Patents Assigned to CHA University Industry-Academic Cooperation Foundation
  • Patent number: 12110509
    Abstract: Provided are stem cells-induced Serotoli-like cells, methods of preparing the same, and uses thereof. Sertoli-like cells according to one embodiment can be differentiated from embryonic stem cells with excellent proliferative capacity, and thus, can be obtained in large quantities. Also, since the Sertoli-like cells secrete immunosuppressive substances and form immune privilege and induce anti-inflammatory functions, they can be used for development of the cell therapeutic agent.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: October 8, 2024
    Assignee: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Dong Ryul Lee, Dong Won Seol
  • Patent number: 12098174
    Abstract: The present invention provides an Oct-3/4 protein variant wherein lysine at position 156; lysine at position 286; or lysines at positions 156 and 286 in the Oct-3/4 protein is (are) substituted with arginine. The Oct-3/4 protein variant according to the present invention can inhibit a protein degradation mechanism through ubiquitination, and shows a higher half-life, compared to the wild-type Oct-3/4, thereby exhibiting high stability.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: September 24, 2024
    Assignee: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Kwang-Hyun Baek, Ji-Hye Choi
  • Publication number: 20240299626
    Abstract: Provided are a biodegradable polymer scaffold including bioactive materials and methods of manufacturing the same. The biodegradable polymer scaffold, preventing inflammatory responses caused by acidic substances produced during a degradation process, has easily controllable mechanical strength, and includes bioactive materials derived from cells of target tissues, and thus may induce tissue regeneration more effectively.
    Type: Application
    Filed: March 8, 2022
    Publication date: September 12, 2024
    Applicant: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Dong Keun HAN, Kyoung-Won KO, So-Yeon PARK
  • Publication number: 20240252547
    Abstract: A pharmaceutical composition for preventing or treating a stroke, the pharmaceutical composition comprising, as an active ingredient, neural precursor cells differentiated from HLA homozygous human induced pluripotent stem cells (hiPSC-NPC), wherein, through the use of a homozygous type, immunorejection may be eliminated and stable therapeutic effects for stroke may be exhibited.
    Type: Application
    Filed: May 26, 2022
    Publication date: August 1, 2024
    Applicants: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, IPS BIO, INC.
    Inventor: Jihwan SONG
  • Publication number: 20240006031
    Abstract: One aspect provides a physiologically based pharmacokinetic core model which may be commonly applied to two or more compounds that share the same core structure, and a method of constructing the physiologically based pharmacokinetic core model. According to the physiologically based pharmacokinetic core model and the method of constructing the physiologically based pharmacokinetic core model, there is the effect of conducting exposure evaluation simply only by deriving a distribution coefficient, without constructing a separate PBPK model for each individual compound.
    Type: Application
    Filed: October 25, 2021
    Publication date: January 4, 2024
    Applicant: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Hea-Young CHO, Go-Wun CHOI, Eun-Jeong CHOI, Ju Hee KIM, Dong Wook KANG
  • Publication number: 20230390326
    Abstract: According to a composition including a cationic substance as an active ingredient according to one aspect, the stability of perforin protein is increased to induce the accumulation of intracellular perforin proteins, thereby increasing the activity of immune cells.
    Type: Application
    Filed: October 27, 2021
    Publication date: December 7, 2023
    Applicants: SUNGKWANG MEDICAL FOUNDATION, CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Kyung-Soon PARK, Keun-Hong PARK, Seung Hee CHOI, Hye Jin KIM, Hee Jung AN
  • Publication number: 20230332079
    Abstract: The present disclosure relates to a biomimetic chip for three-dimensionally simulating an endometrium, and an endometrium simulating method using the biomimetic chip. The biomimetic chip according to an embodiment of the present disclosure is a three-dimensional biomimetic chip including a plate, a plurality of chambers, and a plurality of posts, which are arranged between the plurality of chambers, wherein the plurality of chambers include channels in which different cells are cultured, are arranged on the plate to be parallel to each other in one direction, and are arranged adjacent to each other such that at least some sections communicate with each other.
