Patents Assigned to Centre National de la Recherche Scientifique (Cnrs)
  • Patent number: 12292372
    Abstract: The invention relates to a measuring device (10) for measuring physical characteristics of cells. The device (10) comprises: a microfluidic chip (20) provided with a flow channel (22) for allowing cells to flow through; a manipulator (24) configured to apply deformation force to a cell in a continuous flow; and a sensor (26) configured to sense a physical characteristic of the cell. The manipulator (24) and the sensor (26) are configured to define a width (W2) of the flow channel (22) as a gap formed between them. The manipulator (24) is configured to apply the deformation force to the cell by compressing the cell against the sensor (26).
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: May 6, 2025
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), JUNIA
    Inventors: Dominique Collard, Hiroyuki Fujita, Stanislav Karsten, Mehmet Cagatay Tarhan
  • Patent number: 12291551
    Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.
    Type: Grant
    Filed: April 8, 2024
    Date of Patent: May 6, 2025
    Assignees: Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay
    Inventors: Aurélie Albertini, Yves Gaudin, Hélène Raux, Laura Belot, Jovan Nikolic
  • Patent number: 12291552
    Abstract: The present invention relates to a chimeric protein comprising at least one human amyloid P component and at least one fragment of an Fc region of a human antibody, the human amyloid P component and the fragment of an Fc region with which it is associated being bound to each other by means of a hinge region.
    Type: Grant
    Filed: April 26, 2022
    Date of Patent: May 6, 2025
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉDE LIMOGES
    Inventors: Christophe De Romeuf, Christophe Sirac, Jean-Claude Brouet
  • Patent number: 12287453
    Abstract: An optical device suitable for transmitting/reflecting electromagnetic radiation in a wavelength range of the electromagnetic spectrum. The device comprises at least a first coating layer made of a first material, a substrate made of a material different from the first material, and surface texturing forming cavities in the device. A lower layer, disposed directly below the first coating layer, is either a second coating layer made of a material different from the first material or the substrate itself. The lower layer has a predetermined thickness. The optical device has cavities that extend through the first coating layer and are sunk into the lower layer through at least part of its thickness. This structure enhances the optical properties of the device for specific applications in electromagnetic radiation transmission or reflection.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: April 29, 2025
    Assignees: Hydromecanique et Frottement, Manutech-USD, Université Jean Monnet Saint-Etienne, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Thomas Kämpfe, Laurent Dubost, Xxx Sedao
  • Patent number: 12285433
    Abstract: The present invention relates to diltiazem for use as an agent for activating the expression of at least one gene encoding a type III interferon, in the prevention and/or treatment of infections by at least one pathogenic microorganism of the epithelia of the respiratory and/or intestinal tracts.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: April 29, 2025
    Assignees: UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYON, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE LAVAL
    Inventors: Manuel Rosa-Calatrava, Olivier Terrier, Claire Nicolas De Lamballerie, Guy Boivin, Mario Andres Pizzorno
  • Patent number: 12286497
    Abstract: Process of grafting of a polyethylene-containing material to produce a modified polyethylene composition comprising providing a twin screw extruder with one or more thermal regulation devices; a polyethylene-containing material and a grafting agent and extruding the polyethylene-containing material and the grafting agent to obtain a modified polyethylene composition; the step of extruding comprises a thermal treatment of the polyethylene-containing material by self-heating of the material at a maximum barrel temperature Ts ranging from 315° C. to 410° C. in one or more hot zones of the extruder.
    Type: Grant
    Filed: March 2, 2023
    Date of Patent: April 29, 2025
    Assignees: TOTALENERGIES ONETECH, UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ JEAN MONNET SAINT-ETIENNE, INSTITUT NATIONAL DES SCIENCES APPLIQUÉES DE LYON (INSA LYON)
    Inventors: Olivier Lhost, Pascal Navez, Yves Trolez, Philippe Cassagnau, Mohammad Abou-Taha, Karim Delage, Emmanuel Beyou
  • Patent number: 12269000
    Abstract: The present invention relates to a method for producing a colloid comprising functionalised liquid colloidal particles. The invention also relates to such a colloid and to the uses thereof.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: April 8, 2025
    Assignees: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite
    Inventors: Jacques Fattaccioli, Lea Pinon, Lorraine Montel
  • Patent number: 12269848
    Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.
    Type: Grant
    Filed: April 8, 2024
    Date of Patent: April 8, 2025
    Assignees: Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay
    Inventors: Aurélie Albertini, Yves Gaudin, Hélène Raux, Laura Belot, Jovan Nikolic
  • Patent number: 12269837
    Abstract: Disclosed are chelates resulting from the complexation of bifunctional do2pa derivatives ligands of formula (I), wherein the substituents R1, R1?, R2, R2?, R3, R3?, L1, L1?, L2 and L2? are defined as in the claims, with metallic cations, especially Pb(II) and Bi(III). Also disclosed are bifunctional do2pa derivatives ligands of formula (I), as well as the use of chelates in nuclear medicine and the use of ligands in cations detection or epuration of effluents.
