Patents Assigned to Chimerix, Inc.
  • Nucleoside phosphonate salts
    Patent number: 9006218
    Abstract: The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: (I), wherein M+ is Na+, Li+, K+, Ca2+, Mg2+, or NRcRdReRf+ and Rc, Rd, Re and Rf are each independently hydrogen or C1-5 alkyl, or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: April 14, 2015
    Assignee: Chimerix Inc.
    Inventors: Merrick Almond, Bernhard Lampert, Ernest Randall Lanier, Roy W. Ware
  • Methods of treating viral infections
    Patent number: 8993542
    Abstract: The present invention provides methods of treating human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, including administering a compound described in the invention in an amount effective treat the HIV and/or HBV infection and at least substantially inhibit the development of resistance to said antiviral compounds in the subject. Pharmaceutical compositions are also provided.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: March 31, 2015
    Assignee: Chimerix Inc.
    Inventors: Ernest Randall Lanier, Merrick R. Almond, George R. Painter
  • Morphic forms of hexadecyloxypropyl-phosphonate esters and methods of synthesis thereof
    Patent number: 8962829
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: February 24, 2015
    Assignee: Chimerix, Inc.
    Inventors: Roy Wendell Ware, Jr., Aaron Leigh Downey
  • HEXADECYLOXYPROPYL CIDOFOVIR FOR THE TREATMENT OF DOUBLE-STRANDED DNA VIRUS INFECTION
    Publication number: 20140303092
    Abstract: The present application provides methods and compositions for treatment or prevention of dsDNA virus infection in post-hematopoietic cell transplant (HCT or HSCT) patients.
    Type: Application
    Filed: October 26, 2012
    Publication date: October 9, 2014
    Applicant: CHIMERIX, INC
    Inventors: George R. Painter, Ernest Randall Lanier, Merrick R. Almond, Dorothy Margolskee, Gwendolyn Powell Painter
  • Compounds, Compositions and Methods for Treating Ocular Conditions
    Publication number: 20140121186
    Abstract: The present invention provides methods of treating viral infection of the eye or posterior ocular condition including administering a pharmaceutical composition comprising a compound described in the present application. In some embodiments, the pharmaceutical composition is topically administered. In another embodiment, the pharmaceutical composition is orally administered or intraocularly administered.
    Type: Application
    Filed: December 23, 2013
    Publication date: May 1, 2014
    Applicant: Chimerix, Inc.
    Inventors: George R. Painter, Merrick R. Almond
  • Phosphonate Ester Derivatives and Methods of Synthesis Thereof
    Publication number: 20140046085
    Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
    Type: Application
    Filed: October 18, 2013
    Publication date: February 13, 2014
    Applicant: CHIMERIX, INC.
    Inventors: Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
  • Compounds, compositions and methods for the treatment of poxvirus infections
    Patent number: 8642577
    Abstract: The present application provides methods and compositions for combination therapy with antiviral compounds for the treatment of poxvirus infections, such as orthopox virus infections. In one embodiment, a method of treatment of a poxvirus infection is provided that comprises administering to a host in need thereof cidofovir, cyclic cidofovir, or a salt, ester, or prodrug thereof in combination or alternation with at least a second anti-poxvirus agent. The second anti-poxvirus agent is, for example, a biologic, such as a pegylated interferon.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: February 4, 2014
    Assignee: Chimerix, Inc.
    Inventors: Merrick R. Almond, George R. Painter
  • Compounds, compositions and methods for treating ocular conditions
    Patent number: 8614200
    Abstract: The present invention provides methods of treating viral infection of the eye or posterior ocular condition including administering a pharmaceutical composition comprising a compound described in the present application. In some embodiments, the pharmaceutical composition is topically administered. In another embodiment, the pharmaceutical composition is orally administered or intraocularly administered.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: December 24, 2013
    Assignee: Chimerix, Inc.
    Inventors: George R. Painter, Merrick R. Almond
  • Phosphonate ester derivatives and methods of synthesis thereof
    Patent number: 8569321
    Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: October 29, 2013
    Assignee: Chimerix, Inc.
    Inventors: Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
  • Methods Of Treating Retroviral Infections And Related Dosage Regimes
    Publication number: 20130072460
    Abstract: The present invention relates to compounds and methods for treating retroviral infections and/or Hepatitis B viral infections. Some compounds of the invention are described by Formula (I) or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
    Type: Application
    Filed: April 26, 2011
    Publication date: March 21, 2013
    Applicant: CHIMERIX, INC.
