Abstract: A method for producing electrical energy. An electrolyte solution having a first concentration CA of a solute is placed in a first vessel having an electrode arranged so the electrode is contacted with the electrolyte solution of concentration CA. An electrolyte solution having a concentration CB of the same solute is placed in a second vessel having an electrode arranged so the electrode comes in contact with the electrolyte solution of concentration CB, the concentration CB being lower than the concentration CA. The first and the second vessels are separated by a membrane, the membrane having at least one nanochannel arranged to allow diffusion of the electrolyte solution from the first vessel to the second vessel through the at least one nanochannel. An inner surface of the at least one nanochannel is formed of at least one titanium oxide. Electrical energy generated by a potential difference existing between the electrodes is captured using a device having the first and second vessels.
Type:
Grant
Filed:
February 24, 2021
Date of Patent:
February 7, 2023
Assignees:
Centre National de la Recherche Scientifique (CNRS), Sweetch Energy
Inventors:
Bruno Mottet, Lyderic Bocquet, Alessandro Siria, Mikhael Bechelany
Abstract: The present invention relates to a novel use of total cellular iron, preferably under the form of ferrous iron (Fe2+), as a marker of cancer stem cells (CSCs). The invention also relates to methods using said iron marker, in particular for metastatic cancer diagnosis or treatment, for screening for compounds of interest, as well as for killing CSCs.
Type:
Grant
Filed:
March 8, 2017
Date of Patent:
February 7, 2023
Assignees:
Institute National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université de Paris
Inventors:
Maryam Mehrpour, Raphael Rodriguez, Ahmed Hamai, Trang Mai
Abstract: A full-field optical coherence tomography imaging method, FFOCT, using a system comprising an FFOCT device and a sample, the sample comprising a layer of interest to be imaged, the FFOCT device comprising an incoherent light source, an imager, a beam splitter defining a sample arm and a reference arm, the method comprising-generating sample light containing interest light originating from the layer of interest and reference light traveling from the reference arm, —acquiring an image from reference light and sample light combined in the beam splitter; wherein at least one of the sample arm and the reference arm comprises an optical curvature compensator that modifies a transverse variation distribution of an optical path length to match the transverse variation distributions of the optical path lengths travelled by the reference light and the interest light incident on the imager.
Type:
Application
Filed:
December 18, 2020
Publication date:
February 2, 2023
Applicants:
Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris
Inventors:
Viacheslav Mazlin, Pedro Francisco Baracal De Mece, Albert Claude Boccara
Abstract: The present invention relates to a selective process for preparing sulfones from sulfides by enzymatic catalysis, and to a composition comprising a symmetrical sulfide, an oxidoreductase enzyme catalyzing the oxidation of said symmetrical sulfide to symmetrical sulfone; optionally at least one cofactor C of said enzyme E; and an oxidant, which allows in particular the implementation of said process.
Type:
Application
Filed:
June 12, 2020
Publication date:
January 19, 2023
Applicants:
Arkema France, Centre National de la Recherche Scientifique (CNRS), Universite d'Aix-Marseille
Inventors:
Georges Fremy, Hugo Brasselet, Véronique Alphand, Katia Duquesne
Abstract: A method for identifying a microorganism to be identified, which includes the following steps: obtaining an Excitation-Emission EEM of the microorganism to be identified, analysing the main components of the EEM matrix using at least one reference EEMr matrix, projecting the result of the analysis onto a plane defined by two main components, and identifying the microorganism to be identified.
Type:
Application
Filed:
November 27, 2020
Publication date:
January 5, 2023
Applicants:
UNIVERSITE DU MANS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, UNIVERSITE D'ANGERS, CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERS
Abstract: The invention relates to the extraction of organic compounds from mixtures of said compounds with water, using a nanoporous carbon membrane. The invention can be used in any field where it is desired to separate an organic compound of interest from water, such as the drying of alcohols or alkanes.
Type:
Grant
Filed:
March 27, 2017
Date of Patent:
January 3, 2023
Assignees:
Paris Sciences et Lettres, Université Paris Cité, Centre National De La Recherche Scientifique (CNRS), Sorbonne Universite
Abstract: The invention relates to the use of a ternary Titanium-Zirconium-Oxygen (Ti—Zr—O) alloy, characterized in that it comprises from 83% to 95.15 mass % of titanium, from 4.5% to 15 mass % of zirconium and from 0.35% to 2 mass % of oxygen, with said alloy being capable of forming a single-phase material consisting of a stable and homogeneous ? solid solution of Hexagonal Close Packed (HCP) structure at room temperature in the medical, transport or energy fields.
