Patents Assigned to Chirogate International Inc.
  • Processes and intermediates for the preparations of benzoprostacyclin analogues and benzoprostacyclin analogues prepared therefrom
    Patent number: 11884640
    Abstract: The invention relates to processes for preparing benzoprostacyclin analogues and intermediates prepared from the process, and the benzoprostacyclin analogues prepared therefrom. The invention also relates to cyclopentenone intermediates in racemic or optically active form.
    Type: Grant
    Filed: June 2, 2021
    Date of Patent: January 30, 2024
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Chun-Yu Lin, Tzyh-Mann Wei, Shih-Yi Wei
  • Processes and intermediates for the preparation of carbaprostacyclin analogues
    Patent number: 11884613
    Abstract: The invention relates to processes for preparing carbaprostacyclin analogues and intermediates prepared from the processes. The invention also relates to cyclopentenone intermediates in racemic or optically active form.
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: January 30, 2024
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Chun-Yu Lin, Tzyh-Mann Wei, Shih-Yi Wei
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF CARBAPROSTACYCLIN ANALOGUES
    Publication number: 20240025832
    Abstract: The invention relates to processes for preparing carbaprostacyclin analogues and intermediates prepared from the processes. The invention also relates to cyclopentenone intermediates in racemic or optically active form.
    Type: Application
    Filed: September 27, 2023
    Publication date: January 25, 2024
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: CHUN-YU LIN, TZYH-MANN WEI, SHIH-YI WEI
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF BENZOPROSTACYCLIN ANALOGUES AND BENZOPROSTACYCLIN ANALOGUES PREPARED THEREFROM
    Publication number: 20230416216
    Abstract: A racemic or optically enriched compound of Formula 1: wherein P is H or a protective group for hydroxyl groups; and X is Cl, Br, I, or —CH2CH2CH2COOR1, wherein R1 is C1-7-alkyl or C7-11-aralkyl.
    Type: Application
    Filed: September 14, 2023
    Publication date: December 28, 2023
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: CHUN-YU LIN, TZYH-MANN WEI, SHIH-YI WEI
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF CARBAPROSTACYCLIN ANALOGUES
    Publication number: 20230357118
    Abstract: The invention relates to processes for preparing carbaprostacyclin analogues and intermediates prepared from the processes. The invention also relates to cyclopentenone intermediates in racemic or optically active form.
    Type: Application
    Filed: May 5, 2022
    Publication date: November 9, 2023
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: CHUN-YU LIN, TZYH-MANN WEI, SHIH-YI WEI
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF CARBAPROSTACYCLIN ANALOGUES
    Publication number: 20230357119
    Abstract: The invention relates to processes for preparing carbaprostacyclin analogues and intermediates prepared from the processes. The invention also relates to cyclopentenone intermediates in racemic or optically active form.
    Type: Application
    Filed: May 30, 2023
    Publication date: November 9, 2023
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: CHUN-YU LIN, TZYH-MANN WEI, SHIH-YI WEI
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF CARBOPROST AND CARBOPROST TROMETHAMINE, AND CARBOPROST TROMETHAMINE PREPARED THEREFROM
    Publication number: 20230131316
    Abstract: The invention relates to processes for preparing Carboprost or Carboprost Tromethamine, and intermediates prepared from the process, and 5,6-trans isomer free Carboprost or Carboprost Tromethamine prepared therefrom. The invention also relates to a novel crystalline form of Carboprost Tromethamine.
    Type: Application
    Filed: December 27, 2022
    Publication date: April 27, 2023
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: SHIH-YI WEI, MIN-KUAN HSU, JIAN-BANG JHENG
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF CARBOPROST AND CARBOPROST TROMETHAMINE, AND CARBOPROST TROMETHAMINE PREPARED THEREFROM
    Publication number: 20230097470
    Abstract: The invention relates to processes for preparing Carboprost or Carboprost Tromethamine, and intermediates prepared from the process, and 5,6-trans isomer free Carboprost or Carboprost Tromethamine prepared therefrom. The invention also relates to a novel crystalline form of Carboprost Tromethamine.
    Type: Application
    Filed: August 23, 2021
    Publication date: March 30, 2023
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: SHIH-YI WEI, MIN-KUAN HSU, JIAN-BANG JHENG
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF BENZOPROSTACYCLIN ANALOGUES AND BENZOPROSTACYCLIN ANALOGUES PREPARED THEREFROM
    Publication number: 20230002339
    Abstract: The invention relates to processes for preparing benzoprostacyclin analogues and intermediates prepared from the process, and the benzoprostacyclin analogues prepared therefrom. The invention also relates to cyclopentenone intermediates in racemic or optically active form.
