Patents Assigned to Cerulean Pharma Inc.
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Patent number: 8404662Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: GrantFiled: August 10, 2012Date of Patent: March 26, 2013Assignees: Cerulean Pharma Inc., Insert Therapeutics, Inc., Calando Pharmaceuticals, Inc.Inventors: Jianjun Cheng, Mark Davis, Kay T. Khin
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Patent number: 8404799Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent steam.Type: GrantFiled: May 24, 2012Date of Patent: March 26, 2013Assignee: Cerulean Pharma Inc.Inventors: John Podobinski, J. Michael Ramstack, David S. Dickey
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Patent number: 8399431Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: GrantFiled: July 19, 2012Date of Patent: March 19, 2013Assignees: Cerulean Pharma Inc., Insert Therapeutics, Inc., Calando Pharmaceuticals, Inc.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Publication number: 20130059816Abstract: Provided are methods relating to the use of CDP-therapeutic agent conjugates for the treatment of autoimmune disease, inflammatory disease, or cancer. Also provided are CDP-therapeutic agent conjugates, particles comprising CDP-therapeutic agent conjugates, and compositions comprising CDP-therapeutic agent conjugates.Type: ApplicationFiled: October 24, 2012Publication date: March 7, 2013Applicant: CERULEAN PHARMA INC.Inventor: CERULEAN PHARMA INC
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Patent number: 8389499Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: GrantFiled: July 19, 2012Date of Patent: March 5, 2013Assignees: Cerulean Pharma Inc., Insert Therapeutics, Inc., Calando Pharmaceuticals, Inc.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Publication number: 20130039880Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: ApplicationFiled: August 10, 2012Publication date: February 14, 2013Applicant: CERULEAN PHARMA INC.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Publication number: 20120302622Abstract: Particles and conjugates for delivering nucleic acid agents. Compositions containing the particles, the conjugates, or both. Methods of using the particles, the conjugates, and the compositions.Type: ApplicationFiled: April 10, 2012Publication date: November 29, 2012Applicant: CERULEAN PHARMA INC.Inventors: Scott Eliasof, Oliver S. Fetzer, Jungyeon Hwang, Patrick Lim Soo, Pei-Sze Ng, Sonke Svenson, Donald E. Bergstrom
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Publication number: 20120301424Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: ApplicationFiled: August 10, 2012Publication date: November 29, 2012Applicant: CERULEAN PHARMA INC.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Patent number: 8314230Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: GrantFiled: October 20, 2011Date of Patent: November 20, 2012Assignee: Cerulean Pharma Inc.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Publication number: 20120289480Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: ApplicationFiled: July 19, 2012Publication date: November 15, 2012Applicant: CERULEAN PHARMA INC.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Publication number: 20120283214Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: ApplicationFiled: July 19, 2012Publication date: November 8, 2012Applicant: CERULEAN PHARMA INC.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Publication number: 20120263653Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent steam.Type: ApplicationFiled: May 24, 2012Publication date: October 18, 2012Applicant: CERULEAN PHARMA INC.Inventors: John Podobinski, J. Michael Ramstack, David S. Dickey
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Publication number: 20120225825Abstract: Methods and compositions relating to CDP-taxane conjugates are described herein.Type: ApplicationFiled: April 6, 2012Publication date: September 6, 2012Applicant: CERULEAN PHARMA INC.Inventors: Thomas C. Crawford, Oliver S. Fetzer, Lawrence Alan Reiter, Marc Wolfgang
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Publication number: 20120225129Abstract: Particles and conjugates for delivering nucleic acid agents. Compositions containing the particles, the conjugates, or both. Methods of using the particles, the conjugates, and the compositions.Type: ApplicationFiled: August 18, 2011Publication date: September 6, 2012Applicant: CERULEAN PHARMA INC.Inventors: Scott Eliasof, Oliver S. Fetzer, Jungyeon Hwang, Patrick Lim Soo, Pei-Sze Ng, Sonke Svenson, Donald E. Bergstrom
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Patent number: 8252276Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: GrantFiled: March 15, 2012Date of Patent: August 28, 2012Assignee: Cerulean Pharma Inc.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Publication number: 20120196990Abstract: Systems and methods are provided for filtering a fluid containing nanoparticles. The systems and methods generally include introducing a stream of the nanoparticle-containing fluid into a holding vessel, and extracting at least a part of a nanoparticle-containing fluid accumulated in the holding vessel. The extracted nanoparticle-containing fluid is passed through a filtration module to separate a nanoparticle-containing retentate from a permeate, and the retentate is returned to the vessel. The filtration cycle can be repeated until a desired concentration of the nanoparticles is achieved in the holding vessel. In many embodiments, the generation of the nanoparticle-containing fluid and its filtration are performed concurrently.Type: ApplicationFiled: January 25, 2012Publication date: August 2, 2012Applicant: CERULEAN PHARMA INC.Inventors: J. Michael Ramstack, John Podobinski
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Publication number: 20120178711Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: ApplicationFiled: March 15, 2012Publication date: July 12, 2012Applicant: CERULEAN PHARMA INC.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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Patent number: 8207290Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.Type: GrantFiled: February 8, 2011Date of Patent: June 26, 2012Assignee: Cerulean Pharma Inc.Inventors: John Podobinski, J. Michael Ramstack, David S. Dickey
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Publication number: 20120064107Abstract: Provided are methods relating to the use of CDP-therapeutic agent conjugates for the treatment of autoimmune disease, inflammatory disease, or cancer. Also provided are CDP-therapeutic agent conjugates, particles comprising CDP-therapeutic agent conjugates, and compositions comprising CDP-therapeutic agent conjugates.Type: ApplicationFiled: August 12, 2011Publication date: March 15, 2012Applicant: CERULEAN PHARMA INC.Inventor: Scott Eliasof
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Publication number: 20120065368Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: ApplicationFiled: October 20, 2011Publication date: March 15, 2012Applicant: CERULEAN PHARMA INC.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin