Patents Assigned to Centre National de la Recherche Scientifique (Cnrs)
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Publication number: 20220178828Abstract: A calibration standard for determining an intensity decay related to an evanescent field generated close to the interface between a sample to be tested and a substrate on which the sample is to be deposited, preparation and analysis methods and use thereof.Type: ApplicationFiled: September 12, 2019Publication date: June 9, 2022Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE PARIS, UNIVERSITE BAR-ILANInventors: Martin OHEIM, Adi SALOMON
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Patent number: 11351226Abstract: Cytoablative treatments lead to severe damages on thymic epithelial cells (TECs), which result in delayed de novo thymopoïesis and a prolonged period of T-cell immunodeficiency. Understanding the mechanisms that govern thymic regeneration is of paramount interest for the recovery of a functional immune system notably after bone marrow transplantation (BMT). Here, the inventors show that administration of RANK ligand (RANKL) after total body irradiation and BMT boosts thymic regeneration. Notably, this treatment is also beneficial upon BMT in aged individuals. The inventors show that RANKL can improve thymopoiesis in aged individuals affected by thymic involution. Finally, the inventors show that RANK receptor is conserved in the human thymus. Accordingly, one aspect of the present invention relates to a method of boosting thymic regeneration in a patient suffering from a thymic injury comprising administering to the subject a therapeutically effective amount of a RANKL polypeptide.Type: GrantFiled: February 26, 2018Date of Patent: June 7, 2022Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Magali Irla, Noella Lopes
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Patent number: 11345730Abstract: The present invention relates to a chimeric protein comprising at least one human amyloid P component and at least one fragment of an Fc region of a human antibody, the human amyloid P component and the fragment of an Fc region with which it is associated being bound to each other by means of a hinge region.Type: GrantFiled: May 11, 2018Date of Patent: May 31, 2022Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ DE LIMOGESInventors: Christophe de Romeuf, Christophe Sirac, Jean-Claude Brouet
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Publication number: 20220162266Abstract: The present invention relates to a mutant polypeptide comprising the amino acid sequence of the ectodomain of glycoprotein G of a vesicular stomatitis vims (VSV) strain, wherein said ectodomain comprises the amino acid sequence as set forth in SEQ ID NO: 2 or a sequence having at least 50% of identity with the amino acid sequence as set forth in SEQ ID NO: 2, with at least one substitution of an amino acid residue selected from the group consisting of: a) any amino acid residue located from position 421 to position 429 and any amino acid residue located from position 17 to position 25 of SEQ ID NO:2; or b) any amino acid residue located from a position equivalent to position 421 to a position equivalent to position 429 of SEQ ID NO: 2 and any amino acid residue located from a position equivalent to position 17 to a position equivalent to position 25 of SEQ ID NO: 2, after optimal global alignment with SEQ ID NO:2.Type: ApplicationFiled: March 16, 2020Publication date: May 26, 2022Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS SACLAYInventors: Aurélie ALBERTINI, Hélène RAUX, Yves GAUDIN, Franck PEREZ
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Publication number: 20220162267Abstract: The present invention relates to new adenoviral coat protein based delivery vehicles. They are based on a modified penton base protomers that assemble into VLPs. Exposed areas of the penton base proteins can be modified to allow the VLP to specifically bind to any target and/or to comprise any desired peptide epitope. Additional cargo, e.g. drugs, proteins, or nucleic acids, can reversibly or irreversibly attached to the VLP via engineered fibre protein fragments.Type: ApplicationFiled: February 1, 2022Publication date: May 26, 2022Applicants: THE EUROPEAN MOLECULAR BIOLOGY LABORATORY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Imre BERGER, Frédéric GARZONI, Pascal FENDER
