Abstract: A compound having the following general formula (I): wherein: X is a nitrogen atom and Y is a carbon atom; or X is a carbon atom and Y is a nitrogen atom; the Ar group is an aryl or heteroaryl group; and the RN and RN? groups, together with the carbon atoms to which they are bound, form a monocyclic or bicyclic azacycloalkane group. The pharmaceutically acceptable salts thereof, the hydrates or polymorphic crystalline structures thereof, and to the racemates, diastereoisomers, or enantiomers thereof are also described.
Type:
Grant
Filed:
April 20, 2012
Date of Patent:
August 28, 2018
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), INSTITUT NATIONAL DE LA SANTA ET DE LA RECHERCHE MEDICALE (INSERM)
Abstract: The present invention concerns the use of a compound having the following formula (I), for the preparation of a polymer. The present invention also concerns the polymers obtained from polymerization of compound of formula (I), and their processes of preparation.
Type:
Grant
Filed:
October 10, 2015
Date of Patent:
August 21, 2018
Assignees:
UNIVERSITÉ DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)
Abstract: The invention relates to a process for preparing nanoparticles of a catalyst for cathodic reduction and which is tolerant to methanol, these nanoparticles comprising a metallic center and a submonolayer of a chalcogen.
Type:
Grant
Filed:
June 20, 2013
Date of Patent:
August 14, 2018
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE DE POITIERS
Inventors:
Nicolas Alonso-Vante, Jiwei Ma, Aldo Gago
Abstract: The present invention relates to an isolated bacterium from the genus Pseudoalteromonas for its use as a probiotic, the use of said strain as a preservative, cyclolipopeptides which may be obtained from this bacterium, a composition comprising at least such a cyclolipopeptide, as well as to their uses.
Type:
Application
Filed:
March 27, 2018
Publication date:
August 2, 2018
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), UNIVERSITE DE RENNES 1, UNIVERSITE DE BRETAGNE OCCIDENTALE
Inventors:
Florie DESRIAC, Yannick FLEURY, Patrick LE CHEVALIER, Delphine DESTOUMIEUX, Matthieu SIMON
Abstract: An inertial actuation magnetohydrodynamic wheel (2) comprising a torus-shaped fluid ring (3) filled with a conductive liquid, at least one effective area (24, 26, 28) for setting the liquid into motion, and at least one magnetohydrodynamic pump (4, 6, 8). The ratio of the set back distance of any magnetic conduction element (24, 26, 28) of the air gap of any electromagnetic pump (4, 6, 8) over the internal size of the fluid ring (3) is greater than or equal to 0.5 and the fluid ring (3) comprises at least two distinct effective areas (24, 26), for setting the conductive liquid into motion, angularly spaced apart by at least 120°.
Type:
Grant
Filed:
February 15, 2013
Date of Patent:
June 12, 2018
Assignees:
CENTRE NATIONAL D'ETUDES SPATIALES, INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
Abstract: The present invention relates to novel mu-conotoxin peptides, biologically active fragments thereof, combinations thereof and/or variants thereof. The invention also relates to their use in pharmaceutical composition for the treatment or prevention of pain, and their use in the preparation of an anesthetic.
Type:
Application
Filed:
February 21, 2017
Publication date:
May 31, 2018
Applicant:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
Inventors:
Philippe FAVREAU, Evelyne BENOIT, Jordi MOLGO, Reto STOCKLIN
Abstract: The present invention concerns a process for preparing a polymer comprising at least one gel polymerization step (E) in which the following are contacted: ethylenically unsaturated water-soluble monomers, the same or different; a source of free radicals adapted to the polymerization of the said monomers, typically a redox system; and a radical polymerization control agent, preferably comprising a thiocarbonylthio —S(C?S)— group; with a concentration of monomers in the reaction medium of step (E) sufficiently high to cause gelling of the medium if polymerization was conducted without the control agent.
