient, and thus inhibits transplantation rejection along with mitigating side effects possibly occurring in the administration of a conventional immunosuppressant alone.

Abstract: The inventive concept relates to an eyeball and eyelid protector including an eyeball cover that covers an eyeball, and an eyelid protection part that is bent and extends from one side of the eyeball cover to protect any one of an upper eyelid and a lower eyelid.

Abstract: The present disclosure relates to the preparation of citrullinated vimentin antigen-specific immune tolerogenic dendritic cells and a composition for preventing or treating heart failure after myocardial infarction comprising the same. According to the present disclosure, it is confirmed that immune tolerogenic dendritic cells differentiated by treating immature dendritic cells with citrullinated vimentin regulate the expression of immune-related factors and have an excellent therapeutic effect on heart failure caused by myocardial infarction.

Abstract: The present invention relates to a pharmaceutical composition comprising a novel compound as an active ingredient for prevention or treatment of transplant rejection. The novel compound SD911 of the present invention was identified to repress the migration of immune cells, increase the engraftment and viability of a grafted tissue, and regulate immune cells. In addition, it was found in a kidney transplantation model that the compound restrained human PBMC from suppressing the engraftment and damaging renal tissues and downregulated the expression of the inflammatory cytokine IL-17, with the consequent effective prevention and treatment of transplant rejection.

Abstract: Disclosed is a portable model eye apparatus for intraocular lens evaluation that enables more accurate comparison of intraocular lenses by capturing the same image and situation for different intraocular lenses.

Abstract: Disclosed is a defocus curve measuring apparatus for a multifocal intraocular lens capable of automatically measuring an objective defocus curve. A defocus curve measuring apparatus for a multifocal intraocular lens according to an aspect of the present invention may include a light source passed through a target image for focusing; a first lens that infinitely refracts the focus as the light source passes through it; a beam splitter having a polarization function that passes p-polarized light of the light source that has passed through the first lens and reflects s-polarized light; an intraocular lens module that refracts the light source that has passed through the beam splitter as it passes, thereby determining the focus; and a camera that captures an image of s-polarized light reflected by the beam splitter after the light source reflected from a retina passes through the intraocular lens module.

Abstract: Provided are a method for fabricating a human nasal turbinate-derived mesenchymal stem cell-based 3D bioprinted construct, and a use thereof, wherein the human nasal turbinate-derived mesenchymal stem cell-based, 3D bioprinted construct is advantageous over conventional mesenchymal stem cell-based, 3D bioprinted constructs in that the former can survive and proliferate stably in vitro and/or in vivo and shows high osteogenic differentiation ability as well, therefore is expected to make a great contribution to the practical use of cellular therapeutic agents.

Abstract: A color-light generation system includes a light source emitting first and second area light beams, a reflective grating receiving the first and second area light beams and then generating first and second area reflected light beams, an array optical switch including first and second areas receiving the first and second area reflected light beams respectively, a light mixer including a light mixer first area and a light mixer second area receiving a light beam from the first area and a light beam from the second area respectively, and a controller electrically connected to the array optical switch and controlling the array optical switch, so that the light mixer first area outputs a first color light, and the light mixer second area outputs a second color light. A method of using the system is also provided.

Abstract: The present disclosure relates to an openable/closable vertebral endoscopic device. The openable/closable vertebral endoscopic device includes an endoscope body including a working channel for providing an access route of a surgical instrument to a diseased area of a human body, the working channel having an open channel formed by opening a portion of the working channel such that a portion of the surgical instrument inserted into the working channel is exposed to the outside; and a cover member provided on the endoscope body to selectively open or close the open channel of the endoscope body.

Abstract: The present disclosure is related to a perfusable-type bio-dual proximal tubule cell construct and a producing method thereof capable of applying an in vitro artificial organ model configured to include a first bioink comprising a decellularized substance derived from a mammalian kidney tissue and human umbilical vascular endothelial cells (HUVECs) and a second bioink comprising the decellularized substance and renal proximal tubular epithelial cells (RPTECs), wherein the first bioink and the second bioink are coaxial and printed in tubular constructs having different inner diameters. According to the present disclosure, it is possible to use the renal proximal tubule-on-a-chip as a bioreactor capable of observing a biological drug reaction similar to a real drug by perfusing various drugs to the renal proximal tubule-on-a-chip.

