Patents Assigned to Centre National De La Recherche Scient.
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Publication number: 20120083494Abstract: The present invention provides novel triazole derivatives with improved receptor activity and bioavailability properties as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors.Type: ApplicationFiled: September 16, 2011Publication date: April 5, 2012Applicants: AETERNA ZENTARIS GmbH, University of Montpellier Il, University of Montpellier I, Centre National De La Recherche Scient.Inventors: Babette Aicher, Gilbert Mueller, Klaus Paulini, Lars Blumenstein, Peter Schmidt, Matthias Gerlach, Michael Teifel, Jean Martinez, Jean-Alain Fehrentz, Anne-Laure Blayo
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Publication number: 20120058037Abstract: The invention relates to boron carbide and to a method for making the same, as well as to a super-abrasive material and a machine device including said boron carbide. The boron carbide of the invention has the following formula BC5 and has a diamond-type cubic structure with a mesh parameter a=3.635±0.006 Å. The boron carbide of the invention can particularly be used in the field of machining.Type: ApplicationFiled: April 9, 2008Publication date: March 8, 2012Applicants: Centre National De La Recherche Scient., European Synchrotron Radiation Facility, Universite Pierre Et Marie Curie (Paris)Inventors: Yann Le Godec, Mohamed Mezouar, Denis Andrault, Vladimir Solozhenko, Oleksandr Kurakevych
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SOLVENTS AND NOVEL ELECTROLYTIC COMPOSITIONS HAVING A LARGE RANGE OF STABILITY AND HIGH CONDUCTIVITY
Publication number: 20110128674Abstract: The present invention is concerned with novel polar solvents and novel electrolytic compositions comprising such solvents, and having a high range of stability, as required for applications in the field of electrochemistry. The present solvents have a highly polar amide function, and preferably combine with a salt soluble in the solvent and having an anion with a delocalized charge, and at least one polymer, to form an electrolytic composition.Type: ApplicationFiled: February 7, 2011Publication date: June 2, 2011Applicants: ACEP, INC., Centre National de La Recherche Scient., Universite de MontrealInventors: Christophe MICHOT, Dany Brouillette, Daniel Baril, Jean-Yves Bergeron, Michel Armand -
Publication number: 20110030341Abstract: An aircraft jet engine including a wall centered about a longitudinal axis and surrounding a stream of gas ejected at a downstream end of the wall in the direction of the axis, primary ducts distributed at the periphery of the downstream end of the wall configured on command each to eject a jet of primary fluid to interact with the ejected stream of gas, the primary ducts of each pair converging towards one another near the downstream end of the wall so that the primary jets ejected form two sides of a triangle that meet at the vertex thereof in a view projected onto a plane perpendicular to a transverse plane, and secondary ducts each associated with each pair of primary ducts and configured on command to eject a jet of secondary fluid directed into the triangle formed by the primary jets.Type: ApplicationFiled: March 31, 2009Publication date: February 10, 2011Applicants: AIRBUS OPERATIONS(inc as a Societe par Act Simpl.), CENTRE NATIONAL DE LA RECHERCHE SCIENT. (CNRS), UNIVERSITE DE POITIERSInventors: Jerome Huber, Jean-Paul Nonnet, Joel Delville, Peter Jordan, Francois Strekowski
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Publication number: 20110002148Abstract: A power rectifying circuit for an electric current signal supplied by an alternating power source, which includes: two separate switching assemblies adapted to be connected to a power terminal of the source, wherein at least one switching assembly includes a plurality of boost cells in cascade, each boost cell including a diode, a switch mechanism and a capacitor, the capacitors of the two terminal boost cells of the switching assemblies having one terminal in common. The circuit may include two assemblies of boost cells, and can be used in electric systems onboard aircrafts.Type: ApplicationFiled: January 21, 2009Publication date: January 6, 2011Applicants: AIRBUS OPERATIONS (SAS), CENTRE NATIONAL DE LA RECHERCHE SCIENT. (CNRS), INSTITUT NAT. POLYTECHNIQUE DE TOULOUSE (I.N.P.T.)Inventors: Marcelo Fernando Iturriz, Frederic Richardeau, Thierry Meynard, Hassan Helali
