Patents Assigned to Centre National de la Recherche Scientifique (Cnrs)
  • Patent number: 10047156
    Abstract: The invention provides an isolated antibody or a fragment thereof, which is directed to the human chemokines CXCL1, CXCL7 and CXCL8, said antibody or fragment being capable of binding to the human chemokine CXCL1 with an equilibrium dissociation constant (KD) of at most 16 nM, to the human chemokine CXCL7 with an equilibrium dissociation constant (KD) of at most 5 nM and to the human chemokine CXCL8 with an equilibrium dissociation constant (KD) of at most 45 nM, as determined by surface plasmon resonance. The invention also provides some applications of said isolated antibody.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: August 14, 2018
    Assignees: Centre National De La Recherche Scientifique (CNRS), Universite de Nice Sophia Antipolis
    Inventors: Gilles Pages, Renaud Grepin
  • Publication number: 20180220936
    Abstract: A method is provided for characterising a gait comprising steps of: receiving a signal measuring the movement of a target subject measured beforehand; comparing (204) at least one section of the measuring signal with a plurality of reference signals, the plurality of reference signals comprising at least one movement signal measured beforehand on a reference subject different from the target subject, each comparison of the measuring signal with a reference signal producing a similarity coefficient representative of a probability of similarity between the compared signals; and selecting (208) at least one local maximum of interest among the similarity coefficients produced, wherein the plurality of reference signals comprises at least one movement signal measured beforehand on a reference subject afflicted with a gait disorder, and at least one movement signal measured beforehand on a healthy reference object.
    Type: Application
    Filed: August 5, 2016
    Publication date: August 9, 2018
    Applicants: Universite Paris Descartes, Centre National de la Recherche Scientifique (CNRS), Ecole Normale Superieure De Cachan, Etat Français - Ministére de la Défense - Direction centrale du service de santé des armées, Univ Paris XIII Paris-Nord Villetaneuse
    Inventors: Robert Dadashi, Thomas Moreau, Charles Truong, Catherine De Waele, Alain Yelnik, Rémi Barrois-Muller, Nicolas Vayatis, Laurent Oudre, Pierre Paul Vidal, Damien Ricard
  • Publication number: 20180221313
    Abstract: The present invention relates to the use of hydroxycarbamide (HC) for reducing and/or delaying the extension of capillary nonperfusion, a cause of irreparable visual impairment in patients suffering from central retinal vein occlusion (CRVO). This is the first systemic treatment which makes it possible to reduce retinal ischemic complications in patients in whom (CRVO) has been recently diagnosed and is consequently in a rapidly progressive phase. Given the low toxicity of HC evaluated on a large scale in children and adults in the context of other diseases for decades, the results of the present study open up a new therapeutic approach in the treatment of CRVO.
    Type: Application
    Filed: August 8, 2016
    Publication date: August 9, 2018
    Applicant: Centre National De La Recherche Scientifique (CNRS)
    Inventors: Yves COLIN, Jean-Francois GIRMENS, Olivier HERMINE, Emmanuel HERON, Michel PAQUES
  • Publication number: 20180216138
    Abstract: The present invention relates to a novel polypeptide having the enzymatic activity of reduction of NADP+ using electrons from reduced ferredoxin (Ferredoxin-NADP+ reductase activity), a polynucleotide having a nucleotide sequence encoding such polypeptide and uses thereof. The invention relates to the modulation of the Ferredoxin NADP+ reductase activity in a microorganism by varying the expression level of the polynucleotide coding for such polypeptide. The invention also relates to the production of commodity chemicals, especially ethanol, n-butanol, 1,3-propanediol, 1,2-propanediol, isopropanol and acetone by fermenting microorganisms wherein their Ferredoxin NADP+ reductase activity is modulated.
    Type: Application
    Filed: July 22, 2016
    Publication date: August 2, 2018
    Applicants: Institut National des Sciences Appliquees, Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique
    Inventors: Philippe Soucaille, Isabelle Meynial-Salles, Céline Foulquier, Antoine Riviere
  • Publication number: 20180217051
    Abstract: The invention relates to an acoustic-optical imaging method and system of a zone for observing an environment. The system includes an acquisition device comprising, a network of transducers for generating a plurality of non-focussed sound waves, a light-emitting device for emitting an incident light wave and generating marked light waves comprising an acoustic-optical component that is shifted in frequency by the non-focussed sound waves, and a detector for acquiring measurement signals. The system also comprises a processing device for determining a light intensity in the observation zone from the measurement signals.
    Type: Application
    Filed: June 2, 2015
    Publication date: August 2, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE- INSERM
    Inventors: François Ramaz, Mickaël Tanter, Jean-Baptiste Laudereau, Jean-Luc Gennisson
  • Publication number: 20180217384
    Abstract: Device for shaping a laser beam for an atomic sensor, comprising a retroreflector prism with an entrance area, an exit area and two reflection surfaces forming a right angle therebetween. The device for shaping includes a linear polarizer disposed upstream from the entrance area of the retroreflector prism for linearly polarizing a laser beam entering into the retroreflector prism by the entrance area, and a form birefringence plate disposed downstream from the exit area of the retroreflector prism to circularly polarize a laser beam exiting from the retroreflector prism by the exit area.
