Patents Assigned to Centre National de la Recherche Scientifique
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Publication number: 20250093212Abstract: A probe device for nanoscale thermal measurements including an insulating lever, a tip protruding from the insulating lever, a microstructured layer of Niobium Nitride (NbN) extending over only a part of the tip and covering an apex of the tip and/or covering at least one area adjoining the apex of the tip and/or covering, only partly, the insulating lever and at least two conductive leads extending from the insulating lever to the microstructured NbN layer.Type: ApplicationFiled: January 17, 2023Publication date: March 20, 2025Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Olivier BOURGEOIS, Rahul SWAMI, Gwénaelle JULIE, Jean-François MOTTE
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Publication number: 20250092471Abstract: A method for genotyping a plasmodium comprising: (a) providing a sample containing a Plasmodium; and (b) detecting the presence of an increased copy number of the genomic plasmepsin2-3 cluster. A method for the detection of a plasmodium infection in a patient comprising: (a) providing a blood sample from a patient and (b) detecting the presence or absence of an increased copy number of the genomic plasmepsin2-3 cluster in the blood sample. Kits for genotyping a plasmodium and/or detection of a plasmodium infection. Methods of treating a plasmodium infection.Type: ApplicationFiled: November 25, 2024Publication date: March 20, 2025Applicants: INSTITUT PASTEUR, INSTITUT PASTEUR DU CAMBODGE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: DIDIER MENARD, FREDERIC ARIEY, BENOIT WITKOWSKI, VALENTINE DURU, NIMOL KHIM, JOHANN BEGHAIN, BENJAMIN SAINT PIERRE, ERIC LEGRAND
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Patent number: 12254962Abstract: A method for investigating intra- and/or intermolecular interactions involving RNA is provided. The method includes a) synthesizing a RNA/DNA heteroduplex (RDH) comprising a RNA strand of interest paired to a DNA strand; b) binding a first end of the DNA strand and a corresponding first end of the RNA strand to a first element of a nanoscale manipulating device, and a second end of the DNA strand to a second element of the nanoscale manipulating device, leaving a second end of the RNA strand free; c) moving the first and second elements of the manipulating device apart from each other, stretching the DNA strand and causing the RNA strand to peel off the heteroduplex; and d) moving the first and second elements of the nanoscale manipulating device towards each other, allowing the DNA strand to relax and causing the RNA strand to bind again to it. Measurement of a force-displacement relationship during steps c) and d) provides information on intra- and/or intermolecular interactions involving the RNA strand.Type: GrantFiled: December 31, 2019Date of Patent: March 18, 2025Assignees: Centre National De La Recherche Scientifique, Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De ParisInventor: Ulrich Bockelmann
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Patent number: 12255066Abstract: A method for producing nanostructures having a metal oxide shell, carried by a top face of a substrate whose greatest dimension is greater than or equal to 100 mm by MOCVD metalorganic chemical vapour deposition, including successive steps carried out in a reactor configured for MOCVD deposition of nucleation and growth. The nucleation step includes forming non-contiguous metal nuclei by depositing a metal by MOCVD using a metalorganic precursor on the top face of the substrate and oxidising the metal of the metal nuclei, to form oxidised nuclei and ensure stabilisation of the nuclei. The growth step includes depositing a metal by MOCVD using the metalorganic precursor, to form non-contiguous nanostructures by growth of the oxidised nanostructures, and oxidising the deposited metal of the nanostructures formed in the nucleation to form oxidised nanostructures.Type: GrantFiled: November 26, 2020Date of Patent: March 18, 2025Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE GRENOBLE ALPES, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, ECOLE CENTRALE DE LYON, ECOLE SUPERIEURE CHIMIE PHYSIQUE ELECTRONIQUE LYONInventors: Pierre-Vincent Guenery, Thierry Baron, Jeremy Moeyaert
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Patent number: 12250924Abstract: A method for tracking the activity of animals confined in a facility including at least one cage, a plurality of antennae arranged underneath the at least one cage, an RFID reader to which the plurality of antennae are connected, a computer capable of controlling transmission and reception by the RFID reader, and an RFID tag to be fitted to an animal confined in the cage, the method including that the following steps are carried out:—the animal is fitted with the tag,—the RFID reader generates the transmission of an electromagnetic wave at the plurality of antennae,—the RFID reader identifies which antenna(e) has/have received the response transmitted by the tag,—the computer analyses over a given period which antennae have received a signal transmitted by the tag, thus determining the consecutive positions of the animal.Type: GrantFiled: March 16, 2020Date of Patent: March 18, 2025Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CÔTE D'AZURInventors: Robert Staraj, Georges Carle, Philippe Perrisol, Philippe Le Thuc, Aliou Diallo
