Patents Assigned to Centre National de la Recherche Scientifique (Cnrs)
  • Patent number: 10138278
    Abstract: Disclosed is a functional derivative of a Photoactive Yellow Protein (PYP), or a functional fragment thereof, for fluorescently labelling particles, e.g. proteins, or surfaces, which is capable of binding reversibly a fluorogenic chromophore of formula (I), and which is capable of enhancing the brightness of the fluorogenic chromophore upon complexation thereto; and of inducing the spectral shift of the fluorogenic chromophore through the ionization of an auxochromic group thereof.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: November 27, 2018
    Assignees: PARIS SCIENCES ET LETTRES—QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS), UNIVERSITE PIERRE ET MARIE CURIE—PARIS 6 (UPMC)
    Inventors: Arnaud Gautier, Ludovic Jullien
  • Patent number: 10138200
    Abstract: The present invention relates to a process for preparing polyols. In particular, the present invention relates to the preparation, in a single step, of polyols by a process involving a hydrohydroxymethylation reaction starting from a composition A comprising one or more compounds of formula (I).
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: November 27, 2018
    Assignees: Pivert S.A.S., Centre National De La Recherche Scientifique (CNRS), Universite D'Artois
    Inventors: Frederic Hapiot, Eric Monflier, Theodore Vanbesien
  • Patent number: 10125427
    Abstract: The present invention relates to porphyrins of formula (I): wherein R1 to R6, R1? to R6?, X, X? Y and Y? are as described in claim 1. The invention also relates to complexes of said porphyrins with transition metals, in particular iron, preferably as Fe(III) or Fe(0) complex, and salts thereof, use thereof as catalysts for the selective electrochemical reduction of CO2 into CO, electrochemical cells comprising said complexes, and a method for selectively reducing electrochemically CO2 into CO using said complexes.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: November 13, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS DIDEROT PARIS 7
    Inventors: Cyrille Costentin, Marc Robert, Samuel Drouet, Guillaume Passard, Jean-Michel Saveant, Arnaud Tatin
  • Publication number: 20180318455
    Abstract: The invention relates to a complex between block polymers comprising a first hydrophilic block and a second block comprising at least one ionised function, and optionally carrying at least one additional chemical or biochemical group or comprising a third polymer block, and mixtures of said polymers, and ions selected from the elements Cu, Ga, Sr, Bi, Se, Y, lanthanide, Pb, Te, Zn, Zr at different degrees of ionisation and the mixtures thereof, more particularly for the use thereof in medical imaging, and to a production method and a physiologically acceptable composition containing said complex.
    Type: Application
    Filed: November 4, 2016
    Publication date: November 8, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS ), UNIVERSITE PAUL SABATIER TOULOUSE III
    Inventors: Christophe MINGOTAUD, Jean-Daniel MARTY, Camille FRANGVILLE, Daniel THALHAM
  • Patent number: 10119112
    Abstract: The present invention relates to a unit (1) comprising a microsystem (150) and at least one set of interface connections (16) for the microsystem (150); the microsystem (150) comprising a bottom plate (152) bearing the impression of at least one microstructured dynamic cell culture chamber (15), and a top plate (151), characterized in that the at least one microstructured chamber (15) is fluidically connected at inlet and/or at outlet by a set of connections (16) inserted removably into a hole in the upper plate (151). The present invention also relates to a dynamic cell culture system to this effect.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: November 6, 2018
    Assignees: Universite Technologie De Compiegne—UTC, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Cécile Legallais, Régis Baudoin, Eric Leclerc, Jean-Matthieu Prot, Patrick Paullier
  • Patent number: 10116114
    Abstract: According to the invention, a plurality of elementary laser beams (fi) are generated, the phases of which are adjusted by an electro-optical feedback loop (6, 7i, 8i, 9) implementing the matrix equation of a phase-contrast filtering device (6).