    Type: Application
    Filed: July 21, 2016
    Publication date: August 2, 2018
    Applicants: Centre National de la Recherche Scientifique - CNRS, Universite de Franche Comte
    Inventors: Nicolas Passilly, Christophe Gorecki, Vincent Maurice
  • Publication number: 20180207423
    Abstract: Disclosed is a method for processing asynchronous signals generated by a light sensor, the sensor having a matrix of pixels, the method including: —receiving the asynchronous signals, each signal being associated with a pixel in a group of pixels in the matrix, each signal including successive events issued by the associated pixel; —upon an occurrence of an event in one of the asynchronous signals, updating an integration value associated to the group by adding an additive value to the integration value; —if the integration value is greater than a predetermined threshold, generating an event in an outputted asynchronous signal.
    Type: Application
    Filed: July 18, 2016
    Publication date: July 26, 2018
    Applicants: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Ryad BENOSMAN, Francesco GALLUPI, Guillaume CHENEGROS, Xavier LAGORCE, Christoph POSCH
  • Publication number: 20180209969
    Abstract: The invention relates to a method of identifying molecules which inhibit the virulence machinery of Pseudomonas aeruginosa, to a device for identifying a molecule which inhibits the virulence machinery of Pseudomonas aeruginosa, to novel compounds which inhibit the virulence machinery of Pseudomonas aeruginosa, to compounds for use for preventing and/or treating a pathogenic infection caused by Pseudomonas aeruginosa and also to pharmaceutical compositions for preventing and/or treating a pathogenic infection caused by Pseudomonas aeruginosa.
    Type: Application
    Filed: July 12, 2016
    Publication date: July 26, 2018
    Applicants: Centre National de la Recherche Scientifique (CNRS), Commissariat A L'Energie Atomique et Aux Energies Alternatives
    Inventors: Yung-Sing Wong, Sophie Ple, Ina Attree, Caroline Barette
  • Publication number: 20180210403
    Abstract: The invention relates to a gas cell for an atomic sensor, comprising an optical cavity provided with at least one optical window (9) and fillable with a gas. The cell also comprises a sealing cup comprising a cavity mouth, a channel mouth, and a sealing access, as well as a membrane which hermetically closes the sealing access of the sealing cup. The membrane can be plastically deformed by heating so as to hermetically close the cavity mouth and/or the channel mouth, in such a way as to hermetically separate the optical cavity from the gas inflow channel.
    Type: Application
    Filed: July 13, 2016
    Publication date: July 26, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, UNIVERSITE DE FRANCHE COMTE
    Inventors: Vincent Maurice, Nicolas Passilly, Christophe Gorecki
  • Patent number: 10031326
    Abstract: According to one aspect, the invention concerns a method for microscopy of a thick sample arranged on a sample support, with edge-illumination of the sample. The method comprises, in particular, emitting at least one illumination beam (1), forming, from the illumination beam, an illumination surface, focusing the illumination surface in the sample by means of a microscope lens (120) and deflecting the illumination surface originating from the microscope lens, in order to form a transverse illumination surface, located in a plane substantially perpendicular to the optical axis of the microscope lens.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: July 24, 2018
    Assignees: IMAGINE OPTIC, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Université de Bordeaux
    Inventors: Xavier Levecq, Virgile Viasnoff, Jean-Baptiste Sibarita, Vincent Studer, Rémi Galland
  • Patent number: 10028871
    Abstract: A method for electrically assisting with the propulsion of a rolling system comprising a driving wheel driven by an electric motor, the torque applied by the motor being a function of a propulsion torque transmitted by a user to the driving wheel, wherein the method comprises: a preliminary step of storing in memory an unknown input model representing the weighted system, which is a function of the geometry and of the mass of the weighted system, and having as output data the rotational speed of the driving wheel; a step of estimating unknown input being the total torque applied to the wheel, influencing the rotational speed, the total torque being estimated from the rotational speed by calculating the inverse model; the propulsion torque transmitted by the user being deduced from the total torque estimated on the basis of the other known torques that make up the total torque.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: July 24, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Université de Valenciennes et du Hainaut Cambresis
    Inventors: Sami Mohammad, Thierry-Marie Guerra, Philippe Pudlo
  • Publication number: 20180200408
    Abstract: The present invention relates to hydrogels prepared using silylated organic molecules (such as silylated biomolecules), a method for obtaining same, and uses thereof.
