Patents Assigned to Centre National de la Recherche Scientifique (Cnrs)
  • Patent number: 10843191
    Abstract: An object is to stably, continuously and easily detect reactions of filamentary biomolecules or polymers bridging between a pair of electrodes against reagents without employing any marker or labeling substances.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: November 24, 2020
    Assignee: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Hiroyuki Fujita, Mehmet Cagatay Tarhan, Nicolas Lafitte, Dominique Collard
  • Patent number: 10845333
    Abstract: An object is to make a bridge of DNA expanding between a pair of electrodes, and to characterize the bridge of DNA, to thereby detect DNA easily and surely without employing any marker or labeling substances, such as fluorescent reagents. A method of detecting DNA using a detection device with at least a couple of electrodes, the method comprising immobilizing a primer on the electrodes; making a bridge of the DNA expanded between the electrodes, by immersing the electrodes in a solution including circular templates of single stranded DNA, annealing the circular templates, and generating single stranded DNA product utilizing RCA (Rolling Circle Amplification), with impressing a designated voltage between the electrodes; and characterizing the bridge of DNA which includes multiple single stranded DNA molecules between the electrodes.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: November 24, 2020
    Assignees: The Foundation for the Promotion of Industrial Science, Neuroindx, Inc., Centre National de la Recherche Scientifique (CNRS)
    Inventors: Hiroyuki Fujita, Stanislav L. Karsten, Dominique Collard, Momoko Kumemura
  • Publication number: 20200359992
    Abstract: The invention relates to a method for characterising bone, the method comprising the steps of receiving (102) ultrasonic wave echo signals transmitted into a body, determining (104) a speed of sound in the body's non-bone biological tissue, locating (106) a first demarcation curve between non-bone biological tissue and bone in an image of the body constructed during said determining step, and determining (108) a speed of sound in bone. The steps of determining speed include constructing images from the signals, and a metric calculation indicative of a focus quality in the constructed images.
    Type: Application
    Filed: July 19, 2018
    Publication date: November 19, 2020
    Applicants: Sorbonne University, Centre National de la Recherche Scientifique (CNRS), Institut National de la Sante et de la Recherche Medicale (INSERM), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris
    Inventors: Guillaume RENAUD, Didier CASSEREAU
  • Patent number: 10836940
    Abstract: The present invention relates to a cooling mixture comprising a fluorinated compound and a non-fluorinated compound, wherein the fluorinated compound is a hydrofluoroether and the non-fluorinated compound includes a carbonyl function, which has a flash point no lower than 23° C. and which is characterised by having low relative volatility. The present invention likewise relates to the use of such a mixture as a coolant in a heat-exchange device.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: November 17, 2020
    Assignees: Safran Electrical & Power, Centre National de la Recherche Scientifique (CNRS), INSTITUT NATIONAL POLYTECHNIQUE de TOULOUSE, UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE LILLE
    Inventors: Nicolas Delalandre, Benjamin Roland Stanislas Joossen, Jean-Marie Aubry, Vincent Gerbaud, Ivonne Rodriguez-Donis
  • Patent number: 10837044
    Abstract: The present invention relates to a method of interpreting different antibiogram images in which it is possible to recognize a phenotype of bacterial resistance relative to antibiotics by comparing photographs using a photographic image bank of the reference antibiogram without any need to interpret them using the EUCAST or CA-SFM interpretation data; providing that for a given phenotype, there is available a collection of photographs of a plurality of bacteria of the same species and of the same phenotype.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: November 17, 2020
    Assignees: FONDATION MEDITERRANEE INFECTION, UNIVERSITE D'AIX MARSEILLE, ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Jean-Marc Rolain, Didier Raoult, Stéphanie Le Page, Sylvain Buffet
  • Patent number: 10829598
    Abstract: The present invention relates to a process for preparing a polymer/biological entities alloy, comprising a step of mixing a polymer and biological entities that degrade it, during a heat treatment, said heat treatment being performed at a temperature T above room temperature and said biological entities being resistant to said temperature T, characterized in that said biological entities are chosen from enzymes that degrade said polymer and microorganisms that degrade said polymer.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: November 10, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITE DE POITIERS, VALAGRO CARBONE RENOUVELABLE POITOU-CHARENTES