    Type: Application
    Filed: June 2, 2021
    Publication date: January 5, 2023
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: CHUN-YU LIN, TZYH-MANN WEI, SHIH-YI WEI
  • Treprostinil monohydrate crystals and methods for preparation thereof
    Patent number: 11447440
    Abstract: Novel crystalline forms of Treprostinil monohydrate, a mixture including the same, and preparation methods thereof.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: September 20, 2022
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Jian-Bang Jheng, Chun Hsieh
  • Efficient crystallization process for preparing ultrapure Treprostinil and crystal prepared therefrom
    Patent number: 11339110
    Abstract: There is provided a crystalline Form I of anhydrous Treprostinil and processes for the preparation thereof. The crystalline Form I of anhydrous Treprostnil is a stable crystalline form, which can provide steady physicochemical properties for pharmaceutical formulations, and is advantageous widely and safety used in storage, shipment, and handling for commercially considerations.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: May 24, 2022
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Jian-Bang Jheng, Ming-Kun Hsu, Min-Kuan Hsu, Tzyh-Mann Wei
  • Process for the preparation of latanoprostene bunod and intermediate thereof and compositions comprising the same
    Patent number: 11332433
    Abstract: Processes for preparing latanoprostene bunod and an intermediate prepared from the process. Also latanoprostene bunod compositions having high-purity latanoprostene bunod.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: May 17, 2022
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Ming-Kun Hsu, Tzyh-Mann Wei
  • TREPROSTINIL MONOHYDRATE CRYSTALS AND METHODS FOR PREPARATION THEREOF
    Publication number: 20220135511
    Abstract: Novel crystalline forms of Treprostinil monohydrate, a mixture including the same, and preparation methods thereof.
    Type: Application
    Filed: October 29, 2020
    Publication date: May 5, 2022
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: SHIH-YI WEI, JIAN-BANG JHENG, CHUN HSIEH
  • PROCESS FOR THE PREPARATION OF LATANOPROSTENE BUNOD AND INTERMEDIATE THEREOF AND COMPOSITIONS COMPRISING THE SAME
    Publication number: 20220024849
    Abstract: Processes for preparing latanoprostene bunod and an intermediate prepared from the process. Also latanoprostene bunod compositions having high-purity latanoprostene bunod.
    Type: Application
    Filed: July 24, 2020
    Publication date: January 27, 2022
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: SHIH-YI WEI, MING-KUN HSU, TZYH-MANN WEI
  • EFFICIENT CRYSTALLIZATION PROCESS FOR PREPARING ULTRAPURE TREPROSTINIL AND CRYSTAL PREPARED THEREFROM
    Publication number: 20210188757
    Abstract: There is provided a crystalline Form I of anhydrous Treprostinil and processes for the preparation thereof. The crystalline Form I of anhydrous Treprostnil is a stable crystalline form, which can provide steady physicochemical properties for pharmaceutical formulations, and is advantageous widely and safety used in storage, shipment, and handling for commercially considerations.
    Type: Application
    Filed: December 19, 2019
    Publication date: June 24, 2021
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: SHIH-YI WEI, JIAN-BANG JHENG, MING-KUN HSU, MIN-KUAN HSU, TZYH-MANN WEI
  • Processes and intermediates for the preparations of isomer free prostaglandins
    Patent number: 10822321
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: November 3, 2020
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • Crystals of intermediate for benzindene prostaglandins and methods for preparation thereof
    Patent number: 10787416
    Abstract: Stable crystalline Form I and Form II of compound (I) and methods for preparation thereof are provided, which present advantages in storage, formulation, shipment and handling for commercial considerations.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: September 29, 2020
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Jian-Bang Jheng
  • Hexadecyl Treprostinil crystals and methods for preparation thereof
    Patent number: 10781160
    Abstract: There is provided stable crystalline Form I and Form II of Hexadecyl Treprostinil (C16TR) and processes for the preparation thereof. The stable crystalline Form I and Form II of Hexadecyl Treprostinil present advantages in storage, formulation, shipment and handling for commercially considerations.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: September 22, 2020
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Jian-Bang Jheng
  • Beraprost-314d monohydrate crystals and methods for preparation thereof
    Patent number: 10577341
    Abstract: The present invention provides a monohydrated form of Beraprost-314d, and a novel crystalline form of Beraprost-314d monohydrate, and processes for the preparation thereof.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: March 3, 2020
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Jian-Bang Jheng
  • Beraprost-314d crystals and methods for preparation thereof
    Patent number: 10577340
    Abstract: The present invention provides crystalline Forms II and III of Beraprost-314d, and processes for the preparation thereof.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: March 3, 2020
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Jian-Bang Jheng