    Type: Application
    Filed: June 23, 2021
    Publication date: October 19, 2023
    Applicants: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, SUNGKWANG MEDICAL FOUNDATION
    Inventors: Youn Jung KANG, Jung Ho AHN, Min Ji YOON, Hwi Jae CHA, Seon Hwa HONG
  • Publication number: 20230330151
    Abstract: Provided are a composition and a method for promoting differentiation of neural stem cells into dopaminergic neurons, the composition including fusaric acid, ascorbic acid, nicotinamide adenine dinucleotide, or a combination thereof. The composition and method according to an aspect may not only increase differentiation of neural stem cells isolated at an early stage of development into dopaminergic neurons, but also increase differentiation of subcultured neural stem cells into dopaminergic neurons, and thus, it is possible to secure more dopaminergic neurons, and increase therapeutic effects on Parkinson's disease.
    Type: Application
    Filed: August 24, 2021
    Publication date: October 19, 2023
    Applicants: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, SUNGKWANG MEDICAL FOUNDATION
    Inventors: Jisook MOON, Chul KIM, Jae Hyun PARK, Ji-Min PARK, Young Sook SONG, Chul Woo LIM, Yuri CHOI
  • Publication number: 20230272555
    Abstract: Provided is a vector library for yeast two-hybrid screening of a deubiquitinating enzyme that binds to a target protein and a method for identifying a deubiquitinating enzyme binding to a target protein using the same. Further provided is a method for screening an agent having anti-cancer activity targeting the deubiquitinating enzyme USP1, USP7, USP12, or USP49 identified by the identifying method.
    Type: Application
    Filed: May 11, 2023
    Publication date: August 31, 2023
    Applicant: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Kwang-Hyun BAEK, So-Ra KIM, Seul-Ki KWON, Soo-Yeon KIM, Da-Hye LEE
  • Publication number: 20230213531
    Abstract: Provided are an analytical method for providing information necessary for diagnosing recurrent pregnancy loss, comprising measuring an expression level of HtrA4 protein or an expression level of a gene encoding the same in a subject’s sample, and a kit for diagnosing recurrent pregnancy loss, comprising a molecule capable of measuring an expression level of HtrA4 protein or an expression level of a gene encoding the same
    Type: Application
    Filed: February 26, 2021
    Publication date: July 6, 2023
    Applicant: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Kwang-Hyun BAEK, Chang-Zhu PEI
  • Patent number: 11686014
    Abstract: The present invention provides a vector library for yeast two-hybrid screening of a deubiquitinating enzyme that binds to a target protein and a method for identifying a deubiquitinating enzyme binding to a target protein using the same. Also, the present invention provides a method for screening an agent having anti-cancer activity targeting the deubiquitinating enzyme USP1, USP7, USP12, or USP49 identified by said identifying method.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: June 27, 2023
    Assignee: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Kwang-Hyun Baek, So-Ra Kim, Seul-Ki Kwon, Soo-Yeon Kim, Da-Hye Lee
  • Publication number: 20230131962
    Abstract: According to a composition and a kit for diagnosing ovarian reserve, and a method of providing information for diagnosing ovarian reserve by using the same, according to an aspect, the development of follicles may be predicted early. In addition, by predicting not only the number of oocytes but also the quality of oocytes, a comprehensive diagnosis of ovarian reserve may be made.
    Type: Application
    Filed: August 26, 2020
    Publication date: April 27, 2023
    Applicant: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Kyung-Ah LEE, Kyeoung-Hwa KIM, Mi Kyoung KOONG
  • Publication number: 20230113221
    Abstract: The disclosure relates to a method of producing bankable and subculturable mature microglia, and according to a method according to an aspect, subculture and banking are possible, and freeze storage and thawing are also possible, and thus, it is possible to simply isolate and use only mature microglia whenever necessary. In addition, it is possible to dramatically reduce the number of subjects required for an experiment, and therefore, the method may contribute economically to all research or industrial fields related to microglia.
    Type: Application
    Filed: November 10, 2020
    Publication date: April 13, 2023
    Applicants: SUNGKWANG MEDICAL FOUNDATION, CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Min Soo KWON, Jong Seop RIM, Tae Ho KONG, Min Jung YOU, Ji Hye WON
  • Patent number: 11541151
    Abstract: The present disclosure provides a coacervate composition containing a protein drug, gelatin A, sodium alginate and an acid and a wound-healing agent including the same. The coacervate composition according to the present disclosure can be useful as a wound-healing material delivery system for effectively delivering a protein drug, particularly epidermal growth factor, to a wound site in the wound-healing field.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: January 3, 2023
    Assignee: Cha University Industry-Academic Cooperation Foundation
    Inventors: Aeri Kim, Seong Hee Jeong
  • Publication number: 20220409706
    Abstract: A composition may increase a rate of endometrial blood flow and a composition for increasing implantation potential, including botulinum toxin or a salt thereof, and a pharmaceutical composition may preventing or treating subfertility or infertility, including botulinum toxin or a pharmaceutically acceptable salt thereof. Such compositions can increase a rate of endometrial blood flow and improve embryonic implantation potential just by being applied to the endometrium, and thus may be helpful to patients with subfertility or infertility, especially those who have repetitive failures in embryonic implantation. Since the compositions include botulinum toxin which is a substance that has been widely applied to the human body for cosmetic purposes, studies on human toxicity may have a shortened period, and thus the disclosure is very useful in economical and industrial aspects.
