Patents Assigned to Centre National de la Recherche Scientifique (Cnrs)
  • Publication number: 20220144720
    Abstract: The invention relates to an energy-releasing composite material comprising at least one nanoporous material and at least one inorganic oxidant, characterised in that said nanoporous material is a nanoporous carbon material.
    Type: Application
    Filed: April 9, 2020
    Publication date: May 12, 2022
    Applicants: Ecole Royale Militaire, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Romuald Jean-Pierre VAN RIET, Maria Concepcion OVIN ANIA, Michel Henri Jean-Marie LEFEBVRE, Peter Jean Joseph LODEWYCKX
  • Publication number: 20220133392
    Abstract: The present invention relates to a microfluidic chip for attracting and destroying a specific biological element, said chip comprising: a reservoir (1) consisting of a matrix comprising a chemoattractant compound capable of attracting the biological element at least one network of microchannels (2) arranged between the reservoir (1) and the external environment (3) of the chip and allowing the chemoattractant compound to pass to said environment and the biological element present in said environment to pass to the reservoir (1) at least one electrode (4) arranged between the reservoir (1) and the network of microchannels (2) or at the same location as the network of microchannels (2), said electrode (4) being capable of generating an electric field so as to destroy the biological element during its passage to the reservoir (1).
    Type: Application
    Filed: March 12, 2020
    Publication date: May 5, 2022
    Applicants: UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
    Inventors: Benoît CHARLOT, Jean-Marie RAMIREZ, Sébastien MEANCE, Xavier GARRIC, Coline PINESE, Isabelle GUIRAUD
  • Publication number: 20220131624
    Abstract: A wave shaping device which comprises a tunable impedance surface and a controller connected to the surface in order to control its impedance. The shaping device further comprises a transmission module for receiving a pilot signal used to control the impedance of the surface.
    Type: Application
    Filed: January 10, 2022
    Publication date: April 28, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, UNIVERSITE PARIS DIDEROT - PARIS 7
    Inventors: Mathias Fink, Geoffroy Lerosey, Matthieu Dupre, Nadége Kaina
  • Publication number: 20220127736
    Abstract: The present invention relates to an electrolysis device comprising an anode and a cathode, wherein the anode and the cathode each are an electrode comprising an electrically conductive support of which at least a part of the surface is covered by a metal deposit of copper, wherein the surface of the metal deposit is in an oxidized, sulfurated, selenated and/or tellurized form and the metal deposit has a specific surface area greater than or equal to 1 m2/g. The present invention relates also to a method for reducing CO2 into hydrocarbons using an electrolysis device according to the invention. The method according to the invention comprises: a) providing an electrolysis device according to the invention; b) exposing the cathode of said electrolysis device to a CO2-containing aqueous catholyte solution; c) exposing the anode of said electrolysis device to an aqueous anolyte solution; and d) applying an electrical current between the anode and the cathode in order to reduce the carbon dioxide into hydrocarbons.