    Type: Grant
    Filed: January 24, 2022
    Date of Patent: April 8, 2025
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ DE BRETAGNE OCCIDENTALE
    Inventors: Fatima Oukhatar, Maryline Beyler, Raphaël Tripier
  • Patent number: 12264180
    Abstract: The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.
    Type: Grant
    Filed: April 8, 2024
    Date of Patent: April 1, 2025
    Assignees: Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay
    Inventors: Aurélie Albertini, Yves Gaudin, Hélène Raux, Laura Belot, Jovan Nikolic
  • Patent number: 12257103
    Abstract: Method for non-invasively characterizing a heterogeneous medium using ultrasound, comprising a step of generating a series of incident ultrasonic waves, a step of recording an experimental reflection matrix Rui(t) defined between the input emission basis (i) and an output reception basis (u), a step of determining a response REP(r,?r) of the medium between an input virtual transducer (TVin) calculated based on an input focusing of the experimental reflection matrix that creates an input focal spot around a first point (P1), and an output virtual transducer (TVout) calculated based on an output focusing of the experimental reflection matrix that creates an output focal spot around a second point (P2), said response being expressed as a function of a central point (PC) of spatial position (r) in the medium located midway between the first and second points (P1, P2).
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: March 25, 2025
    Assignees: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris
    Inventors: William Lambert, Alexandre Aubry, Mathias Fink, Laura Cobus
  • Patent number: 12252514
    Abstract: The invention relates to the field of molecular biology and particularly novel genes that encode pesticidal proteins useful for controlling pests, particularly plant pests. These proteins and the nucleic acid sequences that encode them are useful in preparing pesticidal compositions and in the production of transgenic pest-resistant plants.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: March 18, 2025
    Assignees: GENECTIVE, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, PCAS, SEMAE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Carine Bonzom-Audiffrin, Wafa Achouak, Mohamed Barakat, Philippe Ortet, David Vallenet, Thierry Heulin, Christophe Sallaud, Mickael Bosio, Virginie Guyon, Wyatt Paul
  • Patent number: 12250944
    Abstract: The present invention relates to the long-term preservation of biological material. More specifically, it concerns a preservation container comprising: a biological container for containing biological material, a first shield configured for absorbing gamma-rays, a second shield configured for absorbing ambient neutrons, said second shield surrounding the biological container, the preservation container being of low-radioactivity background materials, and a method for preserving a biological material, comprising: a) providing a biological material in a confinement container, b) providing the preservation container of the invention, c) placing the confinement container containing the biological material into said preservation container, d) storing said preservation container containing the biological material in a room located under a material attenuating cosmic rays and induced particles, said material having a thickness equivalent to 1 m to 7000 m of water, for attenuating cosmic rays.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: March 18, 2025
    Assignees: Centre National de la Recherche Scientifique (CNRS), Institut Pasteur, Université Paris Cité, Groupe Hospitalier Universitaire Paris—Psychiatrie et Neurosciences
    Inventors: Maurice Chapellier, Fabrice Chretien, Fabrice Piquemal, Pierre Rocheteau, Guillaume Warot, Michel Zampaolo
  • Publication number: 20250081706
    Abstract: The invention refers to an electronic component, in particular an organic electrochemical transistor (OECT) which comprises at least one gate electrode, a source electrode, a drain electrode, a channel and an electrolyte. The electrolyte is a solid electrolyte comprising a polymer, and the channel comprises an organic semiconductor as channel material. The electrolyte has a low water content and/or a low C1-C3-alcohol content as well as a low maximum halogen alkaline salt or alkaline earth or acetate salt content. The invention further refers to the use of this electronic component as a Schmitt-Trigger or a Muller-C-element or a flip-flop or a 1-bit memory. Further, the invention provides a method for forming such an electronic component.
