Patents Assigned to Centre National de la Recherche Scientifique (Cnrs)
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Patent number: 12292372Abstract: The invention relates to a measuring device (10) for measuring physical characteristics of cells. The device (10) comprises: a microfluidic chip (20) provided with a flow channel (22) for allowing cells to flow through; a manipulator (24) configured to apply deformation force to a cell in a continuous flow; and a sensor (26) configured to sense a physical characteristic of the cell. The manipulator (24) and the sensor (26) are configured to define a width (W2) of the flow channel (22) as a gap formed between them. The manipulator (24) is configured to apply the deformation force to the cell by compressing the cell against the sensor (26).Type: GrantFiled: October 6, 2020Date of Patent: May 6, 2025Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), JUNIAInventors: Dominique Collard, Hiroyuki Fujita, Stanislav Karsten, Mehmet Cagatay Tarhan
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Patent number: 12291551Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.Type: GrantFiled: April 8, 2024Date of Patent: May 6, 2025Assignees: Centre National de la Recherche Scientifique (CNRS), Université Paris-SaclayInventors: Aurélie Albertini, Yves Gaudin, Hélène Raux, Laura Belot, Jovan Nikolic
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Patent number: 12291552Abstract: The present invention relates to a chimeric protein comprising at least one human amyloid P component and at least one fragment of an Fc region of a human antibody, the human amyloid P component and the fragment of an Fc region with which it is associated being bound to each other by means of a hinge region.Type: GrantFiled: April 26, 2022Date of Patent: May 6, 2025Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉDE LIMOGESInventors: Christophe De Romeuf, Christophe Sirac, Jean-Claude Brouet
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Multilayer optical device with surface texturing and extended cavities for electromagnetic radiation
Patent number: 12287453Abstract: An optical device suitable for transmitting/reflecting electromagnetic radiation in a wavelength range of the electromagnetic spectrum. The device comprises at least a first coating layer made of a first material, a substrate made of a material different from the first material, and surface texturing forming cavities in the device. A lower layer, disposed directly below the first coating layer, is either a second coating layer made of a material different from the first material or the substrate itself. The lower layer has a predetermined thickness. The optical device has cavities that extend through the first coating layer and are sunk into the lower layer through at least part of its thickness. This structure enhances the optical properties of the device for specific applications in electromagnetic radiation transmission or reflection.Type: GrantFiled: October 26, 2020Date of Patent: April 29, 2025Assignees: Hydromecanique et Frottement, Manutech-USD, Université Jean Monnet Saint-Etienne, Centre National de la Recherche Scientifique (CNRS)Inventors: Thomas Kämpfe, Laurent Dubost, Xxx Sedao -
Patent number: 12285433Abstract: The present invention relates to diltiazem for use as an agent for activating the expression of at least one gene encoding a type III interferon, in the prevention and/or treatment of infections by at least one pathogenic microorganism of the epithelia of the respiratory and/or intestinal tracts.Type: GrantFiled: May 23, 2019Date of Patent: April 29, 2025Assignees: UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYON, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE LAVALInventors: Manuel Rosa-Calatrava, Olivier Terrier, Claire Nicolas De Lamballerie, Guy Boivin, Mario Andres Pizzorno
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Patent number: 12286497Abstract: Process of grafting of a polyethylene-containing material to produce a modified polyethylene composition comprising providing a twin screw extruder with one or more thermal regulation devices; a polyethylene-containing material and a grafting agent and extruding the polyethylene-containing material and the grafting agent to obtain a modified polyethylene composition; the step of extruding comprises a thermal treatment of the polyethylene-containing material by self-heating of the material at a maximum barrel temperature Ts ranging from 315° C. to 410° C. in one or more hot zones of the extruder.Type: GrantFiled: March 2, 2023Date of Patent: April 29, 2025Assignees: TOTALENERGIES ONETECH, UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ JEAN MONNET SAINT-ETIENNE, INSTITUT NATIONAL DES SCIENCES APPLIQUÉES DE LYON (INSA LYON)Inventors: Olivier Lhost, Pascal Navez, Yves Trolez, Philippe Cassagnau, Mohammad Abou-Taha, Karim Delage, Emmanuel Beyou
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Patent number: 12269000Abstract: The present invention relates to a method for producing a colloid comprising functionalised liquid colloidal particles. The invention also relates to such a colloid and to the uses thereof.Type: GrantFiled: May 24, 2019Date of Patent: April 8, 2025Assignees: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Sorbonne UniversiteInventors: Jacques Fattaccioli, Lea Pinon, Lorraine Montel
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Patent number: 12269848Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.Type: GrantFiled: April 8, 2024Date of Patent: April 8, 2025Assignees: Centre National de la Recherche Scientifique (CNRS), Université Paris-SaclayInventors: Aurélie Albertini, Yves Gaudin, Hélène Raux, Laura Belot, Jovan Nikolic
