Abstract: A thermostable mutant DNA polymerase; a method for obtaining the thernmostable mutant DNA polymerase by identifying a thermostable mutant polypeptide exhibiting enzymatic activity, wherein the thermostable mutant polypeptide is a variant of DNA polymerase I obtained from Thermus aquaticus; a polynucleotide, an expression vector, and a host cell encoding the thermostable mutant DNA polymerase; and a method of performing a reverse transcription polymerase chain reaction (RT-PCR) utilizing the thermostable mutant DNA polymerase, as well as a kit for facilitating the same.

Abstract: The invention relates to peptides which can become fixed to the engrailed transcription factor and which can modulate the activity thereof.

Abstract: The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9WRAX9WRX1LX2RSLX9WX3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.

Abstract: An electrostatic actuation device, including a flexible electrode, having a first and a second end, at least part of the flexible electrode being mobile relative to a substrate, two electrodes fixed relative to the substrate, and a mechanism for forming two pivots of the flexible electrode, located between the two ends of the flexible electrode.

Abstract: KAL protein is identified the active agent in a therapeutic composition for treatment of injury to nerve tissue, including spinal cord tissue, as well as support of treatment for renal grafts. Additionally, therapeutic treatment of renal injury, and kidney transplantation and renal surgery, is effected by administration of KAL protein. The therapeutic agent may be administered locally, or intravenously. Retinal disorders may be similarly treated.

Abstract: The present invention provides hybridomas and antibodies which specifically react with native P. falciparum at a surface of ring stage infected erythrocytes and uses thereof.

Abstract: The present invention is concerned with novel polar solvents and novel electrolytic compositions comprising such solvents, and having a high range of stability, as required for applications in the field of electrochemistry. The present solvents have a highly polar amide function, and preferably combine with a salt soluble in the solvent and having an anion with a delocalized charge, and at least one polymer, to form an electrolytic composition.

Abstract: The invention concerns an acellular immunogenic or vaccine composition for producing antibodies against Bacillus anthracis comprising a protective antigen (PA) and killed and optionally purified spores, obtained from mutating strains of Bacillus anthracis and their uses.

Abstract: The present invention relates to novel synthetic or natural peptides for use in treating viral or parasitic infections or in the treatment of tumors. The peptides of the present invention are less than 30 amino acids in size, preferably less than 20 amino acids, in particular 15 to 20 amino acids, and in vitro the peptides specifically bind a type 2A protein phosphatase holoenzyme or one of its subunits. The invention also relates to a method for identifying said peptides, and to their uses.

Abstract: A subject of the present invention is a method for the selective concentration of a macromolecule or of an agglomerate of molecules of particles contained in a liquid sample, comprising successively the following steps: formation of a stabilized dispersion of foam or emulsion type, from a medium comprising said liquid sample and an interface layer, said interface layer being capable of selectively fixing said macromolecule or said agglomerate to be concentrated; and resorption of the dispersion formed during the preceding step so as to reform said interface layer. The present invention can be applied to the concentration of DNA, of proteins, of prions, of colloidal particles.

Abstract: The present invention provides antibodies that specifically bind RSP-2 proteins which are involved in the cytoadhesion of P. falciparum during ring-stage infection of erythrocytes as well as methods of using these antibodies.

Abstract: The present invention relates to a hepatic cell line derived from wild-type mammalian liver tissue by culture methodology, the cells of the cell line being capable of differentiating into hepatocytes and bile duct cells. The present invention also relates to methods of producing such cells as well as to their applications in therapy and as an investigational tool.

Abstract: The invention concerns a method for detecting intrachromosome imbalance in interphase nuclei, characterised in that it consists in: (a) hybridising in situ the chromosome suspected to be affected by said imbalance using two probes marked with different fluorochromes and specific of said chromosome long arm and short arm respectively; (b) measuring the intensity of the fluorescence emitted in said nuclei with different emission wavelengths corresponding to each of the two fluorochromes; (c) calculating the ratio (Ra) between the two measured values of fluorescence intensity; and (d) comparing the resulting ratio value with at least one reference value. The invention also concerns a kit for implementing said method and uses of said kit and said method, in particular for detecting cancer cells in a biological sample and for diagnosing cancer pathologies.

Abstract: An eddy current detector (4) comprises two poles aligned in the direction of extension of partitions (3) located behind a wall (2) wherein the thickness must be measured, but which interfere with the measurements. The influence of the partitions (3) is decreased if the core (6) of the detector (4) comprises two poles aligned in the direction of the extension of the partitions (3) and if a logical system is used to correct the results obtained according to preliminary results obtained on a reference surface.

Abstract: 3-(amino- or aminoalkyl) pyridinone derivatives having the formula (1) 1