    Inventors: Thierry Ferreira, Frederic Bataille, Cedric Dever, Jacques Barbier
  • Patent number: 10828309
    Abstract: The present invention relates to the cosmetic or pharmaceutical use for a composition comprising a salicylic or nicotinic acid derivative inhibiting chemokines, for preventing or treating chronic internal and/or external inflammatory conditions.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: November 10, 2020
    Assignees: GREENPHARMA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE STRASBOURG
    Inventors: Philippe Bernard, Dayana Abboud, Jean-Luc Galzi, Nelly Frossard, Christelle Pillard, Quoc Tuan Do
  • Patent number: 10823805
    Abstract: In a method and magnetic resonance (MR) apparatus for MR image reconstruction, an image reconstruction algorithm is used that operates on one calibration matrix that is formed by reorganizing a number of individual, undersampled k-space data sets respectively acquired by multiple reception coils in a parallel MR data acquisition from a subject exhibiting motion. The motion causes the k-space data sets to exhibit errors. In order to use the calibration matrix in the reconstruction algorithm, it is subjected to an iterative rank reduction procedure in which, in each iteration, a residual is calculated for each data point that represents how poorly, due to motion-induced corruptions, that data point satisfies the low rank constraint, and non-satisfying data points are removed from the data point for the next iteration. The resulting low rank matrix at the end of the iterations is then used to produce images with fewer motion-induced errors.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: November 3, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ D'AIX-MARSEILLE
    Inventors: Mark Bydder, Olivier Girard, Stanislas Rapacchi
  • Patent number: 10818329
    Abstract: A magnetic tunnel junction with out-of-plane magnetisation includes a storage layer; a reference layer; and a tunnel barrier layer. The two magnetisation states of the storage layer are separated by an energy barrier including a contribution due to the shape anisotropy of the storage layer and a contribution of interfacial origin for each interface of the storage layer. The storage layer has a thickness comprised between 0.8 and 8 times a characteristic dimension of a planar section of the tunnel junction. The contribution to the energy barrier due to the shape anisotropy of the storage layer is at least two times greater and preferably at least 4 times greater than the contributions to the energy barrier of interfacial origin.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: October 27, 2020
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT POLYTECHNIQUE DE GRENOBLE
    Inventors: Nicolas Perrissin-Fabert, Bernard Dieny, Lucian Prejbeanu, Ricardo Sousa
  • Patent number: 10816560
    Abstract: The present invention relates to a method to analyse the ability of a substance (3) to cross a bilayer membrane comprising the following steps: (i) providing in a hydrophobic medium (1) a first droplet D1 of an aqueous solution AS1, wherein the droplet D1 is surrounded by a monolayer of amphiphilic molecules (2), (ii) providing in the said hydrophobic medium (1) a second droplet D2 of an aqueous solution AS2 containing the substance (3) to be analysed, wherein the droplet D2 is surrounded by a monolayer of amphiphilic molecules (2), (iii) putting the first droplet D1 and the second droplet D2 into contact so as to form a bilayer of amphiphilic molecules (2) in the contact area and to have a contact angle 2? between the two droplets D1 and D2 comprised between 10° and 180°, (iv) adding to the hydrophobic medium (1) a solvent capable of separating the droplets D1 and D2 put into contact, (v) collecting the droplet D1, and (vi) analysing the content of the droplet D1 in order to determine the presence or not of
    Type: Grant
    Filed: July 4, 2017
    Date of Patent: October 27, 2020
    Assignees: Paris Sciences Et Lettres—Quartier Latia, Universite Paris Diderot Paris 7, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite
    Inventor: Abdou Rachid Thiam
  • Publication number: 20200335641
    Abstract: A shielding element comprises a rigid substrate and at least one electrically conductive two-dimensional structure which is placed on one of the faces of the substrate. The substrate and the electrically conductive two-dimensional structure are such that the shielding element has optical-transmission and shielding-efficiency values at least one of which varies between two zones of the shielding element. Such a shielding element enables easier assembly of a detection system comprising multiple optical sensors.