    Type: Application
    Filed: August 28, 2024
    Publication date: March 6, 2025
    Applicants: TECHNISCHE UNIVERSITÄT DRESDEN, UNIVERSITÉ PARIS-SACLAY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Hans KLEEMANN, Jann KRAUSSE, Lukas BONGARTZ, Karl LEO, Laurie CALVET, Zonglong LI
  • Patent number: 12241151
    Abstract: The invention concerns a method for manufacturing an aircraft part, the part comprising a monocrystalline nickel-based superalloy substrate, the method consecutively implementing the steps of moulding the part at a moulding temperature greater than the melting temperature of the superalloy, and cooling the part, such that the monocrystalline superalloy has a ? phase and a ? phase, solution heat treatment of the part at a first temperature between the solves temperature of the ?? phase and the melting temperature of the superalloy, homogenising the crystalline structure or the part, cooling the part to ambient temperature, first tempering and second tempering.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: March 4, 2025
    Assignees: SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NATIONALE SUPERIEURE DE MECANIQUE ET D'AEROTECHNIQUE DE POITIERS, UNIVERSITE DE POITIERS
    Inventors: Satoshi Utada, Joël Delautre, Sarah Hamadi, Jonathan Cormier, Patrick Villechaise, Jérémy Rame
  • Patent number: 12232883
    Abstract: The method of modulating epileptogenicity in a brain of an epileptic patient includes: providing a virtual brain; providing a model of an epileptogenic and of a propagation zones and loading the models in the virtual brain to create a virtual epileptic brain; acquiring data of the brain of the epileptic patient; identifying, in the data, a location of at least one possible epileptogenic zone; fitting the virtual epileptic brain against the data acquired from the epileptic patient and parametrizing the at least one possible epileptogenic zone in the virtual epileptic brain as an epileptogenic zone; and simulating, within the virtual epileptic brain, the effect of a network modulation mimicking a clinical intervention of the brain of the patient.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: February 25, 2025
    Assignees: UNIVERSITE D'AIX MARSEILLE (AMU), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE (AP-HM), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Viktor Jirsa, Christophe Bernard, Fabrice Bartolomei, Maxime Guye
  • Publication number: 20250062342
    Abstract: A method for delithiating a lithium and transition metal nitride. The method involves mixing an oxidising agent with the lithium and transition metal nitride and recovering the material obtained. The transition metal may be Mn, Fe, Co, Ni, Cu, or a mixture thereof. The material obtained by the method may be used as a negative electrode material for a lithium-ion battery.
    Type: Application
    Filed: December 23, 2022
    Publication date: February 20, 2025
    Applicants: AMPERE S.A.S., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS EST CRETEIL VAL DE MARNE
    Inventors: Nicolas EMERY, Olivier NGUYEN, Jean-Pierre PEREIRA-RAMOS, Yanlong ZHOU
  • Patent number: 12227767
    Abstract: The present invention is in the field of oncology, and more particularly of cancer stem cells. It relates to a method for producing cancer stem cells based on overexpression of ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms; a method for predicting the risk that treatment with a chemotherapeutic anti-cancer agent induces cancer stem cells in a subject suffering from cancer from a cancer sample of said subject, based on detection of an increase in ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms following chemotherapeutic anti-cancer treatment; to therapeutic uses of a combination of chemotherapeutic anti-cancer agent and an agent reducing ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms expression; and also to screening methods for anti-cancer stem cells agents.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: February 18, 2025
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite de Montpellier
    Inventors: Pierre Roux, Nikola Arsic, Gilles Gadea, Philippe Fort, Fanny Tomas, Véronique Gire
  • Publication number: 20250040942
    Abstract: A medical device for penetrating an anatomic structure, e.g., a bone structure, including a processing unit programmed to execute one or more statistical algorithms, e.g., Bayesian-based perforation detection algorithms, with electrical conductivity measured during penetration of an anatomic structure as an input to detect a breach condition, e.g., a spinal canal perforation, based on the measured electrical conductivity. The medical device may include a drill bit having sensing capabilities coupled to the distal end of a robot arm via a power drill unit mounted on the robot arm. The power drill unit may cease transmission of rotary motion to the drill bit upon detection of the breach condition.
    Type: Application
    Filed: July 25, 2024
    Publication date: February 6, 2025
    Applicants: SpineGuard, Sorbonne Universite, Centre National De La Recherche Scientifique-CNRS, INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Lilyan LEBLANC, Brahim TAMADAZTE, Thibault CHANDANSON, Elie SAGHBINY
  • Patent number: 12213486
    Abstract: A process for preparing a biocidal, bactericidal and/or bacteriostatic material including the preparation of a polymer precursor solution that has (a) at least one monomer A having a porphyrin group and at least one radical polymerizable function, (b) at least one radical polymerizable monomer B, a photoinitiator, and (c) at least one of the monomers chosen from a monomer C having a quaternary amine and a radical polymerizable function; and/or a monomer D having copper and a radical polymerizable function. Also, the material obtainable by the process and its uses.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: February 4, 2025
    Assignees: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (CEA), CONSERVATOIRE NATIONAL DES ARTS ET METIERS (CNAM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Thomas Berthelot, Céline Goulard-Huet, Fanny Hauquier