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: October 30, 2018
    Assignees: COMPAGNIE INDUSTRIELLE DES LASERS CILAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE LIMOGES
    Inventors: Vincent Kermene, Agnes Desfarges-Berthelemot, Paul Armand, Joel Benoist, David Kabeya, Alain Barthelemy, David Sabourdy, Jean-Eucher Montagne
  • Patent number: 10115013
    Abstract: Accurate localization of isolated particles is important in single particle based super-resolution microscopy. It allows the imaging of biological samples with nanometer-scale resolution using a simple fluorescence microscopy setup. Nevertheless, conventional techniques for localizing single particles can take minutes to hours of computation time because they require up to a million localizations to form an image. In contrast, the present particle localization techniques use wavelet-based image decomposition and image segmentation to achieve nanometer-scale resolution in two dimensions within seconds to minutes. This two-dimensional localization can be augmented with localization in a third dimension based on a fit to the imaging system's point-spread function (PSF), which may be asymmetric along the optical axis. For an astigmatic imaging system, the PSF is an ellipse whose eccentricity and orientation varies along the optical axis.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: October 30, 2018
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventor: Jean-Baptiste Sibarita
  • Patent number: 10106722
    Abstract: A copolymer containing a unit including an optionally neutralized styrene sulphonic acid unit and a unit containing at least one optionally neutralized (poly)carboxylic acid unit or a (poly)amido-amine unit, to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil. It also relates to a method to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil, including the injection of a fluid containing the abovementioned copolymer into a wellbore, a subterranean formation or a gas or oil well.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: October 23, 2018
    Assignees: TOTAL SA, UNIVERSITE LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Christian Hurtevent, Salima Baraka-Lokmane, John-Richard Ordonez-Varela, Olivier Tillement, Fabien Rossetti, Mahmoud Ould Metidji
  • Patent number: 10106415
    Abstract: The present invention concerns a process for the production of boron phosphide BP comprising the reduction of boron phosphate BPO4 with at least one alkaline earth metal (EA) according to Equation (1): BPO4+4 EA?BP+4 EA(O)(1).
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: October 23, 2018
    Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIV PARIS XIII PARIS-NORD VILLETANEUSE
    Inventors: Yann Le Godec, Vladimir Mukhanov, Vladimir Solozhenko, Petr Sokolov
  • Publication number: 20180291106
    Abstract: The subject matter of the present invention relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compound to interact with netrin-1 receptor and/or to inhibit the dimerization of the intracellular domain of the netrin-1 receptor expressed in tumor cells. The invention also relates to a method for predicting the presence of metastatic or aggressive cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of netrin-1. The invention further comprises kits and compounds as a medicament for the treatment of cancer such as metastatic breast cancer, related to the overexpression of netrin-1 by the tumor cells.
    Type: Application
    Filed: June 21, 2018
    Publication date: October 11, 2018
    Applicants: Centre National de la Recherche Scientifique (CNRS), Centre Leon Berard
    Inventors: Patrick Mehlen, Agnes Bernet, Julien Fitamant
  • Publication number: 20180289761
    Abstract: The invention relates to a tablet or capsule containing a plant extract, to assist in the treatment or prevention of disorders or diseases. The tablet or capsule includes bioconverted products provided by fermenting Withania Somnifera extract, Emblica officinalis extract, and Bacopa monnieri extract.
    Type: Application
    Filed: May 21, 2018
    Publication date: October 11, 2018
    Applicants: Ethnodyne, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Chérif Rabhi, Léon Cariel, Jamal Ouazzani, Guillaume Arcile
  • Publication number: 20180293505
    Abstract: The invention relates to a method for clustering nodes of a network, said network comprising nodes associated with message edges of text data, the method comprising an initialization step of determination of a first initial clustering of the nodes, and a step of iterative inference of a generative model of text documents. Edges are modeled with a Stochastic Block Model (SBM) and the sets of documents between and within clusters are modeled according to a generative model of documents. The inference step comprises iteratively modelling the text documents and the underlying topics of their textual content, and updating the clustering as a function of said modelling, until a convergence criterion is fulfilled and an optimized clustering and corresponding optimized values of the parameters of the models are output.
    Type: Application
    Filed: April 6, 2017
    Publication date: October 11, 2018
    Applicants: Universite Paris Descartes, Universite Paris 1 Pantheon-Sorbonne, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Charles Bouveyron, Pierre Latouche
  • Patent number: 10094766
    Abstract: According to one aspect, the invention relates to a device (100) for remote polarimetric characterization of a sample (S). It comprises a source (10) for emitting at least one incident light wave at at least one first wavelength (?E); a monomode optical fiber (30) in which the incident light wave is intended to propagate; a polarization state generator (PSG) arranged on the proximal side of the optical fiber; a reflector (40) intended to be arranged on the distal side of the optical fiber; a polarization state analyzer (PSA) arranged on the proximal side of the optical fiber and allowing, for each probe state of the incident wave generated by the polarization state generator, the polarization of the light wave obtained after propagation of the incident wave in the optical fiber (30), reflection from the distal side of the optical fiber and reverse propagation in the optical fiber (30), to be analyzed.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: October 9, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, Ecole Polytechnique
    Inventors: Antonello De Martino, Dominique Pagnoux, Jérémy Vizet, Sandeep Manhas, Jean-Charles Vanel, Stanislas Deby
  • Publication number: 20180280379
    Abstract: Trilobine and its natural triple-bridged bisbenzylisoquinoline alkaloidal analogues as DNMT inhibitors for use as a drug for the treatment of cancer and neurological diseases and for cell reprogramming, in particular to prime for chemotherapy or immunotherapy.