    Type: Application
    Filed: May 22, 2017
    Publication date: October 22, 2020
    Applicants: SAFRAN ELECTRONICS & DEFENSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, UNIVERSITE DE RENNES 1
    Inventors: Cyril DUPEYRAT, Patrice FOUTREL, Philippe BESNIER, Xavier CASTEL, Yonathan CORREDORES
  • Publication number: 20200331852
    Abstract: The invention relates to a process for preparing methyl mercaptan from a mixture of carbon oxide, hydrogen sulfide and hydrogen, in the presence of a catalyst based on molybdenum and potassium supported on zirconia, said catalyst not comprising any promoter.
    Type: Application
    Filed: December 20, 2018
    Publication date: October 22, 2020
    Applicants: Arkema France, Université Lille 1 - Sciences et Technologies, Centre National De La Recherche Scientifique-CNRS
    Inventors: Georges FRÉMY, Hélori SALEMBIER, Carole LAMONIER, Pascal BLANCHARD
  • Patent number: 10799673
    Abstract: The present invention relates to a single-lumen vascular catheter to be inserted into a blood flow channel for the injection of a product by the venous or arterial route, comprising a tube having a hollow longitudinal body with a lumen, the lumen extending along the full length of the tube and being intended to permit the injection of a given volume of product at a prescribed flow rate the tube having lateral orifices which are of substantially identical size and are arranged in the longitudinal body substantially symmetrically about the longitudinal axis, near a distal end of the tube, an end surface at the distal end of the tube reducing a total surface area of the lumen starting from the distal end of the tube.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: October 13, 2020
    Assignees: Centre National de la Recherche Scientifique (CNRS), Université de Paris
    Inventors: Gérard Guiffant, Jacques Merckx, Patrice Flaud
  • Publication number: 20200300100
    Abstract: A turbine component such as a turbine blade or a vane of a distributor, which includes a polycrystalline substrate containing grains, the substrate having at least one Ti3AlC2 phase and the mass fraction of the phase of the alloy is greater than 97%, with the average length of the grains is less than 50 ?m, the average width-to-length ratio is between 0.4 and 0.6, and the average mesh volume of the Ti3AlC2 phase is less than 152.4 ?3.
    Type: Application
    Filed: September 21, 2018
    Publication date: September 24, 2020
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), SAFRAN
    Inventors: Pierre SALLOT, Veronique BRUNET, Jonathan CORMIER, Elodie Marthe Bernadette DROUELLE, Sylvain Pierre DUBOIS, Patrick VILLECHAIS
  • Patent number: 10767165
    Abstract: The present invention is in the field of stem cells. Particularly, the present invention relates to a reprogramming method for producing induced pluripotent stem cells (iPSC) by transducing somatic differentiated cells with a viral vector expressing ?133p53? isoform, ?133p53? isoform or both ?133p53? and ?133p53? isoforms; to induced pluripotent stem cells as produced by this method; to uses thereof in cell therapy and as an in vitro model for studying various diseases; and to a method for detecting iPSC.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: September 8, 2020
    Assignee: Centre National de la Recherche Scientifique (CNRS)
    Inventor: Pierre Roux
  • Patent number: 10766873
    Abstract: The present invention relates to compounds of the following general formula (I) or (II): or a pharmaceutically acceptable salt and/or solvate thereof, for use in the treatment and/or in the prevention of ErbB2 dependent cancers, and pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: September 8, 2020
    Assignees: Centre National de la Recherche Scientifique (CNRS), Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Paris Descartes
    Inventors: Sandrine Bourdoulous, Camille Faure
  • Patent number: 10760100
