Patents Assigned to Cheng Kung University
  • Patent number: 11215399
    Abstract: A high temperature reaction system includes a reaction tube including a heating space, a discharge unit, a cooling unit, a feeding unit and an observation and analysis unit. The discharge unit is disposed opposite to an inlet of the heating space and has a discharge space communicating the heating space, and an observation window and a discharge opening which communicate the discharge space. The cooling unit has a cooling space communicating the discharge opening. The feeding unit includes a carrier holding a sample, and a moving module for moving the carrier and the sample. The observation and analysis unit includes an image capture module and an analysis module for analyzing gas released by the sample.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: January 4, 2022
    Assignee: National Cheng Kung University
    Inventors: In-Gann Chen, Shih-Hsien Liu, Ke-Miao Lu, Chia-Ming Yang, Hao-Hsun Chang
  • Patent number: 11213277
    Abstract: A measuring system for measuring elasticity of biological tissue includes a mobile device and a measuring apparatus including a conducting seat and a measuring device. The conducting seat is for detachable mounting of the mobile device therein, and is adapted to abut against the biological tissue for conducting vibrations produced by the mobile device to the biological tissue to cause the biological tissue to vibrate. The measuring device includes an ultrasonic transducer to emit an ultrasound signal to the biological tissue and an elasticity analyzer to analyze an ultrasound echo signal that results from reflection of the ultrasound signal by the biological tissue which is vibrating to obtain an elasticity data of the biological tissue.
    Type: Grant
    Filed: December 9, 2019
    Date of Patent: January 4, 2022
    Assignee: National Cheng Kung University
    Inventors: Chih-Chung Huang, Pei-Yu Chen, Cho-Chiang Shih
  • Patent number: 11193294
    Abstract: A double variable sliding isolator including a bottom sliding plate, a top sliding plate, and a friction piece is provided. The bottom sliding plate has a bottom sliding surface that has at least two curvatures. The top sliding plate is disposed over the bottom sliding plate and has a top sliding surface that has at least two curvatures. The friction piece is disposed between the top sliding plate and the bottom sliding plate and the friction piece is in contact with the bottom sliding surface and the top sliding surface. When an external force is applied to the bottom sliding plate and the top sliding plate, the bottom sliding plate and the top sliding plate will generate a relative displacement, so that the friction piece slides along the bottom sliding plate and the top sliding plate.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: December 7, 2021
    Assignees: National Cheng-Kung University, WELL-LINK INDUSTRY Co., LTD
    Inventors: Lyan-Ywan Lu, Han-Wei Huang, Chun-Lung Lee
  • Publication number: 20210357476
    Abstract: The present invention relates to computing-implemented method and system that improves matrix multiplication efficiency, especially to method and system optimizing matrix multiplication using sparse basis approach. Matrices to be multiplied are organized into specially ordered vectors with zero values, facilitates speed up during linear combination computation or synthesis process.
    Type: Application
    Filed: May 12, 2020
    Publication date: November 18, 2021
    Applicant: National Cheng Kung University
    Inventors: Gwo Giun Lee, Shih-Yu Chen
  • Publication number: 20210335643
    Abstract: An error measurement device and an error measurement method are provided. The optical measurement assembly of the error measurement device includes a light source, an optical lens, and a photoelectric sensor. The light beam emitted by the light source is transmitted to a sensing area on the photoelectric sensor to form a first optical path illuminating on a first light-spot position of the sensing area. The moving stage is moved by a linear displacement, so that the light beam is transmitted to the photoelectric sensor to form a second optical path illuminating on a second light-spot position of the sensing area. The processor calculates a movement error of the moving stage and controls the actuator to drive one or more of the light source, the optical lens, and the photoelectric sensor to perform a relative motion, so that the light beam illuminates on the first light-spot position again.
