Patents Assigned to Centre National de la Recherche Scientifique (Cnrs)
  • Patent number: 12005523
    Abstract: The invention relates to a process for nanostructuring the surface of a solid material in order to form a regular pattern of nanostructures on said surface, comprising: irradiating the surface by a plurality of pulse trains (20) of a femtosecond laser beam: each pulse train (20) comprises at least two pulses (21, 22), each pulse has a peak fluence, and a sum of the peak fluences of the pulses of a pulse train is between 10% and 70% of a threshold fluence corresponding to a material ablation threshold for one pulse for said material, two consecutive pulses of a pulse train are separated by a peak-to-peak duration ?T between 500 fs and 150 ps, two consecutive pulse trains are separated by a duration greater than 10 ?T, obtaining a regular pattern of nanostructures on said portion of surface, having a spatial periodicity lower than 130 nm.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: June 11, 2024
    Assignees: Universite Jean Monnet Saint Etienne, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Florent Pigeon, Anthony Abou Saleh, Jean-Philippe Colombier-Cinquantin, Florence Garrelie
  • Publication number: 20240116923
    Abstract: The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis.
    Type: Application
    Filed: January 25, 2022
    Publication date: April 11, 2024
    Applicants: Seabelife, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite, Institut National de la Santé et de la Recherche Médicale (INSERM), Université Claude Bernard Lyon 1, Universite de Rennes 1
    Inventors: Stéphane BACH, Arnaud COMTE, Claire DELEHOUZE, Marie-Thérèse DIMANCHE-BOITREL, Peter GOEKJIAN
  • Publication number: 20240118471
    Abstract: An optical structure comprising at least one stack having a central filter (1) and two sandwiching optical elements (2,3) between which the central filter (1) is interposed, wherein the central filter (1) is in a matrix material. The matrix material being doped with at least one doping agent, the central filter (1) and the two optical elements (2,3) on either side thereof being assembled by bonding layers (4a, 4b) of a material based on the same matrix material as that of the central filter, the optical elements (2,3) on either side of the central filter (1) and the bonding layers (4a, 4b) each having a refractive index equal to that of the material of the central filter or only differing from this refractive index within a range of plus or minus 0.05, preferably within a range of plus or minus 0.02.
    Type: Application
    Filed: October 15, 2020
    Publication date: April 11, 2024
    Applicants: UNIVERSITE CALAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYON
    Inventors: Stéphane PAROLA, Cesar LOPES, Denis CHATEAU, Frederic CHAPUT
  • Patent number: 11950919
    Abstract: The invention concerns a method for calibrating a system for real-time measurement of the activity of a cognitive function of a test subject, the method comprising the successive steps of: acquiring electrical signals representative of a neural activity of a test subject; calculating values of markers of the cognitive function activity; generating a plurality of copies of calculated values of markers and adding noise to the generated copies; and, constructing a classifier by machine learning, based on the calculated marker values and noisy copies, the classifier being suitable for measuring the activity of the cognitive function of the test subject by calculating a probability that an electrical signal representative of the neural activity of the test subject results from a predetermined activity state of the cognitive function of the test subject.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: April 9, 2024
    Assignees: Centre National de la Recherche Scientifique (CNRS), Ecole Superieure e Physique Et De Chimie Industrielles De La Ville De Paris, Sorbonne Universite, Paris Sciences et Lettres
    Inventors: François Vialatte, Aldo Mora-Sanchez, Gérard Dreyfus, Antoine Gaume, Alfredo Aram Pulini
  • Publication number: 20240092716
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as a drug, especially as an antibiotic. The present invention also relates to a pharmaceutical composition comprising said compound of formula (I) and at least one pharmaceutically acceptable excipient. The present invention further concerns a method of preparation of a compound of formula (I?).