    Abstract: The present invention relates to a novel polypeptide having the enzymatic activity of reduction of NADP+ using electrons from reduced ferredoxin (Ferredoxin-NADP+ reductase activity), a polynucleotide having a nucleotide sequence encoding such polypeptide and uses thereof. The invention relates to the modulation of the Ferredoxin NADP+ reductase activity in a microorganism by varying the expression level of the polynucleotide coding for such polypeptide. The invention also relates to the production of commodity chemicals, especially ethanol, n-butanol, 1,3-propanediol, 1,2-propanediol, isopropanol and acetone by fermenting microorganisms wherein their Ferredoxin NADP+ reductase activity is modulated.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: September 1, 2020
    Assignees: Institut National des Sciences Appliquees, Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique
    Inventors: Philippe Soucaille, Isabelle Meynial-Salles, Céline Foulquier, Antoine Riviere
  • Patent number: 10751385
    Abstract: The present invention relates to the use of gasdermin, in particular of gasdermin A, gasdermin B, gasdermin C, gasdermin D, DFNA5 or DFNB59 (or pejvakin), and more particularly pejvakin for modulating cellular redox homeostasis. A particularly preferred use of gasdermin, in particular of gasdermin A, gasdermin B, gasdermin C, gasdermin D, DFNA5 or DFNB59 (or pejvakin), and more particularly pejvakin in the context of the present invention is as an antioxidant. The present invention also concerns a virally-mediated gene therapy for restoring genetically-impaired auditory and vestibular functions in subjects suffering from an Usher syndrome. More precisely, this gene therapy takes advantage of an AAV2/8 vector expressing at least one USH1 gene product, preferably SANS.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: August 25, 2020
    Assignees: Institut Pasteur, Centre National de la Recherche Scientifique (CNRS), Sorbonne Université, Université Clermont Auvergne
    Inventors: Christine Petit, Paul Avan, Sedigheh Delmaghani, Jean Defourny, Asadollah Aghaie, Saaid Safieddine, Alice Emptoz
  • Publication number: 20200253996
    Abstract: The present invention relates to the compounds of formula (I) below: wherein: X represents an oxygen atom, a sulfur atom, a nitrogen atom or a CH radical, The bond X—Y and Y are absent if X represents an oxygen or sulfur atom, the bond X—Y and Y are present if X represents a nitrogen atom or a CH radical, When present, Y represents a group R if X represents a nitrogen atom, a hydrogen atom or a group —NR1R2 if X represents a CH radical, (Het)Ar is an aromatic ring selected from the group consisting of aryl and heteroaryl groups, R3, R4, R5, R6 represent, independently of one another, a hydrogen atom, a halogen atom, a —NR12R13, a —SR14 group, a —OR14 group or a —CF3 group, When Y is —NR1R2, the groups —NR1R2 and (Het)Ar are in the cis-conformation, or a pharmaceutically acceptable salt thereof, for use in the treatment of proliferative diseases, infectious diseases, allergies, inflammation and/or asthma.
    Type: Application
    Filed: October 1, 2018
    Publication date: August 13, 2020
    Applicants: UNIVERSITE PARIS-SUD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT GUSTAVE-ROUSSY
    Inventors: Samir MESSAOUDI, Mouad ALAMI, Jean-Daniel BRION, Amélie CHABRIER, Adam TELERMAN, Robert AMSON
  • Patent number: 10738291
    Abstract: The present invention relates to the expression and optimisation of enzymes involved in the breakdown of lignocellulosic biomass. The present invention relates to variants of the exoglucanase 2 of Trichoderma reesei, as well as to the use of said variants with improved efficiency in methods for breaking down cellulose and for producing biofuel.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: August 11, 2020
    Assignees: IFP Energies nouvelles, Proteus, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
    Inventors: Cecile Persillon, Christophe Ullmann, Celine Ayrinhac, Olivier Bonzom, Antoine Margeot, Hugues Mathis, Sebastien Fort, Sylvie Armand, Stephanie Pradeau