    Type: Application
    Filed: November 21, 2019
    Publication date: April 28, 2022
    Applicants: Paris Sciences et Lettres - Quartier Latin, College de France, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite, College de France
    Inventors: Marc Fontecave, Victor Mougel, Huan Tran Ngoc, Daniel Alves Dalla Corte, Sarah Lamaison, Lukas Lutz
  • Patent number: 11311848
    Abstract: A bladeless mixer for mixing a liquid, includes a cylindrical or truncated cone-shaped receptacle having an axis A and a radius R, the radius R being the shortest distance between the axis A and a side wall of the receptacle, the liquid to be mixed being placed in the receptacle and having an exposed surface at a height H measured along axis A; a member for tilting the receptacle such that axis A forms a non-zero-degree angle of up to 30° relative to the vertical direction; a member for imparting a rotational movement to the receptacle along axis A at an angular speed of rotation ?; wherein the aspect ratio H/R of the height H to the radius R and the angular speed of rotation ? are selected such that an inherent mode of inertia of the liquid has an unstable resonance when the receptacle is tilted and rotates.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: April 26, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DAIX MARSEILLE, ECOLE CENTRALE DE MARSEILLE
    Inventors: Patrice Meunier, Richard Manasseh
  • Patent number: 11311484
    Abstract: The present invention relates to a method for treating skin afflictions in a subject comprising a step of administering said subject with a therapeutically effective amount of small extracellular vesicles (sEV) comprising CD98hc. Inventors have demonstrated that healthy dermal fibroblasts produced and secreted EVs bearing characteristic of exosome-like small EVs (sEVs). They have shown that CD98hc was present at the surface of sEVs, transferred and stabilized at the plasma membrane of recipient cells. They observed that the transferred protein was functional both in vitro and in vivo. Furthermore, injection of sEVs in epidermal CD98hc KO mice exhibiting wound healing defect rescued wound closure in vivo. Thus, their findings reveal that CD98hc contained in EVs could potentially be used in vivo to treat and improve multiple skin afflictions by allowing protein rescue.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: April 26, 2022
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université Nice Sophia Antipolis, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Chloé Feral, Floriane Tissot, Laurence Cailleteau, Soline Estrach
  • Patent number: 11300568
    Abstract: The present invention relates to the diagnosis of gastrointestinal stromal tumors (GISTs). The present invention also relates to methods and compositions for the treatment of gastrointestinal stromal tumors (GISTs).
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: April 12, 2022
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Pascal De Santa Barbara, Sandrine Faure-De Santa Barbara
  • Publication number: 20220098552
    Abstract: The method for tin vitro or ex vivo amplification of human adipose tissue stem cells includes: —extracting a stromal vascular fraction of a human adipose tissue including endothelial cells of the human adipose tissue vascular network and human adipose tissue stem cells, and an extracellular matrix of the human adipose tissue, the extracellular matrix including endothelial cells of the human adipose tissue vascular network, human adipose tissue stem cells and collagen; —mixing the stromal vascular fraction and the extracellular matrix; and—culturing the mixture obtained in the preceding step, in suspension, in a culture medium.
    Type: Application
    Filed: January 13, 2020
    Publication date: March 31, 2022
    Applicants: UNIVERSITÉ CÔTE D'AZUR, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), CHU DE NICE
    Inventors: Christian Dani, Alain Doglio, Vincent Dani-Davesne, Philippe Letertre
  • Publication number: 20220100050
    Abstract: A method for frequency-converting a source optical signal in order to produce a useful optical signal, by mixing a plurality of waves, implements a plurality of waveguides that are coupled together. Individual parameter values of the waveguides, as well as at least one coupling parameter, are selected so as to obtain the useful signal with a high intensity. Such a method for producing the useful signal is suitable for a spectroscopic application, in particular a molecular spectroscopy application.
    Type: Application
    Filed: January 15, 2020
    Publication date: March 31, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, UNIVERSITE DE BOURGOGNE
    Inventors: Pierre COLMAN, Alexandre PARRIAUX, Kamal HAMMANI, Guy MILLOT
  • Patent number: 11285219
    Abstract: The present description relates to peptidomimetic foldamers, and their synthesis. In particular, the description provides peptide-amino urea hybrid peptidomimetic foldamers comprising an alpha amino acid peptide portion and an oligourea portion.
