Patents Assigned to Choongwae Pharma Corporation
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Publication number: 20100069333Abstract: The invention provides ?-mimetic structures and a chemical library relating thereto. Additionally, the invention provides methods wherein ?-mimetic compounds are used to treat cancer stem cells.Type: ApplicationFiled: November 11, 2009Publication date: March 18, 2010Applicant: Choongwae Pharma CorporationInventor: Michael Kahn
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Patent number: 7671054Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins as well as their prodrugs are disclosed. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds and prodrugs for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.Type: GrantFiled: October 15, 2007Date of Patent: March 2, 2010Assignee: Choongwae Pharma CorporationInventors: Sung Hwan Moon, Jae Uk Chung, Sung Chan Lee, Masakatsu Eguchi, Michael Kahn, Kwang Won Jeong, Cu Nguyen, Soo Jin Lee
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Patent number: 7662960Abstract: Conformationally constrained compounds of structure: which mimic the secondary structure of ?-strand regions of biologically active peptides and proteins are disclosed. Such ?-strand mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents that inhibit protease, kinase and the like. Libraries containing the ?-strand mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members.Type: GrantFiled: May 30, 2003Date of Patent: February 16, 2010Assignee: Choongwae Pharma CorporationInventors: Michael Kahn, Masakatsu Eguchi, Sung Hwan Moon, Jae Uk Chung
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Patent number: 7585862Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.Type: GrantFiled: October 4, 2005Date of Patent: September 8, 2009Assignee: Choongwae Pharma CorporationInventors: Sung Hwan Moon, Jae Uk Chung, Sung Chan Lee, Masakatsu Eguchi, Michael Kahn, Kwang Won Jeong, Cu Nguyen
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Publication number: 20090215783Abstract: The present invention relates to composition and methods for inducing or inhibiting differentiation of stem cells. The invention also relates to applications in the treatment of medical conditions, e.g., osteoporosis, bone fracture, bone injuries, myocardiac infarction, cardiomyopathy, degenerative muscle diseases, myopathy, and urinary incontinence.Type: ApplicationFiled: May 30, 2007Publication date: August 27, 2009Applicant: CHOONGWAE PHARMA CORPORATIONInventor: Se Woong Oh
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Patent number: 7576084Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.Type: GrantFiled: April 16, 2004Date of Patent: August 18, 2009Assignee: Choongwae Pharma CorporationInventors: Sung Hwan Moon, Jae Uk Chung, Sung Chan Lee, Masakatsu Eguchi, Michael Kahn, Kwang Won Jeong, Cu Nguyen
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Patent number: 7566711Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.Type: GrantFiled: April 15, 2005Date of Patent: July 28, 2009Assignee: Choongwae Pharma CorporationInventors: Sung Hwan Moon, Jae Uk Chung, Sung Chan Lee, Masakatsu Eguchi, Michael Kahn, Kwang Won Jeong, Cu Nguyen, Soo Jin Lee
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Patent number: 7563825Abstract: Methods and agents are disclosed for modulating the interaction of ?-catenin or ?-catenin with CBP or p300. Agents that increase the binding of CBP to ?-catenin are associated with enhancing the ?-catenin-related proliferation of adult stem cells, including hematopoietic stem cells, neural stem cells, skin stem cells, and pancreatic stem cells.Type: GrantFiled: March 16, 2006Date of Patent: July 21, 2009Assignee: Choongwae Pharma CorporationInventor: Michael Kahn
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Patent number: 7531320Abstract: The present invention provides compounds and methods for modulating transcription activated by ?-catenin/TCF, such as the selective inhibition of genes targeted by the Wnt/?-catenin pathway.Type: GrantFiled: August 27, 2004Date of Patent: May 12, 2009Assignee: Choongwae Pharma CorporationInventors: Michael Kahn, SeWoong Oh, DaeHoon Kim, JongRyul Ha, Katayoon Hojjati-Emami
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Patent number: 7495126Abstract: This invention relates to a method for preparing tetrafluorobenzyl-5-aminosalicylic acid derivative and its pharmaceutically acceptable salt compounds. In particular, this invention relates to a method for preparing tetrafluorobenzyl-5-aminosalicylic acid derivative and its pharmaceutically acceptable salts by using tetrafluorobenzilidine-5-aminosalicylic acid derivative as an intermediate.Type: GrantFiled: May 25, 2006Date of Patent: February 24, 2009Assignee: Choongwae Pharma CorporationInventors: Tae-Seop Hwang, Hyun-Gyu Kim
