Patents Assigned to Centre National de la Recherche Scientifique
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Patent number: 11807870Abstract: The invention relates to a cellular microcompartment comprising successively, organized around a lumen, at least one layer of pluripotent cells, an extracellular matrix layer and an outer hydrogel layer. The invention also relates to processes for preparing such cellular microcompartments.Type: GrantFiled: November 23, 2017Date of Patent: November 7, 2023Assignees: UNIVERSITE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT D'OPTIQUE THEORIQUE ET APPLIQUEEInventors: Maxime Feyeux, Kevin Alessandri, Pierre Nassoy, Laurent Cognet, Gaëlle Recher, Erwan Bezard
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Publication number: 20230349871Abstract: An analytical method makes use of an oxygen-containing source having a predetermined content of an isotope of oxygen zO, which is not the same as natural composition and distribution of oxygen isotopes, to detect and/or quantify oxygen in oxidizable compound(s). The analytical method allows detecting and/or quantification with relatively high precision and accuracy oxygen in oxidizable compound(s), even at low content. The method is easy to implement and can be used for in-line analysis.Type: ApplicationFiled: June 30, 2023Publication date: November 2, 2023Applicants: TotalEnergies OneTech, UNIVERSIDAD DE OVIEDO, UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Pierre GIUSTI, Jorge RUIZ ENCINAR, Mariella MOLDOVAN, Brice BOUSSIERE
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Publication number: 20230348934Abstract: The present invention relates to pseudotyped retrovirus-like particles or retroviral vectors comprising both engineered envelope glycoproteins derived from a virus of the Paramyxoviridae family fused to a cell targeting domain and fused to a functional domain. The present invention also relates to the use of said pseudotyped retrovirus-like particles or retroviral vectors to selectively modulate the activity of specific subsets of cells, in particular of specific immune cells. These pseudotyped retrovirus-like particles or retroviral vectors are particularly useful for gene therapy, immune therapy and/or vaccination.Type: ApplicationFiled: March 6, 2023Publication date: November 2, 2023Applicants: Ecole Normale Superieure de Lyon, Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1, Institut National de la Santé et de la Recherche Medicale (INSERM), Centre National de la Recherche ScientifiqueInventors: Caroline COSTA FEJOZ, Els Verhoeyen, François-Loîc Cosset, Ruben Bender, Christian Buchholz, Qi Zhou
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Publication number: 20230346727Abstract: A compound of general formula (III?), or one of its pharmaceutically acceptable salts, for its use for the treatment of hemophilia in a subject, in particular for the restoration of coagulation in the plasma of a subject suffering from hemophilia, this compound being advantageously administered by oral route:Type: ApplicationFiled: July 23, 2021Publication date: November 2, 2023Applicants: UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE HOSPITALIER UNIVERSITAIRE GRENOBLE ALPES, INSTITUT POLYTECHNIQUE DE GRENOBLEInventors: Aline THOMAS, Marie-Claire DAGHER, Muriel JOURDAN, Romain NAVARRO, Benoît POLACK, Raphaël MARLU, Landry SEYVE, Renaud ZELLI
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Publication number: 20230346950Abstract: Food supplements for bees that include molybdenum complexes and a method of administering the food supplements to the bees for preventing the infestation of bees and their larvae by the Varroa destructor mite. Also, the use of the food supplements to increase the production of honey and lower the winter mortality of bees.Type: ApplicationFiled: July 19, 2021Publication date: November 2, 2023Applicants: UNIVERSITE DE VERSAILLES - SAINT-QUENTIN-EN-YVELINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUTUL DE ZOOLOGIE, UNIVERSITATEA DE STAT DIN MOLDOVAInventors: Arcadie FUIOR, Sébastien FLOQUET, Valentina CEBOTARI, Diana CEBOTARI, Aurelian GULEA, Ion TODERAS