    Type: Grant
    Filed: January 16, 2020
    Date of Patent: March 29, 2022
    Assignees: UREKA SARL, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Robert H. Zimmer, Gilles Guichard, Juliette Fremaux, Sebastien Goudreau, Claire Venin, Laura Mauran
  • Patent number: 11278631
    Abstract: The invention is directed to the field of gene therapy, i.e. gene delivery into target cells, tissue, organ and organism, and more particularly to gene delivery via viral vectors. The inventors showed that it is possible by chemical coupling to modulate the coupling of a ligand in the surface of the capsid of AAV, for example AAV2 and AAV3b. In particular, the present invention relates to a recombinant Adeno-Associated Virus (rAAV) vector particle having at least one primary amino group contained in the capsid proteins, chemically coupled with at least one ligand L, wherein coupling of said ligand L is implemented through a bond comprising a —CSNH— bond and an optionally substituted aromatic moiety. Particularly, the inventors tested the chemical coupling of mannose ligand on AAV2 for subretinally injection to rats.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: March 22, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE NANTES, CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
    Inventors: Mathieu Mevel, David Deniaud, Eduard Ayuso
  • Patent number: 11274127
    Abstract: An engineered adenovirus penton base protomer, wherein the penton base protomer comprises a first RGD-loop, a second RGD-loop, a variable loop (V loop), an Adenovirus fiber protein binding cleft, and an N-terminal domain; wherein at least one of the first RGD-loop, the second RGD-loop, and the V loop comprises at least one inserted non-adenoviral antigenic polypeptide; and wherein the engineered adenovirus penton base protomer is capable of assembling into virus-like particles (VLPs).
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: March 15, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), THE EUROPEAN MOLECULAR BIOLOGY LABORATORY
    Inventors: Imre Berger, Frédéric Garzoni, Pascal Fender
  • Patent number: 11266986
    Abstract: The present invention relates to a method for manufacturing a microfluidic device. The microfluidic device includes an input zone adapted to receive a carrier fluid medium and a sample in suspension in the carrier fluid medium, the sample comprising at least one population of cells or microparticles, a confinement zone adapted to confine a selected amount of the sample, and an output zone adapted to discharge the carrier fluid medium and the sample in suspension in the carrier fluid medium.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: March 8, 2022
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Grenoble Alpes
    Inventors: Thibault Honegger, Benoît Maisonneuve
  • Patent number: 11266754
    Abstract: Disclosed are chelates resulting from the complexation of bifunctional do2pa derivatives ligands of formula (I), wherein the substituents R1, R1?, R2, R2?, R3, R3?, L1, L1?, L2 and L2? are defined as in the claims, with metallic cations, especially Pb(II) and Bi(III). Also disclosed are bifunctional do2pa derivatives ligands of formula (I), as well as the use of chelates in nuclear medicine and the use of ligands in cations detection or epuration of effluents.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: March 8, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉDE BRETAGNE OCCIDENTALE
    Inventors: Fatima Oukhatar, Maryline Beyler, Raphaël Tripier
  • Publication number: 20220069306
    Abstract: A negative electrode active material for a lithium-ion battery has the following formula (I): Li1-xOHFe1+xS (I). x varies from 0.00 to 0.25, preferably from 0.05 to 0.20.
    Type: Application
    Filed: December 18, 2019
    Publication date: March 3, 2022
    Applicants: RENAULT s.a.s, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Ecole Nationale Superieure de Chimie de Paris
    Inventors: Philippe BARBOUX, Mohamed CHAKIR, Domitille GIAUME, Caroline MIR
  • Publication number: 20220053766
    Abstract: A process for preparing a biocidal, bactericidal and/or bacteriostatic material including the preparation of a polymer precursor solution that has (a) at least one monomer A having a porphyrin group and at least one radical polymerizable function, (b) at least one radical polymerizable monomer B, a photoinitiator, and (c) at least one of the monomers chosen from a monomer C having a quaternary amine and a radical polymerizable function; and/or a monomer D having copper and a radical polymerizable function. Also, the material obtainable by the process and its uses.
    Type: Application
    Filed: December 19, 2019
    Publication date: February 24, 2022
    Applicants: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (CEA), CONSERVATOIRE NATIONAL DES ARTS ET METIERS (CNAM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS).