Type:
Grant
Filed:
September 27, 2011
Date of Patent:
May 22, 2018
Assignees:
RHODIA OPERATIONS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
Inventors:
Mathias Destarac, Aymeric Guinaudeau, Stéphane Mazieres, James Wilson
Abstract: A method for preparing a novel hydrogel including silico-metallic mineral particles of the formula (Six(Si-A)1?x)4M3O11.n?H2O, in which: x is a real number in the range [0.75; 1], A denotes a group selected from methyl and hydrocarbon groups including at least one heteroatom, and M is a metal selected from the group consisting of magnesium, cobalt, zinc, copper, manganese, iron, nickel and chromium, wherein a coprecipitation reaction is carried out in an aqueous medium between: at least one metal salt of the metal M, sodium metasilicate, Na2OSiO2, and at least one water-soluble oxysilane of formula (I): in which R1, R2 and R3 are selected from hydrogen and linear alkyl groups including 1 to 3 carbon atoms.
Type:
Grant
Filed:
December 19, 2012
Date of Patent:
May 15, 2018
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
Christophe Le Roux, Francois Martin, Pierre Micoud, Angela Dumas
Abstract: The invention relates to a method for the isomerization of glucose into fructose in water in the presence of a solid base catalyst characterized by its reversibility of CO2 adsorption at a low temperature, the catalyst being a catalyst comprising at least one supported or non-supported lanthanide oxide or a molecular sieve based on silicon containing the organic template thereof. The invention also relates to a method for preparing HMF from glucose, comprising the isomerization of glucose into fructose.
Type:
Grant
Filed:
August 24, 2012
Date of Patent:
May 8, 2018
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE CLAUDE BERNARD LYON I
Inventors:
Nadine Essayem, Rodrigo Lopes De Souza, Franck Rataboul, Cyril Feche, Dilson Cardoso, Demian Patrick Fabiano
Abstract: The present invention relates to an isolated bacterium from the genus Pseudoalteromonas for its use as a probiotic, the use of said strain as a preservative, cyclolipopeptides which may be obtained from this bacterium, a composition comprising at least such a cyclolipopeptide, as well as to their uses.
Type:
Grant
Filed:
May 23, 2014
Date of Patent:
May 1, 2018
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE DE RENNES 1, UNIVERSITE DE BRETAGNE OCCIDENTALE
Inventors:
Florie Desriac, Yannick Fleury, Patrick Le Chevalier, Delphine Destoumieux, Matthieu Simon
Abstract: A method for processing plant matter, which involves applying a processing composition including at least one biological agent selected from: bacteria including a DNA sequence, referred to as 16S rDNA, coding for the 16S ribosomal RNA of the bacterium, which is 100% homologous with SEQ ID NO. 1, culture media in which bacteria have grown which include the 16S rDNA sequence that is 100% homologous with SEQ ID NO. 1 and which are substantially free of the bacteria, the culture media including polynucleotides having a DNA sequence which is 100% homologous with SEQ ID NO. 1, and in which the bacteria are selected from bacteria that are consistent with the strain filed and registered on 7 Apr. 2011 with number 1-4467 before the French National Collection of Microorganism Cultures (CNCM) of the Pasteur Institute, and mutant bacteria of the filed strain.
Type:
Grant
Filed:
September 24, 2014
Date of Patent:
May 1, 2018
Assignees:
AGRONUTRITION, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE PAUL SABATIER TOULOUSE III
Inventors:
Rafik Errakhi, Faouzi Attia, Cedric Cabanes, Bernard Dumas, Sophie Vergnes
Abstract: The present invention relates to a genetically engineered algae strain in which the expression of the CGI-58 gene or homologous gene thereof is silenced. The present invention further relates to a method of triacylglycerol accumulation using said genetically engineered diatom and/or diatom strain.
Type:
Grant
Filed:
July 21, 2014
Date of Patent:
April 10, 2018
Assignees:
FERMENTALG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(C.N.R.S), COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Inventors:
Pierre Calleja, Marina Leterrier, Eric Marechal
Abstract: A compound is of formula (I): in which A1 and A1? are independently from each other a linear or branched alkylene radical including from 1 to 20 carbon atom(s); A2 is in particular a linear or branched alkylene radical including from 1 to 200 carbon atom(s); A3 is H or a linear or branched alkyl radical including from 1 to 15 carbon atom(s) and R1 and R1? are independently from each other H or a linear or branched alkyl radical comprising from 1 to 20 carbon atom(s). The compounds of formula (I) can be used in particular for the preparation of poly(hydroxyurethane)s and epoxy resins.
