Abstract: Methods and compositions relating to CDP-epothilone conjugates are described herein.

Abstract: Provided are methods relating to compositions that include a CDP-topoisomerase inhibitor, e.g., a CDP-camptothecin or camptothecin derivative conjugate, e.g., CRLX101.

Abstract: Methods and compositions relating to CDP-taxane conjugates are described herein.

Abstract: Described herein are conjugates (e.g., therapeutic peptide-polymer conjugates and protein-polymer conjugates) and particles, which can be used, for example, in the treatment of a disorder such as cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the conjugates (e.g., therapeutic peptide-polymer conjugates and protein-polymer conjugates) and particles, methods of making the conjugates (e.g., therapeutic peptide-polymer conjugates and protein-polymer conjugates) and particles, methods of storing the particles and methods of analyzing the particles.

Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Abstract: The present invention relates to novel compositions comprising polymeric moieties covalently attached to therapeutic agents, wherein the therapeutic agent is attached to the polymeric moiety through a tether. By selecting from a variety of tether groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein.

Abstract: Described herein is a cyclodextrin containing polymer conjugate.

Abstract: The invention relates to the liquid and lyophilized formulations of small particulates, liposomes, and micelles, and methods for making and using the formulations. In particular, at least in some embodiments, the present invention relates to the production and lyophilization of PEGylated nanoparticles, microparticles, micelles, and liposomes for use and administration in to a subject.

Abstract: In one aspect, the present invention provides a process for forming polymeric nanoparticles, which comprises using a static mixer to create a mixed flowing stream of an anti-solvent, e.g., by introducing a liquid anti-solvent into a static mixer, and introducing a polymer solution into the mixed flowing anti-solvent stream such that controlled precipitation of polymeric nanoparticles occurs. The nanoparticles can then be separated from the anti-solvent stream.

Abstract: An instant messaging graphical user interface (“GUI”) is described comprising: a text entry region in which a user may enter instant messages; an IM conversation window in which a complete IM conversation between the user and a selected contact appears; a video window for displaying real time video of the user and/or the contact during an IM session; and a plurality of user-selectable personal video recorder (“PVR”) controls for performing a respective plurality of PVR functions on the video displayed within the video window, the PVR functions including record, pause, and rewind for recording, pausing, and rewinding the video, respectively.

Abstract: A computer-implemented method is described for instant messaging comprising: categorizing two or more instant messaging contact names into a single meta contact; receiving a request to transmit an instant message directed to the meta contact; selecting one of the two or more instant messaging contact names within the meta contact to which to transmit the instant message based on a specified prioritization scheme.

Abstract: A computer-implemented method is described for instant messaging comprising: categorizing two or more instant messaging contact names into a single meta contact; receiving a request to transmit an instant message directed to the meta contact; selecting one of the two or more instant messaging contact names within the meta contact to which to transmit the instant message based on a specified prioritization scheme.

Abstract: This invention relates to a method for improving the efficiency with which fuel is burnt in a fuel burning apparatus, particularly an internal combustion engine, comprising dispersing an amount of at least one particulate lanthanide oxide, particularly cerium oxide, in the fuel. This invention further relates to tablets, capsules, compositions and liquid fuel additives suitable for dispersing a lanthanide oxide in fuel.

Abstract: Picture filtering technology generates mathematical mathematical models to represent photographic filters for application to digitized frames of picture stock. A desired filter is determined, and reference pictures, one taken with the filter and one taken without the filter, are selected from a picture library. The selected pictures are digitized and stored. The digitized pictures respectively comprise corresponding sets of pixels or digital data units between which a quantitative differencing is performed. The quantitative difference may be based on any number of variables, such as luminance. When the difference in the luminance values of each corresponding pair of pixels is determined, a mathematical model which is representative of this difference is generated. The mathematical model is essentially a mathematical model of the desired filter, “filtering” digital data in a substantially similar manner in which photographic filters affect light.

Abstract: A method of transferring information across a computer network with a server and a client. The information is divided into a plurality of cards and a plurality of card forms. Each card includes a plurality of values. Each card form corresponds to one of the cards and includes a description of the values of a corresponding card. The cards and the card forms are stored in a server data base on the server and a client data base on the client. The information in the server is changed or replaced by attaching a card delta to one of the cards. The card delta indicates which information in the respective card is to be replaced. The card deltas are transferred between the client data base and the server data base when data bases are to be updated.

Abstract: Polygon reshaping methods either add or subtract sides of lines of a polygon around an object of a digitized frame of picture stock. A line may be added by selecting a line of a polygon and adding a point to the line, thereby defining two lines with the point as their vertex. The point may be move along the line and away from the line to create an angle between the two lines on either side of the vertex. A line may be subtracted from a polygon either by selecting a line of the polygon and simply deleting it or by selecting a vertex of the polygon and deleting the two lines which shared the vertex. In the former line-removal case, the now-free endpoints of the lines adjacent to the removed line are moved and connected at a point defined along the removed line. In the latter vertex-removal case, a new line is drawn between the now-free endpoints of the lines which were respectively adjacent the removed lines.

Abstract: Edge detection or region definition technology in picture colorization masks objects of a frame by identifying pixels in the frame which fall within a determined range of luminance values. A seed point is selected within an object to be masked, and a test area is generated around the seed point. The test area may be any arbitrary shape or size. A range of luminance values of the pixels in the test area is generated, with the boundary values of the range representing the pixels having the highest and lowest luminance values. Pixels within the object to be masked which have luminance values falling within the range are identified and highlighted. The boundary values of the range may then be adjusted depending upon the satisfaction of the colorist. A mask is then defined to comprise the identified and highlighted pixels.