Patents Assigned to Centre National de la Recherche Scientifique
  • Publication number: 20210325391
    Abstract: A method for the evaluation of the efficacy of a drug aiming to eradicate a cellular reservoir of mammalian cells infected with a mammalian immunodeficiency virus, the method including: a) quantifying, the presence of lymphocyte cells expressing a CD89 differentiation marker on their surface; and b) concluding that the drug is efficient to eradicate the cellular reservoir of mammalian cells infected with the mammalian immunodeficiency virus when lymphocyte cells expressing a CD89 differentiation marker are absent.
    Type: Application
    Filed: May 7, 2021
    Publication date: October 21, 2021
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE MONTPELLIER
    Inventors: Monsef BENKIRANE, Gael PETITJEAN, Benjamin DESCOURS
  • Patent number: 11148957
    Abstract: Disclosed is a method and system for recovering at least rare earth elements from within an object A consisting of at least one first rare earth portion or a mixture of rare earth elements and a second metal portion. The method includes a solvothermal treatment step that places the object in contact with a fluid for causing at least one rare earth portion and/or mixture of rare earth elements and the metal portion to oxidize in order to separate same, the value of the reaction temperature Tr is selected according to the nature of the object, the reaction following a R-M?R(X)x+M(X)y scheme, where R is the rare earth element or a mixture of rare earth elements, M is the transition metal, and (X) is a group which depends on the fluid used.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: October 19, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE ROUEN-NORMANDIE, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN NORMANDIE
    Inventors: Jean-Marie Le Breton, Nicolas Maât, Virginie Nachbaur
  • Patent number: 11142548
    Abstract: Disclosed are agents activating CD47 and their use in the treatment of inflammation, in particular non-resolving low grade inflammation, characterized by chronic MP infiltration, such as age-related macular degeneration. Also disclosed are pharmaceutical compositions, medicaments and kits including the agents.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: October 12, 2021
    Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
    Inventors: Florian Sennlaub, Michael Housset, Xavier Guillonneau, José-Alain Sahel, Philippe Karoyan
  • Patent number: 11141130
    Abstract: In order to obtain a predetermined ultrasonic wave field in a homogeneous internal part of a medium masked by an aberrating barrier, an ultrasonic lens is interposed between the emitting ultrasonic probe and the aberrating barrier. The ultrasonic lens is calculated by using a model of the medium comprising a mapping of ultrasonic wave propagation properties obtained from actual imaging of the medium such that when the ultrasound probe sends a predetermined ultrasonic wave, said predetermined wave generates the predetermined objective ultrasonic wave field in the medium.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: October 12, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE)
    Inventors: Mickaël Tanter, Jean-François Aubry, Thomas Deffieux, Mathieu Pernot
  • Publication number: 20210309611
    Abstract: A compound of formula (I) or any of its pharmaceutically acceptable salt for use in the treatment and/or prevention of a RNA virus infection, and a RNA virus infection from group IV or V of the Baltimore classification wherein R3 represents a chlorine atom or a hydrogen atom, R represents a (C1-C4)alkyl group, a (C3-C6)cycloalkyl group, a halogen atom, a (C1-C5)alkoxy group, a —SO2—NRaRb group, a —SO3H group, a —OH group, a —O—SO2—ORc group or a —O—P(?O)—(ORc)(ORd) group, R1 represents (i) a CF3 group, (ii) a (C1-C10)alkyl group, (iii) a (C3-C6)cycloalkyl or a (C3-C6)heterocycloalkyl group or (iv) a phenyl group or a naphthyl group, and R2 represents a hydrogen atom, a (C1-C10)alkyl group, a (C3-C6)cycloalkyl or a (C3-C6)heterocycloalkyl group and further relates to new compounds, to pharmaceutical compositions containing them and to synthesis process for manufacturing them.
    Type: Application
    Filed: July 9, 2019
    Publication date: October 7, 2021
    Applicants: ABIVAX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER, INSTITUT CURIE
    Inventors: Didier SCHERRER, Jamal TAZI, Florence MAHUTEAU-BETZER, Romain NAJMAN, Julien SANTO, Cécile APOLIT
  • Publication number: 20210310787
    Abstract: The present invention relates to a method for the non-invasive optical characterization of a heterogeneous medium, comprising: a step of illuminating, by means of a series of incident light waves, a given field of view of the heterogeneous medium, positioned in a focal plane of a microscope objective (30); a step of determining a first distortion matrix (Dur, Drr) in an observation basis defined between a conjugate plane of the focal plane (FP) and an observation plane, said first distortion matrix corresponding, in a correction basis defined between a conjugate plane of the focal plane and an aberration correction plane, to the term-by-term matrix product of a first reflection matrix (Rur) of the field of view, determined in the correction basis, with the phase conjugate matrix of a reference reflection matrix, defined for a model medium, in said correction basis; and a step of determining, from the first distortion matrix, at least one mapping of a physical parameter of the heterogeneous medium.