    Type: Application
    Filed: December 9, 2021
    Publication date: March 21, 2024
    Applicant: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Jamal-Eddine OUAZZANI CHAHDI, Géraldine LE GOFF, Jean-Félix DALLERY, Jean-François BETZER, Arnaud VOITURIEZ, Angela MARINETTI, Fanny CACHEUX
  • Patent number: 11905253
    Abstract: The present invention relates the field of reducing CD95-mediated cell motility in a subject, in particular for their use in the reduction of CD-95 mediated cancer cell motility, the reduction of CD95-mediated lymphocyte motility and/or B cell maturation, or the treatment of B-cell tumors, in a subject. The inventors identified a novel family of compounds having the ability to disrupt CD95/PLC?1 interaction and to neutralize the CD95-mediated calcium signaling pathway and cell migration in human peripheral blood lymphocytes (PBLs) and Th17 cells.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: February 20, 2024
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE RENNES 1, CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX, INSTITUT BERGONIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BORDEAUX
    Inventors: Pierre Vacher, Patrick Legembre, Mickael Jean, Patrick Blanco, Pierre Van De Weghe
  • Publication number: 20240050957
    Abstract: The invention concerns a system for controlling the temperature of a microfluidic chip comprising a Peltier module (10) having a cold face (10a) and a hot face (10b) and connected to a power generator (11), a thermal regulation device (12) having a thermal regulated face (12a) applied against one of the faces of the Peltier module, at least one temperature sensor (17) being applied on the other face of the Peltier module and being intended to be applied against one of the main faces of a microfluidic chip and control means (18) configured to control the power generator (11) of the Peltier module depending on a temperature of the face of the Peltier module provided with said at least one temperature sensor and at least one temperature setting information selected from a target temperature and a target temporal temperature profile to regulate a temperature of the face of the Peltier module to said temperature setting information.
    Type: Application
    Filed: December 16, 2021
    Publication date: February 15, 2024
    Applicants: TotalEnergies OneTech, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, UNIVERSITE DE RENNES
    Inventors: Alexis MAURAY, Patrick CHASLE, Jean-Charles POTIER, Marie-Caroline JULLIEN, Ahmad AL FARRA, Bernard MONASSE, Enric SANTANACH CARRERAS
  • Publication number: 20240032889
    Abstract: Method for non-invasively characterizing a heterogeneous medium using ultrasound, comprising a step of generating a series of incident ultrasonic waves, a step of recording an experimental reflection matrix Rui(t) defined between the input emission basis (i) and an output reception basis (u), a step of determining a response REP(r, ?r) of the medium between an input virtual transducer (TVin) calculated based on an input focusing of the experimental reflection matrix that creates an input focal spot around a first point (P1), and an output virtual transducer (TVout) calculated based on an output focusing of the experimental reflection matrix that creates an output focal spot around a second point (P2), said response being expressed as a function of a central point (PC) of spatial position (r) in the medium located midway between the first and second points (P1, P2).
    Type: Application
    Filed: July 31, 2020
    Publication date: February 1, 2024
    Applicants: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris
    Inventors: William LAMBERT, Alexandre AUBRY, Mathias FINK, Laura COBUS
  • Publication number: 20240034791
    Abstract: The present invention relates to antibodies having specificity to Nectin-4 and uses thereof.
    Type: Application
    Filed: March 31, 2022
    Publication date: February 1, 2024
    Applicants: EMERGENCE THERAPEUTICS AG, UNIVERSITE D’AIX-MARSEILLE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), INSTITUT JEAN PAOLI & IRENE CALMETTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE – CNRS –
    Inventors: Jack ELANDS, Florence LHOSPPICE, Xavier PRÉVILLE, Daniel OLIVE, Marc LOPEZ
  • Patent number: 11889671
    Abstract: The disclosure provides for a composite material suitable for use as EMI shielding material, remarkable in that it comprises a component A being a polymer resin being at least one amorphous polymer resin and/or at least one semi-crystalline polymer resin selected from polyethylene resin and/or polypropylene resin; from 15.0 to 60.0 wt. % of component B being at least one metal-coated particle based on the total weight of the composite material; and from 0.5 to 5.0 wt. % of component C being one or more dispersants based on the total weight of the composite material; wherein one or more dispersants are selected from fatty acids, fatty acid derivatives, ethylene bis stearamide, functionalized waxes, maleic anhydride-grafted polymers and any mixture thereof; wherein the blend of components A, B and C shows a density ranging from 0.8 to 2.0 g/cc.
