Patents Assigned to Centre National de la Recherche Scientifique (Cnrs)
  • Publication number: 20180105872
    Abstract: The present invention relates to a method of preparation of substrates for nucleic acid sequencing reactions. More specifically, the present invention provides a new method of preparing hairpins using force-induced strand invasion. Hairpins prepared by this method and methods of nucleic acid analysis using these hairpins are also part of the present invention.
    Type: Application
    Filed: May 4, 2016
    Publication date: April 19, 2018
    Applicants: PARIS SCIENCES ET LETTRES-QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE PARIS DIDEROT PARIS 7
    Inventors: Vincent CROQUETTE, Jimmy OUELLET
  • Patent number: 9944669
    Abstract: The present invention relates to hybrid fumarate-CO-releasing molecules capable of increasing heme oxygenase-1 (HO-1) activity and HO-1 protein expression and simultaneously releasing CO, their synthesis and their use in therapeutic applications, in particular their use in the treatment of inflammatory or cardiovascular diseases.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: April 17, 2018
    Assignees: UNIVERSITE PARIS EST CRETEIL VAL DE MARNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Roberto Motterlini, Roberta Foresti, Thierry Martens, Michael Rivard
  • Publication number: 20180100887
    Abstract: Method of contactless measurement of the conductivity of semiconductors, said method being implemented by: a first assembly comprising a signal emission/reception system —a second assembly comprising at least one semi-conducting target and an inductor element, —a third assembly, said method comprising at least the following steps: a) the first assembly emits a multifrequency signal, b) the second assembly reflects or transmits at least one part of the multifrequency signal emitted, c) the first assembly receives the reflected multifrequency signal reflected by the second assembly, d) the third assembly calculates the coefficient of reflection or of transmission of the emitted signal, e) the third assembly provides the conductivity of the semiconducting target.
    Type: Application
    Filed: April 7, 2016
    Publication date: April 12, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, UNIVERSITE PARIS-SUD, ECOLE SUPERIEURE D'ELECTRICITE
    Inventors: Denis Mencaraglia, Yann Le Bihan, Florent Loete
  • Patent number: 9938456
    Abstract: This deals with a luminescent salt comprising a metal cluster anion and an organic cation, wherein the metal cluster anion comprises a metal cluster with at least two metal atoms, and ligands, the metal atoms being chosen from the group consisting of molybdenum, rhenium, tungsten, thallium, niobium, and mixtures thereof, wherein the organic cation comprises a cationic head substituted by at least one substituent including a polymerizable functional group. It also deals with a polymeric material comprising a polymer matrix which has polymerized with this luminescent salt.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: April 10, 2018
    Assignees: Universite de Rennes 1, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Yann Molard, Maria De Los Angeles Amela-cortes, Stephane Cordier
  • Patent number: 9937232
    Abstract: The present invention concerns particles containing at least one covalently cross-linked polysaccharide and at least one growth factor, a method of preparation, and uses thereof.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: April 10, 2018
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERISITE DE ROUEN, UNIVERSITE DE REIMS, CENTRE HOSPITALIER UNIVERSITE DE ROUEN
    Inventors: Ebba Brakenhielm, Sébastien Banquet, Florence Edwards-Levy, Christian Thuillez
  • Publication number: 20180097563
    Abstract: The invention relates to a free space optical communications device (10) multiplexed in wavelengths of between 400 nm and 1600 nm, said device including demultiplexing means (11) that are designed so as to separately dissociate a number n1 of wavelengths from one another, the demultiplexing means (11) including one or more detectors (110) having a number n2 of optical filters (111) and active elements (112) which correspond to the number n1 of wavelengths, each active element (112) being arranged to selectively detect one wavelength from among said wavelengths (Id. . . An) via an optical filter (111) separate from the active element (112) which is included in a housing (113), the optical filter (111) being in contact with a protection means (114), inserted between the optical filter (111) and the active element (112), said protection means (114) closing said housing (113).