Type:
Grant
Filed:
March 10, 2021
Date of Patent:
January 3, 2023
Assignees:
Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Biotech Dental
Abstract: The invention relates to the use of an iron-score based on the expression level of at least 1 gene, in particular at least 3, preferably at least 5, and even preferably 8 genes selected in the group consisting of APEX1, TFRC, HIF1A, ABCG2, SCARA3, IREB2, SFXN4 and SLC39A14 involved in the iron metabolism, as a prognosis marker in subjects having MCL, in particular for identifying subjects with a poor outcome such as a relapse and/or death.
Type:
Application
Filed:
November 6, 2020
Publication date:
December 15, 2022
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), UNIVERSITE DE MONTPELLIER, INSTITUT CURIE
Abstract: The invention relates a fluorescent compound of formula I: wherein A is selected from P, P?O and N; ·R1 is a residue comprising an oxygen atom·R2 is a residue comprising an oxygen atom, or a halogen, ·R3, R4 and R5 are alkyls, possibly substituted or a salt or a solvate thereof. The compound is useful as a fluorescent probe sensitive to membrane fluidity and for diagnosing cancer.
Type:
Application
Filed:
September 22, 2020
Publication date:
December 8, 2022
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, CPE LYON FORMATION CONTINUE ET RECHERCHE pouvant être précédée ou suivie par CPE LYON FCR, CENTRE LEON BERARD, HOSPICES CIVILS DE LYON
Inventors:
Thierry GRANJON, Ofelia MANITI, Olivier MARCILLAT, Peter GOEKJIAN, Mouhedine CHENIOUR, Arnaud VIGNERON, David GUEYRARD, Sébastien IBANEZ
Abstract: The present invention relates to a pharmaceutical or veterinary composition for its use in preventing and/or treating a MERS-CoV (Middle-East Respiratory Syndrome) coronavirus infection, characterised in that it comprises, in a suitable pharmaceutical vehicle, at least one compound chosen from apigenin and berberine.
Type:
Grant
Filed:
October 20, 2017
Date of Patent:
November 29, 2022
Assignees:
UNIVERSITE CLAUDE BERNARD LYON 1, INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Inventors:
Manuel Rosa-Calatrava, Olivier Terrier, Anaïs Proust, Vincent Moules
Abstract: A method for the preparation of a gelled polysaccharide foam, which includes the following steps: (a) the preparation of a mixture including at least one solubilized polysaccharide chosen from alginates, pectic substances, carrageenans, and mixtures thereof, at least one solvent of the polysaccharide, at least one ionic crosslinking agent of the polysaccharide, the crosslinking agent being not available, optionally a plasticizer soluble into the solvent, optionally a surfactant, and optionally an additive, (b) foaming and gelling the mixture prepared at step (a) by incorporating a pH modifying gas, and (c) optionally drying the gelled foam obtained at step (b). Also, the gelled foam obtained from such a method as well as the uses thereof.
Type:
Application
Filed:
October 27, 2020
Publication date:
November 24, 2022
Applicants:
URGO RECHERCHE INNOVATION ET DEVELOPPEMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -
Abstract: A kit of two compositions comprising the same odorants in mixtures of different proportions is used for the measurement of olfactory discrimination capacity in subjects affected by a psychiatric disorder or disease involving mood disturbance, more particularly mood depression.
Type:
Grant
Filed:
January 21, 2020
Date of Patent:
November 22, 2022
Assignees:
INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Abstract: A part includes a substrate having, adjacent to a surface of the substrate, at least a portion that is made of a material that contains silicon, and an environmental barrier formed on the surface of the substrate, the environmental barrier including a first layer including at least one first rare earth silicate and presenting grains with a mean size less than or equal to 1 ?m; and a second layer covering the first layer, the second layer including at least one rare earth silicate and presenting grains with a mean size greater than 1 ?m.
Type:
Grant
Filed:
December 29, 2017
Date of Patent:
November 22, 2022
Assignees:
SAFRAN CERAMICS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BORDEAUX
Inventors:
Lisa Pin, Simon Arnal, Francis Rebillat, Fabrice Mauvy
Abstract: The present invention relates to an attenuated virus strain derived from a human metapneumovirus strain comprising the genome sequence represented by sequence SEQ ID NO. 1, said attenuated strain comprising one or more genetic modifications of said sequence SEQ ID NO. 1 attenuating the virulence of said strain.