    Inventors: Thomas BERTHELOT, Céline GOULARD-HUET, Fanny HAUQUIER
  • Publication number: 20220054424
    Abstract: The treatment of cancer using platinum-based compounds includes certain drawbacks such as biocompatibility, loading efficacy, leakage of drugs during storage and in the bloodstream, more particularly due to the nature of the nanocarriers for platinum delivery. A nanosystem that allows improving platinum-based drug in vivo performance, kinetics and efficacy. In particular, nanoparticles useful as drug delivery system, these nanoparticles being formed from at least: (a) platinum-based drug, (b) poly-L-arginine, and (c) hyaluronic acid. Particularly, these nanoparticles have been tested in terms of entrapment efficiency and also carried out in vitro experiments in 2D cell culture (viability studies on B6KPC3, A549 and HT-29 cells) and 3D cell model (spheroids made of HTC-116) and in vivo experiments (by injecting intravenously to mice the nanoparticles or comparative oxaliplatin solution) to prove their efficiency.
    Type: Application
    Filed: September 16, 2019
    Publication date: February 24, 2022
    Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, UNIVERSITE D'ANGERS, CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERS
    Inventors: Giovanna LOLLO, Jean-Pierre BENOIT, Marie BRACHET - BOTINEAU
  • Patent number: 11253674
    Abstract: An in-ear stimulation system including a first device configured to be worn at least partially in a first ear canal of a subject and a second device configured to be worn at least partially in a second ear canal of the subject. Each of the first device and the second device includes: at least one in-ear active electrode configured to receive a bio-signal and at least one in-ear reference electrode configured to receive a bio-signal; at least one stimulation device configured for emitting at least one electrical or sensory stimulus; and an electronic system configured to detect at least one bio-signal pattern from the bio-signals measured from the electrodes.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: February 22, 2022
    Assignees: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE, APHP (ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), SORBONNE UNIVERSITE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE)
    Inventors: Michel Le Van Quyen, Alexis Genin, Alexis Steiner, Mario Valderrama, Miguel Navarrete
  • Patent number: 11253537
    Abstract: Polypeptides having the ability to specifically form connections of glucosyl units in alpha 1,3 on an acceptor having at least one hydroxyl moiety are presented. The polypeptides include i) the pattern I of sequence SEQ ID NO: 1, ii) the pattern II of sequence SEQ ID NO: 2, iii) the pattern III of sequence SEQ ID NO: 3, and iv) the pattern IV of sequence SEQ ID NO: 4, or derivates from one or several of said patterns, wherein the polypeptide furthermore has an aspartic residue (D) at position 5 of the pattern II (SEQ ID NO: 2), a glutamic acid residue (E) at position 6 of the pattern III (SEQ ID NO: 3) an an aspartic acid residue (D) at position 6 of the pattern IV (SEQ ID NO: 4). Methods for producing acceptors connected to glucosyl units in alpha 1,3 using the polypeptides are also provided.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: February 22, 2022
    Assignees: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Magali Remaud-Simeon, Marlene Vuillemin, Claire Moulis, Pierre Monsan, Sandrine Morel
  • Patent number: 11253835
    Abstract: The present invention relates to a microfluidic or millifluidic device (1) comprising: —a support (2) made at least partially of a dielectric material, the support (2) comprising a first inlet (21a) adapted to be connected to a first reservoir containing gas, a second inlet (21b) adapted to be connected to a second reservoir containing liquid, an outlet (22) adapted to be connected to a receiver container containing gas and/or liquid, and a main microchannel or millichannel (3) present in the dielectric material allowing the liquid and the gas to flow from the inlets towards the outlet, —one or several ground electrode(s) (4) embedded in said dielectric material and extending along the main microchannel or millichannel (3), and —one or several high-voltage electrode(s) (5) embedded in said dielectric material and extending along the main microchannel or millichannel (3), wherein the high-voltage electrode(s) (5) and the ground electrode(s) (4) are located on opposite sides of the main microchannel or millicha
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: February 22, 2022
    Assignees: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite
    Inventors: Michael Tatoulian, Stéphanie Ognier, Mengxue Zhang