Patents Assigned to Chimerix, Inc.
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Patent number: 11111264Abstract: The present disclosure relates to crystalline morphic forms of 4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide. The morphic form can be a stable hemihydrate crystalline form.Type: GrantFiled: September 21, 2018Date of Patent: September 7, 2021Assignee: Chimerix, Inc.Inventors: Roy W. Ware, Venkat Lakshmanan, Aaron Leigh Downey
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Patent number: 11066373Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.Type: GrantFiled: October 11, 2019Date of Patent: July 20, 2021Assignee: Chimerix, Inc.Inventors: Roy Wendell Ware, Aaron Leigh Downey
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Patent number: 10941175Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.Type: GrantFiled: August 6, 2019Date of Patent: March 9, 2021Assignees: Chimerix, Inc., The Regents of the University of MichiganInventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
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Patent number: 10487061Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.Type: GrantFiled: September 19, 2018Date of Patent: November 26, 2019Assignee: Chimerix, Inc.Inventors: Roy Wendell Ware, Aaron Leigh Downey
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Patent number: 10407457Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.Type: GrantFiled: May 18, 2017Date of Patent: September 10, 2019Assignees: Chimerix, Inc., The Regents of the University of MichiganInventors: John Henry Bougher, III, Ramamurty V S Changalvala, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
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Patent number: 10112909Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.Type: GrantFiled: December 1, 2017Date of Patent: October 30, 2018Assignee: Chimerix, Inc.Inventors: Roy Wendell Ware, Aaron Leigh Downey
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Patent number: 9956239Abstract: The present invention relates to compounds and methods for treating retroviral infections and/or Hepatitis B viral infections. Some compounds of the invention are described by Formula I: or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.Type: GrantFiled: June 20, 2017Date of Patent: May 1, 2018Assignee: Chimerix, Inc.Inventor: Ernest Randall Lanier
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Patent number: 9862687Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.Type: GrantFiled: May 20, 2016Date of Patent: January 9, 2018Assignee: Chimerix, Inc.Inventors: Roy Wendell Ware, Jr., Aaron Leigh Downey
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Patent number: 9765100Abstract: The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: wherein M+ is Na+, Li+, K+, Ca2+, Mg2+, or NRcRdReRf+ and Rc, Rd, Re and Rf are each independently hydrogen or C1-5 alkyl, or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.Type: GrantFiled: March 30, 2015Date of Patent: September 19, 2017Assignee: Chimerix, Inc.Inventors: Merrick Almond, Bernhard Lampert, Ernest Randall Lanier, Roy W. Ware
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Patent number: 9708359Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.Type: GrantFiled: August 8, 2016Date of Patent: July 18, 2017Assignees: Chimerix, Inc., The Regents of the University of MichiganInventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
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Patent number: 9701706Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.Type: GrantFiled: November 22, 2016Date of Patent: July 11, 2017Assignees: Chimerix, Inc., The Regents of the University of MichiganInventors: John Henry Bougher, III, Ramamurty V S Changalvala, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
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Patent number: 9694024Abstract: The present invention relates to compounds and methods for treating retroviral infections and/or Hepatitis B viral infections. Some compounds of the invention are described by Formula I: or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.Type: GrantFiled: February 16, 2016Date of Patent: July 4, 2017Assignee: Chimerix, Inc.Inventor: Ernest Randall Lanier
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Patent number: 9371344Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.Type: GrantFiled: January 23, 2015Date of Patent: June 21, 2016Assignee: Chimerix, Inc.Inventors: Roy Wendell Ware, Jr., Aaron Leigh Downey
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Patent number: 9303051Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.Type: GrantFiled: July 24, 2015Date of Patent: April 5, 2016Assignee: Chimerix Inc.Inventors: Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
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Patent number: 9278135Abstract: The present invention relates to compounds and methods for treating retroviral infections and/or Hepatitis B viral infections. Some compounds of the invention are described by Formula I: or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.Type: GrantFiled: April 26, 2011Date of Patent: March 8, 2016Assignee: Chimerix Inc.Inventor: Ernest Randall Lanier
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Patent number: 9006218Abstract: The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: (I), wherein M+ is Na+, Li+, K+, Ca2+, Mg2+, or NRcRdReRf+ and Rc, Rd, Re and Rf are each independently hydrogen or C1-5 alkyl, or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.Type: GrantFiled: February 14, 2011Date of Patent: April 14, 2015Assignee: Chimerix Inc.Inventors: Merrick Almond, Bernhard Lampert, Ernest Randall Lanier, Roy W. Ware
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Patent number: 8993542Abstract: The present invention provides methods of treating human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, including administering a compound described in the invention in an amount effective treat the HIV and/or HBV infection and at least substantially inhibit the development of resistance to said antiviral compounds in the subject. Pharmaceutical compositions are also provided.Type: GrantFiled: January 23, 2009Date of Patent: March 31, 2015Assignee: Chimerix Inc.Inventors: Ernest Randall Lanier, Merrick R. Almond, George R. Painter
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Patent number: 8962829Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.Type: GrantFiled: October 10, 2014Date of Patent: February 24, 2015Assignee: Chimerix, Inc.Inventors: Roy Wendell Ware, Jr., Aaron Leigh Downey
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Publication number: 20140303092Abstract: The present application provides methods and compositions for treatment or prevention of dsDNA virus infection in post-hematopoietic cell transplant (HCT or HSCT) patients.Type: ApplicationFiled: October 26, 2012Publication date: October 9, 2014Applicant: CHIMERIX, INCInventors: George R. Painter, Ernest Randall Lanier, Merrick R. Almond, Dorothy Margolskee, Gwendolyn Powell Painter
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Publication number: 20140121186Abstract: The present invention provides methods of treating viral infection of the eye or posterior ocular condition including administering a pharmaceutical composition comprising a compound described in the present application. In some embodiments, the pharmaceutical composition is topically administered. In another embodiment, the pharmaceutical composition is orally administered or intraocularly administered.Type: ApplicationFiled: December 23, 2013Publication date: May 1, 2014Applicant: Chimerix, Inc.Inventors: George R. Painter, Merrick R. Almond