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Patent number: 11339191Abstract: The present invention relates to peptidomimetic macrocycles comprising at least one macrocycle-forming linker and an amino acid sequence chosen from the group consisting of: i) an amino acid sequence with at least about 50%, 60%, 70%, 80%, 90%, or 95% sequence identity to a human sequence IRAK2 54-71 (SEQ ID No1) and 100% identity with the amino acids in the positions 5-6, 9-11, 14-15 or ii) an amino acid sequence with at least about 50%, 60%, 70, 80%, 90%, or 95% sequence identity to a human sequence IRAKM 66-83 (SEQ ID No2) and 100% identity with the amino acids in the positions 5-6, 9-11, 13-14, wherein the peptidomimetic macrocycle comprises an a-helix and at least two natural or two non-natural amino acids crosslinked by a macrocycle-forming linker. It also concerns method of preparation of said peptidomimetic macrocycles and uses thereof, pharmaceutical composition and uses thereof, in particular as inhibitors of inflammatory pathways.Type: GrantFiled: December 22, 2017Date of Patent: May 24, 2022Assignees: Universite de Montpellier, Centre National de la Recherche Scientifique (CNRS)Inventors: Guillaume Laconde, Muriel Amblard-Caussil, Jean Martinez, Christian Jorgensen, Florence Apparailly-Sechan, Isabelle Duroux-Richard
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Publication number: 20220144720Abstract: The invention relates to an energy-releasing composite material comprising at least one nanoporous material and at least one inorganic oxidant, characterised in that said nanoporous material is a nanoporous carbon material.Type: ApplicationFiled: April 9, 2020Publication date: May 12, 2022Applicants: Ecole Royale Militaire, Centre National de la Recherche Scientifique (CNRS)Inventors: Romuald Jean-Pierre VAN RIET, Maria Concepcion OVIN ANIA, Michel Henri Jean-Marie LEFEBVRE, Peter Jean Joseph LODEWYCKX
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Publication number: 20220143635Abstract: The invention relates to a system for dropping a liquid, comprising a liquid storage reservoir (2) provided with a liquid outlet area (3) that comprises an outlet nozzle (4) and a dropping hatch (5). Furthermore, the dropping System (1) comprises means for varying the air pressure in the storage reservoir (2) depending on the level of liquid in the reservoir (2).Type: ApplicationFiled: February 27, 2020Publication date: May 12, 2022Applicants: INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), KEPPLAIR EVOLUTIONInventors: David Joubert, Dominique Legendre, Grégory Ehses
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Publication number: 20220133392Abstract: The present invention relates to a microfluidic chip for attracting and destroying a specific biological element, said chip comprising: a reservoir (1) consisting of a matrix comprising a chemoattractant compound capable of attracting the biological element at least one network of microchannels (2) arranged between the reservoir (1) and the external environment (3) of the chip and allowing the chemoattractant compound to pass to said environment and the biological element present in said environment to pass to the reservoir (1) at least one electrode (4) arranged between the reservoir (1) and the network of microchannels (2) or at the same location as the network of microchannels (2), said electrode (4) being capable of generating an electric field so as to destroy the biological element during its passage to the reservoir (1).Type: ApplicationFiled: March 12, 2020Publication date: May 5, 2022Applicants: UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIERInventors: Benoît CHARLOT, Jean-Marie RAMIREZ, Sébastien MEANCE, Xavier GARRIC, Coline PINESE, Isabelle GUIRAUD
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Publication number: 20220127736Abstract: The present invention relates to an electrolysis device comprising an anode and a cathode, wherein the anode and the cathode each are an electrode comprising an electrically conductive support of which at least a part of the surface is covered by a metal deposit of copper, wherein the surface of the metal deposit is in an oxidized, sulfurated, selenated and/or tellurized form and the metal deposit has a specific surface area greater than or equal to 1 m2/g. The present invention relates also to a method for reducing CO2 into hydrocarbons using an electrolysis device according to the invention. The method according to the invention comprises: a) providing an electrolysis device according to the invention; b) exposing the cathode of said electrolysis device to a CO2-containing aqueous catholyte solution; c) exposing the anode of said electrolysis device to an aqueous anolyte solution; and d) applying an electrical current between the anode and the cathode in order to reduce the carbon dioxide into hydrocarbons.Type: ApplicationFiled: November 21, 2019Publication date: April 28, 2022Applicants: Paris Sciences et Lettres - Quartier Latin, College de France, Centre National de la Recherche Scientifique (CNRS), Sorbonne Universite, College de FranceInventors: Marc Fontecave, Victor Mougel, Huan Tran Ngoc, Daniel Alves Dalla Corte, Sarah Lamaison, Lukas Lutz