    Type: Grant
    Filed: October 1, 2021
    Date of Patent: January 30, 2024
    Assignees: TOTALENERGIES ONETECH, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL)
    Inventors: Olivier Lhost, Yves Trolez, Anatoli Serghei, Hubert Lecocq, Philippe Cassagnau
  • Patent number: 11879038
    Abstract: The present invention relates to a polymer foam, said polymer foam comprising pores forming an open-cell polymer foam, said polymer foam comprising a supramolecular gel inside pores, and said polymer foam comprising at least one enzyme. The present invention relates to a supramolecular gel; its preparation and its applications, notably in chemical synthesis and kinetic resolution, in particular of organic compounds. The present invention also relates to flow chemistry.
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: January 23, 2024
    Assignees: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventors: Loïc Jierry, Christophe Serra, Pierre Schaaf, Jennifer Rodon Fores, Fouzia Boulmedais
  • Publication number: 20240018197
    Abstract: A hook fusion protein, which includes a hook domain and at least one cytoplasmic carboxyl endoplasmic reticulum (ER) retention signal and/or at least one cytoplasmic amino terminal endoplasmic reticulum (ER) retention signal; wherein the hook fusion protein is a soluble protein that localizes in the cytoplasm. Also, a nucleic acid system for intracellular targeting control including a nucleic acid encoding a target fusion protein including a hook fusion protein, and a nucleic acid encoding a target fusion protein including a hook-binding domain; wherein the target fusion protein is a membrane protein; and wherein the hook fusion protein localizes in the ER when bound to the target fusion protein. Additionally, a vector system, viral particle system, host cell and kit include these nucleic acids. Further, the vector system, viral particle system, host cell or kit for use as a medicament, in particular for immunotherapy.
    Type: Application
    Filed: September 11, 2023
    Publication date: January 18, 2024
    Applicants: INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Franck PEREZ, Zelia GOUVEIA, Gaelle BONCOMPAIN
  • Publication number: 20240018715
    Abstract: The present disclosure relates to a method for the preparation, from a mixture comprising (i) plant proteins, (ii) one or more plant tanning agents, (iii) one or more plasticizers, of a biobased material that may resemble animal leather.
    Type: Application
    Filed: October 15, 2021
    Publication date: January 18, 2024
    Applicants: Centre National de la Recherche Scientifique (CNRS), Universite Jean Monnet Saint Etienne, La Tannerie Vegetale, Université Claude Bernard Lyon 1
    Inventors: Fanny DELEAGE, Yvan CHALAMET
  • Patent number: 11865185
    Abstract: The invention is directed to a recombinant Adeno-Associated Virus (rAAV) vector particle having at least one primary amino group contained in the capsid proteins, chemically coupled with at least one ligand L, wherein coupling of said ligand L is implemented through a bond comprising a —CSNH— bond and an optionally substituted aromatic moiety. The present invention further relates to a method for chemically coupling an Adeno-Associated Virus (AAV) vector particle with at least one ligand L and to a Recombinant Adeno-Associated Virus (rAAV) vector particle obtained by said method as well as a pharmaceutical composition comprising it and their corresponding medical use.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: January 9, 2024
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), NANTES UNIVERSITE, CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
    Inventors: Mathieu Mevel, David Deniaud, Eduard Ayuso
  • Patent number: 11866484
    Abstract: The invention relates to the identification of a highly stable single domain antibody scaffold (hs2dAb) and its use in generating synthetic single domain antibody library (hs2dAb-L1). The invention also relates to antigen-binding proteins comprising said stable single domain antibody scaffold and their uses, in particular as therapeutics.
    Type: Grant
    Filed: March 3, 2021
    Date of Patent: January 9, 2024
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), INSTITUT CURIE, UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Aurelien Olichon, Sandrine Moutel, Franck Perez
  • Patent number: 11864807
    Abstract: A device for forcibly inserting a surgical implant into a receiving bone (4), by impaction, comprising an impactor (10) which exerts an impact force on the implant and is associated with at least one sensor (12). The sensor (12) measures the deformation of the impactor (10), and provides a measurement signal representing the temporal variation of the deformation during an impact. The sensor (12) is connected to a processing unit (30) configured to calculate, on the basis of the temporal variation of the deformation of the impactor (10) during the impact, an indicator representative of the level of contact between the implant and the receiving bone (4).
