Patents Assigned to Centre National de la Recherche Scientifique (Cnrs)
  • Publication number: 20180293505
    Abstract: The invention relates to a method for clustering nodes of a network, said network comprising nodes associated with message edges of text data, the method comprising an initialization step of determination of a first initial clustering of the nodes, and a step of iterative inference of a generative model of text documents. Edges are modeled with a Stochastic Block Model (SBM) and the sets of documents between and within clusters are modeled according to a generative model of documents. The inference step comprises iteratively modelling the text documents and the underlying topics of their textual content, and updating the clustering as a function of said modelling, until a convergence criterion is fulfilled and an optimized clustering and corresponding optimized values of the parameters of the models are output.
    Type: Application
    Filed: April 6, 2017
    Publication date: October 11, 2018
    Applicants: Universite Paris Descartes, Universite Paris 1 Pantheon-Sorbonne, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Charles Bouveyron, Pierre Latouche
  • Publication number: 20180291106
    Abstract: The subject matter of the present invention relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compound to interact with netrin-1 receptor and/or to inhibit the dimerization of the intracellular domain of the netrin-1 receptor expressed in tumor cells. The invention also relates to a method for predicting the presence of metastatic or aggressive cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of netrin-1. The invention further comprises kits and compounds as a medicament for the treatment of cancer such as metastatic breast cancer, related to the overexpression of netrin-1 by the tumor cells.
    Type: Application
    Filed: June 21, 2018
    Publication date: October 11, 2018
    Applicants: Centre National de la Recherche Scientifique (CNRS), Centre Leon Berard
    Inventors: Patrick Mehlen, Agnes Bernet, Julien Fitamant
  • Publication number: 20180289761
    Abstract: The invention relates to a tablet or capsule containing a plant extract, to assist in the treatment or prevention of disorders or diseases. The tablet or capsule includes bioconverted products provided by fermenting Withania Somnifera extract, Emblica officinalis extract, and Bacopa monnieri extract.
    Type: Application
    Filed: May 21, 2018
    Publication date: October 11, 2018
    Applicants: Ethnodyne, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Chérif Rabhi, Léon Cariel, Jamal Ouazzani, Guillaume Arcile
  • Patent number: 10094766
    Abstract: According to one aspect, the invention relates to a device (100) for remote polarimetric characterization of a sample (S). It comprises a source (10) for emitting at least one incident light wave at at least one first wavelength (?E); a monomode optical fiber (30) in which the incident light wave is intended to propagate; a polarization state generator (PSG) arranged on the proximal side of the optical fiber; a reflector (40) intended to be arranged on the distal side of the optical fiber; a polarization state analyzer (PSA) arranged on the proximal side of the optical fiber and allowing, for each probe state of the incident wave generated by the polarization state generator, the polarization of the light wave obtained after propagation of the incident wave in the optical fiber (30), reflection from the distal side of the optical fiber and reverse propagation in the optical fiber (30), to be analyzed.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: October 9, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, Ecole Polytechnique
    Inventors: Antonello De Martino, Dominique Pagnoux, Jérémy Vizet, Sandeep Manhas, Jean-Charles Vanel, Stanislas Deby
  • Publication number: 20180282243
    Abstract: A process for the selective partial hydrogenation of conjugated diene compounds includes at least one, preferably terminal, diene function and at least one additional carbon-carbon double bond, the process including reacting the conjugated diene compounds with hydrogen in the presence of a nickel-NHC based catalyst. The disclosure also relates to a reaction mixture that can be obtained at the end of the process and to a catalyst that can be used in the process. The disclosure also relates to the use of the reaction mixture.
    Type: Application
    Filed: May 6, 2016
    Publication date: October 4, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS ), TOTAL RAFFINAGE CHIMIE
    Inventors: Chloé THIEULEUX, Emmanuel LACÔTE, Delphine CROZET
  • Publication number: 20180280379
    Abstract: Trilobine and its natural triple-bridged bisbenzylisoquinoline alkaloidal analogues as DNMT inhibitors for use as a drug for the treatment of cancer and neurological diseases and for cell reprogramming, in particular to prime for chemotherapy or immunotherapy.
