Patents Assigned to Charles River Laboratories
  • Patent number: 6725859
    Abstract: Apparatus and methods for delivery of air-borne materials from pulsatile delivery devices by passing the emissions from such devices and air in a coaxial manner through a suitable mixing chamber. Preferred apparatus include a chamber defining an axis of air flow, a plurality of pulsatile delivery devices, an actuator in communication with the devices for selective actuation thereof, and a device for introducing air at a first end of the chamber and for flowing that air substantially along the axis. The pulsatile delivery devices are positioned at the first end of the chamber such that actuation of the devices emits an air-borne substance substantially along the axis of air flow.
    Type: Grant
    Filed: January 14, 1998
    Date of Patent: April 27, 2004
    Assignee: Charles River Laboratories
    Inventors: Simon J. Rothenberg, Hsu Chi Yeh, Bernard J. Greenspan
  • Publication number: 20030104501
    Abstract: The invention provides methods and compositions for the detection and/or quantification of bacterial endotoxins. In particular, provided herein is an inexpensive and reproducible method for producing an improved amebocyte lysate preparation having reduced Factor G activity. Provided also is an endotoxin-specific amebocyte lysate preparation produced by such a method. In addition, the invention provides methods and compositions for enhancing the sensitivity to endotoxins of amebocyte lysate preparations having reducing Factor G activity. In particular, the sensitivity of such amebocyte lysate preparations to endotoxins can be enhanced by the addition of exogenous (1→3) &bgr;-D-glucan.
    Type: Application
    Filed: April 26, 2002
    Publication date: June 5, 2003
    Applicant: Charles River Laboratories
    Inventors: Foster T. Jordan, Hui-Ti Chiang, James F. Cooper, Norman R. Wainwright
  • Patent number: 6391570
    Abstract: The invention provides methods and compositions for the detection and/or quantification of bacterial endotoxins. In particular, provided herein is an inexpensive and reproducible method for producing an improved amebocyte lysate preparation having reduced Factor G activity. Provided also is an endotoxin-specific amebocyte lysate preparation produced by such a method. In addition, the invention provides methods and compositions akin for enhancing the sensitivity to endotoxins of amebocyte lysate preparations having reducing Factor G activity. In particular, the sensitivity of such amebocyte lysate preparations to endotoxins can be enhanced by the addition of exogenous (1→3) &bgr;-D-glucan.
    Type: Grant
    Filed: September 18, 2000
    Date of Patent: May 21, 2002
    Assignee: Charles River Laboratories
    Inventors: Foster T. Jordan, Hui-Ti Chiang, James F. Cooper, Norman R. Wainwright
  • Patent number: 6270982
    Abstract: The invention provides methods and compositions for the detection and/or quantification of bacterial endotoxins. In particular, provided herein is an inexpensive and reproducible method for producing an improved amebocyte lysate preparation having reduced Factor G activity. Provided also is an endotoxin-specific amebocyte lysate preparation produced by such a method. In addition, the invention provides methods and compositions for enhancing the sensitivity to endotoxins of amebocyte lysate preparations having reducing Factor G activity. In particular, the sensitivity of such amebocyte lysate preparations to endotoxins can be enhanced by the addition of exogenous (1→3) &bgr;-D-glucan.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: August 7, 2001
    Assignee: Charles River Laboratories
    Inventors: Foster T. Jordan, Hui-Ti Chiang, James F. Cooper, Norman R. Wainwright
  • Patent number: 5370079
    Abstract: A container for transporting laboratory-type animals comprises a base and a lid, wherein the base and the lid when assembled define a volume for receiving one or more laboratory animals therewithin. The base includes a flange for contacting the lid, wherein the lid is removably attached to the flange of the base with removable stitching.
    Type: Grant
    Filed: May 3, 1993
    Date of Patent: December 6, 1994
    Assignee: Charles River Laboratories
    Inventor: Roger W. Smith
  • Patent number: D705439
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 20, 2014
    Assignees: Charles River Laboratories, ReaMetrix, Inc.
    Inventors: Norman R. Wainwright, Bala S. Manian, Eric Stimpson, Brian J. Kolonia, Robert K. Kolonia