Patents Assigned to Centre National de la Recherche Scientifique (Cnrs)
  • Patent number: 10208318
    Abstract: The present invention relates to compositions and methods for the delivery of therapeutic proteins to the CNS using recombinant AAV vectors. More specifically, the invention relates to compositions and methods for delivering proteins into the cerebrospinal fluid of mammalian subjects through peripheral administration of AAV vectors. The invention may be used to treat various disorders of the central nervous system, including degenerative diseases and motor neuron diseases.
    Type: Grant
    Filed: July 22, 2008
    Date of Patent: February 19, 2019
    Assignees: GENETHON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventor: Martine Barkats
  • Patent number: 10207287
    Abstract: The invention relates to a machine for chromatogenous grafting treatment of a scrolling substrate (S) having a hydroxylated face (Fh), comprising: an application device (3) of a grafting reagent on the hydroxylated face (Fh) of the substrate, a heating roller (4) for the development of the grafting reaction on the hydroxylated face (Fh) of the substrate, said roller (4) being provided with a bar-end system (5a, 5b) for applying a face of the substrate (S) against said heating roller (4), an extraction device (6) of the hydrochloric acid produced during the grafting reaction, an application device (7) of an air knife on the treated face of the substrate for eliminating the residual grafting reagent. The invention also relates to a chromatogenous grafting process used in said machine.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: February 19, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), CENTRE TECHNIQUE DU PAPIER
    Inventors: Daniel Samain, David Guerin, André Lemaitre, Laurent Lyannaz, Jean-Luc Guillouty
  • Patent number: 10209505
    Abstract: The invention relates to an optical device for measuring the position of an object along a first axis, the object being subjected to light radiations emitted by a light source.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: February 19, 2019
    Assignees: Paris Sciences Et Lettres—Quartier Latin, Centre National de la Recherche Scientifique (CNRS), Universite Paris Diderot Paris 7, Sorbonne Universite
    Inventors: Vincent Croquette, Jean-François Allemand, Thibault Vielle
  • Publication number: 20190046981
    Abstract: An object is to stably, continuously and easily detect reactions of filamentary biomolecules or polymers bridging between a pair of electrodes against reagents without employing any marker or labeling substances.
    Type: Application
    Filed: November 20, 2015
    Publication date: February 14, 2019
    Applicant: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Hiroyuki Fujita, Mehmet Cagatay Tarhan, Nicolas Lafitte, Dominique Collard
  • Patent number: 10196683
    Abstract: The present invention relates to a method of preparation of substrates for nucleic acid sequencing reactions. More specifically, the present invention provides a new method of preparing hairpins using force-induced strand invasion. Hairpins prepared by this method and methods of nucleic acid analysis using these hairpins are also part of the present invention.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: February 5, 2019
    Assignees: PARIS SCIENCES ET LETTRES—QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (cnrs), SORBONNE UNIVERSITE, UNIVERSITE PARIS DIDEROT PARIS 7
    Inventors: Vincent Croquette, Jimmy Ouellet
  • Patent number: 10199376
    Abstract: A cell includes at least two semiconductor structures of the same nature, these two structures both employing voltages and currents that are unidirectional, each structure having an anode (10), a cathode (14) and optionally a gate (16). The structures are integrated into the volume of one and the same semiconductor substrate (4). The cathodes (14), and possibly the gates (16), are arranged on a first side of the semiconductor substrate (4). The anodes (10) are each arranged on a second side of the semiconductor substrate (4), which side is opposite the first side, facing the cathodes and possibly the corresponding gates. Two electrodes, anodes or cathodes, of two separate structures, are electrically connected to each other.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: February 5, 2019
    Assignees: Centre National de la Recherche Scientifique (CNRS), Institut National Polytechnique de Toulouse (I.N.P.T.)
    Inventors: Abdelhakim Bourennane, Marie Breil-Dupuy, Frederic Richardeau, Jean-Louis Sanchez
  • Publication number: 20190030126
    Abstract: The present invention relates to a competitive inhibitor of the binding of the protein Bcl-2 L10 to the ligand binding domain of at least one of the IP3R receptors, for its use in the treatment of cancers, the cells of which express the protein Bcl-2 L10.