    Type: Application
    Filed: October 15, 2020
    Publication date: October 28, 2021
    Applicant: National Cheng Kung University
    Inventors: Chien-Sheng LIU, Jie-Yu ZENG
  • Patent number: 11156695
    Abstract: A Doppler radar sensor includes a radar and a bondwire interconnection. The bondwire interconnection is connected to a signal generator and an antenna of the radar and configured to transmit a radio frequency signal generated by the signal generator to the antenna and transmit a reflected signal received by the antenna to a demodulator of the radar. A metal strip, a first shunt bondwire and a second shunt bondwire of the bondwire interconnection can be used as a matching circuit of the antenna to decrease the transmission loss and increase the detection distance of the radar.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: October 26, 2021
    Assignees: Sil Radar Technology Inc., National Cheng Kung University, NCKU Research and Development Foundation
    Inventors: Huey-Ru Chuang, Cheng-Hsueh Chan, Chien-Chang Chou
  • Publication number: 20210325436
    Abstract: A pulse measurement device is provided, including a first signal source, a second signal source, two microwave resonators, two mixers, and a signal processing unit. The first signal source and the second signal source output a first high-frequency signal and a second high-frequency signal, respectively. Each of the microwave resonators generates an electric field according to the first high-frequency signal, and senses a variation in the electric field which is interfered by a pulse to obtain a sensing signal. Each of the mixers is coupled to one of the microwave resonators, to mix the sensing signal and the second high-frequency signal to output a down-converted signal. The signal processing unit respectively demodulates amplitudes of the down-converted signals of the two mixers to obtain amplitude signals.
    Type: Application
    Filed: March 25, 2021
    Publication date: October 21, 2021
    Applicant: National Cheng Kung University
    Inventors: Ching-Lung YANG, Chia-Hui CHEN
  • Publication number: 20210310266
    Abstract: A double variable sliding isolator including a bottom sliding plate, a top sliding plate, and a friction piece is provided. The bottom sliding plate has a bottom sliding surface that has at least two curvatures. The top sliding plate is disposed over the bottom sliding plate and has a top sliding surface that has at least two curvatures. The friction piece is disposed between the top sliding plate and the bottom sliding plate and the friction piece is in contact with the bottom sliding surface and the top sliding surface. When an external force is applied to the bottom sliding plate and the top sliding plate, the bottom sliding plate and the top sliding plate will generate a relative displacement, so that the friction piece slides along the bottom sliding plate and the top sliding plate.
    Type: Application
    Filed: April 6, 2020
    Publication date: October 7, 2021
    Applicants: National Cheng-Kung University, WELL-LINK INDUSTRY Co.,LTD
    Inventors: Lyan-Ywan Lu, Han-Wei Huang, Chun-Lung Lee
  • Patent number: 11120249
    Abstract: The present disclosure is to provide a computer-aided cell segmentation method for determining cellular Nuclear-to-Cytoplasmic ratio, which comprises acts of obtaining a cytological image using non-invasive in vivo biopsy technique; performing a nuclei segmentation process to identify a position and a contour of each of identified nuclei in the cytological image; performing a cytoplasmic process with an improved active contour model to obtain a cytoplasmic region for each identified nucleus based; and determine a cellular Nuclear-to-Cytoplasmic ratio based on the obtained nucleus and cytoplasmic regions.