    Type: Application
    Filed: July 16, 2019
    Publication date: October 7, 2021
    Applicants: Centre National de la Recherche Scientifique, ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Alexandre Aubry, Amaury Badon, Victor Barolle, Claude Boccara, Laura Cobus, Mathias Fink, William Lambert
  • Patent number: 11139167
    Abstract: A method making it possible to obtain, on an upper surface of a crystalline substrate, a semipolar layer of nitride material comprising any one from among gallium, aluminium or indium, the method comprises the following steps: obtaining, on the upper surface of the crystalline substrate, a plurality of parallel grooves which extend in a first direction, one of the two opposite facets exhibiting a crystal orientation; etching a plurality of parallel slices which extend in a second direction that has undergone a rotation with respect to the first direction of the grooves in such a way as to obtain individual facets exhibiting a crystal orientation; epitaxial growth of the material from the individual facets.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: October 5, 2021
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Michel El Khoury Maroun, Guy Feuillet, Philippe Vennegues, Jesus Zuniga Perez
  • Patent number: 11135319
    Abstract: The application relates to a compound with the following formula (I): its preparation method, its synthesis intermediates and its uses as an imaging agent of hypoxia.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: October 5, 2021
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Anne-Elodie Lafargue, Cecile Perrio
  • Patent number: 11139099
    Abstract: The invention relates to a directional magnetic field generator with a magnetic circuit comprising: a first vertical-axis pole end (37) arranged above a horizontal plane; and at least two second pole ends (28A to 28D) symmetrically arranged on said horizontal plane, the generator further comprising coils arranged such that each magnetic circuit portion connecting two pole ends passes inside at least one coil, these coils being suitable for being connected to circuits for circulating currents of adjustable intensity in selected directions therein.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: October 5, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES
    Inventors: Isabelle Joumard, Ricardo Sousa
  • Patent number: 11136499
    Abstract: The invention relates to an aqueous composition comprising a suspension of ZnO particles and a polymer stabiliser containing carboxylic acid functions and carboxylic acid salt functions.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: October 5, 2021
    Assignees: UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Stéphane Daniele, Audrey Valette, Thibaut Cornier
  • Patent number: 11139433
    Abstract: The invention concerns a solution of tungstate ions W6+ (VI) comprising as solvent at least one optionally partly etherified polyalcohol, a preparation method and uses thereof. The invention further concerns a layer comprising at least one tungsten oxide WOz comprising one or more polyoxotungstate complexes, methods for preparing the same and uses thereof, and in particular a photovoltaic device comprising said layer of material.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: October 5, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES, UNIVERSITE DE NANTES
    Inventors: Luc Brohan, Mireille Richard-Plouet, Moustafa El Kass, Noëlla Lemaitre, Solenn Berson
  • Patent number: 11139474
    Abstract: A method for preparing a material having an Sn:Sb intermetallic phase includes at least the steps of mixing chemical elements Sn and Sb, and treating the mixture with microwaves. An electrode is manufactured by using the material having an Sn:Sb intermetallic phase; forming the material in a form of powder; mixing the powder with carbon, a binder and a solvent to form an ink; coating a current collector with the ink; and drying the electrode.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: October 5, 2021
    Assignees: HUTCHINSON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE MONTPELLIER
    Inventors: David Ayme-Perrot, Philippe Sonntag, Philippe Antitomaso, Laure Monconduit, Francoise Morato-Lallemand, Philippe Girard
  • Publication number: 20210300871
    Abstract: A compound: wherein X1 represents an alkenylene group, a —NH—CO— group, a —CO—NH— group, Y1 represents an aryl group selected from pyridyl, pyrazinyl or pyrimidinyl, X2 represents —O—, —CO—NH—, —NH—CO—NH—, —OCH2—, —NH—CO—, a divalent 5-membered heteroaromatic ring comprising 1 to 4 heteroatoms or —SO2—NH—, and Y2 represents a hydrogen atom, a hydroxyl group, a morpholinyl group, a piperidinyl group, optionally substituted by a (C1-C4)alkyl group, a piperazinyl group, optionally substituted by a (C1-C4)alkyl group, or —CR1R2R3 or alternatively X2—Y2 represents —CONRcRd, wherein Rc and Rd form, together with the nitrogen atom a heterocyclic ring, optionally substituted by one or two (C1-C4)alkyl group, by a cyclopentyl group thus forming a spirocyclopentyl, or by a trifluoromethyl group, or any of its pharmaceutically acceptable salt, for use in the treatment and/or prevention of a RNA virus infection caused by a RNA virus belonging to group IV or V of the Baltimore classification.