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Patent number: 12269837Abstract: Disclosed are chelates resulting from the complexation of bifunctional do2pa derivatives ligands of formula (I), wherein the substituents R1, R1?, R2, R2?, R3, R3?, L1, L1?, L2 and L2? are defined as in the claims, with metallic cations, especially Pb(II) and Bi(III). Also disclosed are bifunctional do2pa derivatives ligands of formula (I), as well as the use of chelates in nuclear medicine and the use of ligands in cations detection or epuration of effluents.Type: GrantFiled: January 24, 2022Date of Patent: April 8, 2025Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ DE BRETAGNE OCCIDENTALEInventors: Fatima Oukhatar, Maryline Beyler, Raphaël Tripier
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Patent number: 12264180Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.Type: GrantFiled: April 8, 2024Date of Patent: April 1, 2025Assignees: Centre National de la Recherche Scientifique (CNRS), Université Paris-SaclayInventors: Aurélie Albertini, Yves Gaudin, Hélène Raux, Laura Belot, Jovan Nikolic
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Patent number: 12257103Abstract: Method for non-invasively characterizing a heterogeneous medium using ultrasound, comprising a step of generating a series of incident ultrasonic waves, a step of recording an experimental reflection matrix Rui(t) defined between the input emission basis (i) and an output reception basis (u), a step of determining a response REP(r,?r) of the medium between an input virtual transducer (TVin) calculated based on an input focusing of the experimental reflection matrix that creates an input focal spot around a first point (P1), and an output virtual transducer (TVout) calculated based on an output focusing of the experimental reflection matrix that creates an output focal spot around a second point (P2), said response being expressed as a function of a central point (PC) of spatial position (r) in the medium located midway between the first and second points (P1, P2).Type: GrantFiled: July 31, 2020Date of Patent: March 25, 2025Assignees: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de ParisInventors: William Lambert, Alexandre Aubry, Mathias Fink, Laura Cobus
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Patent number: 12252514Abstract: The invention relates to the field of molecular biology and particularly novel genes that encode pesticidal proteins useful for controlling pests, particularly plant pests. These proteins and the nucleic acid sequences that encode them are useful in preparing pesticidal compositions and in the production of transgenic pest-resistant plants.Type: GrantFiled: March 13, 2020Date of Patent: March 18, 2025Assignees: GENECTIVE, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, PCAS, SEMAE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Carine Bonzom-Audiffrin, Wafa Achouak, Mohamed Barakat, Philippe Ortet, David Vallenet, Thierry Heulin, Christophe Sallaud, Mickael Bosio, Virginie Guyon, Wyatt Paul
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Patent number: 12250944Abstract: The present invention relates to the long-term preservation of biological material. More specifically, it concerns a preservation container comprising: a biological container for containing biological material, a first shield configured for absorbing gamma-rays, a second shield configured for absorbing ambient neutrons, said second shield surrounding the biological container, the preservation container being of low-radioactivity background materials, and a method for preserving a biological material, comprising: a) providing a biological material in a confinement container, b) providing the preservation container of the invention, c) placing the confinement container containing the biological material into said preservation container, d) storing said preservation container containing the biological material in a room located under a material attenuating cosmic rays and induced particles, said material having a thickness equivalent to 1 m to 7000 m of water, for attenuating cosmic rays.Type: GrantFiled: October 18, 2018Date of Patent: March 18, 2025Assignees: Centre National de la Recherche Scientifique (CNRS), Institut Pasteur, Université Paris Cité, Groupe Hospitalier Universitaire Paris—Psychiatrie et NeurosciencesInventors: Maurice Chapellier, Fabrice Chretien, Fabrice Piquemal, Pierre Rocheteau, Guillaume Warot, Michel Zampaolo
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Publication number: 20250081706Abstract: The invention refers to an electronic component, in particular an organic electrochemical transistor (OECT) which comprises at least one gate electrode, a source electrode, a drain electrode, a channel and an electrolyte. The electrolyte is a solid electrolyte comprising a polymer, and the channel comprises an organic semiconductor as channel material. The electrolyte has a low water content and/or a low C1-C3-alcohol content as well as a low maximum halogen alkaline salt or alkaline earth or acetate salt content. The invention further refers to the use of this electronic component as a Schmitt-Trigger or a Muller-C-element or a flip-flop or a 1-bit memory. Further, the invention provides a method for forming such an electronic component.Type: ApplicationFiled: August 28, 2024Publication date: March 6, 2025Applicants: TECHNISCHE UNIVERSITÄT DRESDEN, UNIVERSITÉ PARIS-SACLAY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Hans KLEEMANN, Jann KRAUSSE, Lukas BONGARTZ, Karl LEO, Laurie CALVET, Zonglong LI
