Patents Assigned to Chiesi Farmaceutici S.p.A.
  • Compounds having muscarinic receptor antagonist and BETA2 adrenergic receptor agonist activity
    Patent number: 10004728
    Abstract: Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating broncho-obstructive and inflammatory diseases.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: June 26, 2018
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Fabio Rancati, Andrea Rizzi, Laura Carzaniga, Ian Linney, Chris Knight, Wolfgang Schmidt
  • Kinase inhibitors
    Patent number: 9994565
    Abstract: Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: June 12, 2018
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Carmelida Capaldi, Elisabetta Armani, Andrew Steven Robert Jennings, Christopher Hurley
  • Animal model of Krabbe's disease
    Patent number: 9986722
    Abstract: The present invention relates to an animal model for infantile globoid cell leucodystrophy, and use of said animal model for screening and/or validation of agents which may be useful as a medicament for treatment of globoid cell leukodystrophy.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: June 5, 2018
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Jens Fogh, Claes Andersson
  • USE OF MAGNESIUM STEARATE IN DRY POWDER FORMULATIONS FOR INHALATION
    Publication number: 20180133161
    Abstract: Addition of magnesium stearate to a powder formulation for inhalation comprising carrier particles and an active ingredient bearing a group susceptible to hydrolysis is useful for inhibiting or reducing the chemical degradation of the active ingredient.
    Type: Application
    Filed: January 12, 2018
    Publication date: May 17, 2018
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Daniela COCCONI, Massimiliano DagIi ALBERI, Andrea BUSCA, Francesca SCHIARETTI
  • Chromene derivatives as phoshoinositide 3-kinases inhibitors
    Patent number: 9968604
    Abstract: Chromene compounds of formula (I), defined herein, inhibit phosphoinositide 3-kinases (PI3K) and are useful for the treatment of disorders associated with a PI3K enzyme mechanism, such as asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: May 15, 2018
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Anna Maria Capelli, Matteo Biagetti, Alessandro Accetta
  • KINASE INHIBITORS
    Publication number: 20180127410
    Abstract: Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
    Type: Application
    Filed: December 22, 2016
    Publication date: May 10, 2018
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Carmelida CAPALDI, Elisabetta ARMANI, Andrew Steven Robert JENNINGS, Christopher HURLEY
  • PROCESS FOR THE PREPARATION OF A PDE4 INHIBITOR
    Publication number: 20180118686
    Abstract: The present invention relates to a process for the preparation of compounds endowed with phosphodiesterase (PDE4) inhibitory activity having formula (I). The invention also relates to the process for the isolation by crystallization of the compound (I) and to its use for the preparation of pharmaceutical compositions for inhalation in combination with suitable carriers or vehicles. The present invention also relates to solvates and crystal forms of a compound of formula (I). The synthesized product is suitable for use in pharmaceutical applications for instance in the treatment of respiratory diseases.
    Type: Application
    Filed: November 3, 2017
    Publication date: May 3, 2018
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Alessandro FALCHI, Emilio LUTERO, Emanuele FERRARI, Fausto PIVETTI, Rocco BUSSOLATI, Edoardo MARIANI, Orsola VECCHI, Erhard BAPPERT, Caterina VENTRICI
  • METHOD AND SYSTEM FOR EFFECTIVE BREATH-SYNCHRONIZED DELIVERY OF MEDICAMENT TO THE LUNGS
    Publication number: 20180110948
    Abstract: The method and system according to preferred embodiments of the present invention allows an effective breath-synchronized delivery of atomized liquid medicament (e.g. a pulmonary surfactant) to the patient's lungs. According to a preferred embodiment, the method of the present invention provides an efficient delivery of the aerosol medicament, controlling the behavior of the infusion pump to make the rising and falling time faster even though the intrinsic time constant of the system is long. Additionally, in an embodiment of the present invention, at the same time the information about the breathing activity contained either directly on the surfactant line or stored in the controller action can be used to extrapolate the breathing pattern.
    Type: Application
    Filed: April 21, 2016
    Publication date: April 26, 2018
    Applicant: CHIESI FARMACEUTICI S.p.A
    Inventors: Raffaele DELLACA, Ilaria MILESI
  • 1-phenyl-2-pyridinyl alkyl alcohol derivatives as phosphodiesterase inhibitors
    Patent number: 9944612
    Abstract: Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an allergic disease state or a disease of the respiratory tract characterized by airway obstruction.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: April 17, 2018
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Elisabetta Armani, Gabriele Amari, Oriana Esposito, Laura Carzaniga, Carmelida Capaldi
  • DEVICE FOR FACILITATING THE ADMINISTRATION OF A MEDICAMENT TO THE LUNG BY A CATHETER
    Publication number: 20180099111
    Abstract: A device (100) for facilitating the positioning of a catheter for the delivery of liquid medicament to spontaneously breathing patient, including: —an elongated main body (101) shaped to follow the internal shape of the patient's upper airways, the elongated main body (101) being provided with guiding means (107) adapted to house a catheter; —a substantially ring-shaped terminal element (103) adapted to engage the internal wall of the patient's retro-pharynx, the substantially ring-shaped terminal element (103) being connected to the elongated main body (101) by means of at least one spoke (105), the substantially ring-shaped element (103) and the at least one spoke (105) creating a chamber where the medicament can be delivered through the catheter.
    Type: Application
    Filed: April 28, 2015
    Publication date: April 12, 2018
    Applicant: CHIESI FARMACEUTICI S.p.A
    Inventors: Raffaele DELLACA, llaria MILESI, Emanuela ZANNIN
  • Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
    Patent number: 9931327
    Abstract: Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and the treatment of certain conditions such as COPD.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: April 3, 2018
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Elisabetta Armani, Gabriele Amari, Laura Carzaniga, Carmelida Capaldi, Oriana Esposito, Gino Villetti, Renato De Fanti
  • Compounds having muscarinic receptor antagonist and BETA2 adrenergic receptor agonist activity
    Patent number: 9932338
    Abstract: Compounds of formula (I), defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: April 3, 2018
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Laura Carzaniga, Fabio Rancati, Andrea Rizzi, Ian Linney
  • Methods of treating or preventing stent thrombosis
    Patent number: 9925265
    Abstract: The present invention is directed to the following: methods of treating or preventing stent thrombosis using pharmaceutical compositions comprising cangrelor and optionally bivalirudin; methods of reducing mortality in a subject undergoing stent implantation using pharmaceutical compositions comprising cangrelor and optionally bivalirudin; medicaments comprising cangrelor and optionally bivalirudin useful for treating or preventing stent thrombosis, or useful for reducing mortality in a subject undergoing stent implantation; pharmaceutical compositions comprising cangrelor and bivalirudin; and methods of preparing a medicament comprising cangrelor and optionally bivalirudin useful for treating or preventing stent thrombosis, or useful for reducing mortality in a subject undergoing stent implantation.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: March 27, 2018
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Clive Arthur Arculus-Meanwell, Simona Skerjanec
  • Preparation of micronized particles of an antimuscarinic compound by hydrodynamic cavitation
    Patent number: 9925168
    Abstract: Crystalline micronized particulate of a glycopyrronium salt may be prepared by hydrodynamic cavitation. The resulting drug particles are physically stable with regard to agglomeration and/or aggregation on storage.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: March 27, 2018
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Stephen P. Davanzo, Barry E. Nall, Timothy J. Rouse, Michele Miozzi
  • ISOXAZOLIDINE DERIVATIVES
    Publication number: 20180066010
    Abstract: Anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, according to formula (I) according to formula (I) defined herein are useful for treating diseases of the respiratory tract characterized by airway obstruction.
    Type: Application
    Filed: November 8, 2017
    Publication date: March 8, 2018
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Eleonora GHIDINI, Andrea Rizzi
  • STABLE PHARMACEUTICAL FORMULATION COMPRISING A RECONSTITUTED PULMONARY SURFACTANT COMPOSITION
    Publication number: 20180055914
    Abstract: Physically and chemically stable pharmaceutical formulations in the form of an aqueous suspension comprising a reconstituted pulmonary surfactant are useful for the prophylaxis and/or treatment of respiratory distress syndrome (RDS) and other respiratory disorders.
    Type: Application
    Filed: August 23, 2017
    Publication date: March 1, 2018
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Franco Sartor, Marisa Pertile, Annamaria Soliani Raschini
  • 3,5-dichloro,4-(3,4-(cyclo-)alkoxyphenyl)- 2-carbonyloxy)ethyl)pyridine derivatives as PDE-4 inhibitors
    Patent number: 9890151
    Abstract: The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: February 13, 2018
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Gabriele Amari, Elisabetta Armani, Mauro Riccaboni, Charles Baker-Glenn
  • Process for the preparation of a PDE4 inhibitor
    Patent number: 9890122
    Abstract: The present invention relates to a process for the preparation of compounds endowed with phosphodiesterase (PDE4) inhibitory activity having formula (I). The invention also relates to the process for the isolation by crystallization of the compound (I) and to its use for the preparation of pharmaceutical compositions for inhalation in combination with suitable carriers or vehicles. The present invention also relates to solvates and crystal forms of a compound of formula (I). The synthesized product is suitable for use in pharmaceutical applications for instance in the treatment of respiratory diseases.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: February 13, 2018
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Alessandro Falchi, Emilio Lutero, Emanuele Ferrari, Fausto Pivetti, Rocco Bussolati, Edoardo Mariani, Orsola Vecchi, Erhard Bappert, Caterina Ventrici
  • Triazolinone compounds as HNE inhibitors
    Patent number: 9890169
    Abstract: Triazolinone compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the therapy of diseases and conditions in which HNE is implicated.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: February 13, 2018
    Assignee: CHIESI FARMACEUTICI S.P.A.
    Inventors: Elisabetta Armani, Carmelida Capaldi
  • Particle size reduction of an antimuscarinic compound
    Patent number: 9889094
    Abstract: A stable crystalline micronized particulate of a glycopyrronium salt may be prepared by suspending the drug in a water-immiscible anti-solvent in which the drug has little or no solubility and micronizing the suspension. The resulting drug particles are physically stable with regard to agglomeration and/or aggregation on storage.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: February 13, 2018
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Irene Pasquali, Andrea Casazza, Elena Losi, Mark Saunders