    Inventor: Ernest Randall Lanier
  • Methods of Treating Viral Associated Diseases
    Publication number: 20130072458
    Abstract: The present invention provides methods of treating diseases associated with at least one virus. The methods include administering a compound described in the invention in a therapeutically effective amount. According to some aspects of the present invention, the methods may further comprise at least one immunosuppressant agent to treat diseases associated with at least one virus of a subject in need of immunosuppressant agents.
    Type: Application
    Filed: October 29, 2010
    Publication date: March 21, 2013
    Applicant: Chimerix, Inc.
    Inventors: George R. Painter, Ernest Randall Lanier, Gwendolyn Powell Painter
  • Composition and Methods of Treating Viral Infections and Viral Induced Tumors
    Publication number: 20120164104
    Abstract: The present invention provides methods of treating viral induced tumor or viral infections, including administering a compound described in the invention in a therapeutically effective amount. According to some aspect of the present invention, the methods may further comprise at least one immunosuppressant agent to treat viral infection and/or viral induced tumor to a subject in need of immunosuppressant agents.
    Type: Application
    Filed: August 2, 2010
    Publication date: June 28, 2012
    Applicant: Chimerix, Inc.
    Inventors: Ernest Randall Lanier, George R. Painter
  • Compounds, Compositions and Methods for Treating Ocular Conditions
    Publication number: 20120165295
    Abstract: The present invention provides methods of treating viral infection of the eye or posterior ocular condition including administering a pharmaceutical composition comprising a compound described in the present application. In some embodiments, the pharmaceutical composition is topically administered. In another embodiment, the pharmaceutical composition is orally administered or intraocularly administered.
    Type: Application
    Filed: July 21, 2010
    Publication date: June 28, 2012
    Applicant: Chimerix, Inc.
    Inventors: George R. Painter, Merrick R. Almond
  • Phosphonate Ester Derivatives and Methods of Synthesis Thereof
    Publication number: 20120058976
    Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
    Type: Application
    Filed: August 31, 2011
    Publication date: March 8, 2012
    Applicant: Chimerix, Inc.
    Inventors: Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
  • Methods of Treating Orthopox Virus Infections and Associated Diseases
    Publication number: 20110263536
    Abstract: The present invention provides methods of treating diseases associated with at least one virus. The methods include administering a compound described in the invention in a therapeutically effective amount. According to some aspects of the present invention, the methods provide treatment of an orthopox virus infection or a disease related to orthopox virus.
    Type: Application
    Filed: April 22, 2011
    Publication date: October 27, 2011
    Applicant: Chimerix, Inc.
    Inventors: Ernest R. Lanier, George R. Painter
  • Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates
    Patent number: 7994143
    Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: August 9, 2011
    Assignees: Chimerix, Inc., The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Jacqueline Ruiz, Merrick R. Almond, George R. Painter, Timothy A. Riley, Paula Francom
  • COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTION
    Publication number: 20100297079
    Abstract: The present invention describes compounds of formulae I and II and methods for treating viral infection, such as Flaviviridae virus infection, including Hepatitis C infection (HCV).
    Type: Application
    Filed: May 20, 2010
    Publication date: November 25, 2010
    Applicant: Chimerix, Inc.
    Inventors: Merrick Almond, Ernest R. Lanier, David L. Musso, Roy Ware
  • Metabolically Stable Alkoxyalkyl Esters of Antiviral or Antiproliferative Phosphonates, Nucleoside Phosphonates and Nucleoside Phosphates
    Publication number: 20100249056
    Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
    Type: Application
    Filed: June 9, 2010
    Publication date: September 30, 2010
    Applicants: CHIMERIX, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Karl Y. Hostetler, James R. Beadle, Jacqueline Ruiz, Merrick R. Almond, George R. Painter, Tim Riley, Paula Francom
  • Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates
    Patent number: 7749983
    Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: July 6, 2010
    Assignees: Chimerix, Inc., The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Jacqueline Ruiz, Merrick R. Almond, George R. Painter, Timothy A. Riley, Paula Francom
  • Metabolically Stable Alkoxyalkyl Esters of Antiviral or Antiproliferative Phosphonates, Nucleoside Phosphonates and Nucleoside Phosphates
    Publication number: 20080009462
    Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
    Type: Application
    Filed: April 18, 2007
    Publication date: January 10, 2008
    Applicants: CHIMERIX, INC., UNIVERSITY OF CALIFORNIA, SAN DIEGO
    Inventors: Karl Hostetler, James Beadle, Jacqueline Ruiz, Merrick Almond, George Painter, Tim Riley, Paula Francom