Abstract: In a machine tool having at least one tool spindle which is displaceable in relation to a device for holding workpieces in at least one of three spatial directions and in which the tools (W1-W7) for processing the workpieces can be chucked, there are provided a machine magazine (36) in which tools (W1-W7) provided for exchange in the tool spindle (23) are kept in store and a background magazine (31) in which tools (W1-W7) provided for exchange in the machine magazine (36) are kept in store. In the machine magazine (36), not more than four storage places (42, 43, 44, 45) for accommodating tools (W1-W7) are provided (FIG. 2).

Abstract: The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.

Abstract: The present invention relates to a machine tool and a corresponding method for machining, in particular for turning and milling, a workpiece having a central bore, said machine tool including a tool holder for holding a tool, a work rest for seating the workpiece, a work mounting for holding the workpiece in place, and a drive mechanism for rotating the workpiece about a central rotation axis, wherein the work rest has an arbor for attaching the workpiece, such that a section of the arbor projects into the central bore on a first side of the workpiece, and wherein the work mounting has a counter-holder movable in the direction of the bore axis of the central bore for applying a contact pressure, acting in the direction of the bore axis, to the workpiece on a second side opposite the first side.

Abstract: Congeneric, halogenated, fluorinated aromatic compounds A and B are each phenyl radicals, L=oxygen atom, sulfur atom or alkylene radical and p=0 or 1; processes for their preparation and their use.

Abstract: New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

Abstract: In the case of a method for chip-removing machining of workpieces (14), in particular for making bores in workpieces (14), wherein a tool (18) is put into rotation (20) relative to the workpiece (14) and the tool (18) is moved relative to the workpiece (14) with a feed motion, the tool (18) executes an oscillating motion in the direction (z) of the feed motion relative to the workpiece (14), a settable oscillation component being imparted to the feed motion through control means.

Abstract: A machine tool (10) is equipped with a main spindle (24) movable via a machine control (26) and associated measuring systems (26a) relative to a workpiece holder (12) in a coordinate system (27) with a coordinate origin (28), and with a tool magazine (31) having storage spaces (30) for tools (25, 32, 33, 34). The main spindle (24) is moved into a tool change position in which a used tool (25) is exchanged for a new tool (32) to be used. A separate measuring system (43, 46) indicates whether the main spindle (24), in connection with the tool change, has assumed a measuring position (50) in which the position of the main spindle (24) relative to the coordinate origin (28) is determined via a machine control (26) and associated measuring systems (26a). This position is used in order to determine at least one correction value (?y, ?z).

Abstract: The present invention relates to a machine tool for machining of workpieces, having a workpiece support for mounting the workpiece, a tool holder, which can be moved at least along one axis, for holding a tool for machining the workpiece, and workpiece holding units for fixing the workpiece during the machining, the workpiece holding units being arranged outside the workpiece support surface of the workpiece support, which is covered by the workpiece in the mounted state, and each having a holding element for fixing the workpiece. In order that also workpieces of greater diameter can be machined, the machine tool otherwise being of the same dimensions, it is provided according to the invention that the holding elements can each be moved, substantially parallel to the workpiece support surface, in the direction of the workpiece, in particular in the direction of a central workpiece axis, which runs perpendicular to the workpiece support surface, for the purpose of centering and fixing the workpiece.

Abstract: The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distress of the lungs. The spreading agents are sequence-specific oligomers, including retrosequence-specific oligomers, based on a peptide backbone, that are designed as analogs of surfactant protein-B or surfactant protein-C.

Abstract: A spindle unit has a working spindle, which is mounted, so as to be rotatable about its longitudinal axis, in its own bearing housing and in which there is provided a receiver for tools for machining workpieces. Via a repositioning unit, the working spindle is repositioned automatically and controllably in relation to the bearing housing when in operation (FIG. 1).

