Abstract: A device and method is disclosed for manufacturing optical fiber preforms utilizing microwave plasma assisted chemical vapor deposition. Precursor gas is introduced to the face of a vertically mounted dielectric rod, and a plasma is struck by means of simultaneous excitation of an E01 type wave and an H type wave with rotating linear polarization. The silica rod is positioned so that its face is at the bottom of the tube. Precursor gas is delivered from a position below the face of the silica rod, and microwave energy, which travels through the rod to the rod face, is delivered from a source positioned above the rod. With this configuration, a uniformly dense plasma localized on the face of the rod can simultaneously deposit both a pure or doped core and a doped cladding. It is also useful for creating waveguides, preform cores for use as substrates in creating optical fiber preforms, capillaries and ceramic rods.

Abstract: A method is disclosed for the manufacture of optical fiber preforms using plasma enhanced chemical vapor deposition (PECVD). The invention consists of a cylindrical reactor in which material such as flourine-doped silica glass is deposited on a cylindrical silica rod. A furnace for regulating reactor temperature encases the reactor. A microwave generator coupled with a resonator and an H10 waveguide delivers microwave energy to the reactor, producing simultaneously symmetrical excitations in the E010 mode and a plasma surface wave in E01 mode located at the surface of the rod. A microwave plasma is scanned along the length of the rod through a slit in the reactor to deposit a homogeneous film of a desired thickness. The benefits of the present invention over the prior art include increased absorption of delivered power, and the ability to uniformly deposit films such as flourine-doped silica on rods with diameters of up to 30-35 mm and thus produce optical fiber preforms with diameters greater than 40 mm.

Abstract: A device and method is disclosed for permanent or semi-permanent removal of hair through the activation of microparticles introduced into hair follicles. Microparticles are incorporated into a composition that is topically applied to the skin. These microparticles containing or consisting of chromophores or chemically activated molecules are of a variety of shapes and sizes. Microparticles are within a size range of 1 micron to 70 microns, and preferably between 10 and 50 microns. Microparticles of this size and variety of shapes enter hair follicles on all areas of the skin without entering other areas of the skin, such as the stratum corneum or sweat gland channels. Treatment of the skin with electromagnetic radiation, ultrasonic radiation or chemical means activates the chromophore or chemically activated compounds, thus destroying the hair follicle without damaging other areas of the skin.

Abstract: An improved device and method to pump fiber lasers in order to enhance performance and reliability is provided. A fiber laser is bent into a coil having a moderate curvature so as to avoid radiation losses. A cladding is partly polished to produce coupling surfaces along the length of the spring-like coil. Radiation emitters are imaged with one or more micro lenses that are attached to the coupling surface. In a preferred embodiment, banks of high power laser diodes are utilized as pump sources. Coupling surfaces are preferably created along the length of the fiber at intervals where pump radiation from the previous pump edge has been absorbed. Although the system may be used to pump single mode fibers, the preferred application is to pump multimode fibers, having greater core diameters and higher luminescent capacity, wherein only a single cladding can be used.

Abstract: A system and method is provided to accurately treat sites on an eye's retina employing computer based image generation, processing and central control means in conjunction with diode laser sources and optical fibers. The system is designed such that different photocoagulation and photochemical treatment methods alone or in combination can be performed and controlled to for simultaneous or consecutive treatment. The system and method accurately determines geometry of a treatment zone of a specific eye's fundus and adjust a treatment beam to irradiate the treatment zone with minimal coverage of adjacent tissue. Accordingly, also “forbidden zones” which would be severely damaged by the treatment beam are determined and their irradiation is prevented. The treatment zone is accurately determined with digital processing of angiographic data and slit lamp image data. Such image processing includes matching or alignment of two distinct images.

Abstract: A drug delivery system and methods are provided wherein a therapeutic/diagnostic agent or a component of the immune system is directed to particular cells in a selected organ or a specific site. Such a system can be formed by a photoselective compound generally described as V-M-P-C. V is a vector component suitable to target particular cells in a selected organ or site, where the type of the cell or antigen does not have to be specific to the desired treatment site. M is a marker component that is capable of being targeted by a therapeutic/diagnostic agent or a component of the immune system. P is a photocleavable or photosensitive bond, and C is a cap component rendering M ineffective. C is connected to M by the photocleavable or photosensitive bond. The photoselective compound is administered and marks targets of a certain kind of cell or a specific site.

