Patents Assigned to Chirogate International Inc.
  • Process for the preparation of Lubiprostone and intermediates thereof
    Patent number: 10457623
    Abstract: The present invention relates to a novel process for preparing Lubiprostone and novel intermediates prepared from the process. The process of the present invention does not generate hydrogenated by-products that are difficult to be removed, and thus enables the production of Lubiprostone in an efficient and economical way.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: October 29, 2019
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Min-Kuan Hsu
  • Lubiprostone crystals and methods for preparing the same
    Patent number: 10253011
    Abstract: This present invention relates to novel Lubiprostone crystals and methods for preparing the same. The preparation methods provided by the invention can effectively reduce or eliminate impurity in the obtained Lubiprostone crystals.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: April 9, 2019
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Jian-Bang Jheng
  • Processes for preparing cyclopenta[b]naphthalenol derivatives and intermediates thereof
    Patent number: 10106499
    Abstract: Novel processes for preparing cyclopenta[b]naphthalenol derivatives of Formula 1 which are useful for the synthesis of corresponding benzindene prostaglandins are provided. The present invention also relates to novel intermediates prepared from the processes.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: October 23, 2018
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Shih-Hsun Su
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF ISOMER FREE PROSTAGLANDINS
    Publication number: 20180251442
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Application
    Filed: May 3, 2018
    Publication date: September 6, 2018
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • Processes and intermediates for the preparations of isomer free prostaglandins
    Patent number: 9994543
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: June 12, 2018
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF ISOMER FREE PROSTAGLANDINS
    Publication number: 20180050999
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Application
    Filed: October 27, 2017
    Publication date: February 22, 2018
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • Processes and intermediates for the preparations of isomer free prostaglandins
    Patent number: 9890135
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: February 13, 2018
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • Processes and intermediates for the preparations of isomer free prostaglandis
    Patent number: 9828356
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: November 28, 2017
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF ISOMER FREE PROSTAGLANDINS
    Publication number: 20170073323
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Application
    Filed: November 23, 2016
    Publication date: March 16, 2017
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF ISOMER FREE PROSTAGLANDINS
    Publication number: 20170015646
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Application
    Filed: July 17, 2015
    Publication date: January 19, 2017
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • Processes and intermediates for the preparations of isomer free prostaglandins
    Patent number: 9540311
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: January 10, 2017
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • Processes and intermediates for the preparations of isomer free prostaglandins
    Patent number: 9464028
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: October 11, 2016
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF ISOMER FREE PROSTAGLANDINS
    Publication number: 20160016883
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Application
    Filed: July 17, 2015
    Publication date: January 21, 2016
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF ISOMER FREE PROSTAGLANDINS
    Publication number: 20150336921
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Application
    Filed: July 17, 2015
    Publication date: November 26, 2015
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF ISOMER FREE PROSTAGLANDINS
    Publication number: 20150336923
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Application
    Filed: July 17, 2015
    Publication date: November 26, 2015
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • Processes and intermediates for the preparations of isomer free prostaglandins
    Patent number: 9115109
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: August 25, 2015
    Assignee: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • PROCESSES AND INTERMEDIATES FOR THE PREPARATIONS OF ISOMER FREE PROSTAGLANDINS
    Publication number: 20150051410
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Application
    Filed: August 15, 2013
    Publication date: February 19, 2015
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • Intermediates for the synthesis of benzindene prostaglandins and preparations thereof
    Patent number: 8658837
    Abstract: Novel processes for preparing optically active cyclopentanones 1 which are useful for the preparation of benzindene Prostaglandins and novel cyclopentanones are provided. The invention also provides novel processes of preparing benzindene Prostaglandins and novel intermediates for benzindene Prostaglandins.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: February 25, 2014
    Assignee: Chirogate International Inc.
    Inventors: Shih-Yi Wei, Min-Kuan Hsu, Ming-Kun Hsu
  • INTERMEDIATES FOR THE SYNTHESIS OF BENZINDENE PROSTAGLANDINS AND PREPARATIONS THEREOF
    Publication number: 20130317245
    Abstract: Novel processes for preparing optically active cyclopentanones 1 which are useful for the preparation of benzindene Prostaglandins and novel cyclopentanones are provided. The invention also provides novel processes of preparing benzindene Prostaglandins and novel intermediates for benzindene Prostaglandins.
    Type: Application
    Filed: July 30, 2013
    Publication date: November 28, 2013
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi WEI, Min-Kuan HSU, Ming-Kun HSU
  • Processes for the preparation of optically active cyclopentenones and cyclopentenones prepared therefrom
    Patent number: 8546114
    Abstract: The present invention relates to novel processes for preparing optically active Cyclopentenones of Formula (R)-1, which are useful for the preparation of Prostaglandins and analogs thereof. The invention also relates to novel Cyclopentenones prepared from the processes.
    Type: Grant
    Filed: January 18, 2006
    Date of Patent: October 1, 2013
    Assignee: Chirogate International Inc.
    Inventors: Yu-Chih Yeh, Ming-Kun Hsu, Shih-Yi Wei