    Type: Application
    Filed: March 8, 2017
    Publication date: January 31, 2019
    Applicants: Universite Claude Bernard - Lyon 1, Centre Leon Berard, Centre National de la Recherche Scientifique (CNRS ), Institut National de la Sante et de la Recherche M edicale (INSERM)
    Inventors: Adrien Nougarede, Ruth Rimokh, Germain Gillet, Nikolay Georgiev
  • Publication number: 20190031639
    Abstract: The present invention relates to compounds of the following general formula (I) or (II): or a pharmaceutically acceptable salt and/or solvate thereof, for use in the treatment and/or in the prevention of ErbB2 dependent cancers, and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: January 11, 2017
    Publication date: January 31, 2019
    Applicants: Centre National de la Recherche Scientifique (CNRS), Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Paris Descartes
    Inventors: Sandrine Bourdoulous, Camille Faure
  • Publication number: 20190028641
    Abstract: According to one aspect, the present description relates to a system for high resolution imaging of an object comprising a fiber bundle (1) comprising an array of optical fiber cores (A), said fiber bundle being adapted to receive a plurality of light beams issued from spatially incoherent point sources of an object; the system further comprises a two-dimensional detector (240) with a detection plane, located at a proximal end of the fiber bundle, adapted to receive speckle patterns, each speckle pattern resulting from the transmission of one of said light beams through at least a plurality of the fiber bundle cores, the ensemble of speckle patterns detected by the two-dimensional detector forming a multiple speckles image; and a processing unit (250) adapted to determine an image of the object from said multiple speckles image.
    Type: Application
    Filed: December 17, 2015
    Publication date: January 24, 2019
    Applicants: Université d'Aix-Marseille, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNR S, Ecole Centrale de Marseille (ECM), Weizmann Institute of Science (WIS)
    Inventors: Hervé Rigneault, Esben Andresen, Amir Porat, Dan Oron, Ori Katz, Sylvain Gigan
  • Publication number: 20190023645
    Abstract: The present invention relates to the design of novel molecules, referred to as “multi-target” molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDACs) and as inhibitors of tubulin polymerisation. The invention also describes the method for synthesising the “multi-target” molecules and their use in the treatment of cancer, a pharmaceutical composition comprising at least one “multi-target” molecule, and the use of such compositions in the treatment of cancer.
    Type: Application
    Filed: January 5, 2017
    Publication date: January 24, 2019
    Applicants: UNIVERSITE PARIS-SUD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Mouâd ALAMI, Abdallah HAMZE, Jean-Daniel BRION, Jérôme BIGNON, Joëlle DUBOIS
  • Publication number: 20190016093
    Abstract: The present invention relates to a process for grafting polymers onto a metallic material, comprising the following steps: a) oxidation of the surface of the metallic material, resulting in an oxidized metallic material; b) grafting of a polymer at the surface of said oxidized metallic material by radical polymerization of a monomer, said radical polymerization comprising an initiation step and a propagation step, said initiation step being carried out by UV irradiation with a UV source diffusing a power at the surface of the material of greater than 72 mW·cm?2, said UV irradiation being carried out for a duration greater than 15 minutes and less than 180 minutes, said process resulting in a grafted metallic material. The present invention also relates to the materials capable of being obtained by this process, and applications of the latter, in particular as articular or dental implants.
    Type: Application
    Filed: August 8, 2016
    Publication date: January 17, 2019
    Applicants: Univ Paris XIII Paris-Nord Villetaneuse, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Véronique Migonney, Jean-Sébastien Baumann, Céline Falentin-Daudre, Hamza Chouirfa
  • Patent number: 10180427
    Abstract: Novel grafted dinuclear metal complexes having formula (I) or of formula (II) wherein M represents a metal ion, and also the use thereof as sensors in a method for detecting and/or characterising cellular microparticles.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: January 15, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE CAEN BASSE-NORMANDIE, UNIVERSITE GRENOBLE ALPES
    Inventors: Catherine Belle, Gisele Gellon, Laurent Plawinski, Loic Doeuvre, Eduardo Angles Cano
  • Publication number: 20190010413
    Abstract: The use, as markers of petroleum products, crude oils, biofuels or lubricants, of rare earth complexes or one of the constituents thereof chosen from rare earth ligands or salts, being capable of forming a rare earth complex after the addition of a developing solution. Preferably, the rare earth complex can be detected by time-resolved fluorescence. Also, a marking method and a method for detecting a rare earth complex as a marker of petroleum products, crude oils, biofuels or lubricants.
