Abstract: Ultra-stable aqueous foam comprises hydrophobic silica particles residing within bubbles in an aqueous solution of a hydrophilic polymer, a protein, or aqueous dispersible colloidal particles. The combination of the hydrophobic and hydrophilic components stabilizes the foam interfaces to result in long term stability of the foam. The foams can be crosslinked to stable monolithic foams and used for structural foams, coatings, and thermal insulating for construction.
Abstract: It provides novel fusion proteins that are capable of self-crystallization and exhibit improved physical properties such as enhanced tolerance to organic solvents and increased thermostability. Polynucleotides encoding the fusion proteins as well as methods of making and using such fusion proteins are also described.
Type:
Grant
Filed:
July 10, 2017
Date of Patent:
November 7, 2023
Assignee:
The Chinese University of Hong Kong
Inventors:
Michael Chan, Marianne Lee, Bradley Heater
Abstract: The present invention provides an aptamer that specifically hinds CD44, composition comprising the aptamer, as well as methods for detecting CD44 and for targeted delivery to CD44-expressing cells.
Type:
Grant
Filed:
March 14, 2022
Date of Patent:
November 7, 2023
Assignee:
The Chinese University of Hong Kong
Inventors:
Nathalie Wong, Wing Sze Lo, James Y.W. Lau
Abstract: Denoising of magnetic resonance (MR) images can be achieved using a deep neural network and an image acquisition process that uses multi-NEX (Number of Excitations) or multi-NSA (Number of Signal Averages or Acquisitions) to produce two or more complex-valued images of a region of interest. The set of images resulting from the image acquisition process can be input to a deep neural network that has been trained to produce a denoised MR image from a set of multi-NEX or multi-NSA images. The deep neural network can be implemented using a two-dimensional or three-dimensional convolutional neural network to match the dimensionality of the input images. Training of the denoising neural network can use real MR images.
Abstract: The subject invention pertains to a pneumatic, hydraulic, or otherwise inflatable or pressurized artificial muscle. Also provided are methods for making, controlling, and using such a muscle useful for prostheses, movement aids, or wearable robots to assist the movement of impaired subjects or to improve the function of healthy subjects. Muscles can be made by densely winding tension wires around pressurized expandable tubes having one or more specific geometric shapes removed from the tube cross section. The curve of output characteristics such as output force vs. contraction ratio can be adjustable by changing parameters of the sectional view of the tube. The appropriate shape of tube and related output characteristics can be selected according to application area or body part to be assisted to achieve the most flexible and optimal design for one or more muscle groups.
Type:
Grant
Filed:
May 19, 2022
Date of Patent:
October 17, 2023
Assignee:
The Chinese University of Hong Kong
Inventors:
Kai Yu Tong, Disheng Xie, Jing Shu, Junming Wang
Abstract: The invention provides novel high-energy density and low-cost flow electrochemical devices incorporating solid-flow electrodes, and further provides methods of using such electrochemical devices. Included are anode and cathode current collector foils that can be made to move during discharge or recharge of the device. Solid-flow devices according to the invention provide improved charging capability due to direct replacement of the conventional electrode stack, higher volumetric and gravimetric energy density, and reduced battery cost due to reduced dimensions of the ion-permeable layer.
Type:
Grant
Filed:
December 7, 2016
Date of Patent:
October 10, 2023
Assignee:
The Chinese University of Hong Kong
Inventors:
Yi-Chun Lu, Zengyue Wang, Long Yin Simon Tam, Qingli Zou, Guangtao Cong
Abstract: A microtome comprises a support assembly; an actuator, mounted to the support assembly; a pair of oscillating flexure assemblies, held by the support assembly and each of which being located on one side of the actuator and oscillated by the actuator; and a blade assembly, mounted to each of the oscillating flexure assemblies so as to move in a direction same as the oscillating flexure assemblies.
Abstract: The present invention provides a method for diagnosing and determining prognosis of certain cancers (e.g., esophageal squamous cell carcinoma or ESCC) in a subject by detecting suppressed expression of the DLEC1 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating cancer by increasing DLEC1 gene expression or activity.
Abstract: Methods, systems, and apparatus are provided for determining whether a nucleic acid sequence imbalance exists within a biological sample. One or more cutoff values for determining an imbalance of, for example, the ratio of the two sequences (or sets of sequences) are chosen. The cutoff value may be determined based at least in part on the percentage of fetal DNA in a sample, such as maternal plasma, containing a background of maternal nucleic acid sequences. The percentage of fetal DNA can be calculated from the same or different data used to determine the cutoff value, and can use a locus where the mother is homozygous and the fetus is heterozygous. The cutoff value may be determined using many different types of methods, such as sequential probability ratio testing (SPRT).
Type:
Grant
Filed:
January 11, 2019
Date of Patent:
August 15, 2023
Assignee:
The Chinese University of Hong Kong
Inventors:
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Benny Chung Ying Zee, Ka Chun Chong
Abstract: Particular forward and reverse primers may be used to link distant regions of the same large DNA molecule into a smaller DNA molecule. A reverse primer R1 can have a first portion complementary to an ending sequence of region A and can have a second portion having an overlapping sequence. A forward primer F2 can have a first portion complementary to a starting sequence of region B, where the forward primer includes a complementary overlapping sequence (e.g., the same first portion or a second portion) that is complementary to the overlapping sequence. The first portion of F2 may be the entire primer. The smaller DNA molecules can be used to determine haplotypes of regions. Kits including the particular forward and reverse primers are also described.
Type:
Grant
Filed:
May 11, 2020
Date of Patent:
August 8, 2023
Assignee:
The Chinese University of Hong Kong
Inventors:
Kwan Chee Chan, Wanxia Gai, Yuk-Ming Dennis Lo
Abstract: Systems and methods for fast and robust quantification of magnetization transfer (MT) use off-resonance spin-lock MRI with as few as two or three image acquisitions. Each image acquisition can be performed using an off-resonance spin-lock pulse having a different RF amplitude and frequency offset. A parameter representing the difference of the relaxation rate in the rotating frame between the acquisitions can be computed. This parameter can be used to compute other parameters of magnetization transfer.
Abstract: Systems and methods for articular cartilage thickness mapping and lesion quantification operate on 3D medical image data to reconstruct cartilage surfaces, estimate surface normals, determine cartilage thickness, and identify regions of full-thickness cartilage loss (FCL). Reconstructed cartilage surfaces can be parcellated into subregions using a rule-based approach.
Abstract: The present invention resides in the discovery that combined use of kuraridin (or any one of its analogs) and epicatechin gallate (ECG) can provide heightened level of antimicrobial activity, especially for the suppression of bacteria of the Staphylococcus aureus and Staphylococcal species. Compositions, kits, and methods for the combination use are disclosed.
Type:
Grant
Filed:
November 14, 2019
Date of Patent:
July 4, 2023
Assignee:
The Chinese University of Hong Kong
Inventors:
Margaret Ip, Kwok Pui Fung, Ping Chung Leung, Clara Bik San Lau, Quan Bin Han, Chung Lap Chan, Chit Tsui, Quande Wang
Abstract: The present invention provides for a fungus, especially in the form of fungal mycelium, that has altered glycogen synthase kinase-3 (GSK-3) expression and/or activity level and therefore exhibits modified characteristics in fruiting body development. Also provided are compositions and methods for generating living fungal mycelium with altered fruiting body development.
Type:
Grant
Filed:
September 20, 2018
Date of Patent:
June 6, 2023
Assignee:
The Chinese University of Hong Kong
Inventors:
Jinhui Chang, Hoi Shan Kwan, Man Chun Wong, Po Lam Chan, Yichun Xie, Wing Chee Beatrice Ho
Abstract: The present invention provides novel allergens isolated from grass carp Ctenopharyngodon idella, recombinant or modified polypeptides comprising such allergens, nucleic acids encoding the polypeptides as well as related compositions. Also provided are methods and kits for diagnosing fish allergy.
Type:
Grant
Filed:
September 30, 2019
Date of Patent:
May 23, 2023
Assignee:
The Chinese University of Hong Kong
Inventors:
Sze Yin Agnes Leung, Ting Fan Leung, Yat Hin Nicki Leung, Yee Yan Christine Wai
Abstract: In some embodiments, a control system, a control method and a storage medium are provided. In the method, first motion information of a machine acquired by a first sensor is received; the first motion information is inputted into a deep learning model to obtain a model output, the deep learning model comprising a convolutional neural network (CNN) and a long short-term memory (LSTM); the deep learning model is trained using the first motion information and second motion information acquired by a second sensor; the first sensor and the second sensor having different ways of detecting information and processing the detected information. The model output is used to control the machine.
Abstract: The present invention provides novel compositions and methods for assessing the size of tandem repeat sequences, e.g., telomeres, within a genome, using specially designed Molecular Inversion Probes (MIPs) and reaction conditions.
Type:
Grant
Filed:
June 3, 2020
Date of Patent:
May 2, 2023
Assignee:
The Chinese University of Hong Kong
Inventors:
Leung Sang Nelson Tang, Suk Ling Ma, Jean Woo
Abstract: The present invention provides for a novel peptide and method for treating polyglutamine (polyQ) diseases. Also disclosed are related compositions and kits for therapeutic use in the treatment of polyQ diseases.
Type:
Grant
Filed:
February 17, 2016
Date of Patent:
May 2, 2023
Assignee:
The Chinese University of Hong Kong
Inventors:
Ho Yin Edwin Chan, Jacky Chi-Ki Ngo, Qian Zhang
Abstract: An endoscope manipulator for performing robot-assisted endoscope manipulation comprises a movable robot base with a hollow trunk and a vertical lifting joint; a passive joint set with one end mounted to an upper end of the vertical lifting joint, for manually setting an initial pose of the endoscope; an active joint set mounted to another end of the passive joint set, for adjusting pose control of the endoscope intra-operatively; and a compliant endoscope holder mountable to an end-effector of the active joint set, which passively changes to a compliant state upon an external force exceeding a threshold being applied to an endoscopic lens held by the compliant endoscope holder.
Abstract: The present disclosure provides methods of inducing EBV early lytic cycle genes with high specificity. These methods slow or stop cancer cell growth in vitro and in vivo.
Type:
Application
Filed:
February 26, 2021
Publication date:
April 13, 2023
Applicants:
The Jackson Laboratory, The Chinese University of Hong Kong
Inventors:
Albert Cheng, Kwok Wai Lo, Pok Man Tom Hau, Man Wu