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Patent number: 12251673Abstract: The invention relates to a chemical synthesis method, the said method comprising “Spray Flash Evaporation”, also commonly referred to by the corresponding initialism SFE, which comprises the chemical reaction of at least one first compound with at least one second compound, under conditions in which the first compound and the second compound react to form at least one third compound. The invention also relates to a device for implementing this method and the compounds obtained by this method.Type: GrantFiled: October 22, 2019Date of Patent: March 18, 2025Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ISL—INSTITUT FRAN CO-ALLEMAND DE RECHERCHES, UNIVERSITÉ DE STRASBOURGInventors: Denis Spitzer, Marc Comet, Valérie Keller, Martin Klaumünzer
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Patent number: 12250944Abstract: The present invention relates to the long-term preservation of biological material. More specifically, it concerns a preservation container comprising: a biological container for containing biological material, a first shield configured for absorbing gamma-rays, a second shield configured for absorbing ambient neutrons, said second shield surrounding the biological container, the preservation container being of low-radioactivity background materials, and a method for preserving a biological material, comprising: a) providing a biological material in a confinement container, b) providing the preservation container of the invention, c) placing the confinement container containing the biological material into said preservation container, d) storing said preservation container containing the biological material in a room located under a material attenuating cosmic rays and induced particles, said material having a thickness equivalent to 1 m to 7000 m of water, for attenuating cosmic rays.Type: GrantFiled: October 18, 2018Date of Patent: March 18, 2025Assignees: Centre National de la Recherche Scientifique (CNRS), Institut Pasteur, Université Paris Cité, Groupe Hospitalier Universitaire Paris—Psychiatrie et NeurosciencesInventors: Maurice Chapellier, Fabrice Chretien, Fabrice Piquemal, Pierre Rocheteau, Guillaume Warot, Michel Zampaolo
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Patent number: 12253530Abstract: A method for diagnosing or prognosing, multiple sclerosis including the steps of (a) measuring the amount of at least one first protein as set forth in SEQ ID NO: 1, the at least first protein belonging to the group of proteins: a first protein, a second protein, a third protein, a fourth protein and a fifth protein, as set forth in SEQ ID NO 1 to 5, (b) comparing the amount of the at least first protein with the amount of the same protein in a control sample, and (c) determining the status of the biological sample.Type: GrantFiled: May 22, 2019Date of Patent: March 18, 2025Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICAL (INSERM), UNIVERSITE DE MONTPELLIER, CENTRE HOSPITALIER UNIVERSITAIRE DE NÎMESInventors: Eric Thouvenot, Philippe Marin, Serge Urbach, Geoffrey Hinsinger
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Patent number: 12252807Abstract: A process for obtaining a nitride (N) layer preferably obtained from at least one of gallium (Ga), indium (In) and aluminium (Al), may include: on a stack including a substrate and at least the following layers successively disposed from the substrate: a creep layer having a glass transition temperature, Tglass transition, and a crystalline layer, forming pads by etching the stack so that each pad includes at least a creep segment formed by at least a portion of the creep layer, and a crystalline segment formed by the crystalline layer; and growing by epitaxy a crystallite on each of the pads and continuing the epitaxial growth of the crystallites so as to form the nitride layer. The epitaxial growth may be carried out at a temperature Tepitaxy, such that Tepitaxy?k1×Tglass transition, with k1 being 0.8.Type: GrantFiled: December 24, 2018Date of Patent: March 18, 2025Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Guy Feuillet, Blandine Alloing, Virginie Brandli, Benoit Mathieu, Jesus Zuniga Perez
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Patent number: 12252514Abstract: The invention relates to the field of molecular biology and particularly novel genes that encode pesticidal proteins useful for controlling pests, particularly plant pests. These proteins and the nucleic acid sequences that encode them are useful in preparing pesticidal compositions and in the production of transgenic pest-resistant plants.Type: GrantFiled: March 13, 2020Date of Patent: March 18, 2025Assignees: GENECTIVE, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, PCAS, SEMAE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Carine Bonzom-Audiffrin, Wafa Achouak, Mohamed Barakat, Philippe Ortet, David Vallenet, Thierry Heulin, Christophe Sallaud, Mickael Bosio, Virginie Guyon, Wyatt Paul