    Type: Application
    Filed: July 9, 2019
    Publication date: September 30, 2021
    Applicants: ABIVAX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER, INSTITUT CURIE
    Inventors: Didier SCHERRER, Jamal TAZI, Florence MAHUTEAU-BETZER, Romain NAJMAN, Julien SANTO, Cécile APOLIT
  • Patent number: 11129864
    Abstract: The invention relates to a tablet or capsule containing a plant extract, to assist in the treatment or prevention of disorders or diseases. The tablet or capsule includes bioconverted products provided by fermenting Withania Somnifera extract, Emblica officinalis extract, and Bacopa monnieri extract.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: September 28, 2021
    Assignees: Ethnodyne, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Chérif Rabhi, Léon Cariel, Jamal Ouazzani, Guillaume Arcile
  • Publication number: 20210290142
    Abstract: The invention concerns a method for calibrating a system for real-time measurement of the activity of a cognitive function of a test subject, the method comprising the successive steps of: acquiring electrical signals representative of a neural activity of a test subject; calculating values of markers of the cognitive function activity; generating a plurality of copies of calculated values of markers and adding noise to the generated copies; and, constructing a classifier by machine learning, based on the calculated marker values and noisy copies, the classifier being suitable for measuring the activity of the cognitive function of the test subject by calculating a probability that an electrical signal representative of the neural activity of the test subject results from a predetermined activity state of the cognitive function of the test subject.
    Type: Application
    Filed: November 21, 2018
    Publication date: September 23, 2021
    Applicants: Paris Sciences Et Lettres - Quartier Latin, Centre National de la Recherche Scientifique (CNRS), Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris, Sorbonne Universite
    Inventors: François Vialatte, Aldo Mora-Sanchez, Gérard Dreyfus, Antoine Gaume, Alfredo Aram Pulini
  • Publication number: 20210292328
    Abstract: The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing said compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.
    Type: Application
    Filed: September 20, 2017
    Publication date: September 23, 2021
    Applicants: CENTRE LEON BERARD, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Toufic RENNO, Isabelle COSTE-INVERNIZZI, Stéphane GIRAUD, Serge LEBECQUE
  • Publication number: 20210296699
    Abstract: The present invention relates to a solid polymer electrolyte comprising: at least one comb polymer comprising a main chain formed from 1-ethenyl- and/or 1-allyl-2,3,4,5,6-pentafluorobenzene monomers, some of the monomer units of the main chain bearing polymeric side chains based on polymers that are solvents for alkali metal or alkaline-earth metal salts; said chains being grafted in the para position of the pentafluorophenyl groups; and at least one alkali metal or alkaline-earth metal salt, in particular a lithium salt. The invention also relates to a process for preparing a solid polymer electrolyte film and to the use thereof in an electrochemical system, in particular a lithium battery.
    Type: Application
    Filed: February 12, 2021
    Publication date: September 23, 2021
    Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Lionel PICARD, Thomas CLEMENT, Patrice RANNOU
  • Patent number: 11124428
    Abstract: The invention relates to a porous material in the form of microspheres based on iridium and/or iridium oxide, its preparation process, its use as anodic catalyst in a water electrolyser based on a solid polymer electrolyte, also called PEM water electrolyser (with PEM meaning “Proton Exchange Membrane” or “Polymer Electrolyte Membrane”) or for the manufacture of light-emitting diodes for various electronic devices or for cars, and a PEM water electrolyser comprising such a material as an anode catalyst.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: September 21, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE
    Inventors: Cédric Boissiere, Deborah Jones, Marco Faustini, Jennifer Peron, Cédric Tard, Marion Giraud
  • Patent number: 11124584
    Abstract: The invention pertains to an improved PVDC composition including certain dienophiles qualified for food contact, which possess an optimized balance of effectiveness in preventing discoloration upon exposure to radiation, with no negative impact on the barrier properties, in particular sorbate esters of formula (I), wherein R1 is a C1-C12 hydrocarbon group, preferably a C1-C6 alkyl group, to layers made therefrom, to multi-layer assemblies comprising the same, and to the use of said assemblies for packaging, in particular for packaging foodstuffs.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: September 21, 2021
    Assignees: Solvay SA, Centre National de la Recherche Scientifique, Université d'Aix-Marseille
    Inventors: Elodie Chauvet, Didier Gigmes, Yohann Guillaneuf, Agnès Chapotot, Jérôme Vinas, Pascal Dewael, Yves Vanderveken
  • Patent number: 11123701
    Abstract: A process including introducing, into a device, an aqueous fluid containing at least one inorganic salt, the water of the aqueous fluid being in supercritical conditions or close to the supercritical range in the device, and measuring the concentration or the amount of inorganic salt in the device, this measurement preferably being carried out before the entry of the inorganic salt into the device, Then bringing the inorganic salt into contact with an aqueous flow containing at least one hydroxide salt to obtain in the device an aqueous fluid mixture containing an inorganic salt and a hydroxide salt and adjusting the concentration or amount of the hydroxide salt as a function of the concentration or amount of the inorganic salt needed to at least partially solubilize the inorganic salt. Preferably the measurement of the concentration or the amount of inorganic salt leaving the device is also performed.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: September 21, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NAT SUPERIEURE ARTS ET METIERS ENSAM, UNIVERSITÉ DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX
    Inventor: Cyril Aymonier