    Type: Application
    Filed: March 30, 2016
    Publication date: April 5, 2018
    Applicants: UNIVERSITÉ DE PICARDIE JULES VERNE, UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Frederic LAMARQUE, Christine PRELLE, Hani AL HAJJAR, Jeremy TERRIEN, Andreas ZEINERT
  • Patent number: 9933609
    Abstract: The invention relates to an optical device for measuring the position of an object along a first axis, the object being subjected to light radiations emitted by a light source.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: April 3, 2018
    Assignees: Paris Sciences Et Lettres—Quartier Latin, Centre National de la Recherche Scientifique (CNRS), Universite Pierre Et Marie Curie (Paris 6), Universite Paris Diderot Paris 7
    Inventors: Vincent Croquette, Jean-François Allemand, Thibault Vielle
  • Patent number: 9931341
    Abstract: The present invention relates to the treatment or prevention of skeletal disorders, in particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FGFR3), in particular by expression of a constitutively activated mutant of FGFR3.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: April 3, 2018
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PARIS DESCARTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSITANCE PUBLIQUE HOPITAUX DE PARIS, UNIVERSITE PARIS DIDEROT-PARIS 7, IMAGINE
    Inventors: Laurence Legeai-Mallet, Arnold Munnich, Patricia Busca, Florent Barbault
  • Patent number: 9932410
    Abstract: The invention relates to human neutralizing anti-KIT antibodies and uses thereof. More particularly, the invention relates to an antibody comprising a heavy chain variable region comprising SEQ ID NO: 2 in the H-CDR1 region, SEQ ID NO: 3 in the H-CDR2 region and SEQ ID NO: 4 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO: 7 in the L-CDR2 region and SEQ ID NO: 8 in the L-CDR3 region. The invention also relates to an antibody comprising a heavy chain variable region comprising SEQ ID NO: 10 in the H-CDR1 region, SEQ ID NO: 11 in the H-CDR2 region and SEQ ID NO: 12 in the H-CDR3 region; and a light chain variable region comprising SEQ ID NO: 14 in the L-CDR1 region, SEQ ID NO: 15 in the L-CDR2 region and SEQ ID NO: 16 in the L-CDR3 region.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: April 3, 2018
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique (CNRS), Universite de Montpellier, Universite Paris- Sud, Institut Regional du Cancer du Montpellier, Ecole Normale Superieure de Cachan
    Inventors: Marie-Alix Poul, Mariane Le Gall, Ronan Crepin
  • Patent number: 9931433
    Abstract: The present invention relates generally to a hydrogel releasing glucose in a time-controlled manner, to medical applications thereof, and to a method for preparing said hydrogel.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: April 3, 2018
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Paris Diderot Paris 7, Universite Cergy-Pontoise, Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Mickael Deschepper, Hervé Petite, Delphine Logeart Avramoglou, Joseph Paquet, Emmanuel Pauthe, Laurent Bidault, Véronique Larreta Garde
  • Patent number: 9932556
    Abstract: The present invention relates to a method for in vitro differentiation of a population of blood circulating cells, such as monocytes and preferably pluripotent macrophages derived therefrom, into cells displaying functional and phenotypic neuronal characteristics. The invention further encompasses neuronal-like cells obtainable according to the present method, compositions comprising said cells, and applications thereof.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: April 3, 2018
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Paris Descartes, Institut Ntaitonal de la Sante et de la recherche Medicale (INSERM), Assistance Publique—Hopitaux de Paris
    Inventors: Anne Hosmalin, Vincent Feuillet, Marie-Odile Krebs, Thérèse Jay, Alfredo Bellon
  • Patent number: 9926574
    Abstract: The present invention relates to compositions and methods, in particular to methods based on systemic injection of rAAV, for delivering genes to cells of the central nervous system in mammals, such as brain neurons or glial cells, and in particular to motor neurons or glial cells of the spinal cord The invention also relates to methods of treating motor neuron disorders in mammals by expression of therapeutic genes. The invention stems from the unexpected discovery that peripheral injection of AAV vectors leads to a bypass of the blood brain barrier and a massive infection of motor neurons. The invention may be used in any mammal, including human subjects.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: March 27, 2018
    Assignees: GENETHON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventor: Martine Barkats
  • Patent number: 9919029
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of bacterial infections. In particular, the present invention relates to a Toll-like receptor (TLR) agonist for use in a method for the treatment of a bacterial infection in a subject in need thereof wherein the TLR agonist is administered to the subject in combination with at least one antibiotic.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: March 20, 2018
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Universite de Droit et de la Sante de Lille 2, Centre National de la Recherche Scientifique (CNRS), Institut Pasteur de Lille, Universite de Lille 1 Sciences et Technologies, ETH Zurich, Universidad de la Republica