    Type: Application
    Filed: July 7, 2016
    Publication date: July 19, 2018
    Applicants: Universite de Montpellier, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Jean Martinez, Ahmad Mehdi, Gilles Subra, Said Jebors, Cécile Echalier
  • Publication number: 20180192990
    Abstract: In order to obtain a predetermined ultrasonic wave field in a homogeneous internal part of a medium masked by an aberrating barrier, an ultrasonic lens is interposed between the emitting ultrasonic probe and the aberrating barrier. The ultrasonic lens is calculated by using a model of the medium comprising a mapping of ultrasonic wave propagation properties obtained from actual imaging of the medium such that when the ultrasound probe sends a predetermined ultrasonic wave, said predetermined wave generates the predetermined objective ultrasonic wave field in the medium.
    Type: Application
    Filed: June 30, 2016
    Publication date: July 12, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
    Inventors: Mickaël Tanter, Jean-François Aubry, Thomas Deffieux, Mathieu Pernot
  • Patent number: 10016424
    Abstract: The present invention relates to a compound which is an antagonist of the GluK2/GluK5 receptor or an inhibitor of the GluK2/GluK5 receptor expression for use in the treatment or the prevention of epilepsy.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: July 10, 2018
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BORDEAUX
    Inventors: Valerie Crepel, Christophe Mulle, Angelique Peret
  • Patent number: 10017559
    Abstract: The invention relates to the identification of a highly stable single domain antibody scaffold (hs2d Ab) and its use in generating synthetic single domain antibody library (hs2d Ab-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: July 10, 2018
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, INSTITUT CURIE, UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Aurellen Olichon, Sandrine Moutel, Franck Perez
  • Publication number: 20180186934
    Abstract: The present invention relates to a cross-linkable composition comprising: i) a fluorinated ?,?-bis(propargyl) oligomer of formula (I): in which m is 1 to 100, e.g. 1 to 93, n is 2 to 150, e.g. 1 to 128, p is 0 to 2 preferably 0 or 1.75, and, n, m and p are selected such that the fluorinated ?,?-bis(propargyl) oligomer of formula (I) has a number average molar mass Mn of 400 to 25000; ii) a cross-linking agent comprising at least three azide-N3 groups; and iii) optionally, a fluorinated oligomer comprising two terminal azide-N3 or fluorinated ?,?-bis(azide) oligomer groups. The invention also relates to a material comprising the click chemistry reaction product of the cross-linkable composition of the invention, to a method for preparing said material and to the uses thereof.
    Type: Application
    Filed: July 1, 2016
    Publication date: July 5, 2018
    Applicants: SAFRAN ELECTRICAL & POWER, UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Mathieu CHARLAS, Donatien Henri Edouard MARTINEAU, Gerald Pierre Maurice LOPEZ, Jean-Pierre HABAS, Bruno AMEDURI
  • Patent number: 10011852
    Abstract: The present invention relates to the biological production of methane (Biogas) by co-culture in an aerobic atmosphere of a methanogenic bacterium and of an anaerobic bacterium capable of producing hydrogen, in a culture medium comprising or being supplemented with carbohydrate compound(s), notably starch and/or sugars, and supplemented with antioxidant compound(s).
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: July 3, 2018
    Assignees: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Didier Raoult, Saber Khelaifia, Michel Drancourt
  • Patent number: 10004780
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of age-related macular degeneration (AMD). In particular the present invention relates to RdCVFL polypeptide or polynucleotide for use in the treatment of AMD.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: June 26, 2018
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Thierry Leveillard, Jose-Alain Sahel, Therese Cronin, Leah Byrne, Ram Fridlich
  • Publication number: 20180172974
    Abstract: The invention relates to an optical device for measuring the position of an object along a first axis, the object being subjected to light radiations emitted by a light source.
    Type: Application
    Filed: February 15, 2018
    Publication date: June 21, 2018
    Applicants: Paris Sciences Et Lettres - Quartier Latin, Centre National de la Recherche Scientifique (CNRS), Universite Pierre Et Marie Curie (Paris 6), Universite Paris Diderot Paris 7
    Inventors: Vincent Croquette, Jean-François Allemand, Thibault Vielle
  • Publication number: 20180171134
    Abstract: The invention relates to a process for reducing the defectivity of a block copolymer (BCP1) film, the lower surface of which is in contact with a preneutralized surface (N) of a substrate (S) and the upper surface of which is covered by an upper surface neutralization layer (TC) in order to make it possible to obtain an orientation of the nanodomains of the block copolymer (BCP1) perpendicularly to the two lower and upper interfaces, where the upper surface neutralization layer (TC) employed to cover the upper surface of the block copolymer (BCP1) film comprises a second block copolymer (BCP2).
    Type: Application
    Filed: May 26, 2016
    Publication date: June 21, 2018
    Applicants: ARKEMA FRANCE, INSTITUT POLYTECHNIQUE DE BORDEAUX, UNIVERSITE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Xavier Chevalier, Celia NICOLET, Christophe NAVARRO, Georges HADZIIOANNOU