    Type: Application
    Filed: October 3, 2016
    Publication date: October 4, 2018
    Applicants: PIERRE FABRE MEDICAMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Yoann MENON, Christophe LONG, François SAUTEL, Paola B. ARIMONDO
  • Publication number: 20180282243
    Abstract: A process for the selective partial hydrogenation of conjugated diene compounds includes at least one, preferably terminal, diene function and at least one additional carbon-carbon double bond, the process including reacting the conjugated diene compounds with hydrogen in the presence of a nickel-NHC based catalyst. The disclosure also relates to a reaction mixture that can be obtained at the end of the process and to a catalyst that can be used in the process. The disclosure also relates to the use of the reaction mixture.
    Type: Application
    Filed: May 6, 2016
    Publication date: October 4, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS ), TOTAL RAFFINAGE CHIMIE
    Inventors: Chloé THIEULEUX, Emmanuel LACÔTE, Delphine CROZET
  • Patent number: 10083775
    Abstract: The invention relates to a conductive material comprising a first phase including a thermoset compound, a second phase, consisting of a smaller volume, including a thermoplastic compound, and a conductive compound, wherein the second phase is dispersed in the first phase, the two phases are bicontinuous, and the conductive compound is situated at the interface between the first and second phases.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: September 25, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-(CNRS), UNIVERSITE DU MAINE
    Inventors: Jean-François Tassin, Radouane Sellak, Frédérick Niepceron, Lazhar Benyahia
  • Patent number: 10072107
    Abstract: A process for preparing a long chain branched polypropylene in presence of two metallocene-based active catalyst systems is provided. The polypropylene obtained therefrom has new molecular architecture and improved elasticity properties. The polypropylene is further characterized by new signals in its 13C NMR spectrum.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: September 11, 2018
    Assignees: Total Research & Technology Feluy, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Manuela Bader, Jean-françois Carpentier, Evgueni Kirillov, Olivier Lhost, Christian Lamotte, Katty Den Dauw
  • Patent number: 10064948
    Abstract: The present invention relates to a macromolecule-loaded bioresorbable crosslinked polymer wherein the polymer is obtainable from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K wherein: —K represents O—Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; —R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker, and wherein the macromolecule is chosen in the group consisting of proteins and nucleic acids.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: September 4, 2018
    Assignees: Occlugel, Centre National de la Recherche Scientifique (CNRS), Assistance Publique Hopitaux de Paris, Universite Paris Diderot—Paris 7
    Inventors: Laurence Moine, Alexandre Laurent, Michel Wassef, Laurent Bedouet, Stephanie Louguet, Valentin Verret, Emeline Servais
  • Patent number: 10065979
    Abstract: The invention relates to nanoparticles made from organometallic hybrid materials made from iron carboxylates, used for example as contrast agents. The particles can also be used for the encapsulation and vectoring of molecules of interest such as active3 pharmaceutical agents, cosmetically interesting compounds and markers. Apart from the intrinsic properties thereof for imaging, said nanoparticles give good results in terms of capacity for loading with medicaments and in biocompatibility.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: September 4, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITÉ DE VERSAILLES—SAINT-QUENTIN-EN-YVELINES
    Inventors: Patricia Horcajada-Cortes, Gérard Ferey, Christian Serre, Ruxandra Gref, Patrick Couvreur
  • Publication number: 20180248247
    Abstract: The invention relates to a three-dimensional LC electrical resonator device having a given resonant frequency of 100 gigahertz or more, comprising: a separating layer; a first track made of a conductor and comprising two overlapping portions; and a second track made of a conductor, the second track comprising two overlapping portions and an inductive loop connecting the two overlapping portions, the first track and the second track respectively being formed on either side of the separating layer, each overlapping portion of the first track being placed facing a respective overlapping portion of the second track so as to form two capacitors that are spatially spaced apart from each other.
    Type: Application
    Filed: February 24, 2016
    Publication date: August 30, 2018
    Applicants: Universite Paris Diderot Paris 7, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Pascal Desfonds, Yanko Todorov, Carlo Sirtori