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Publication number: 20250087610Abstract: An electronic chip including a support and connection pillars, each connection pillar including a trunk including an end portion and an intermediate portion coupling the end portion to the support, and including a collar at the junction between the end portion and the intermediate portion.Type: ApplicationFiled: September 5, 2024Publication date: March 13, 2025Applicants: Commissariat à I'Énergie Atomique et aux Énergies Alternatives, Centre National de la Recherche Scientifique, Université de Bordeaux 1, Institut Polytechnique de BordeauxInventors: Céline Feautrier, Jean-Charles Souriau, Julie Gougeon, Mona Treguer-Delapierre
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Publication number: 20250085405Abstract: A method for processing a signal from a lidar including digitizing the amplified electrical signal (s0e(t)), applying at least one time correction function, referred to as the correcting filter (Ce(t)), to the digitizing amplified electrical signal in order to generate a processed signal (sf(t)), the correcting filter (Ce(t)) being determined based on the impulse response and a predetermined time analysis function, the analysis function having at least one non-zero value, referred to as the discontinuity, at a given time referred to as the discontinuity time, with a return to substantially zero values around the discontinuity; and determining a distance (di) of the at least one element (Ei) based on the processed signal.Type: ApplicationFiled: December 16, 2022Publication date: March 13, 2025Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS-SACLAYInventor: Jean-Paul CROMIERES
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Patent number: 12247785Abstract: A cold crucible having application in the field of making monocrystalline materials at high temperature. The cold crucible includes: a cold cage having sectors made of a good electrical conductor material and in which a charge is molten, and a cooling device with a heat-transfer fluid, configured so as to cool down, from inside, each segment of the cold cage. At least one sector of the cold crucible includes a housing and is removable, the housing being proper and intended to accommodate at least one so-called functionalising device of the cold crucible. Henceforth, it is possible to functionalise each sector independently of the others, by accommodating therein, a functionalising device configured, inter alia, so as to modify and/or analyse at least one property of the charge, in particular the molten charge, in the cold cage.Type: GrantFiled: February 6, 2020Date of Patent: March 11, 2025Assignees: INSTITUT POLYTECHNIQUE DE GRENOBLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE GRENOBLE ALPESInventors: Kader Zaidat, Christian Garnier, Ghatfan Hasan
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Patent number: 12248850Abstract: A quantum device includes several spin qubits arranged as a matrix and each comprising a quantum dot; several electrometers each electrostatically coupled to a potential well of one of the quantum dots; and circuits for applying an excitation signal to an input electrode of each electrometer. The circuits are configured such that a value of the frequency, phase or maximum amplitude of each excitation signal is different from that of the other excitation signals, and the circuits apply a same excitation signal on electrometers coupled to a same row of qubits. The device also includes a transimpedance amplifier having an input coupled to output electrodes of the electrometers and a demultiplexing circuit including an input electrically coupled to an output of the transimpedance amplifier and configured to demultiplex the output signals to be delivered by the electrometers.Type: GrantFiled: December 8, 2021Date of Patent: March 11, 2025Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Adrien Morel, Gérard Billiot, Gaël Pillonnet, Tristan Meunier
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Patent number: 12247018Abstract: A compound of formula (Ic) wherein X2 represents a —CO—NRk— group, wherein Rk represents a hydrogen atom or a methyl group, a —NH—CO—NH— group, a —OCH2— group, a —CH(OH)— group, a —NH—CO— group, a —O— group, a —O—(CH2)s—O—, a —CO— group, a —SO2— group, a divalent 5-membered heteroaromatic ring comprising 1, 2, 3 or 4 heteroatoms, a —NH—SO2— or a —SO2—NH— group; Y2 represents a hydrogen atom, a halogen atom, a hydroxyl group, a (C1-C4)alkoxy group, a a group, a group, a morpholinyl group, optionally substituted by a (C1-C4)alkyl group, a piperazinyl group, a piperidinyl group, or a —CR1R2R3 group, or any of its pharmaceutically acceptable salt.Type: GrantFiled: July 9, 2019Date of Patent: March 11, 2025Assignees: ABIVAX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER, INSTITUT CURIEInventors: Didier Scherrer, Jamal Tazi, Florence Mahuteau-Betzer, Romain Najman, Julien Santo, Cécile Apolit