    Type: Grant
    Filed: December 22, 2019
    Date of Patent: September 14, 2021
    Assignee: National Cheng Kung University
    Inventors: Gwo Giun Lee, Yi-Hsuan Chou, Chen-Han Sung
  • Patent number: 11054922
    Abstract: The present invention discloses a using method of a rewritable board. It comprises applying or removing a fluid on the rewritable board for writing repeatedly, wherein the rewritable board is an aluminum based material sequentially having a porous aluminum oxide layer and a metal layer thereon, and wherein the porous aluminum oxide layer has a porosity ranging from 10% to 80%.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: July 6, 2021
    Assignee: National Cheng Kung University
    Inventors: Chen-Kuei Chung, Chung-Yu Yu
  • Patent number: 10997719
    Abstract: A method of training neural network for obtaining medical sagittal image includes: using a first neural network on a 3-D medical image to generate a prediction sagittal mask; generating a prediction result according to the 3-D medical image and the prediction sagittal mask; generating a ground truth result according to the 3-D medical image and a ground truth sagittal mask; using a second neural network on the prediction result and the ground truth result; generating a loss function data according to an output of the second neural network; and adjusting parameters of the first neural network or the second neural network according to the loss function data.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: May 4, 2021
    Assignee: National Cheng Kung University
    Inventors: Yung-Nien Sun, Pei-Yin Tsai, Chia-Ju Hsieh, Shih-Ting Huang, Yu-Han Huang
  • Publication number: 20210108230
    Abstract: The present invention provides a carboxylated nanodiamond-mediated CRISPR-Cas9 delivery system for gene editing comprising nanodiamond (ND) particles as the carriers of CRISPR-Cas9 components designed to introduce the mutation in a given gene for repairing a tissue damage.
    Type: Application
    Filed: October 15, 2020
    Publication date: April 15, 2021
    Applicants: Taipei Veterans General Hospital, National Chiao Tung University, National Cheng Kung University
    Inventors: Shih-Hwa CHIOU, Tien-Chun YANG, Chia-Ching CHANG, Yon-Hua TZENG
  • Patent number: 10947634
    Abstract: A method for preparing invisible anodic aluminum oxide (AAO) patterns is revealed. The method includes a plurality of steps. First take an aluminum substrate. Then anodize the aluminum substrate for the first time to get a first anodic aluminum oxide (AAO). Next perform photolithography so that a photoresist forms a pattern on the aluminum substrate with the first AAO. Lastly anodize the aluminum substrate for the second time so that a second AAO is formed on the pattern and the pattern becomes invisible.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: March 16, 2021
    Assignee: National Cheng Kung University
    Inventors: Chen-Kuei Chung, Yun Chen, Chung-Yu Yu
  • Patent number: 10912843
    Abstract: A method for treating a disease caused by protein retention in the endoplasmic reticulum (ER) with a sarcoplasmic/endoplasmic reticulum calcium ATPase pump inhibitor encapsulated in a polymer nanoparticle. The polymer nanoparticle is surface-modified such that it is targeted to the ER. The inhibitor reduces protein retention in the ER and the encapsulation lowers side effects of the inhibitor, e.g., cytotoxicity, as compared to administering the inhibitor without encapsulation. Also disclosed is a pharmaceutical composition that can be used for carrying out the method. Further provided is a transgenic mouse carrying in its genome a heterologous nucleic acid that encodes an H338Y mutant gp91phox protein. The transgenic mouse can serve as a model for human chronic granulomatous disease.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: February 9, 2021
    Assignee: National Cheng Kung University
    Inventors: Chi-Chang Shieh, Chia-Liang Yen, Dar-Bin Shieh, Si-Tse Jiang
  • Patent number: 10870684
    Abstract: Disintegrin variants that bind specifically to one or more of ?5?1 and ?v integrins, such as ?v?1, ?v?3, ?v?5, ?v?6 and ?v?8, but with reduced binding activity to ?IIb?3, are described. Also described are uses of the disintegrin variants for the treatment or prevention of a disease associated with an ?v integrin or an ?5?1 integrin.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: December 22, 2020
    Assignee: National Cheng Kung University
    Inventor: Woei-Jer Chuang
  • Publication number: 20200366209
    Abstract: A method for estimating an output voltage of an isolated resonant converter is disclosed. The proposed method, wherein the isolated resonant converter includes a transformer having an auxiliary winding and a secondary winding, a first output diode electrically connected to the secondary winding in series and a voltage holder coupled to the auxiliary winding, includes: obtaining the output voltage V o = [ v aux_dh ? ( t ) + V F ] ยท N s N aux - V F , where vaux_dh(t) is an output voltage of the voltage holder, VF is a forward voltage drop of the first output diode, NS is a number of turns of the secondary winding and Naux is a number of turns of the auxiliary winding.