    Type: Application
    Filed: April 28, 2020
    Publication date: December 29, 2022
    Applicant: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Youn Jung KANG, Hwa Seon KOO, Jung Jae KO
  • Patent number: 11435368
    Abstract: Provided are a biomarker for diagnosing of the level of senescence, a composition and kit for diagnosing of the level of senescence to detect the biomarker, and a method of diagnosing the same. According to the composition and kit for the diagnosis of the level of senescence and the method of diagnosing senescence, the level of senescence of a subject is easily diagnosed, the health conditions of the subject are monitored, and a senescence-associated disease is prevented or diagnosed.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: September 6, 2022
    Assignees: CHA University Industry-Academic Cooperation Foundation, The General Hospital Corporation
    Inventors: Ji Sook Moon, Hak Ho Lee, Ala Jo, Jae Hyun Park, Ji Min Park, Chul Woo Lim, Yu Ri Choi
  • Publication number: 20220259562
    Abstract: Provided are a composition and a kit, each for culturing natural killer cells, and a method of using the same. According to the composition for culturing natural killer cells according to aspect, and a method of culturing natural killer cells using the same, when natural killer cells are cultured in peripheral blood mononuclear cells, they are cultured in a medium including the composition for culturing natural killer cells, the composition including magnetic particles, of which at least one surface is bound with an activating receptor ligand, an inhibitory receptor ligand, a costimulatory receptor ligand, a cytokine, a cytokine receptor, an immune checkpoint ligand, a blocking antibody, or a combination thereof, thereby proliferating natural killer cells in a large quantity and promoting activation or inhibition of natural killer cells, or expansion of natural killer cells. Accordingly, the natural killer cells cultured using the same may be usefully applied to immune cell therapy products.
    Type: Application
    Filed: May 14, 2020
    Publication date: August 18, 2022
    Applicant: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: KyuBum KWACK, Sooyeon OH, Hae Jong LEE, Jeong Min SIM, Jae Joon LIM
  • Publication number: 20220194998
    Abstract: The present invention provides an Oct-3/4 protein variant wherein lysine at position 156; lysine at position 286; or lysines at positions 156 and 286 in the Oct-3/4 protein is (are) substituted with arginine. The Oct-3/4 protein variant according to the present invention can inhibit a protein degradation mechanism through ubiquitination, and shows a higher half-life, compared to the wild-type Oct-3/4, thereby exhibiting high stability.
    Type: Application
    Filed: February 6, 2020
    Publication date: June 23, 2022
    Applicant: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Kwang-Hyun BAEK, Ji-Hye CHOI
  • Publication number: 20220106564
    Abstract: Provided are a composition and a kit for differentiation of stem cells into neural crest stem cells (NCSCs), each including a transforming growth factor beta (TGF-?) I receptor inhibitor and 0.001 ?M to 2.5 ?M of a bone morphogenetic protein (BMP) inhibitor, and a method using the same. Accordingly, stem cells may be efficiently differentiated into neural crest stem cells using the simple, low-cost composition.
    Type: Application
    Filed: January 10, 2020
    Publication date: April 7, 2022
    Applicant: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventor: Dong Youn HWANG
  • Publication number: 20220099686
    Abstract: Provided are a brain-derived vesicle-specific marker and a brain disease diagnostic method using the same. According to one aspect, by using a marker which specifically expresses in brain-derived vesicles, brain-derived vesicles may be isolated in a highly efficient and highly specific manner without having to collect tissue, and vesicles which specifically express in each region of the brain may be isolated. Also, a brain disease condition may be diagnosed by means of an expression profile of a marker specific to a brain region in brain-derived vesicles which have been isolated by means of the marker according to one aspect.
    Type: Application
    Filed: November 29, 2019
    Publication date: March 31, 2022
    Applicant: CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventor: Ji Sook MOON