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Publication number: 20100320088Abstract: A device for forming at least one circulating flow, or vortex, at the surface of a drop of liquid, including at least two first electrodes forming a plane and having edges facing each other, such that the contact line of a drop, deposited on the device and fixed relatively to the device, has a tangent forming, when projected onto the plane of the electrodes, an angle between 0° and 90° with the edges facing each other of the electrodes.Type: ApplicationFiled: December 3, 2007Publication date: December 23, 2010Applicants: Commissariat A L'Energie, Centre National De La Recherche ScientInventors: Yves Fouillet, Laurent Davoust
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Publication number: 20100266576Abstract: Use of camelid single-domain antibodies for detecting an oligomeric form of the amyloid ? peptide 42 and their therapeutic and diagnostic applications.Type: ApplicationFiled: June 26, 2008Publication date: October 21, 2010Applicant: Centre National De La Recherche Scient.Inventors: Francois Rougeon, Pierre Lafaye
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Publication number: 20100255038Abstract: The present invention relates to a purified polypeptide comprising or consisting of a C-terminus MSP1 antigen from Plasmodium falciparum carrying a Glycosyl-phosphatidyl-inositol group (GPI), an immunogenic composition and a vaccine against a Plasmodium infection comprising said purified polypeptide.Type: ApplicationFiled: January 12, 2007Publication date: October 7, 2010Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENT, INSTITUT PASTEURInventors: Shirley Longacre, Sarah Bonnet, Thierry Fontaine, Charles Roth, Faridabano Nato
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Publication number: 20100240040Abstract: The invention relates to methods for screening for selective modulator of NF-?B pathway activation. The invention concerns methods for primary screening molecules that potentially modulate (activate or inhibit) the NF-?B pathway activation by identifying and selecting molecules modulate the interaction of NEMO with other proteins. The invention also concerns methods for secondary screening for modulator (activator or inhibitor) of the NF-?B pathway activation.Type: ApplicationFiled: June 20, 2008Publication date: September 23, 2010Applicants: INSTITUT PASTEUR, Centre National De La Recherche Scient.Inventors: Fabrice Agou, Jeanne Chiaravalli, Yves-Marie Coic, Francoise Baleux, Alain Israel, Michel Veron
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Publication number: 20100216990Abstract: The invention relates to hybrid organic-inorganic materials containing molybdenum and having photochromic properties. The invention also relates to the use thereof, particularly in cosmetics and in the glass industry, e.g. in glazing applications or in the production of ocular glasses.Type: ApplicationFiled: July 16, 2008Publication date: August 26, 2010Applicant: Centre National De La Recherche ScientInventors: Stephane Jobic, Martine Bujoli-Doeuff, Violaine Coue, Remi Dessapt
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SOLVENTS AND NOVEL ELECTROLYTIC COMPOSITIONS HAVING A LARGE RANGE OF STABILITY AND HIGH CONDUCTIVITY
Publication number: 20100112455Abstract: The present invention is concerned with novel polar solvents and novel electrolytic compositions comprising such solvents, and having a high range of stability, as required for applications in the field of electrochemistry. The present solvents have a highly polar amide function, and preferably combine with a salt soluble in the solvent and having an anion with a delocalized charge, and at least one polymer, to form an electrolytic composition.Type: ApplicationFiled: December 30, 2009Publication date: May 6, 2010Applicants: ACEP inc., Centre National De La Recherche Scient., Universite de MontrealInventors: Christophe MICHOT, Dany Brouillette, Daniel Baril, Jean-Yves Bergeron, Michel Armand -
Publication number: 20100041072Abstract: The invention relates to the therapeutic use of a SMR1-peptide or a pharmaceutically active amount of said SMR1-peptide, for the preparation of a therapeutic composition for preventing or treating diseases wherein a modulation of the activity of a membrane metallopeptidase, notably a membrane-zinc metallopeptidase, is sought, in a mammal, specifically in a human.Type: ApplicationFiled: October 16, 2009Publication date: February 18, 2010Applicants: INSTITUT PASTEUR, Centre National De La Recherche Scient.Inventors: Catherine Rougeot, Francois Rougeon
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SOLVENTS AND NOVEL ELECTROLYTIC COMPOSITIONS HAVING A LARGE RANGE OF STABILITY AND HIGH CONDUCTIVITY