    Inventors: Wolf-Dietrich Hardt, Patrick Kaiser, Jean-Claude Sirard, Christophe Carnoy, Delphine Fougeron, Jose Alejandro Chabalgoity, Natalia Munoz
  • Patent number: 9914691
    Abstract: The first subject matter of the invention is the (3R) epimer of octahydro-7,7-dimethyl-8-methylene-1H-3a,6-methanoazulen-3-yl acetate [(octahydro-7,7-dimethyl-8-methylene-[3R,3aR,6R,8aR]-1H-3a,6-methanoazulen-3-yl acetate) or (R)-norzizaenylacetate] of formula I (I). The subject matter of the invention is also compositions comprising (R)norzizaenyl acetate and also a novel synthesis process and the use of said ester.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: March 13, 2018
    Assignees: ROBERTET SA, UNIVERSITE DE NICE SOPHIA ANTIPOLIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Jean-Jacques Filippi, Emilie Belhassen, Nicolas Baldovini, Hugues Brevard
  • Patent number: 9915655
    Abstract: The present invention relates to a method for determining whether a protein binds to a specific DNA sequence. This method is useful in particular for identifying modifications to the DNA sequence (e.g. methylations) via the binding of proteins that specifically recognize those modifications (e.g. antibodies), but also to identify the binding sequence on DNA of a variety of proteins.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: March 13, 2018
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: David Bensimon, Vincent Croquette, Harold Gouet, Jean-Francois Allemand, Fang-Yuan Ding
  • Publication number: 20180069090
    Abstract: Heterojunction structure, also referred to as a heterostructure, of semiconductor material, in particular for a high electron mobility transistor (HEMT), includes a substrate, a stack of at least three buffer layers of a same semiconductor material with a wide bandgap EG1 based on a column-III nitride, namely an unintentionally doped first buffer layer, a second buffer layer, an unintentionally doped third buffer layer, an unintentionally doped intermediate layer, and a barrier layer arranged on the intermediate layer, said barrier layer being of a semiconductor material with a wide bandgap EG2 based on a column-III nitride; the second buffer layer has constant P+ doping throughout some or all of its thickness; and the third buffer layer includes a first region which is unintentionally doped throughout its entire thickness and at least one second region adjacent to said first region with N+ doping surrounding the first region.
    Type: Application
    Filed: December 15, 2015
    Publication date: March 8, 2018
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, UNIVERSITE LIBANAISE
    Inventors: Frédéric MORANCHO, Saleem HAMADY, Bilal BEYDOUN
  • Publication number: 20180066338
    Abstract: A single-phase alloy is formed, as weight percentages, of N % of gold, M % of tungsten, with N+M=100, M?8 and N?60. Also disclosed is a process for preparing such an alloy use of such an alloy and decorative sheets made from such an alloy.
    Type: Application
    Filed: March 21, 2016
    Publication date: March 8, 2018
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS )
    Inventor: Cyrile DERANLOT
  • Patent number: 9907860
    Abstract: This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Said organic molecule comprises a 5 to 21 amino acid anionic polypeptide. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: March 6, 2018
    Assignees: INSTITUT PASTEUR, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE PARIS-SUD, UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Francoise Baleux, Hugues Lortat-Jacob, David Bonnaffe, Yves-Marie Coic
  • Publication number: 20180063506
    Abstract: The present invention concerns a method for the 3D reconstruction of a scene comprising the matching (610) of a first event from among the first asynchronous successive events of a first sensor with a second event from among the second asynchronous successive events of a second sensor depending on a minimisation (609) of a cost function (E).
    Type: Application
    Filed: March 15, 2016
    Publication date: March 1, 2018
    Applicants: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Ieng SIO-HOI, Benosman RYAD, Shi BERTRAM
  • Publication number: 20180059412
    Abstract: The invention concerns a method for tuning at a targeted resonance wavelength at least one micro and/or nanophotonic resonator, the resonator having dimensions defining resonance wavelength of said resonator, the resonator being immersed in a fluid containing ions so that the resonator is surrounded by said fluid, wherein the method comprises a step of injecting light, having a light wavelength equal to the resonance wavelength, into the resonator, so that the injected light resonates within the resonator and triggers a photo-electrochemical etching process enabled by the surrounding fluid containing ions, said etching process being enhanced by the optical resonance which amplifies light intensity in the photonic resonator, the etching decreasing dimensions of the photonic resonator, hereby lowering and tuning the resonance wavelength of the photonic resonator.
    Type: Application
    Filed: March 4, 2016
    Publication date: March 1, 2018
    Applicants: Universite Paris Diderot Paris 7, Centre National de la Recherche Scientifique (CNRS )
    Inventors: Ivan Favero, Christopher Baker, Eduardo Gil Santos