Abstract: A photonic scanning and delivery system capable of controllable transmission of light energy to an irregularly shaped treatment area are disclosed. The desired uniformity (controllability) of light energy application is ensured by a tracking device, which monitors the position of the radiation applicator and thereby prevents over- or under-radiation. The system employs a light energy delivery hand-piece. By these means, structures in the lower dermis are irradiated. Because of the large size of the treatment area, damage to surface tissue is avoided. The hand-piece can operate while in contact with the treatment surface. Treatment surfaces include non-medical work sites. Alternatively, the hand-piece can operate in a non-contact mode. The system can also be used in non-medical applications such as UV curing.

Abstract: A diode pumped fiber laser is described that utilizes highly erbium-doped fluoride glass to produce 1 W and higher outputs at about 3 &mgr;m. High dopant concentrations in fluoride glass make it possible to efficiently pump the laser around 975 nm which in turn leads to higher slope efficiencies for the laser. Furthermore, by using this pumping wavelength, saturation of laser output due to bleaching of the ground state is overcome. The fluoride glass composition is a modified version of the standard ZBLAN composition. This altered composition achieves high glass quality, enables fiber drawing, and avoids the problem of crystallization.

Abstract: A cyclodextrin oligomer comprising two cyclodextrins connected through a spacer at the secondary side, characterized in that said spacer comprises the unit B which is a rigid and preferably hydrophilic structural element.

Abstract: A novel device and method for preventing restenosis and streamlining the angioplasty procedure. The device and method provide a fiberoptic guidewire, or, alternatively, a light-conducting catheter, to decrease the size of the angioplasty device, decrease the overall time of the procedure, and increase the safety of the procedure. The present invention delivers radiation to a sclerotized area after balloon angioplasty treatment to prevent restenosis Radiation delivered via the catheter or fiberoptic guidewire discourages the cell proliferation and cell growth after angioplasty, thereby improving the chances of avoiding restenosis.

Abstract: A handpiece for topical application of electromagnetic radiation is disclosed, consisting of a single monolithic transparent block covered by a semitransparent coating on the faces of the block not directed toward a treatment site. The block and coating are transparent to visible radiation, allowing the user a direct view of the treatment site. At the same time, for the safety of the user and a patient, the monolithic block has a coating of radiation blocking or absorbing material to selectively prevent treatment radiation from harming a user or patient. In a preferred embodiment, an optical fiber or fiber bundle coupled to a suitable power source is directly molded into the monolithic block. This invention is useful for a broad variety of laser applications, including the treatment of dermatological diseases and paint removal. The simple monolithic structure allows the device to be portable and practical in open environments.

Abstract: A composition and method for self-cleaning of the teeth and mouth using a source of light in the visible range in conjunction with a photosensitive liquid oral hygiene composition possessing a broad absorption spectrum in the visible range. The composition and method selectively eliminates harmful bacteria by use of a photosensitive agent and a light source. The composition also includes resistive elements to protect the photosensitizers from the degrading effects of blood serum, saliva, and other materials located naturally within the oral cavity. The method involves the use of a light-providing dental device to activate a photosensitive agent and destroy harmful bacteria in the oral cavity. It prevents or deters oral diseases, inflammations, and infections.

Abstract: Molecular conjugates for the treatment and prevention of infectious diseases due to pathogenic microorganisms are provided. These conjugates comprise at least one photosensitizer coupled to a microorganism receptor (vector) that binds selectively to the surface of a microorganism, such as bacteria, viruses, mycoplasma, fungi, parasites and others. Complex aggregates formed by self-association of carbohydrate-photosensitizer conjugates or that are constructed on the base of a carrier form multiple interactions with the binding sites on the surface of the selected microorganism due to their polyligand carbohydrate surrounding. The property of the conjugates to bind selectively to sites on targeted microbes and to block these sites defines their ability to act as inhibitors of microbial cell adhesion and thereby provides an ability to prevent infectious disease. Methods for treatment and prevention of infectious diseases due to pathogenic microorganisms are also provided.

Abstract: A rigidly spaced, cyclodextrin dimers having a preselected breaking point within the spacer sequence so as to controllably release the active pharmaceutically active substance only after it reaches the desired treatment site is described. These preselected breaking points are stable in blood but are cleavable within cells. In preferred embodiments, the cyclodextrin-pharmaceutically active substance complex is targeted to specific sites via incorporation of specific antibodies for the targeted sites, typically by complexing a biotin-avidin system to specific antibodies which thereby targets the complex to a specific site. Once at the site as the complex is taken up into the cell the preselected break point is cleaved and the encapsulated pharmaceutically active substance becomes available for action within the targeted cell.

