Abstract: Apparatus and methods for delivery of air-borne materials from pulsatile delivery devices by passing the emissions from such devices and air in a coaxial manner through a suitable mixing chamber. Preferred apparatus include a chamber defining an axis of air flow, a plurality of pulsatile delivery devices, an actuator in communication with the devices for selective actuation thereof, and a device for introducing air at a first end of the chamber and for flowing that air substantially along the axis. The pulsatile delivery devices are positioned at the first end of the chamber such that actuation of the devices emits an air-borne substance substantially along the axis of air flow.
Type:
Grant
Filed:
January 14, 1998
Date of Patent:
April 27, 2004
Assignee:
Charles River Laboratories
Inventors:
Simon J. Rothenberg, Hsu Chi Yeh, Bernard J. Greenspan
Abstract: The invention provides methods and compositions for the detection and/or quantification of bacterial endotoxins. In particular, provided herein is an inexpensive and reproducible method for producing an improved amebocyte lysate preparation having reduced Factor G activity. Provided also is an endotoxin-specific amebocyte lysate preparation produced by such a method. In addition, the invention provides methods and compositions for enhancing the sensitivity to endotoxins of amebocyte lysate preparations having reducing Factor G activity. In particular, the sensitivity of such amebocyte lysate preparations to endotoxins can be enhanced by the addition of exogenous (1→3) &bgr;-D-glucan.
Type:
Application
Filed:
April 26, 2002
Publication date:
June 5, 2003
Applicant:
Charles River Laboratories
Inventors:
Foster T. Jordan, Hui-Ti Chiang, James F. Cooper, Norman R. Wainwright
Abstract: The invention provides methods and compositions for the detection and/or quantification of bacterial endotoxins. In particular, provided herein is an inexpensive and reproducible method for producing an improved amebocyte lysate preparation having reduced Factor G activity. Provided also is an endotoxin-specific amebocyte lysate preparation produced by such a method. In addition, the invention provides methods and compositions akin for enhancing the sensitivity to endotoxins of amebocyte lysate preparations having reducing Factor G activity. In particular, the sensitivity of such amebocyte lysate preparations to endotoxins can be enhanced by the addition of exogenous (1→3) &bgr;-D-glucan.
Type:
Grant
Filed:
September 18, 2000
Date of Patent:
May 21, 2002
Assignee:
Charles River Laboratories
Inventors:
Foster T. Jordan, Hui-Ti Chiang, James F. Cooper, Norman R. Wainwright
Abstract: The invention provides methods and compositions for the detection and/or quantification of bacterial endotoxins. In particular, provided herein is an inexpensive and reproducible method for producing an improved amebocyte lysate preparation having reduced Factor G activity. Provided also is an endotoxin-specific amebocyte lysate preparation produced by such a method. In addition, the invention provides methods and compositions for enhancing the sensitivity to endotoxins of amebocyte lysate preparations having reducing Factor G activity. In particular, the sensitivity of such amebocyte lysate preparations to endotoxins can be enhanced by the addition of exogenous (1→3) &bgr;-D-glucan.
Type:
Grant
Filed:
October 9, 1997
Date of Patent:
August 7, 2001
Assignee:
Charles River Laboratories
Inventors:
Foster T. Jordan, Hui-Ti Chiang, James F. Cooper, Norman R. Wainwright
Abstract: A container for transporting laboratory-type animals comprises a base and a lid, wherein the base and the lid when assembled define a volume for receiving one or more laboratory animals therewithin. The base includes a flange for contacting the lid, wherein the lid is removably attached to the flange of the base with removable stitching.