    Type: Application
    Filed: January 12, 2017
    Publication date: January 10, 2019
    Applicants: INOVENTEAM, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Arthur MARAIS, Mahmoud OULD-METIDJI, Florian LEPOIVRE, Anatole COLLET, Matteo MARTINI, Fabien ROSSETTI, Olivier TILLEMENT, Antoine VANLAER, François GHILLEBAERT
  • Patent number: 10173226
    Abstract: The invention concerns a device for controlling the charge of an aerosol comprising: —an aerosol inlet area; —a discharge area having dielectric barriers, in which charged species are generated, the discharge area and the aerosol inlet area being arranged relative to one another in such a way that the aerosol introduced in this way does not flow via the discharge area; —a mixing area for mixing the aerosol with a portion of the charged species from the discharge area; —a post-discharge area linked to the discharge area, the aerosol inlet area and the mixing area being arranged in such a way that at least a portion of a stream flowing in the post-discharge area drives at least a portion of the charged species formed in the discharge area and expelled from the discharge area by electrostatic repulsion towards said mixing area.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: January 8, 2019
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Jean-Pascal Borra, Nicolas Jidenko
  • Patent number: 10177541
    Abstract: The invention concerns an aerosol charger having electrical discharge comprising: a body (2); an ion source (3) comprising two electrodes (31, 32); the charger being characterized in that the body (2) and at least a first electrode (32) of the ion source (3) are aligned along a same axis of longitudinal symmetry (AA?) of the charger, the body (2) surrounding the first electrode (32) in such a way as to define an area (5) for an aerosol to flow between a space defined between the body (2) and the first electrode (32); and in that the first electrode (32) comprises a hole (321) in communication with the area (5) for the aerosol (Ae) to flow, the hole (321) being designed to allow ions formed at the ion source (3) to pass therethrough in order for them to mix with an aerosol (Ae) flowing in the area (5) for the aerosol (Ae) to flow.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: January 8, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUD, SONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
    Inventors: Jean-Pascal Borra, Manuel Alonso, Nicolas Jidenko
  • Patent number: 10174105
    Abstract: Use of a variable fragment (VHH antibody) of a camelid single-chain antibody for the preparation of a peptide vector for delivering a substance of interest across the blood-brain barrier or into a cell.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: January 8, 2019
    Assignees: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Francois Rougeon, Pierre Lafaye, Jean-Pierre Bourgeois
  • Patent number: 10167565
    Abstract: A method and device for electrodeposition in cylindrical geometry. A method for electrochemically depositing a thin layer on a flexible substrate, comprising: providing, in an electrolysis bath, a first closed cylinder in a second hollow cylinder, applying the flexible substrate to one of the surfaces chosen from the outer surface of the first cylinder and the inner surface of the second, the flexible substrate forming a first electrode, providing, in the electrolysis bath, a second electrode, and applying a potential difference between the first electrode and the second electrode in order to electrodeposit the thin layer on the flexible substrate.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: January 1, 2019
    Assignees: ELECTRICITE DE FRANCE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS-
    Inventors: Gregory Savidand, Nicolas Loones, Daniel Lincot, Elisabeth Chassaing
  • Patent number: 10167450
    Abstract: The present invention relates to a method for preparing commercial scale quantities of human functional Betacells and to the establishment of cell lines. It also relates to a method of diagnosis using Beta cell tumors or cells derived thereof. The method comprises sub-transplantation procedure to enrich the graft in proliferating Betacells, allowing to generate human Betacell lines. Such lines express little amount of insulin and have a gene expression profile that resembles to adult Betacells. In addition, the human Betacell lines are able to normalize glycemia of diabetic mice when transplanted, demonstrating their insulin secretion capabilities.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: January 1, 2019
    Assignees: SARL ENDOCELLS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Paul Czernichow, Raphaël Scharfmann, Philippe Ravassard
  • Patent number: 10167374
    Abstract: The invention relates to a method for recovering organic fibers from a composite material comprising a polymer matrix and organic fibers, wherein the method comprises the following steps: providing a solution comprising a mixture of water and alcohol; placing the composite material inside a reactor; contacting the mixture and the composite material in order to perform a solvolysis reaction of the composite material; and recovering the organic fibers; wherein the pressure and the temperature in the reactor are adjusted such as to fall within the homogeneous sub-critical range of the phase diagram, within the super-critical range or near the critical point; and wherein the temperature is lower than the melting temperature of the organic fibers.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: January 1, 2019
    Assignees: UNIVERSITY DE BORDEAUX, AIRBUS OPERATIONS (S.A.S), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Cyril Aymonier, Anne Loppinet Serani, Antoine Debeauvais
  • Publication number: 20180375140
    Abstract: A proton-conductive electrochemical device. The device comprising a positive electrode able to reduce an oxidizing species, a negative electrode able to oxidize a reducing species, and a proton-conductive electrolyte, in contact with the positive electrode and the negative electrode. In addition, the device further comprises a layer able to diffuse protons and electrons, said layer forming a protective barrier against contaminants for the proton-conductive electrolyte. The layer is in contact with the proton-conductive electrolyte on the one hand and the negative electrode on the other hand. A method for manufacturing such device is also provided.
    Type: Application
    Filed: December 16, 2016
    Publication date: December 27, 2018
    Applicants: ELECTRICITE DE FRANCE, UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS-
    Inventors: Mathieu Marrony, Gilles Taillades, Jacques Roziere, Julian Dailly