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Publication number: 20220131624Abstract: A wave shaping device which comprises a tunable impedance surface and a controller connected to the surface in order to control its impedance. The shaping device further comprises a transmission module for receiving a pilot signal used to control the impedance of the surface.Type: ApplicationFiled: January 10, 2022Publication date: April 28, 2022Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, UNIVERSITE PARIS DIDEROT - PARIS 7Inventors: Mathias Fink, Geoffroy Lerosey, Matthieu Dupre, Nadége Kaina
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Patent number: 11311848Abstract: A bladeless mixer for mixing a liquid, includes a cylindrical or truncated cone-shaped receptacle having an axis A and a radius R, the radius R being the shortest distance between the axis A and a side wall of the receptacle, the liquid to be mixed being placed in the receptacle and having an exposed surface at a height H measured along axis A; a member for tilting the receptacle such that axis A forms a non-zero-degree angle of up to 30° relative to the vertical direction; a member for imparting a rotational movement to the receptacle along axis A at an angular speed of rotation ?; wherein the aspect ratio H/R of the height H to the radius R and the angular speed of rotation ? are selected such that an inherent mode of inertia of the liquid has an unstable resonance when the receptacle is tilted and rotates.Type: GrantFiled: March 1, 2017Date of Patent: April 26, 2022Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DAIX MARSEILLE, ECOLE CENTRALE DE MARSEILLEInventors: Patrice Meunier, Richard Manasseh
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Patent number: 11311484Abstract: The present invention relates to a method for treating skin afflictions in a subject comprising a step of administering said subject with a therapeutically effective amount of small extracellular vesicles (sEV) comprising CD98hc. Inventors have demonstrated that healthy dermal fibroblasts produced and secreted EVs bearing characteristic of exosome-like small EVs (sEVs). They have shown that CD98hc was present at the surface of sEVs, transferred and stabilized at the plasma membrane of recipient cells. They observed that the transferred protein was functional both in vitro and in vivo. Furthermore, injection of sEVs in epidermal CD98hc KO mice exhibiting wound healing defect rescued wound closure in vivo. Thus, their findings reveal that CD98hc contained in EVs could potentially be used in vivo to treat and improve multiple skin afflictions by allowing protein rescue.Type: GrantFiled: April 30, 2019Date of Patent: April 26, 2022Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université Nice Sophia Antipolis, Centre National de la Recherche Scientifique (CNRS)Inventors: Chloé Feral, Floriane Tissot, Laurence Cailleteau, Soline Estrach
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Patent number: 11300568Abstract: The present invention relates to the diagnosis of gastrointestinal stromal tumors (GISTs). The present invention also relates to methods and compositions for the treatment of gastrointestinal stromal tumors (GISTs).Type: GrantFiled: February 10, 2017Date of Patent: April 12, 2022Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Pascal De Santa Barbara, Sandrine Faure-De Santa Barbara
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Publication number: 20220100050Abstract: A method for frequency-converting a source optical signal in order to produce a useful optical signal, by mixing a plurality of waves, implements a plurality of waveguides that are coupled together. Individual parameter values of the waveguides, as well as at least one coupling parameter, are selected so as to obtain the useful signal with a high intensity. Such a method for producing the useful signal is suitable for a spectroscopic application, in particular a molecular spectroscopy application.Type: ApplicationFiled: January 15, 2020Publication date: March 31, 2022Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, UNIVERSITE DE BOURGOGNEInventors: Pierre COLMAN, Alexandre PARRIAUX, Kamal HAMMANI, Guy MILLOT