    Type: Application
    Filed: April 27, 2020
    Publication date: November 19, 2020
    Applicant: National Cheng Kung University
    Inventors: Tsorng-Juu Liang, Chi-Hung Lin, Wei-Jing Tseng
  • Patent number: 10826513
    Abstract: An analog to digital converter includes a coarse ADC circuit composed of L offset-adjustable comparators and a fine ADC circuit composed of M offset-adjustable comparators. Each offset-adjustable comparator in the coarse ADC circuit has a constant embedded offset. Each offset-adjustable comparator in the fine ADC circuit has an adaptive embedded offset digitally determined by outputs of the coarse ADC circuit. With the constant and adaptive embedded offsets, the analog to digital converter requires no resistor ladder. Therefore, power consumption and area of the analog to digital converter is reduced, and faster conversion speed is achieved.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: November 3, 2020
    Assignee: National Cheng Kung University
    Inventors: Chung-Ming Yang, Tai-Haur Kuo
  • Patent number: 10814478
    Abstract: A joint module has a base, a motion mechanism, a linear driving mechanism, a driving motor assembly, and a transmission. The motion mechanism, the linear driving mechanism, and the driving motor assembly are disposed on the base. The transmission is disposed between the linear driving mechanism and the driving motor assembly. A first transmitting assembly and a second transmitting assembly of the motion mechanism are disposed on the base in parallel. A first linear driving assembly and a second linear driving assembly of the linear driving mechanism are non-coaxial and are disposed on the base in parallel. A first wheel transmitting assembly of the transmission is connected to the driving motor assembly and the first linear driving assembly. A second wheel transmitting assembly of the transmission is connected to the driving motor assembly and the second linear driving assembly.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: October 27, 2020
    Assignee: National Cheng Kung University
    Inventor: Chao-Chieh Lan
  • Patent number: 10787992
    Abstract: A regenerative displacer for use in a stirling engine includes two opposite covers with respective through openings, a body engaging the covers to define an accommodation space therein, a regenerator disposed in the accommodation space, and a rod inserted through the regenerator and one of the covers into a cooling portion of the stirling engine. The regenerator has a plurality of channels. Each channel has two open ends and a heat collecting net engaging each open end. Working gas passing through the regenerative displacer can be concentrated at the open ends and can absorb and release heat quickly because of the heat collecting nets, thereby increasing the efficiency of heat exchange and a temperature difference of the working gas in a thermodynamic cycle. Accordingly, pressure is increased to facilitate a quick reciprocation of a power piston of the stirling engine, and this increases output power and saves energy.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: September 29, 2020
    Assignee: National Cheng Kung University
    Inventors: Wen-Lih Chen, Yueh-Heng Li, Yu-Ting Wu, Chao-Wei Huang
  • Patent number: 10781289
    Abstract: A method includes the steps of (a) adding an organosilicon compound containing methyl groups and a surfactant into water, mixing well and carrying out hydrolysis to get a mixed aqueous solution; (b) mixing the mixed aqueous solution with 0.1-0.2M ammonium hydroxide and a remaining percentage of an organic solvent, and stirring the mixture under nitrogen atmosphere for emulsion polymerization to get a water-in-oil (w/o) emulsion; and (c) removing the organic solvent and drying the w/o emulsion to get aerogel particles. Thereby the aerogel particles are produced by the present method without hydrophobic treatment and solvent exchange. Therefore the cost and time used for preparing the aerogel particles are saved.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: September 22, 2020
    Assignee: National Cheng Kung University
    Inventors: Hsun-Ku Lee, Pei-Chian Tsai, Hsin-Ying Yu, Dong-Wei Wu