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Patent number: 11802336Abstract: The present disclosure relates to an apparatus for fluidised-bed chemical vapour deposition from a gaseous phase allowing the temperature of the fluidised bed to be stabilised during the deposition and also to an associated method for its implementation, the apparatus being characterised in that it comprises a porous thermal insulator present in an inlet zone and configured to be passed through by the gaseous phase, said porous thermal insulator having an effective thermal conductivity at 20° C. less than or equal to 3.5 W·m-1·K-1.Type: GrantFiled: June 21, 2021Date of Patent: October 31, 2023Assignees: SAFRAN CERAMIC, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BORDEAUXInventors: Amine El Mansouri, Nathalie Dominique Bertrand, Sébastien Couthures, Alain Jean-Michel Guette
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Patent number: 11802214Abstract: A process for preparing in situ an aqueous gel ink with variable color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising an N-Acyl-aminophenol, wherein the hydroxyl group is preferably in meta or para position on the benzenic group, and (ii) adding a solution of silver salts to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with variable color with silver nanoparticles disposed therein. An aqueous gel ink with variable color obtained according to process for preparing, comprising an N-Acyl-aminophenol, wherein the hydroxyl group is preferably in meta or para position on the benzenic group and silver nanoparticles. A writing instrument comprising an aqueous gel ink with variable color.Type: GrantFiled: August 28, 2020Date of Patent: October 31, 2023Assignees: SOCIETE BIC, UNIVERSITE DE HAUTE ALSACE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Olivier Albenge, Romain Metillon, Karine Mougin, Feriel Ghellal, Arnaud Spangenberg
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Patent number: 11802836Abstract: A process for detecting the sensitivity of one or more polymers and/or of one or more, mixtures of polymers to a compound, including the steps of exposing at least one lens-shaped micro-deposit, including the polymer(s) and/or the mixture(s) of polymers, to the compound, and detecting, by illuminating the surface of this micro-deposit, a change in the spatial distribution of the intensity of the light reflected or transmitted by this micro-deposit, linked to a variation in the dimensions and/or refractive index of this micro-deposit, under the effect of an interaction between the polymer(s) and/or the mixture(s) of polymers and the compound.Type: GrantFiled: June 1, 2018Date of Patent: October 31, 2023Assignees: Universite De Lille, Centre National De La Recherche ScientifiqueInventors: Alexis Vlandas, Julien Wengler, Sebastien Lamant, Vincent Senez
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Publication number: 20230340672Abstract: A nanowire forming method, including the forming of a DNA origami having through openings, and the forming in the through openings of portions forming all or part of the nanowires.Type: ApplicationFiled: December 1, 2020Publication date: October 26, 2023Applicants: Commissariat à I'Énergie Atomique et aux Énergies Alternatives, Universite Grenoble Alpes, Institut Polytechnique de Grenoble, Centre National de la Recherche ScientifiqueInventors: Xavier Baillin, Vincent Consonni, Stéphane Fanget, Bassem Salem, Raluca Tiron
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Publication number: 20230340546Abstract: The use of UV-activated Copper Radical Oxidase (CRO) enzymes in the implementation of oxidation reactions. Also, a process for oxidizing organic compounds using enzymes which are activated by UV light. The process also leads to concomitant formation of hydrogen peroxide, that can optionally be used in hydrogen peroxide mediated processes. Further, the process relates to the oxidation of alcohols in aldehydes.Type: ApplicationFiled: July 21, 2021Publication date: October 26, 2023Applicants: INSTITUT NATIONAL DE LA RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX MARSEILLE, ECOLE CENTRALE DE MARSEILLEInventors: Bastien BISSARO, Jean-Guy BERRIN, Michael LAFOND
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Patent number: 11795465Abstract: The present invention relates to new transcriptional promoters that are functional during meiosis. It thus provides new tools, methods and compositions for the expression of proteins during meiosis in a eukaryotic cell, and more particularly in a plant cell.Type: GrantFiled: May 23, 2019Date of Patent: October 24, 2023Assignees: MEIOGENIX, INTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE LYONInventors: Giacomo Bastianelli, Alain Nicolas, Peter Rogowsky