Publication number: 20090206299Abstract: The present invention is concerned with novel polar solvents and novel electrolytic compositions comprising such solvents, and having a high range of stability, as required for applications in the field of electrochemistry. The present solvents have a highly polar amide function, and preferably combine with a salt soluble in the solvent and having an anion with a delocalized charge, and at least one polymer, to form an electrolytic composition.Type: ApplicationFiled: April 23, 2009Publication date: August 20, 2009Applicants: ACEP inc., Centre National De La Recherche Scient., Universite de MontrealInventors: Christophe MICHOT, Dany BROUILLETTE, Daniel BARIL, Jean-Yves BERGERON, Michel ARMAND -
Publication number: 20090202815Abstract: The present invention relates to the use of a nanostructured material, as a protective coating for metallic surfaces, said nanostructured material comprising functionalized nano-building blocks and a polymer or hybrid organic/inorganic matrix. It also relates to a particular nanostructured material in which the matrix is prepared from at least three silicon alkoxides.Type: ApplicationFiled: April 12, 2007Publication date: August 13, 2009Applicants: EURO. AERONAUTIC DEFENCE AND SPACE CO. EADS FRANCE, UNIVERSITE PARIS 6 PIERRE ET MARIE CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENT. (CNRS)Inventors: Elisa Campazzi, Valerie Goletto, Clement Sanchez
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Publication number: 20090156503Abstract: The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8(SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.Type: ApplicationFiled: December 30, 2008Publication date: June 18, 2009Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENT, GENOSPECTRA, INC.Inventors: GILLES DIVITA, FREDERIC HEITZ, CATHERINE MAY MORRIS, GUDRUN ALDRIAN-HERRADA
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Publication number: 20090131320Abstract: The invention relates to peptides which can become fixed to the engrailed transcription factor and which can modulate the activity thereof.Type: ApplicationFiled: September 8, 2008Publication date: May 21, 2009Applicants: Centre National De La Recherche Scient., Ecole Normale Superieure, Universite Paris 13 NORDInventors: Alain PROCHIANTZ, Brigitte Lesaffre, Michel Volovitch, Laure Sonnier
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Publication number: 20090120997Abstract: The invention relates to a saturable absorber component comprising an absorbent material located between a front mirror and a rear mirror as well as a method for manufacturing a saturable absorber component. The metallic rear mirror is a metallic buried mirror fixed via a welding joint on a heat conductive substrate. The invention applies to the field of high-rate optical transmission.Type: ApplicationFiled: January 12, 2009Publication date: May 14, 2009Applicant: Centre National De La Recherche Scient.Inventors: Jean-Louis Oudar, Constantin Nelep, Houtai Choumane
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Publication number: 20090110700Abstract: The invention concerns an acellular immunogenic or vaccine composition for producing antibodies against Bacillus anthracis comprising a protective antigen (PA) and killed and optionally purified spores, obtained from mutating strains of Bacillus anthracis and their uses.Type: ApplicationFiled: December 22, 2008Publication date: April 30, 2009Applicants: INSTITUT PASTEUR, Centre National De La Recherche ScientInventor: Michele MOCK
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Publication number: 20090017454Abstract: The invention relates to biosensors, methods for obtaining them and their use for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of the active site is naturally present in the form of a cystein (Cys) residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.Type: ApplicationFiled: August 16, 2007Publication date: January 15, 2009Applicants: INSTITUT PASTEUR, Centre National De La Recherche Scient.Inventors: Martial Renard, Laurent Belkadi, Patrick England, Hugues Bedouelle
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Publication number: 20080102057Abstract: The present invention relates to a hepatic cell line derived from wild-type mammalian liver tissue by culture methodology, the cells of the cell line being capable of differentiating into hepatocytes and bile duct cells. The present invention also relates to methods of producing such cells as well as to their applications in therapy and as an investigational tool.Type: ApplicationFiled: January 4, 2008Publication date: May 1, 2008Applicants: INSERM, Centre National De La Recherche Scient., INSTITUT PASTEURInventors: Helene Strick-Marchand, Mary Weiss, Serban Morosan, Dina Kremsdorf, Pierre Charneau