Type:
Grant
Filed:
July 12, 2019
Date of Patent:
November 22, 2022
Assignees:
UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYON, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE LAVAL
Inventors:
Manuel Rosa-Calatrava, Guy Boivin, Julia Dubois, Mario Andres Pizzorno, Olivier Terrier, Marie-Eve Hamelin, Marie-Helene Cavanagh
Abstract: A medical device for penetrating a bone structure including a processing unit having a transfer function that associates an electrical conductivity value S with a depth value d, wherein the processing unit is configured to detect a threshold selected from amongst an absolute threshold, a relative threshold and a critical gradient, and to emit a warning signal and/or control signal responsive to detection of the threshold.
Type:
Application
Filed:
May 2, 2022
Publication date:
November 17, 2022
Applicants:
SpineGuard, Sorbonne Universite, Centre National de la Recherche Scientifique - CNRS, INSERM (Institut National de la Sante et de la Recherche Medicale)
Inventors:
Stephane BETTE, Jimmy DA SILVA, Thibault CHANDANSON, Guillaume MOREL, Maurice BOURLION
Abstract: The present invention concerns novel Lactobacillus plantarum strains capable of promoting the growth of a subject, and more particularly the juvenile or prenatal growth of farm animals, and their uses as probiotics.
Type:
Grant
Filed:
August 17, 2018
Date of Patent:
November 15, 2022
Assignees:
ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1
Abstract: Process for the conversion of non-oxidative coupling of methane to ethylene, under non-oxidative conditions, comprising: providing a first stream containing at least 50 vol. % of methane based on the total volume of said first stream; providing a catalyst; putting in contact said first stream with said catalyst at a weight hour space velocity ranging from 0.5 to 100 h?1, a temperature ranging from 500° C. to 1100° C. and a pressure ranging from 0.1 MPa to 5 Mpa in the absence of oxygen; recovering a second stream containing unconverted methane if any, ethylene and hydrocarbons having at least 2 carbon atoms. Said process is remarkable in that said catalyst is a synthetic zeolite material, containing at least one metal M with silicon to metal M molar ratio Si/M as determined by inductively coupled plasma optical emission spectrometry ranging from 100 to 65440 and in that said metal M is incorporated inside of the zeolite tetrahedral sites.
Type:
Grant
Filed:
October 26, 2020
Date of Patent:
November 15, 2022
Assignees:
TOTALENERGIES ONETECH, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Inventors:
Florent Dubray, Svetlana Mintova, Jean-Pierre Gilson, Stanislav Konnov, Stijn Van Daele, Nikolai Nesterenko
Abstract: The present invention relates to a digital multiplex method for detecting and/or quantifying multiple target biomolecules in a sample, said biomolecules being selected from DNA, RNA, and proteins. The present invention further relates to different applications of the digital multiplex method and to a kit.
Type:
Application
Filed:
May 27, 2020
Publication date:
November 10, 2022
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, PARIS SCIENCES ET LETTRES, UNIVERSITE DE PARIS
Inventors:
Guillaume GINES, Yannick RONDELEZ, Thomas JET, Valérie TALY
Abstract: The present invention relates to a method for treating a Leber congenital amaurosis in a patient harbouring the mutation c.2991+1655 A>G in the CEP290 gene, comprising the step of administering to said patient at least one antisense oligonucleotide complementary to nucleic acid sequence that is necessary for preventing splicing of the cryptic exon inserted into the mutant c. 2991+1655 A>G CEP290 mRNA.
Type:
Grant
Filed:
March 3, 2020
Date of Patent:
November 8, 2022
Assignees:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), GENETHON, UNIVERSITE PARIS DESCARTES, ENSCP—CHIMIE PARISTECH—ECOLE NATIONALE SUPERIEURE DE CHIME DE PARIS, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
Inventors:
Jean-Michel Rozet, Antoine Kichler, Isabelle Perrault, Josseline Kaplan, Xavier Gerard, Daniel Scherman, M. Arnold Munnich
Abstract: The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing the compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.
Type:
Application
Filed:
June 3, 2022
Publication date:
November 3, 2022
Applicants:
CENTRE LEON BERARD, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)