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Patent number: 11795144Abstract: The present invention concerns a compound having the following formula (I): wherein: A is in particular —N(R?a)—C(?O)—R, R?a being H or a (C1-C6)alkyl group, and R being preferably a group having the following formula (II): X is in particular chosen from the group consisting of: —SO2—N(R?b)—, R?b being H or a (C1-C6)alkyl group, —N(R?b)—SO2—, R?b being H or a (C1-C6)alkyl group, —CO—NH—, and —NH—CO—, for use for the treatment of cancers, such as metastatic cancers.Type: GrantFiled: June 6, 2018Date of Patent: October 24, 2023Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE NANTES, CHU NANTESInventors: Vincent Sauzeau, Gervaise Loirand, Jacques Lebreton, Arnaud Tessier, Agnès Quemener
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Patent number: 11796582Abstract: The method for monitoring the electrical network comprises the identification of critical element(s) of the network, for at least one source-load pair that are connected to the network; the parametric estimation of a value of the electrical characteristic of each critical element, by using a numerical model modelling an electrical behavior of the network as a function of said electrical characteristic and of electrical measurements performed by means of sensors positioned in the network, a sensor being positioned in the network for each critical element on at least one network element or on at least one network path formed by a plurality of network elements affected by a disturbance in the electrical characteristic of this critical element; the evaluation, for said at least one source-load pair and the determination of a state of the electrical network by taking into account the operational criterion.Type: GrantFiled: December 12, 2018Date of Patent: October 24, 2023Assignees: SAFRAN ELECTRICAL & POWER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE GRENOBLE ALPESInventors: Anca-Lucia Dieudonne, Etienne Goddet, Nicolas Marie Henri Retiere, Jean-Michel Guichon
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Publication number: 20230334301Abstract: The invention relates to a method for quantizing a deep neural network including several layers, previously trained during a training phase determining for each layer a set of weights. The method includes a phase of quantizing the deep neural network including determining a disruption limit value of at least one weight of the weight set of the layer, beyond which the output of the deep neural network is erroneous, determining, for a target inference precision of the neural network, and from the disruption limit value, an adjustment limit value of at least one weight of the set of weights, and decreasing an arithmetic precision of at least one weight of the set of weights as a function of the adjustment limit value. The invention also relates to a computer program, a device implementing such a method, and a deep neural network obtained by such a method.Type: ApplicationFiled: April 13, 2023Publication date: October 19, 2023Applicants: BULL SAS, INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE, UNIVERSITE TOULOUSE III - PAUL SABATIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Stéphane PRALET, Théo BEUZEVILLE, Alfredo BUTTARI, Serge GRATTON
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Publication number: 20230332299Abstract: The invention relates to an electrolysis device and method for producing molecular hydrogen, the device comprising a negative electrode compartment for reducing H2O into H2 and a positive electrode compartment comprising circulating supercapacitive particles in contact with a conductive substrate. Such a device or method advantageously comprises a power supply provided by one or more photovoltaic cells.Type: ApplicationFiled: June 29, 2021Publication date: October 19, 2023Applicants: Centre national de la recherche scientifique, INSTITUT PHOTOVOLTAÏQUE D'ILE DE FRANCE (IPVF), L'AIR LIQUIDE, SOCIETE ANONYME POUR L'ETUDE ET L'EXPLOITATION DES PROCEDES GEORGES CLAUDE, ELECTRICITE DE FRANCE, TotalEnergies OneTechInventor: David AYME-PERROT
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Publication number: 20230330440Abstract: Devices and methods for reversibly stimulating neuronal cells in a subject. The devices include a module for generating ultrasounds at 4 MHz or more to stimulate neuronal cells expressing mechanosensitive channels with the ultrasounds. The methods include expressing mechanosensitive channels into neuronal cells and exposing the cells to ultrasounds at 4 MHz or more. Also, the use of the methods or devices for visual restoration in a subject.Type: ApplicationFiled: September 9, 2021Publication date: October 19, 2023Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)Inventors: Serge PICAUD, Sara CADONI, José-Alain SAHEL, Mickaël TANTER, Charlie DEMENE