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Publication number: 20220098552Abstract: The method for tin vitro or ex vivo amplification of human adipose tissue stem cells includes: —extracting a stromal vascular fraction of a human adipose tissue including endothelial cells of the human adipose tissue vascular network and human adipose tissue stem cells, and an extracellular matrix of the human adipose tissue, the extracellular matrix including endothelial cells of the human adipose tissue vascular network, human adipose tissue stem cells and collagen; —mixing the stromal vascular fraction and the extracellular matrix; and—culturing the mixture obtained in the preceding step, in suspension, in a culture medium.Type: ApplicationFiled: January 13, 2020Publication date: March 31, 2022Applicants: UNIVERSITÉ CÔTE D'AZUR, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), CHU DE NICEInventors: Christian Dani, Alain Doglio, Vincent Dani-Davesne, Philippe Letertre
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Patent number: 11285219Abstract: The present description relates to peptidomimetic foldamers, and their synthesis. In particular, the description provides peptide-amino urea hybrid peptidomimetic foldamers comprising an alpha amino acid peptide portion and an oligourea portion.Type: GrantFiled: January 16, 2020Date of Patent: March 29, 2022Assignees: UREKA SARL, Centre National de la Recherche Scientifique (CNRS)Inventors: Robert H. Zimmer, Gilles Guichard, Juliette Fremaux, Sebastien Goudreau, Claire Venin, Laura Mauran
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Patent number: 11278631Abstract: The invention is directed to the field of gene therapy, i.e. gene delivery into target cells, tissue, organ and organism, and more particularly to gene delivery via viral vectors. The inventors showed that it is possible by chemical coupling to modulate the coupling of a ligand in the surface of the capsid of AAV, for example AAV2 and AAV3b. In particular, the present invention relates to a recombinant Adeno-Associated Virus (rAAV) vector particle having at least one primary amino group contained in the capsid proteins, chemically coupled with at least one ligand L, wherein coupling of said ligand L is implemented through a bond comprising a —CSNH— bond and an optionally substituted aromatic moiety. Particularly, the inventors tested the chemical coupling of mannose ligand on AAV2 for subretinally injection to rats.Type: GrantFiled: February 10, 2021Date of Patent: March 22, 2022Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE NANTES, CENTRE HOSPITALIER UNIVERSITAIRE DE NANTESInventors: Mathieu Mevel, David Deniaud, Eduard Ayuso
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Patent number: 11274127Abstract: An engineered adenovirus penton base protomer, wherein the penton base protomer comprises a first RGD-loop, a second RGD-loop, a variable loop (V loop), an Adenovirus fiber protein binding cleft, and an N-terminal domain; wherein at least one of the first RGD-loop, the second RGD-loop, and the V loop comprises at least one inserted non-adenoviral antigenic polypeptide; and wherein the engineered adenovirus penton base protomer is capable of assembling into virus-like particles (VLPs).Type: GrantFiled: March 31, 2017Date of Patent: March 15, 2022Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), THE EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Imre Berger, Frédéric Garzoni, Pascal Fender
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Patent number: 11266986Abstract: The present invention relates to a method for manufacturing a microfluidic device. The microfluidic device includes an input zone adapted to receive a carrier fluid medium and a sample in suspension in the carrier fluid medium, the sample comprising at least one population of cells or microparticles, a confinement zone adapted to confine a selected amount of the sample, and an output zone adapted to discharge the carrier fluid medium and the sample in suspension in the carrier fluid medium.Type: GrantFiled: October 21, 2016Date of Patent: March 8, 2022Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Grenoble AlpesInventors: Thibault Honegger, Benoît Maisonneuve