Abstract: A system and method is disclosed for improved treatment of oral tissues using 980 nm laser radiation and a handpiece with means for concurrently delivering the laser radiation and a liquid/gas spray onto the treatment area to improve the treatment effects. Unwanted heating and carbonization of surrounding tissues is reduced. The liquid/gas spray may be mixed inside the handpiece or in a separate device. The combination of cooling sprays with radiation wavelengths having high absorption in water has previously been avoided due to the thought that energy absorption by the cooling fluid would render the energy delivered to the tissue uncontrollable and of minimal benefit. Preferably, pulsed laser light provides a localized energy deposition and heating to avoid unwanted heating of underlying tissue. The liquid spray flushes way tissue debris in addition to cooling the treated tissue.

Abstract: The present invention provides improved diffusion tips for optical fibers and methods of making the same. Nanoporous silica clad optical fibers are used to make fibers having integrally formed diffusion tips and diffusion tips that can be fused to other fibers. The disclosed diffusers can be fabricated to be cylindrical with light diffusing along its length, spherical with light radiating outwardly in a spherical pattern, or custom shaped to illuminate irregular surfaces or volumes. Gradient and step index properties can also be achieved. Several fabrication methods to achieve the desired effects are described. The problems in the prior art methods associated with epoxy, such as curing, bond strength, embrittlement, power handling limitations, and refractive index matching are avoided.

Abstract: A method and device is disclosed for wound debridement and wound healing that is equally effective for both diabetic and non-diabetic patients. A non-ablative laser beam or non-coherent radiation of a wavelength between 193 nm and 10.6 microns, preferably between 400 and 1350 nm, is applied in combination with a mechanical or laser debriding apparatus. The radiation is delivered at a power density of at least approximately 1 W/cm2 over a time period ranging from 1 second to 3 minutes. Typically, radiation power is in the range of 1 Watt to 15 Watts. Power density and treatment duration are adjusted to the parameters of the individual wound. Delivery means include, but are not limited to, optical fibers, articulating arms or direct exposure to radiation-emitting sources. In a preferred embodiment, pulsed or continuous wave high power radiation of an appropriate wavelength and a laser or mechanical scraping apparatus are intermittently or simultaneously applied to a wound.

Abstract: The present invention provides for an apparatus and method to manufacture optical fiber in a way that produces controlled and patterned diffusion of optical radiation along its length. The novelty of the described invention is that the patterns of diffusion are produced at the time the optical fiber is manufactured. The “in-line” manufacturing method avoids the need for post-production treatment of the fiber, which makes the process highly efficient and economical. Light diffusing optical fibers of significant length can be produced. Several manufacturing configurations to achieve the desired effects and their inclusion in the fiber production process are described. The processes can be configured to process optical fibers constructed from a wide variety of known glass, polymeric or other materials. The partially diffusing optical fibers of this invention have applications ranging from illuminated fabrics and toys and to lighting systems and medical instruments.

Abstract: A device and method is disclosed for the treatment of early stage wounds, i.e. those wounds that have resulted in little or no breach of the skin tissue. The invention utilizes non-ablative laser or non-coherent electromagnetic radiation applied to a stage one or two wound to stimulate wound healing, destroy viral and bacterial bodies, and prevent the development of such wounds into higher stage wounds. An appropriate wavelength is chosen from the range of 193 nm to 10.6 microns, and is delivered at a power density of about at least 1 W/cm2 over a predetermined treatment duration typically in the range of 1 second to 3 minutes. To achieve the desired energy density, radiation is typically delivered at a power between 1 Watt and 15 Watts, with an average power of 5-10 Watts. Early stage wounds that can be addressed with this invention include but are not limited to spider or other insect bites, bee stings, rashes, eczema, psoriasis, and poison ivy.

Abstract: The present invention describes a multi-component handpiece that is both economical and practical for surgical laser treatment. A disposable optical fiber is inserted into a reusable handpiece. The distal end of the optical fiber is protected by a micro-walled protective tube to prevent the disposable fiber from chipping before and during insertion into the handpiece. Once the optical fiber is protected, it is inserted into the handpiece by threading the optical fiber through the cap, body, and cannula of the handpiece until the fiber extends slightly beyond the distal end of the needle. The micro-walled protective tube is removed from the end of the optical fiber, the optical fiber is positioned, and the cap is tightened. The cap and body of the handpiece cooperate to produce a tight friction fit that prevents longitudinal movement of the optical fiber during laser therapy.