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Patent number: 12241151Abstract: The invention concerns a method for manufacturing an aircraft part, the part comprising a monocrystalline nickel-based superalloy substrate, the method consecutively implementing the steps of moulding the part at a moulding temperature greater than the melting temperature of the superalloy, and cooling the part, such that the monocrystalline superalloy has a ? phase and a ? phase, solution heat treatment of the part at a first temperature between the solves temperature of the ?? phase and the melting temperature of the superalloy, homogenising the crystalline structure or the part, cooling the part to ambient temperature, first tempering and second tempering.Type: GrantFiled: June 26, 2020Date of Patent: March 4, 2025Assignees: SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NATIONALE SUPERIEURE DE MECANIQUE ET D'AEROTECHNIQUE DE POITIERS, UNIVERSITE DE POITIERSInventors: Satoshi Utada, Joël Delautre, Sarah Hamadi, Jonathan Cormier, Patrick Villechaise, Jérémy Rame
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Patent number: 12232883Abstract: The method of modulating epileptogenicity in a brain of an epileptic patient includes: providing a virtual brain; providing a model of an epileptogenic and of a propagation zones and loading the models in the virtual brain to create a virtual epileptic brain; acquiring data of the brain of the epileptic patient; identifying, in the data, a location of at least one possible epileptogenic zone; fitting the virtual epileptic brain against the data acquired from the epileptic patient and parametrizing the at least one possible epileptogenic zone in the virtual epileptic brain as an epileptogenic zone; and simulating, within the virtual epileptic brain, the effect of a network modulation mimicking a clinical intervention of the brain of the patient.Type: GrantFiled: October 25, 2021Date of Patent: February 25, 2025Assignees: UNIVERSITE D'AIX MARSEILLE (AMU), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE (AP-HM), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)Inventors: Viktor Jirsa, Christophe Bernard, Fabrice Bartolomei, Maxime Guye
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Publication number: 20250062342Abstract: A method for delithiating a lithium and transition metal nitride. The method involves mixing an oxidising agent with the lithium and transition metal nitride and recovering the material obtained. The transition metal may be Mn, Fe, Co, Ni, Cu, or a mixture thereof. The material obtained by the method may be used as a negative electrode material for a lithium-ion battery.Type: ApplicationFiled: December 23, 2022Publication date: February 20, 2025Applicants: AMPERE S.A.S., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS EST CRETEIL VAL DE MARNEInventors: Nicolas EMERY, Olivier NGUYEN, Jean-Pierre PEREIRA-RAMOS, Yanlong ZHOU
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Patent number: 12227767Abstract: The present invention is in the field of oncology, and more particularly of cancer stem cells. It relates to a method for producing cancer stem cells based on overexpression of ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms; a method for predicting the risk that treatment with a chemotherapeutic anti-cancer agent induces cancer stem cells in a subject suffering from cancer from a cancer sample of said subject, based on detection of an increase in ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms following chemotherapeutic anti-cancer treatment; to therapeutic uses of a combination of chemotherapeutic anti-cancer agent and an agent reducing ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms expression; and also to screening methods for anti-cancer stem cells agents.Type: GrantFiled: February 3, 2021Date of Patent: February 18, 2025Assignees: Centre National de la Recherche Scientifique (CNRS), Universite de MontpellierInventors: Pierre Roux, Nikola Arsic, Gilles Gadea, Philippe Fort, Fanny Tomas, Véronique Gire
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Publication number: 20250040942Abstract: A medical device for penetrating an anatomic structure, e.g., a bone structure, including a processing unit programmed to execute one or more statistical algorithms, e.g., Bayesian-based perforation detection algorithms, with electrical conductivity measured during penetration of an anatomic structure as an input to detect a breach condition, e.g., a spinal canal perforation, based on the measured electrical conductivity. The medical device may include a drill bit having sensing capabilities coupled to the distal end of a robot arm via a power drill unit mounted on the robot arm. The power drill unit may cease transmission of rotary motion to the drill bit upon detection of the breach condition.Type: ApplicationFiled: July 25, 2024Publication date: February 6, 2025Applicants: SpineGuard, Sorbonne Universite, Centre National De La Recherche Scientifique-CNRS, INSERM (Institut National de la Sante et de la Recherche Medicale)Inventors: Lilyan LEBLANC, Brahim TAMADAZTE, Thibault CHANDANSON, Elie SAGHBINY
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Patent number: 12213486Abstract: A process for preparing a biocidal, bactericidal and/or bacteriostatic material including the preparation of a polymer precursor solution that has (a) at least one monomer A having a porphyrin group and at least one radical polymerizable function, (b) at least one radical polymerizable monomer B, a photoinitiator, and (c) at least one of the monomers chosen from a monomer C having a quaternary amine and a radical polymerizable function; and/or a monomer D having copper and a radical polymerizable function. Also, the material obtainable by the process and its uses.Type: GrantFiled: December 19, 2019Date of Patent: February 4, 2025Assignees: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (CEA), CONSERVATOIRE NATIONAL DES ARTS ET METIERS (CNAM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Thomas Berthelot, Céline Goulard-Huet, Fanny Hauquier