Patents Assigned to Chimerix, Inc.
  • 7-BENZYL-4-(2-METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZO[l,2-A]PYRIDO[3,4-E] PYRIMIDIN-5 (1 H)-ONE, ANALOGS THEREOF, AND SALTS THEREOF AND METHODS FORTHEIR USE IN THERAPY
    Publication number: 20250109133
    Abstract: This disclosure relates to methods of treatment using compound (1) or analogs thereof, and pharmaceutically acceptable salts thereof. Also disclosed are compounds of formula (10): as defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the same. Methods of treatment, such as for cancer, are provided that comprise administering the compounds and their salts to a subject in need of such treatment.
    Type: Application
    Filed: December 12, 2024
    Publication date: April 3, 2025
    Applicant: CHIMERIX, INC.
    Inventors: Joshua E. Allen, Martin STOGNIEW, Richard S. POTTORF, Bhaskara Rao NALLAGANCHU, Gary OLSON, Yanjun SUN
  • 7-BENZYL-4-(2-METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZ0[1,2-A]PYRID0[3,4-E] PYRIMIDIN-5 (1 H)-ONE, ANALOGS THEREOF, AND SALTS THEREOF AND METHODS FOR THEIR USE IN THERAPY
    Publication number: 20240270746
    Abstract: This disclosure relates to methods of treatment using compound (1) or analogs thereof, and pharmaceutically acceptable salts thereof. Also disclosed are compounds of formula (10): as defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the same. Methods of treatment, such as for cancer, are provided that comprise administering the compounds and their salts to a subject in need of such treatment.
    Type: Application
    Filed: March 12, 2024
    Publication date: August 15, 2024
    Applicant: CHIMERIX, INC.
    Inventors: Joshua E. Allen, Martin STOGNIEW, Richard S. POTTORF, Bhaskara Rao NALLAGANCHU, Gary OLSON, Yanjun SUN
  • 7-BENZYL-4-(METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZ0[1,2-A]PYRID0[3,4-E] PYRIMIDIN-5 (1 H)-ONE, SALTS THEREOF AND METHODS OF USING THE SAME IN COMBINATION THERAPY
    Publication number: 20240216379
    Abstract: This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.
    Type: Application
    Filed: January 31, 2024
    Publication date: July 4, 2024
    Applicant: CHIMERIX, INC.
    Inventors: Martin Stogniew, Joshua E. Allen
  • PYRROLOPYRIMIDINE NUCLEOSIDES FOR TREATING OR PREVENTING A SARS-COV-2 INFECTION
    Publication number: 20240207299
    Abstract: The present disclosure provides methods of treating or preventing a SARS-CoV-2 infection or a SARS-CoV-2-infection associated disease or disorder (e.g. COVID-19) comprising administering to a subject in need thereof an effective amount of a pyrrolopyrimidine nucleoside analog of the Formula I, Formula IA, Formula IB or Formula II and pharmaceutical compositions thereof wherein Rc and A are defined herein.
    Type: Application
    Filed: March 29, 2022
    Publication date: June 27, 2024
    Applicant: Chimerix, Inc.
    Inventors: Heidi Muth COLTON, Mohammed Anowrul KABIR, Ernest Randall LANIER, Jr., Phiroze Behram SETHNA, Roy W. WARE
  • Pyrrolopyrimidine nucleosides and analogs thereof
    Patent number: 11981700
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: May 14, 2024
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof
    Patent number: 11111264
    Abstract: The present disclosure relates to crystalline morphic forms of 4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide. The morphic form can be a stable hemihydrate crystalline form.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: September 7, 2021
    Assignee: Chimerix, Inc.
    Inventors: Roy W. Ware, Venkat Lakshmanan, Aaron Leigh Downey
  • Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
    Patent number: 11066373
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: July 20, 2021
    Assignee: Chimerix, Inc.
    Inventors: Roy Wendell Ware, Aaron Leigh Downey
  • Pyrrolopyrimidine nucleosides and analogs thereof
    Patent number: 10941175
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: March 9, 2021
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
    Patent number: 10487061
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: November 26, 2019
    Assignee: Chimerix, Inc.
    Inventors: Roy Wendell Ware, Aaron Leigh Downey
  • Pyrrolopyrimidine nucleosides and analogs thereof
    Patent number: 10407457
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: September 10, 2019
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
    Patent number: 10112909
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: October 30, 2018
    Assignee: Chimerix, Inc.
    Inventors: Roy Wendell Ware, Aaron Leigh Downey
  • Methods of treating retroviral infections and related dosage regimes
    Patent number: 9956239
    Abstract: The present invention relates to compounds and methods for treating retroviral infections and/or Hepatitis B viral infections. Some compounds of the invention are described by Formula I: or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: May 1, 2018
    Assignee: Chimerix, Inc.
    Inventor: Ernest Randall Lanier
  • Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
    Patent number: 9862687
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: January 9, 2018
    Assignee: Chimerix, Inc.
    Inventors: Roy Wendell Ware, Jr., Aaron Leigh Downey
  • Nucleoside phosphonate salts
    Patent number: 9765100
    Abstract: The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: wherein M+ is Na+, Li+, K+, Ca2+, Mg2+, or NRcRdReRf+ and Rc, Rd, Re and Rf are each independently hydrogen or C1-5 alkyl, or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: September 19, 2017
    Assignee: Chimerix, Inc.
    Inventors: Merrick Almond, Bernhard Lampert, Ernest Randall Lanier, Roy W. Ware
  • Pyrrolopyrimidine nucleosides and analogs thereof
    Patent number: 9708359
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: July 18, 2017
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Pyrrolopyrimidine nucleosides and analogs thereof
    Patent number: 9701706
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: July 11, 2017
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Methods of treating retroviral infections and related dosage regimes
    Patent number: 9694024
    Abstract: The present invention relates to compounds and methods for treating retroviral infections and/or Hepatitis B viral infections. Some compounds of the invention are described by Formula I: or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: July 4, 2017
    Assignee: Chimerix, Inc.
    Inventor: Ernest Randall Lanier
  • Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
    Patent number: 9371344
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: June 21, 2016
    Assignee: Chimerix, Inc.
    Inventors: Roy Wendell Ware, Jr., Aaron Leigh Downey
  • Phosphonate ester derivatives and methods of synthesis thereof
    Patent number: 9303051
    Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: April 5, 2016
    Assignee: Chimerix Inc.
    Inventors: Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
  • Methods of treating retroviral infections and related dosage regimes
    Patent number: 9278135
    Abstract: The present invention relates to compounds and methods for treating retroviral infections and/or Hepatitis B viral infections. Some compounds of the invention are described by Formula I: or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: March 8, 2016
    Assignee: Chimerix Inc.
    Inventor: Ernest Randall Lanier