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Publication number: 20080167492Abstract: This invention relates to a method for preparing tetrafluorobenzyl-5-aminosalicylic acid derivative and its pharmaceutically acceptable salt compounds. In particular, this invention relates to a method for preparing tetrafluorobenzyl-5-aminosalicylic acid derivative and its pharmaceutically acceptable salts by using tetrafluorobenzilidine-5-aminosalicylic acid derivative as an intermediate.Type: ApplicationFiled: May 25, 2006Publication date: July 10, 2008Applicant: Choongwae Pharma CorporationInventors: Tae-Seop Hwang, Hyun-Gyu Kim
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Patent number: 7232822Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.Type: GrantFiled: March 17, 2004Date of Patent: June 19, 2007Assignee: Choongwae Pharma CorporationInventors: Sung Hwan Moon, Jae Uk Chung, Sung Chan Lee, Masakatsu Eguchi, Michael Kahn, Kwang Won Jeong, Cu Nguyen
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Patent number: 7205418Abstract: The present invention relates to new process for preparing as a key chiral intermediate compound of formula (I) obtained from an epoxy-?-hydroxy carboxylic acid ester of formula (II) prepared from epoxide compound of formula (III), in which said compound of formula (I) is useful for preparing the therapeutic agent for hyperlipidemia, such as Astrovastatin and Fluvastatin. Wherein R1 denotes a hydrogen atom, alkyl, aryl or alkylaryl, R2 and R3 which can be identical or different, are a lower alkyl or phenyl and are capable of forming a six-membered ring, R4 stands for hydroxy, amino, alkylamino, azido, cyano, halogeno, aryloxy, alkyloxy, arylalkyloxy, alkyl, alkenyl, aryl, or aminomethyl, etc.Type: GrantFiled: August 13, 2002Date of Patent: April 17, 2007Assignee: Choongwae Pharma CorporationInventors: Inhee Lee, Seungjoo Lee
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Patent number: 7186751Abstract: The disclosure concerns an injectable composition of paclitaxel, more particularly, an injectable composition of paclitaxel having excellent anticancer effect comprising solubilizer such as polyoxyl hydrogenated castor oil, anhydrous ethanol and stabilizer such as N-acetyl amino acid. The injectable compositions of paclitaxel provide a medical effect higher than that of the known compositions showing not only a lower toxicity but also superior solubility of paclitaxel and stability at room temperature, thus enabling venous injection by having fine particles.Type: GrantFiled: September 9, 2002Date of Patent: March 6, 2007Assignee: Choongwae Pharma CorporationInventors: Woo-Young Lee, Sang-Heon Lee, Kye-Hyun Kim
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Publication number: 20070043052Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.Type: ApplicationFiled: April 15, 2005Publication date: February 22, 2007Applicant: Choongwae Pharma CorporationInventors: Sung Moon, Jae Chung, Sung Lee, Masakatsu Eguchi, Michael Kahn, Kwang Jeong, Cu Nguyen, Soo Lee
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Publication number: 20070021431Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.Type: ApplicationFiled: March 17, 2004Publication date: January 25, 2007Applicant: Choongwae Pharma CorporationInventors: Sung Moon, Jae Chung, Sung Lee, Masakatsu Eguchi, Michael Kahn, Kwang Jeong, Cu Nguyen
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Publication number: 20070021425Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.Type: ApplicationFiled: April 16, 2004Publication date: January 25, 2007Applicant: Choongwae Pharma CorporationInventors: Sung Moon, Jae Chung, Sung Lee, Masakatsu Eguchi, Michael Kahn, Kwang Jeong, Cu Nguyen
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Publication number: 20060084655Abstract: Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.Type: ApplicationFiled: October 4, 2005Publication date: April 20, 2006Applicant: Choongwae Pharma CorporationInventors: Sung Moon, Jae Chung, Sung Lee, Masakatsu Eguchi, Michael Kahn, Kwang Jeong, Cu Nguyen
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Publication number: 20050059628Abstract: The present invention provides compounds and methods for modulating transcription activated by ?-catenin/TCF, such as the selective inhibition of genes targeted by the Wnt/?-catenin pathway.Type: ApplicationFiled: August 27, 2004Publication date: March 17, 2005Applicant: Choongwae Pharma CorporationInventors: Michael Kahn, SeWoong Oh, DaeHoon Kim, JongRyul Ha, Katayoon Hojjati-Emami
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Compounds useful for treatment of cancer, compositions containing the same, and methods of their use
Patent number: 6762185Abstract: The invention involves compounds having the general formula (I) as described in the claims and pharmaceutical compositions comprising such compounds. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer.Type: GrantFiled: March 1, 2002Date of Patent: July 13, 2004Assignee: Choongwae Pharma CorporationInventors: Michael Kahn, Masakatsu Eguchi, Sung Hwan Moon, Jae Uk Chung, Kwang Won Jeong