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: January 9, 2024
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Université Paris XII Val de Marne
    Inventors: Guillaume Haiat, Giuseppe Rosi, Antoine Tijou
  • Publication number: 20230421094
    Abstract: A method for optimizing an existing generator system based on photovoltaic cells and provided with an existing photovoltaic panel or a group of existing photovoltaic panels, each panel having a first plurality of cells of a first type interconnected in series or in series/in parallel. The method includes: determining an operating voltage of the panel(s); producing additional panel module(s) having a second plurality of thin-film cells of a second type and having a different band gap width than the cells of the panel(s), the additional module(s) being configured to supply an operating voltage equal, within ±10%, to the voltage of the panel(s); positioning the additional module to overlap on or under the panel or one of the panel(s), the module being connected in parallel to the panel(s), or positioning several additional modules to overlap on or under several panels, the several modules being connected in parallel to panels.
    Type: Application
    Filed: November 19, 2021
    Publication date: December 28, 2023
    Applicants: ELECTRICITE DE FRANCE, INSTITUT PHOTOVOLTAIQUE D'ILE DE FRANCE (IPVF), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, TOTALENERGIES ONETECH, ECOLE POLYTECHNIQUE
    Inventors: Sébastien JUTTEAU, Pierre-Philippe GRAND, Cédric GUERARD, Etienne DRAHI
  • Patent number: 11852704
    Abstract: The present disclosure is directed to a motor for a magnetic resonance (MR) tomography room, to a patient table for the MR room, to a MR elastography device, and to a MR tomography device. A MR tomography device for a MR elastography imaging protocol is arranged within the MR tomography room, and includes a rotational drive for supplying rotational energy to power a MR elastography transducer usable during the MR elastography imaging protocol, and a support structure. The rotational drive comprises a terminal for connecting the MR elastography transducer to the rotational drive, and a bearing means configured such that the position of the terminal relative to the support structure is adaptable along a trajectory predetermined by the bearing means. The rotational drive is mounted to the support structure via the bearing means.
    Type: Grant
    Filed: March 17, 2022
    Date of Patent: December 26, 2023
    Assignees: Siemens Healthcare GmbH, Centre National de la Recherche Scientifique (CNRS), Institut National de La Sante et de la Recherche Medicale (INSERM), King's College London, Department of Health and Human Services, UNIV PARIS XIII PARIS-NORD VILLETANEUSE, Universite de Paris
    Inventors: Giacomo Annio, Verena Muller-Reinwald, Ralph Sinkus, Omar Darwish, Wilfried Schnell, Tamara Elisabeth Falkner, Ahmed M. Gharib
  • Patent number: 11856093
    Abstract: A method for performing spacetime-constrained oblivious transfer between various laboratories of a first party A and various laboratories of a second party B. The method includes providing the spacetime-constrained oblivious transfer to satisfy various conditions. The method further includes encoding, by the laboratories of the first party A, various messages in a quantum state selected from various non-orthogonal quantum states. The method further includes transmitting, by the laboratories of the first party A, the quantum state to a first laboratory of the second party B. The method further includes applying, by the first laboratory of the second party B, a quantum measurement on the quantum state to obtain a classical measurement outcome. The method further includes transmitting, by the first laboratory of the second party B, the classical measurement outcome to the laboratories of the second party B.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: December 26, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ PARIS CITÉ
    Inventors: Damián Pitalúa García, Iordanis Kerenedis
  • Publication number: 20230397490
    Abstract: An active light-emitting layer composition including a thermally activated delayed fluorescence (TADF) molecule with TADF properties as a host material and a luminescent molecule with circularly polarized (CP) properties as a dopant. Also, a light-emitting device, such as an organic light-emitting diodes (OLED), including the active light-emitting layer made of this composition.
    Type: Application
    Filed: October 29, 2021
    Publication date: December 7, 2023
    Applicants: UNIVERSITE DE RENNES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE RENNES, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE RENNES, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Ludovic FAVEREAU, Jeanne CRASSOUS, Sitthichok KASEMTHAVEECHOK, Kais DHBAIBI, Grégory PIETERS, Benoît RACINE, Etienne QUESNEL