Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
Type:
Application
Filed:
October 18, 2013
Publication date:
February 13, 2014
Applicant:
CHIMERIX, INC.
Inventors:
Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
Abstract: The present application provides methods and compositions for combination therapy with antiviral compounds for the treatment of poxvirus infections, such as orthopox virus infections. In one embodiment, a method of treatment of a poxvirus infection is provided that comprises administering to a host in need thereof cidofovir, cyclic cidofovir, or a salt, ester, or prodrug thereof in combination or alternation with at least a second anti-poxvirus agent. The second anti-poxvirus agent is, for example, a biologic, such as a pegylated interferon.
Abstract: The present invention provides methods of treating viral infection of the eye or posterior ocular condition including administering a pharmaceutical composition comprising a compound described in the present application. In some embodiments, the pharmaceutical composition is topically administered. In another embodiment, the pharmaceutical composition is orally administered or intraocularly administered.
Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
Type:
Grant
Filed:
August 31, 2011
Date of Patent:
October 29, 2013
Assignee:
Chimerix, Inc.
Inventors:
Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
Abstract: The present invention relates to compounds and methods for treating retroviral infections and/or Hepatitis B viral infections. Some compounds of the invention are described by Formula (I) or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
Abstract: The present invention provides methods of treating diseases associated with at least one virus. The methods include administering a compound described in the invention in a therapeutically effective amount. According to some aspects of the present invention, the methods may further comprise at least one immunosuppressant agent to treat diseases associated with at least one virus of a subject in need of immunosuppressant agents.
Type:
Application
Filed:
October 29, 2010
Publication date:
March 21, 2013
Applicant:
Chimerix, Inc.
Inventors:
George R. Painter, Ernest Randall Lanier, Gwendolyn Powell Painter
Abstract: The present invention provides methods of treating viral induced tumor or viral infections, including administering a compound described in the invention in a therapeutically effective amount. According to some aspect of the present invention, the methods may further comprise at least one immunosuppressant agent to treat viral infection and/or viral induced tumor to a subject in need of immunosuppressant agents.
Type:
Application
Filed:
August 2, 2010
Publication date:
June 28, 2012
Applicant:
Chimerix, Inc.
Inventors:
Ernest Randall Lanier, George R. Painter
Abstract: The present invention provides methods of treating viral infection of the eye or posterior ocular condition including administering a pharmaceutical composition comprising a compound described in the present application. In some embodiments, the pharmaceutical composition is topically administered. In another embodiment, the pharmaceutical composition is orally administered or intraocularly administered.
Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
Type:
Application
Filed:
August 31, 2011
Publication date:
March 8, 2012
Applicant:
Chimerix, Inc.
Inventors:
Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
Abstract: The present invention provides methods of treating diseases associated with at least one virus. The methods include administering a compound described in the invention in a therapeutically effective amount. According to some aspects of the present invention, the methods provide treatment of an orthopox virus infection or a disease related to orthopox virus.
Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
Type:
Grant
Filed:
June 9, 2010
Date of Patent:
August 9, 2011
Assignees:
Chimerix, Inc., The Regents of the University of California
Inventors:
Karl Y. Hostetler, James R. Beadle, Jacqueline Ruiz, Merrick R. Almond, George R. Painter, Timothy A. Riley, Paula Francom
Abstract: The present invention describes compounds of formulae I and II and methods for treating viral infection, such as Flaviviridae virus infection, including Hepatitis C infection (HCV).
Type:
Application
Filed:
May 20, 2010
Publication date:
November 25, 2010
Applicant:
Chimerix, Inc.
Inventors:
Merrick Almond, Ernest R. Lanier, David L. Musso, Roy Ware
Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
Type:
Application
Filed:
June 9, 2010
Publication date:
September 30, 2010
Applicants:
CHIMERIX, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors:
Karl Y. Hostetler, James R. Beadle, Jacqueline Ruiz, Merrick R. Almond, George R. Painter, Tim Riley, Paula Francom
Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
Type:
Grant
Filed:
April 18, 2007
Date of Patent:
July 6, 2010
Assignees:
Chimerix, Inc., The Regents of the University of California
Inventors:
Karl Y. Hostetler, James R. Beadle, Jacqueline Ruiz, Merrick R. Almond, George R. Painter, Timothy A. Riley, Paula Francom
Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
Type:
Application
Filed:
April 18, 2007
Publication date:
January 10, 2008
Applicants:
CHIMERIX, INC., UNIVERSITY OF CALIFORNIA, SAN DIEGO
Inventors:
Karl Hostetler, James Beadle, Jacqueline Ruiz, Merrick Almond, George Painter, Tim Riley, Paula Francom
Abstract: Compounds are disclosed for treating AIDS, herpes, and other viral infections by means of lipid derivatives of antiviral agents. The compounds consist of nucleoside analogues having antiviral activity which are linked, commonly through a phosphate group at the 5′ position of the pentose residue, to one of a selected group of lipids. The lipophilic nature of these compounds provide advantages over the use of the nucleoside analogue alone. It also makes it possible to incorporate them into the lamellar structure of liposomes, either alone or combined with similar molecules. In the form of liposomes, these antiviral agents are preferentially taken up by macrophages and monocytes, cells which have been found to harbor the target HIV virus. Additional site specificity may be incorporated into the liposomes with the addition of ligands, such as monoclonal antibodies or other peptides or proteins which bind to viral proteins.
Type:
Grant
Filed:
May 1, 2001
Date of Patent:
July 29, 2003
Assignee:
Chimerix, Inc.
Inventors:
Karl Y. Hostetler, Raj Kumar, Louise M. Stuhmiller
Abstract: Compounds are disclosed for treating AIDS, herpes, and other viral infections by means of lipid derivatives of antiviral agents. The compounds consist of nucleoside analogues having antiviral activity which are linked, commonly through a phosphate group at the 5′ position of the pentose residue, to one of a selected group of lipids. The lipophilic nature of these compounds provide advantages over the use of the nucleoside analogue alone. It also makes it possible to incorporate them into the lamellar structure of liposomes, either alone or combined with similar molecules. In the form of liposomes, these antiviral agents are preferentially taken up by macrophages and monocytes, cells which have been found to harbor the target HIV virus. Additional site specificity may be incorporated into the liposomes with the addition of ligands, such as monoclonal antibodies or other peptides or proteins which bind to viral proteins.
Type:
Grant
Filed:
April 3, 1995
Date of Patent:
September 10, 2002
Assignee:
Chimerix, Inc.
Inventors:
Karl Y. Hostetler, Raj Kumar, Louise M. Stuhmiller