Patents Assigned to Chiesi Farmaceutici S.p.A.
  • AEROSOL INHALATION DEVICE
    Publication number: 20170080168
    Abstract: Actuators for an aerosol inhalation device containing a housing adapted to receive an aerosol canister containing a pressurized medicament formulation, a mouthpiece portion through which the user inhales, a nozzle block and an orifice and a tubular element extending in the mouthpiece portion from the orifice aperture in a longitudinal axis substantially aligned with a longitudinal axis of the mouthpiece portion provide a significant reduction in the non-respirable, coarse fraction of the emitted aerosol medicament via inertial impaction and retention in the actuator than in the oro-pharynx, with consequent less associated side effects and oral candidiasis in the patient. In addition the presence of the tubular element has minimal, negligible impact on the fine particle dose and on the particle size distribution (PSD) of the delivered particles having aerodynamic diameter lower than 9 ?m.
    Type: Application
    Filed: September 26, 2016
    Publication date: March 23, 2017
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Gaetano BRAMBILLA, Robert JOHNSON, David Andrew LEWIS
  • Aminoester derivatives
    Patent number: 9597323
    Abstract: Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: March 21, 2017
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Gabriele Amari, Elisabetta Armani, Herve Van De Poeol, Charles Baker-Glenn, Naimisha Trivedi
  • 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment
    Patent number: 9592210
    Abstract: Administration of certain 1-phenylalkanecarboxylic acid derivatives is useful for improving Cognitive Function; treating Cognitive Impairment, in particular Mild Cognitive Impairment; and preventing and/or reducing the risk of developing Alzheimer's Disease in a cognitively normal subject.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: March 14, 2017
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventor: Bruno Pietro Imbimbo
  • PHARMACEUTICAL SOLUTION FORMULATIONS FOR PRESSURISED METERED DOSE INHALERS
    Publication number: 20170065518
    Abstract: The invention relates to the prevention and/or treatment of a severe broncho-pulmonary disease by administering a solution formulation from a pressurized metered dose inhaler capable of providing therapeutical doses of two or more active drug substances to the lung, wherein all the active drug substances are fully dissolved in the formulation as well as the two or more active drug substances are delivered with substantially the same particle size distribution.
    Type: Application
    Filed: November 17, 2016
    Publication date: March 9, 2017
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: DAVID ANDREW LEWIS, BRIAN JOHN MEAKIN, GAETANO BRAMBILLA
  • Compounds having muscarinic receptor antagonist and BETA2 adrenergic receptor agonist activity
    Patent number: 9579314
    Abstract: Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating broncho-obstructive and inflammatory diseases.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: February 28, 2017
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Fabio Rancati, Andrea Rizzi, Laura Carzaniga, Ian Linney, Chris Knight, Wolfgang Schmidt
  • Derivatives of [1, 2, 4] triazolo [4, 3-a] pyridine as P38—MAP kinase inhibitors
    Patent number: 9573949
    Abstract: Mitogen activated protein kinase (MAPK) inhibitors disclosed herein are useful for the treatment of diseases of the respiratory tract, such as chronic eosinophilic pneumonia, asthma, COPD, adult respiratory distress syndrome (ARDS), exacerbation of airways hyper-reactivity consequent to other drug therapy, and airways disease that is associated with pulmonary hypertension.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: February 21, 2017
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Lilian Alcaraz, Terry Aaron Panchal, Andrew Stephen Robert Jennings, Andrew Peter Cridland, Christopher Hurley
  • Inhalation particles comprising a combination of an anticholinergic, a corticosteroid and a beta-adrenergic
    Patent number: 9554992
    Abstract: Microparticles comprising a combination of an anticholinergic, a beta2-adrenoceptor agonist, and an inhaled corticosteroid are useful for the prevention and/or treatment of respiratory diseases.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: January 31, 2017
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Gaetano Brambilla, Michele Miozzi, Timothy J Rouse
  • Kinase inhibitors
    Patent number: 9527846
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: December 27, 2016
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Monique Bodil Van Niel, Nicholas Charles Ray, Lilian Alcaraz, Terry Aaron Panchal, Andrew Stephen Robert Jennings, Elisabetta Armani, Andrew Peter Cridland, Christopher Hurley
  • Indolizine derivatives as phoshoinositide 3-kinases inhibitors
    Patent number: 9527869
    Abstract: Compounds of formula (I), defined herein, inhibit phosphoinositide 3-kinases (PI3K) and are useful for the treatment of disorders associated with PI3K enzymes.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: December 27, 2016
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Matteo Biagetti, Alessandro Accetta, Anna Maria Capelli, Matilde Guala, Michele Retini
  • PROCESS FOR PREPARING CARRIER PARTICLES FOR DRY POWDERS FOR INHALATION
    Publication number: 20160354314
    Abstract: Carrier particles in which at least 60% of the surface is coated with magnesium stearate are useful for preparing dry powder formulations for inhalation.