    Type: Application
    Filed: October 3, 2016
    Publication date: October 4, 2018
    Applicants: PIERRE FABRE MEDICAMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Yoann MENON, Christophe LONG, François SAUTEL, Paola B. ARIMONDO
  • Patent number: 10083775
    Abstract: The invention relates to a conductive material comprising a first phase including a thermoset compound, a second phase, consisting of a smaller volume, including a thermoplastic compound, and a conductive compound, wherein the second phase is dispersed in the first phase, the two phases are bicontinuous, and the conductive compound is situated at the interface between the first and second phases.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: September 25, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-(CNRS), UNIVERSITE DU MAINE
    Inventors: Jean-François Tassin, Radouane Sellak, Frédérick Niepceron, Lazhar Benyahia
  • Patent number: 10072107
    Abstract: A process for preparing a long chain branched polypropylene in presence of two metallocene-based active catalyst systems is provided. The polypropylene obtained therefrom has new molecular architecture and improved elasticity properties. The polypropylene is further characterized by new signals in its 13C NMR spectrum.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: September 11, 2018
    Assignees: Total Research & Technology Feluy, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Manuela Bader, Jean-françois Carpentier, Evgueni Kirillov, Olivier Lhost, Christian Lamotte, Katty Den Dauw
  • Patent number: 10065979
    Abstract: The invention relates to nanoparticles made from organometallic hybrid materials made from iron carboxylates, used for example as contrast agents. The particles can also be used for the encapsulation and vectoring of molecules of interest such as active3 pharmaceutical agents, cosmetically interesting compounds and markers. Apart from the intrinsic properties thereof for imaging, said nanoparticles give good results in terms of capacity for loading with medicaments and in biocompatibility.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: September 4, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITÉ DE VERSAILLES—SAINT-QUENTIN-EN-YVELINES
    Inventors: Patricia Horcajada-Cortes, Gérard Ferey, Christian Serre, Ruxandra Gref, Patrick Couvreur
  • Patent number: 10064948
    Abstract: The present invention relates to a macromolecule-loaded bioresorbable crosslinked polymer wherein the polymer is obtainable from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K wherein: —K represents O—Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; —R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker, and wherein the macromolecule is chosen in the group consisting of proteins and nucleic acids.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: September 4, 2018
    Assignees: Occlugel, Centre National de la Recherche Scientifique (CNRS), Assistance Publique Hopitaux de Paris, Universite Paris Diderot—Paris 7
    Inventors: Laurence Moine, Alexandre Laurent, Michel Wassef, Laurent Bedouet, Stephanie Louguet, Valentin Verret, Emeline Servais
  • Publication number: 20180244718
    Abstract: The present description provides compositions and methods for producing therapeutic oligomeric compounds. In another aspect the description provides methods for administering the oligomeric compounds for the treatment and prevention of disease in a mammal. In particular, the disclosure relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the disclosure may optionally be administered with at least one of a pharmaceutically acceptable excipient, additional pharmacologically active agent or a combination thereof.
    Type: Application
    Filed: August 31, 2016
    Publication date: August 30, 2018
    Applicants: UREKA SARL, Centre National De La Recherche Scientifique (CNRS)
    Inventors: Gilles Guichard, Gavin W. Colle, Karolina Pulka-ziach, Caterina Maria Lombardo, Juliette Fermaux
  • Publication number: 20180248247
    Abstract: The invention relates to a three-dimensional LC electrical resonator device having a given resonant frequency of 100 gigahertz or more, comprising: a separating layer; a first track made of a conductor and comprising two overlapping portions; and a second track made of a conductor, the second track comprising two overlapping portions and an inductive loop connecting the two overlapping portions, the first track and the second track respectively being formed on either side of the separating layer, each overlapping portion of the first track being placed facing a respective overlapping portion of the second track so as to form two capacitors that are spatially spaced apart from each other.
    Type: Application
    Filed: February 24, 2016
    Publication date: August 30, 2018
    Applicants: Universite Paris Diderot Paris 7, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Pascal Desfonds, Yanko Todorov, Carlo Sirtori
  • Publication number: 20180248104
    Abstract: The invention relates to a method for controlling the movement of an Abrikosov vortex of an element consisting of a supraconductive material, a so-called supraconductive element, comprising a step of inhomogeneously heating the supraconductive element with the Abrikosov vortex in a heating zone in such a way as to move the Abrikosov vortex towards the heating zone.