Abstract: The present disclosure provides a method for treating hypertension by using a compound, wherein the compound is selected from the group consisting of: (E)-4-(3-(3-methyl benzyloxy)benzylidene)-1-phenylpyrazolidine-3,5-dione, (2R)-2-amino-3-(2,3-dihydro-1H-inden-1-yl)-N?-((E)-quinolin-7-ylmethylene)propane hydrazide, and a combination thereof. The present disclosure uses a small molecule compound (E)-4-(3-(3-methyl benzyloxy)benzylidene)-1-phenylpyrazolidine-3,5-dione, (2R)-2-amino-3-(2,3-dihydro-1H-inden-1-yl)-N?-((E)-quinolin-7-ylmethylene)propane hydrazide or a combination thereof, which can be developed as a therapeutic drug for lowering blood pressure, whether it is taken orally or injected.

Abstract: Disclosed herein are a method and system for predicting an occurrence of acute kidney injury. A method of predicting an occurrence of acute kidney injury, according to some embodiments of the present disclosure, may train a model for predicting a risk of an occurrence of postoperative acute kidney injury using a dataset of a plurality of patients, and accurately and early predict the risk of an occurrence of postoperative acute kidney injury for a specific patient using the trained model.

Abstract: Provided is an intraocular lens exchanger for moving a foldable intraocular lens (IOL), the intraocular lens exchanger including: an outer tube having a first passage formed in a forward/rearward direction; an inner tube disposed to be movable along the first passage and having a second passage formed in the forward/rearward direction; and a variable tube extending from a front end of the inner tube to form a variable passage connected to the second passage, in which the variable tube has an extension part having a width that increases forward in an unconstrained state in which the variable tube is not positioned in the first passage, and the extension part is provided to be elastically deformed when the unconstrained state changes to a constrained state in which at least a part of the extension part is received in the first passage.

Abstract: A cervical spine endplate preparation apparatus is provided. To this end, the present invention comprises: a handle part having a handle to be held by hand and a leading rod extending from the handle in the length direction and for guiding to a space inside the spine of a part to be operated on; a rotating shaft part having an adjustment grip, which generates a driving force by means of rotation by hand, and a rotating shaft passing through the inside of the handle and leading rod; and a shaver part which has a case, provided on the leading rod and inserted into the space of the spine, and a shaver installed inside the case and mating with the rotating shaft to rotate by means of the driving force of the adjustment grip, and having a part of a blade exposed to the top of the case and rotating.

Abstract: The present invention relates to a novel antibody specifically binding to a specific epitope of GKN1 (gastrokine 1) protein, and a gastric cancer diagnostic use thereof. An antibody specific to GKN1 according to the present invention specifically binds to a new epitope, and can be used to confirm the level of GKN1 protein in serum and thereby detect (diagnose) gastric cancer with 100% sensitivity and specificity. Thus, the antibody can be useful for screening and diagnosing gastric cancer.

Abstract: The present disclosure relates to a machine learning method and apparatus using steps feature selection based on a genetic algorithm, and the machine learning method includes defining a feature set including a plurality of features, generating a plurality of feature combinations including n-dimensional features (n is a natural number) for the feature set, independently constructing feature models for the plurality of feature combinations and calculating prediction accuracy for each of the feature models as a prediction result for a predetermined data set, arranging the feature models according to the prediction accuracy to determine at least one good feature model that satisfies a preset criterion, determining at least one good feature from among features included in a corresponding feature set of the at least one good feature model, and updating the feature set to include only the at least one good feature and re-determining a good feature model for a (n+1)-dimensional feature combination based on the update

Abstract: A customized artificial temporomandibular joint unit according to an embodiment of the present disclosure includes a first plate provided along a lower line of a lower jawbone forming a temporomandibular joint and having an insertion groove that is outwardly open, a second plate provided at a temporal bone forming the temporomandibular joint together with the lower jawbone, and a main prothesis detachably combined to the first plate without a separate fastening device by being forcibly fit into the insertion groove while approaching the first plate, and arranged in a customized manner at a facing surface location facing the second plate.

Abstract: Provided is forceps for internal fixation, including: a first member having a first holding portion for holding a first side of bone fragments and a first grip extending from the first holding portion; and a second member having a second holding portion for holding a second side spaced a predetermined distance from the first side of the bone fragments and a second grip extending from the second holding portion.

Abstract: Provided is a customizable surgical bone-cutting jigsaw puzzle-type guide device. The customizable surgical bone-cutting jigsaw puzzle-type guide device includes: a main guide portion that includes a main contact surface lengthily formed along a required main incision line of a bone to be cut and shaped to be brought into contact with the bone, and a main guide surface forming a guide line together with the main contact surface along the same line as the main incision line and shaped to be brought into contact with a cutting blade for guiding the movement of the cutting blade during cutting of the bone; and a connection portion extending from the main guide portion and connected to a side of the bone such that the main guide portion may be supported on the bone, the connection portion being configured to be detachably attached to the side of the bone.