Patents Assigned to Cepheid
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Patent number: 11927600Abstract: A fluidic bridge device for transport of a fluid sample between a first sample processing device and a second sample processing device. The fluidic bridge may include one or more fluid channels extending between fluid-tight couplings attachable to transfer ports of the first and second sample processing device. In one aspect the first device is a sample preparation device and the second device is an assay device. The fluidic bridge can include at least two fluid conduits, at least one for transport of the prepared sample, and at least one other to facilitate displacement of air to allow flow of the prepared sample through the other fluid conduit. The fluid channels can include one or more of an amplification chamber, a processing chamber, a gas-permeable vent, a bubble trap, a filter, and an external port. Methods of preparing and transporting a fluid sample between devices are provided herein.Type: GrantFiled: September 28, 2017Date of Patent: March 12, 2024Assignee: CepheidInventor: Douglas B. Dority
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Patent number: 11891219Abstract: A lid apparatus for a multi-chambered container. The lid apparatus has a top-lid that is hingedly attached to a bottom-cap. The top-lid includes one or more openings for fluid filling multiple passages that extend from the bottom-cap. A lower bottom-cap includes welding features for welding to the multi-chambered container.Type: GrantFiled: June 8, 2021Date of Patent: February 6, 2024Assignee: CepheidInventor: Paul Jordan
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Patent number: 11876479Abstract: A DC electric motor having a stator mounted to a substrate, the stator having a coil assembly having a magnetic core, a rotor mounted to the stator with a first set of permanent magnets distributed radially about the rotor to facilitate rotation of the rotor and a second set of permanent magnets on the rotor to facilitate determination of an absolute position of the rotor. The motor further includes first and second set of sensors for detection of the magnets of the inner and outer rings. During operation of the motor passage of the permanent magnets over the sensors produces a substantially sinusoidal signal of varying voltage substantially without noise and/or saturation, allowing an absolute position of the rotor relative the substrate to be determined from the sinusoidal signals without requiring use of an encoder or position sensors and without requiring noise-reduction or filtering of the signal.Type: GrantFiled: January 29, 2021Date of Patent: January 16, 2024Assignee: CepheidInventor: Tien Phan
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Patent number: 11840728Abstract: Provided are methods and compositions for activating oligonucleotide aptamer-deactivated DNA polymerases, comprising cleaving the aptamer by endonuclease V enzymatic activity to reduce or eliminate binding of the oligonucleotide aptamer to the DNA polymerase, thereby activating DNA synthesis activity of the DNA polymerase in a reaction mixture. Mixtures for use in methods of the invention are also provided. In some aspects, the oligonucleotide aptamer comprises one or more deoxyinosine nucleotides providing for aptamer-specific recognition and cleavage of the aptamer by the endonuclease V enzymatic activity. Exemplary oligonucleotide aptamers, mixtures and methods employing endonuclease V enzymatic activity are provided. The methods can be practiced using kits comprising a DNA polymerase-binding oligonucleotide aptamer and at least one endonuclease V enzymatic activity having oligonucleotide aptamer-specific recognition to provide for specific cleavage of the aptamer by the endonuclease V enzymatic activity.Type: GrantFiled: October 22, 2021Date of Patent: December 12, 2023Assignee: CepheidInventors: Igor V. Kutyavin, Sergey G. Lokhov
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Patent number: 11819584Abstract: Methods and cleaning compositions for reduction of nucleic acid contamination on surfaces, in air, and in solutions using modified pectin are provided.Type: GrantFiled: August 16, 2019Date of Patent: November 21, 2023Assignee: CepheidInventors: Alex I. Kutyavin, Kevin P. Lund, Oliver Z. Nanassy, Alexander A. Gall, William Brabant
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Patent number: 11807643Abstract: Automated oligonucleotide synthesis-compatible fluorescent dye phosphoramidite compounds, solid supports, and labeled polynucleotides incorporating the compounds are provided. The compounds allow universal incorporation of the fluorescent label into any position of the polynucleotide.Type: GrantFiled: July 13, 2021Date of Patent: November 7, 2023Assignee: CepheidInventors: Kevin P. Lund, Dmitri Sergueev, Alexander Gall
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Patent number: 11795506Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate. The well chamber is in fluidic communication between the pre-amplification chamber and the fluidic outlet.Type: GrantFiled: November 24, 2020Date of Patent: October 24, 2023Assignee: CepheidInventors: Yuh-Min Chiang, Douglas Dority, Dustin Dickens, Jennifer Glass, Reuel Van Atta
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Patent number: 11739383Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate.Type: GrantFiled: August 13, 2020Date of Patent: August 29, 2023Assignee: CepheidInventors: Yuh-Min Chiang, Doug Dority, Dustin Dickens, Jennifer Glass, Reuel Van Atta