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Patent number: 12249361Abstract: The present disclosure concerns a method for fabricating a magnetoresistive element comprising a magnetic tunnel junction including a tunnel barrier layer, a first ferromagnetic layer and a second ferromagnetic layer; a writing current layer; and an interconnect layer configured for supplying the writing current to the writing current layer. A gap is provided in the interconnect layer such that the latter comprises two discontinuous interconnect segments extending along a layer plane and connecting the writing current layer in series. The method comprises: depositing the interconnect layer, writing current layer, second ferromagnetic layer, tunnel barrier layer and first ferromagnetic layer; forming the gap in the interconnect layer; filling the gap with the gap material; and forming the pillar by performing a single etch step until the interconnect layer, acting as a stop layer, is reached.Type: GrantFiled: March 17, 2021Date of Patent: March 11, 2025Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Sylvain Martin, Julien Louche, Marc Drouard
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Patent number: 12249882Abstract: An electrical machine for use in an aircraft, including a rotor. The rotor includes a plurality of rotor poles, and a stator including a plurality of phases. Each respective phase occupies at least one elementary block and the at least one elementary block of each phase includes a set of conductors of the respective phase wound around a plurality of slots of the respective elementary block in a concentrated winding configuration. A mechanical shift angle between the respective concentrated windings of each pair of adjacent elementary blocks is greater than a rotor pole pitch. The rotor pole pitch is an angle between adjacent poles of the rotor.Type: GrantFiled: April 8, 2020Date of Patent: March 11, 2025Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SAFRAN ELECTRICAL & POWER, SAFRAN LANDING SYSTEMSInventors: Nadhem Boubaker, Daniel Matt, Florent Nierlich
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Patent number: 12247279Abstract: The technique relates to a method for preparing a nanomesh metal membrane 5 transferable on a very wide variety of supports of different types and shapes comprising at least one step of de-alloying 1 a thin layer 6 of a metal alloy deposited on a substrate 7, said method being characterized in that said thin layer 6 has a thickness less than 100 nm, and in that said de-alloying step 1 is carried out by exposing said thin layer 6 to an acid vapor in the gas phase 8, in order to form said nanomesh metal membrane 5.Type: GrantFiled: February 11, 2022Date of Patent: March 11, 2025Assignees: Centre national de la recherche scientifique, Nantes UniversityInventors: Abdel-Aziz El Mel, Pierre-Yves Tessier, Adrien Chauvin
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Patent number: 12247306Abstract: The present invention describes an electrochemical system (1) to electrochemically reduce carbon monoxide (CO) into liquid methanol and gaseous H2, comprising an electrochemical cell with an anodic compartment with an anode (2) with a current collector (2A), at least a catalyst to electrochemically oxidize H2O, and a cathodic compartment with a cathodic electrolyte solution comprising the solvent (3), and a cathodic supporting electrolyte, the solvent (3) being water at basic pH of between 10.5 and 13.5, the reagent CO; a cathode (4) which comprises, on a current collector (4A) which is electrochemically inert, at least a cobalt molecular catalyst (4B) to electrochemically reduce CO into liquid methanol and the gas H2, a power supply (5) providing the energy necessary to trigger the electrochemical reactions involving the reagent.Type: GrantFiled: April 24, 2020Date of Patent: March 11, 2025Assignees: UNIVERSITÉ PARIS CITÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Marc Robert, Etienne Boutin
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Publication number: 20250081706Abstract: The invention refers to an electronic component, in particular an organic electrochemical transistor (OECT) which comprises at least one gate electrode, a source electrode, a drain electrode, a channel and an electrolyte. The electrolyte is a solid electrolyte comprising a polymer, and the channel comprises an organic semiconductor as channel material. The electrolyte has a low water content and/or a low C1-C3-alcohol content as well as a low maximum halogen alkaline salt or alkaline earth or acetate salt content. The invention further refers to the use of this electronic component as a Schmitt-Trigger or a Muller-C-element or a flip-flop or a 1-bit memory. Further, the invention provides a method for forming such an electronic component.Type: ApplicationFiled: August 28, 2024Publication date: March 6, 2025Applicants: TECHNISCHE UNIVERSITÄT DRESDEN, UNIVERSITÉ PARIS-SACLAY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Hans KLEEMANN, Jann KRAUSSE, Lukas BONGARTZ, Karl LEO, Laurie CALVET, Zonglong LI