Abstract: Congeneric, halogenated, fluorinated aromatic compounds where A and B are each phenyl radicals, L=oxygen atom, sulfur atom or alkylene radical and p=0 or 1; processes for their preparation and their use.

Abstract: A machine tool has a work space (17) in which a device (15) for accommodating workpieces (16) to be machined is arranged. The machine tool further has a work spindle (18) for machining the workpieces (16) and a slide (34) which carries the work spindle (18) and is traversable in a longitudinal direction relative to the device (15), a respective cover (25), variable in length in the longitudinal direction (x), for the work space (17) being provided on the slide (34) on each of its sides, said cover (25) being connected with its respective first end to the slide (34) and with its respective second end to a side wall (21, 22; 51) of the work space (17). Each cover (25) variable in length has a respective rear wall (26) and a respective top (27), whereby the top (27) is connected to the rear wall (26) in a detachable, push-in, manner. A further flexible cover (31) is arranged in front of the slide (34) to protect the work space (17) at the bottom.

Abstract: Methods for treating renal cell carcinoma using low doses of IL-2 are disclosed. In particular, the invention relates to methods of treating metastatic renal cell carcinoma in patients who are renally impaired and/or intolerant of high dose IL-2 therapy. The therapeutic regimen described herein significantly inhibits tumor growth with reduced toxicity and adverse side effects compared to high dose IL-2 therapy.

Abstract: The invention relates to compositions comprising combinations of Chlamydia trachomatis antigens and their use in vaccines. Specific combinations may be selected from a first antigen group of PepA, LcrE, ArtJ, DnaK, and CT398, and a second antigen group of PepA, LcrE, ArtJ, DnaK, CT398, OmpH-like, L7/L12, OmcA, AtoS, CT547, Eno, HtrA and MurG. The invention further relates to the use of combinations of adjuvants for use with antigens associated with a sexually transmissible disease, such as Chlamydia trachomatis antigens. Preferred adjuvant combinations include mineral salts, such as aluminium salts and oligonucleotides comprising a CpG motif.

Abstract: Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.

Abstract: Conjugated meningococcal capsular saccharides will be introduced into immunisation schedules in the near future, but the phenomenon of “carrier suppression” must first be addressed, particularly where multiple conjugates are to be used. In the invention, tetanus toxoid is used as the carrier protein, even where multiple meningococcal conjugates are administered at the same time and where a patient has previously been exposed to the carrier protein, either in the form of a previous immunogen (e.g. in a DTP vaccine) or as a previous carrier protein (e.g. in a Hib or pneumococcal conjugate vaccine). The invention provides a method for immunising a patient, comprising administering multiple conjugates of meningococcal capsular saccharides, wherein each conjugate comprises a tetanus toxoid carrier protein, and the capsular saccharide, and wherein the patient has been pre-immunised with a tetanus toxoid.

Abstract: This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.

Abstract: Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titres than OMVs prepared by normal production processes. Thus the invention provides a bacterium having a knockout mutation of its mltA gene. The invention also provides a bacterium, wherein the bacterium: (i) has a cell wall that includes peptidoglycan; and (ii) does not express a protein having the lytic transglycosylase activity of MltA protein. The invention also provides compositions comprising vesicles that, during culture of bacteria of the invention, are released into the culture medium.

Abstract: M-CSF-specific antibody RX1 is provided, along with pharmaceutical compositions containing antibody RX1, kits containing a pharmaceutical composition, and methods of preventing and treating bone loss in a subject afflicted with an osteolytic disease.

Abstract: The invention relates to the identification of a new adhesin islands within the genomes of several Group A and Group B Streptococcus serotypes and isolates. The adhesin islands are thought to encode surface proteins which are important in the bacteria's virulence. Thus, the adhesin island proteins of the invention may be used in immunogenic compositions for prophylactic or therapeutic immunization against GAS or GBS infection. For example, the invention may include an immunogenic composition comprising one or more of the discovered adhesin island proteins.