    Type: Application
    Filed: August 19, 2016
    Publication date: December 8, 2016
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Rossella MUSA, Daniela COCCONI, Alain CHAMAYOU, Laurence GALET
  • AMINOESTER DERIVATIVES
    Publication number: 20160346260
    Abstract: Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.
    Type: Application
    Filed: May 31, 2016
    Publication date: December 1, 2016
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Gabriele AMARI, Elisabetta ARMANI, Herve VAN DE POEOL, Charles BAKER-GLENN, Naimisha TRIVEDI
  • AMINOESTER DERIVATIVES
    Publication number: 20160346268
    Abstract: Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratrory tract.
    Type: Application
    Filed: May 31, 2016
    Publication date: December 1, 2016
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Gabriele AMARI, Elisabetta Armani, Wesley Blackaby, Herve Van De Poeol, Charles Baker-Glenn, Naimisha Trivedi
  • COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY
    Publication number: 20160346271
    Abstract: Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating diseases of the respiratory tract.
    Type: Application
    Filed: May 31, 2016
    Publication date: December 1, 2016
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Laura CARZANIGA, Fabio RANCATI, Andrea RIZZI, Ian LINNEY, Wolfgang SCHMIDT, Michael BARNES, Chris KNIGHT
  • PROCESS FOR THE PREPARATION OF A PDE4 INHIBITOR
    Publication number: 20160326117
    Abstract: The present invention relates to a process for the preparation of compounds endowed with phosphodiesterase (PDE4) inhibitory activity having formula (I). The invention also relates to the process for the isolation by crystallization of the compound (I) and to its use for the preparation of pharmaceutical compositions for inhalation in combination with suitable carriers or vehicles. The present invention also relates to solvates and crystal forms of a compound of formula (I). The synthesized product is suitable for use in pharmaceutical applications for instance in the treatment of respiratory diseases.
    Type: Application
    Filed: July 22, 2016
    Publication date: November 10, 2016
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Alessandro FALCHI, Emilio Lutero, Emanuele Ferrari, Fausto Pivetti, Rocco Bussolati, Edoardo Mariani, Orsola Vecchi, Erhard Bappert, Caterina Ventrici
  • CRYSTALLINE MICROPARTICLES OF A BETA-AGONIST COATED WITH A FATTY ACID
    Publication number: 20160324792
    Abstract: Crystalline microparticles consisting of a phenylalkylamino beta2-adrenergic agonist coated with a C12-C20 fatty acid are useful for the preparation of pharmaceutical aerosol formulations in form of suspension in a liquefied propellant gas or powder formulations.
    Type: Application
    Filed: May 12, 2016
    Publication date: November 10, 2016
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: Gaetano Brambilla, Paolo Colombo, Francesca Buttini, Michele Miozzi
  • AMINOESTER DERIVATIVES
    Publication number: 20160326147
    Abstract: Compounds of formula (I) are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
    Type: Application
    Filed: May 6, 2016
    Publication date: November 10, 2016
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Elisabetta ARMANI, Gabriele AMARI, Wesley BLACKABY, Herve VAN DE POEL, Charles BAKER-GLENN, Naimisha TRIVEDI
  • Compounds
    Patent number: 9487528
    Abstract: Compounds of formula (I), described herein, exhibit human neutrophil elastase inhibitory properties, and are useful for the treatment of diseases and conditions in which HNE is implicated.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: November 8, 2016
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Elisabetta Armani, Carmelida Capaldi, Jonathan Mark Sutton, Robert Andrew Heald
  • STABLE PRESSURIZED AEROSOL SOLUTION COMPOSITION OF GLYCOPYRRONIUM BROMIDE AND FORMOTEROL COMBINATION
    Publication number: 20160303044
    Abstract: Aerosol solution compositions intended for use with a pressurized metered dose inhaler, comprising glycopyrronium bromide and formoterol, or a salt thereof, optionally in combination with one or more additional active ingredients, and stabilized by a selected amount of a mineral acid, exhibit improved stability when contained in an aerosol can provided with a metering valve having at least a butyl rubber gasket.
    Type: Application
    Filed: June 29, 2016
    Publication date: October 20, 2016
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Sauro BONELLI, Diego Copelli, Massimiliano Dagli Alberi, Francesca Usberti, Enrico Zambelli
  • CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS
    Publication number: 20160303123
    Abstract: Chromene compounds of formula (I), defined herein, inhibit phosphoinositide 3-kinases (PI3K) and are useful for the treatment of disorders associated with a PI3K enzyme mechanism, such as asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis.
    Type: Application
    Filed: March 24, 2016
    Publication date: October 20, 2016
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Anna Maria CAPELLI, Matteo BIAGETTI, Alessandro ACCETTA
  • Graduated catheter
    Patent number: D775330
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: December 27, 2016
    Assignee: CHIESI FARMACEUTICI S.P.A.
    Inventors: Mats Blennow, Kajsa Bohlin, Peter Anderson Dargaville, Valentina Comito, Linda Storari