    Type: Application
    Filed: August 23, 2016
    Publication date: August 30, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, UNIVERSITE DE BORDEAUX
    Inventors: Alexandre Bouzdine, Brahim Lounis, Philippe Tamarat
  • Patent number: 10059748
    Abstract: The present invention relates to methods and compositions for the prevention or treatment of neurodegenerative diseases.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: August 28, 2018
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6), ICM (INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE)
    Inventors: Daniel Dunia, Marion Szelechowski, Alexandre Betourne, Stephane Hunot
  • Patent number: 10062145
    Abstract: The invention relates to a method for mapping the crystal orientations of a polycrystalline material, the method comprising: receiving (21) a series of images of the polycrystalline material, which images are acquired by an acquiring device in respective irradiation geometries; estimating (22) at least one intensity profile for at least one point of the material from the series of images, each intensity profile representing the intensity associated with the point in question as a function of irradiation geometry; and determining (24) a crystal orientation for each point in question of the material by comparing (23) the intensity profile associated with said point in question to theoretical signatures of intensity profiles of known crystal orientations, which signatures are contained in a database.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: August 28, 2018
    Assignees: INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1
    Inventor: Cyril Langlois
  • Publication number: 20180236271
    Abstract: A method and system for secure ultrasound treatment of living tissues using an ultrasound probe comprising a reflective cavity in acoustic communication with living tissues, a transducer to emit an ultrasound wave in the reflective cavity and a transducer to acquire a backscattered signal in the reflective cavity. The method comprises the steps of a) emitting a first ultrasound wave in the reflective cavity that generates a backscattered ultrasound wave in the reflective cavity, b) acquiring a backscattered signal in the reflective cavity, c) determining whether an insonification can be safely performed by computing a similarity value between the backscattered signal and a predefined reference signal, and d) if an insonification can be safely performed, treating the living tissues with a second ultrasound wave emitted in the reflective cavity.
    Type: Application
    Filed: February 19, 2018
    Publication date: August 23, 2018
    Applicants: Cardiawave, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, INSERM (Institut National de la Santé et de la Recherche Médicale), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, Université Paris Diderot - Paris 7
    Inventors: Mickaël Tanter, Mathieu Pernot, Justine Robin
  • Patent number: 10053502
    Abstract: Selective inhibitor of c-Fos and their antiproliferative properties The invention relates to selective inhibitor of c-Fos for use in the prevention and/or treatment of cancers and restenosis.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: August 21, 2018
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Peter Vanhoutte, Jocelyne Caboche
  • Patent number: 10056266
    Abstract: A method for manufacturing a resistive device, includes depositing a first electrically conductive layer on a substrate; forming an etching mask on the first conductive layer; etching the first conductive layer through the mask, such as to obtain a plurality of electrically conductive pillars separated from one another; and forming storage elements with variable electrical resistance at the tops of the electrically conductive pillars, such that each storage element is supported by one of the electrically conductive pillars, the step of forming the storage elements including the following operations depositing a first layer by non-collimated cathode sputtering at normal incidence relative to the substrate; and depositing a second layer on the first layer by cathode sputtering, the second layer including a first chemical species sputtered at an oblique incidence.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: August 21, 2018
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE GRENOBLE ALPES
    Inventors: Bernard Dieny, Maxime Darnon, Gabriele Navarro, Olivier Joubert
  • Patent number: 10047156
    Abstract: The invention provides an isolated antibody or a fragment thereof, which is directed to the human chemokines CXCL1, CXCL7 and CXCL8, said antibody or fragment being capable of binding to the human chemokine CXCL1 with an equilibrium dissociation constant (KD) of at most 16 nM, to the human chemokine CXCL7 with an equilibrium dissociation constant (KD) of at most 5 nM and to the human chemokine CXCL8 with an equilibrium dissociation constant (KD) of at most 45 nM, as determined by surface plasmon resonance. The invention also provides some applications of said isolated antibody.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: August 14, 2018
    Assignees: Centre National De La Recherche Scientifique (CNRS), Universite de Nice Sophia Antipolis
    Inventors: Gilles Pages, Renaud Grepin
  • Publication number: 20180220936
    Abstract: A method is provided for characterising a gait comprising steps of: receiving a signal measuring the movement of a target subject measured beforehand; comparing (204) at least one section of the measuring signal with a plurality of reference signals, the plurality of reference signals comprising at least one movement signal measured beforehand on a reference subject different from the target subject, each comparison of the measuring signal with a reference signal producing a similarity coefficient representative of a probability of similarity between the compared signals; and selecting (208) at least one local maximum of interest among the similarity coefficients produced, wherein the plurality of reference signals comprises at least one movement signal measured beforehand on a reference subject afflicted with a gait disorder, and at least one movement signal measured beforehand on a healthy reference object.
    Type: Application
    Filed: August 5, 2016
    Publication date: August 9, 2018
    Applicants: Universite Paris Descartes, Centre National de la Recherche Scientifique (CNRS), Ecole Normale Superieure De Cachan, Etat Français - Ministére de la Défense - Direction centrale du service de santé des armées, Univ Paris XIII Paris-Nord Villetaneuse
    Inventors: Robert Dadashi, Thomas Moreau, Charles Truong, Catherine De Waele, Alain Yelnik, Rémi Barrois-Muller, Nicolas Vayatis, Laurent Oudre, Pierre Paul Vidal, Damien Ricard