Type:
Grant
Filed:
December 16, 2014
Date of Patent:
March 27, 2018
Assignees:
UNIVERSITÉ DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), INSTITUT DES CORPS GRAS ETUDES ET RECHERCHES TECHNIQUES—ITERG
Inventors:
Henri Cramail, Etienne Grau, Carine Alfos, Lise Maisonneuve
Abstract: The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
Type:
Grant
Filed:
November 14, 2014
Date of Patent:
March 13, 2018
Assignees:
GRAFTYS, UNIVERSITE DE NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
Inventors:
Jean-Michel Bouler, Bruno Bujoli, Pascal Janvier, Ibrahim Khairoun, Jean-Noël Argenson
Abstract: The invention concerns a mono- or polyfunctional polysilylated organosilane compound, and the method for preparing same.
Type:
Grant
Filed:
July 8, 2013
Date of Patent:
February 20, 2018
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S), ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER, UNIVERSITE MONTPELLIER, 2 SCIENCES ET TECHNIQUES
Inventors:
Michel Wong Chi Man, Xavier Cattoën, Kristyna Bürglova, Jana Hodacova
Abstract: The invention concerns a method for extemporaneous and reversible concentration of liposomes, the mixed liposome-cyclodextrin aggregates obtainable by the method, and uses thereof in the pharmaceutical, diagnostic and cosmetic field.
Type:
Grant
Filed:
April 30, 2007
Date of Patent:
February 20, 2018
Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
Abstract: A process for preparing a composition including synthetic mineral particles, in which a hydrogel which is a precursor of the synthetic mineral particles is prepared via a coprecipitation reaction between at least one compound including silicon, and at least one compound including at least one metal element, characterized in that the coprecipitation reaction takes place in the presence of at least one carboxylate salt of formula R2—COOM? in which: —M? denotes a metal chosen from the group made up of Na and K, and —R2 is chosen from H and alkyl groups including fewer than 5 carbon atoms. A composition including synthetic mineral particles which is obtained by such a process is also described.
Type:
Grant
Filed:
July 6, 2012
Date of Patent:
February 6, 2018
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), UNIVERSITE PAUL SABATIER (TOULOUSE III)
Inventors:
Christophe Le Roux, Francois Martin, Pierre Micoud, Angela Dumas
Abstract: Novel nucleic acids include non-integrative chimeric retroviral genomes including the 5? and 3? long terminal repeat sequences (LTRs) of the caprine lentivirus: the Caprine Arthritis Encephalitis Virus (CAEV) or of another retrovirus not integrating human cells and at least one viral gene of another retrovirus. A vector including such a nucleic acid, an immunogenic or vaccinal composition including the vector or the nucleic acid, as well as their use for treating and/or preventing an infection by a retrovirus or a disease induced by a pathogenic agent are also described.
Type:
Grant
Filed:
September 12, 2012
Date of Patent:
January 30, 2018
Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)
Abstract: An aqueous liquid medium for analyzing, purifying or separating species in an element having walls or for treating the walls of an element. The medium includes at least a polymer consisting of several polymeric segments. The polymer is of the irregular block-copolymer or irregular comb-like polymer type and has on the average at least three junction points between polymeric segments of different chemical or topological nature. The medium may be used in methods for analyzing, purifying or separating species and methods for treating an element to be contacted with a fluid and/or species contained in the fluid during preservation, transport, analysis, purification or separation of the fluid.
Type:
Application
Filed:
May 8, 2017
Publication date:
January 25, 2018
Applicants:
INSTITUTE CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N. R.S.)
Abstract: The present invention concerns a process for creating a Carbon-Carbon bond (C—C) or a Carbon-Heteroatom bond (C—HE) by reacting a compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) that can substitute for the leaving group, creating a C—C or C—HE bond, wherein the reaction takes place in the presence of an effective quantity of a. a catalytic system comprising a ligand and at least a metal-based catalyst, such a metal catalyst being chosen among iron or copper compounds proviso that only a single metal is present.
Type:
Grant
Filed:
January 19, 2016
Date of Patent:
January 9, 2018
Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)
Inventors:
Marc Taillefer, Ning Xia, Florian Monnier, Anis Tlili