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Patent number: 11740256Abstract: Systems for processing a fluid sample to facilitate analysis with a semiconductor detection chip are provided herein. Such systems can include a sample processing cartridge coupleable with a chip carrier device configured for transport of the processed fluid sample from the sample cartridge. The chip carrier device can include one or more fluid channels extending between fluid-tight couplings attachable to transfer ports of the sample processing cartridge. The chip carrier device can include multiple portions or adapters, including a fluid sample portion, a flowcell portion and a chip carrier. Also provided are methods of preparing and transporting a fluid sample from a sample cartridge into a chip carrier device for analysis with a semiconductor detection chip carried within the chip carrier device.Type: GrantFiled: September 20, 2019Date of Patent: August 29, 2023Assignee: CepheidInventors: Douglas B Dority, Jonathan Siegrist, Ronald Chang
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Patent number: 11689125Abstract: A DC electric motor having a stator mounted to a substrate, the stator having a coil assembly having a magnetic core, a rotor mounted to the stator with permanent magnets distributed radially about the rotor, the permanent magnets extending beyond the magnetic core, and sensors mounted to the substrate adjacent the permanent magnets. During operation of the motor passage of the permanent magnets over the sensors produces a substantially sinusoidal signal of varying voltage substantially without noise and/or saturation, allowing an angular position of the rotor relative the substrate to be determined from linear portions of the sinusoidal signal without requiring use of an encoder or position sensors and without requiring noise-reduction or filtering of the signal.Type: GrantFiled: March 30, 2021Date of Patent: June 27, 2023Assignee: CepheidInventors: Tien Phan, Doug Dority
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Publication number: 20230167490Abstract: Described herein are methods and compositions that make use of pseudo-complementary bases to reduce unwanted hybridization in assays to detect and/or quantify particular nucleotide sequences, as well as in nucleic acid sequencing protocols.Type: ApplicationFiled: April 27, 2021Publication date: June 1, 2023Applicant: CepheidInventors: Russell Higuchi, Nicholas Wang
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Patent number: 11628435Abstract: Diagnostic detection chip device designs that reduce cost of fabrication and assembly are described herein. Such chip device designs include features that facilitate use of the chip within a chip carrier device with integrated fluid flow control features and compatibility with conventional sample cartridges and sample processing systems. Associated methods of manufacture and assembly of the chip devices are also provided herein.Type: GrantFiled: December 13, 2019Date of Patent: April 18, 2023Assignee: CepheidInventor: Douglas B. Dority
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Publication number: 20230096557Abstract: Described herein are methods and compositions that provide highly efficient nucleic acid amplification. In some embodiments, this allows a 3-fold or greater increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR. Modified bases can be employed in primers to provide this base-3 or greater amplification with satisfactory PCR cycle times, which are improved, as compared to those observed in the absence of modified bases.Type: ApplicationFiled: May 5, 2022Publication date: March 30, 2023Applicant: CepheidInventor: Russell Higuchi
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Patent number: 11603555Abstract: In various embodiments methods of determining methylation of DNA are provided.Type: GrantFiled: June 14, 2016Date of Patent: March 14, 2023Assignee: CEPHEIDInventors: Edwin W. Lai, Andrew Kohlway, Reuel Vanatta, Russell Higuchi, Alexander Gall, Kriszten Kocmond
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Patent number: 11594309Abstract: A remote monitoring system for medical data collection can include a data-flagging process embeds authorization and settings information into a file containing the test results. Such data flagging can occur at a medical device or testing site, and may be based in policy settings received from a remote system. A file containing the test results can also include data category information that can be used to protect sensitive information by preventing such information from being communicated to the wrong server.Type: GrantFiled: April 22, 2021Date of Patent: February 28, 2023Assignee: CepheidInventor: Jan Steuperaert
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Patent number: 11587686Abstract: The present invention provides systems and methods for rapid screening of individuals who may have been exposed to and carrying biological agents potentially contagious or otherwise harmful to the general public.Type: GrantFiled: October 12, 2015Date of Patent: February 21, 2023Assignee: CepheidInventor: William E. Murray
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Patent number: 11524301Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.Type: GrantFiled: January 9, 2020Date of Patent: December 13, 2022Assignee: CepheidInventors: Douglas B Dority, Tien Phan, David Fromm, Richard J. Casler, Jr., Dustin Dickens, Stuart Morita, Matthew Piccini
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Publication number: 20220389427Abstract: The present disclosure relates to aptamers for temperature-dependent reversible inhibition of thermostable polymerase activity in order to improve sensitivity and specificity of various reactions and assays involving hot start polynucleotide synthesis. Methods for use of the aptamers and related compositions and kits are also provided.Type: ApplicationFiled: March 4, 2022Publication date: December 8, 2022Applicant: CepheidInventors: Sergey G. Lokhov, Alexander A. Gall, Vera Baraznenok, Ekaterina V. Viazovkina, Irina Shishkina, David H. Persing
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Patent number: D973655Type: GrantFiled: January 10, 2020Date of Patent: December 27, 2022Assignee: CepheidInventors: Ronald Chang, Stephen M. Montgomery, Gregory E. Mote
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Patent number: D978369Type: GrantFiled: September 21, 2020Date of Patent: February 14, 2023Assignee: CepheidInventors: Ronald Chang, Gregory Mote, Steven M. Montgomery