Abstract: The invention relates to modified Bordetella adenylate cyclase toxins which are deficient for CD11b/CD18 binding and to their use in the preparation of pharmaceutical composition for the treatment of whooping cough and/or for the protection against Bordetella infection. The invention also relates to specific fragments of Bordetella adenylate cyclase comprising the CD11b/CD18 interaction domain and their use, especially for targeting a molecule of interest to CD11b expressing cells.

Abstract: The present invention relates to complete rpoB genes, rpoB gene fragments SEQ. ID. no 9 to 32 and fragments of hypervariable sequences of said rpoB genes SEQ. ID. no 33 to 56 and 77 to 100, and to nucleic acid fragments of non-coding hypervariable sequences flanking the rpoB gene of sequences SEQ. ID. no 121 to 144 and 165 to 188, and also to oligonucleotides of species-specific sequences taken from said fragments of hypervariable sequences and to consensus oligonucleotides between the different species of Acinetobacter bacteria of sequences SEQ. ID. no 1 to 8 for the following 24 species: A. calcoaceticus (genomic species 1), A. baumannii (genomic species 2), genomic species 3, A. haemolyticus (genomic species 4), A. junii (genomic species 5), genomic species 6, A. johnsonii (genomic species 7), A. lwoffii (genomic species 8), genomic species 9, genomic species 10, genomic species 11, A. radioresistens (genomic species 12), genomic species 13, genomic species 16, A. schindleri, A. ursingii, A. baylyi, A.

Abstract: Process for the specific fluorination of the phosphorus atom of a phosphonocinnamic compound of the general formula (II) or (II?): X being selected from: an oxygen atom, a sulfur atom, R1, R2, R3, R4, R5 and R6 being selected from: H, an alkyl group, an aryl group, OH, O-alkyl, S-alkyl, NH2, NH-alkyl, N-(alkyl)2; R7 being selected from: H, an alkyl group, an aryl group, a silyl group; R8 being selected from: H, an alkyl group, an aryl group, TBDPS representing a tert-butyldiphenylsilyl group; in the process the compound is reacted with a fluorinating agent comprising a complex formed between a tertiary amine and hydrogen fluoride.

Abstract: DNA and peptide sequences encoding a novel mammalian secreted group IIF phospholipase A2 wherein said enzyme is Ca2+-dependent, maximally active at pH 7-8, and hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference and more particularly, a novel human group IIF phospholipase A2. The invention also concerns the use of this enzyme in methods for screening various chemical compounds.

Abstract: The invention relates to an improved thermodynamic apparatus for cooling or heating by adsorption of a refrigerating fluid on a solid adsorbent. The apparatus includes--a hot circuit adapted to heat and circulate a heating fluid;--a cold circuit adapted to cool and circulate a cooling fluid;--a cooling circuit for an enclosure to be air-conditioned;--two tanks containing a solid compound with large capacities but having a low energy of adsorption, said tanks, connected together and to the different.