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Patent number: 11791129Abstract: A method for imaging a material to atomic scale by means of a field-ion microscope having a vacuum chamber configured to accommodate the material prepared in the form of a tip and an imaging gas, and an ion detector is provided. The method includes application of a DC electrical potential (VDC) and of a pulsed electrical potential, of which the maximum pulse value is denoted Vimp, so that the tip erodes for a potential value equal to VDC+Vimp; acquisition, by the detector between at least two pulses of the pulsed potential, of series of at least two ion images of the impacts of the ions repelled by the tip onto the detector; and calculation of a quantity characteristic of a trend of the erosion of the tip based on the series of ion images acquired and the adjustment, between each series of images, of the values of VDC and of Vimp such that the quantity characteristic of the trend and the ratio VDC/Vimp remain constant.Type: GrantFiled: February 20, 2020Date of Patent: October 17, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN (INSA), UNIVERSITE DE ROUEN NORMANDIEInventors: François Vurpillot, Rodrigue Larde, Benjamin Klaes, Gérald Da Costa
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Publication number: 20230324485Abstract: A system is described for emitting a radiofrequency field for a magnetic resonance imaging device, including a volumetric antenna that emits a radiofrequency field, a device for homogenizing the radiofrequency field arranged between said volume antenna and a part of the body to be imaged. The device may include a first continuous metal track with an overall length of approximately 0.5 to approximately 1.5 times said wavelength of the radio frequency field. The first metallic track may occupy a surface with a largest dimension ranging between approximately 5% and approximately 15% of said wavelength of the radio frequency field. The first metal track is arranged in a pattern including a plane of symmetry that is normal to the electrical component of the radio frequency field, so as to give the device an electric dipole property including a natural frequency strictly greater than the frequency of the radio frequency field.Type: ApplicationFiled: June 15, 2021Publication date: October 12, 2023Applicants: UNIVERSITÉ D'AIX MARSEILLE, Centre National de la Recherche Scientifique, Ecole Centrale de Marseille, Multiwave ImagingInventors: Marc Dubois, Kaizad Rustomji, Tania Del Socorro Vergara Gomez, Elodie Virginie Emilia Georget, Frank Kober, Redha Abdeddaim, Stanislas Pierre Alain Rapacchi, Stefan Enoch, Tryfon Antonakakis
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Publication number: 20230321059Abstract: The present invention relates to a compound selected from mepyramine, prodrugs thereof and pharmaceutically acceptable salts thereof, or a composition comprising such a compound, for use in the topical treatment and prevention of neuropathic pain.Type: ApplicationFiled: September 10, 2021Publication date: October 12, 2023Applicants: Assistance Publique - Hopitaux de Paris, Centre National de la Recherche ScientifiqueInventors: Céline Greco, Patrick Delmas
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Publication number: 20230325659Abstract: A method of training an artificial neural network, the method comprising: initially training a first artificial neural network with first input data and first pseudo data, wherein the first pseudo data is or was generated by a second artificial neural network in a virgin state, or by the first artificial neural network while in a virgin state; generating second pseudo data using the first artificial neural network, or using the second artificial neural network following at least partially transferring knowledge from the first artificial neural network to the second artificial neural network; and training the first artificial neural network, or another artificial neural network, with the second pseudo data and second input data.Type: ApplicationFiled: September 8, 2021Publication date: October 12, 2023Applicants: Commissariat à I'Énergie Atomique et aux Énergies Alternatives, Universite Grenoble Alpes, Centre National de la Recherche Scientifique, Université de Chambéry - Université Savoie Mont BlancInventors: Miguel-Angel Solinas, Martial Mermillod, Marina REyboz, Stephane Rousset