Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.
Type:
Application
Filed:
April 9, 2003
Publication date:
April 15, 2004
Applicant:
Choongwae Pharma Corporation
Inventors:
Sung Hwan Moon, Jae Uk Chung, Sung Chan Lee, Masakatsu Eguchi, Michael Kahn, Kwang Won Jeong, Cu Nguyen
Abstract: Conformationally constrained compounds which mimic the secondary structure of &bgr;-strand regions of biologically active peptides and proteins are disclosed. Such &bgr;-strand mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the &bgr;-strand mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members.
Type:
Application
Filed:
May 30, 2003
Publication date:
March 18, 2004
Applicant:
Choongwae Pharma Corporation
Inventors:
Michael Kahn, Masakatsu Eguchi, Sung Hwan Moon, Jae Uk Chung
Abstract: The present invention relates to a method and composition of an oral preparation of itraconazole, an excellent azole antifungal drug. More particularly, it relates to an oral preparation of itraconazole having improved bioavailability, which is prepared by following steps of: i) dissolving itraconazole and bydrophilic polymer with solvent, ii) spray-drying said mixture, and iii) preparing the solid dispersions for oral preparation. The solid dispersions prepared in this invention may be useful in preparing tablets, granules and other oral dosage forms.
Type:
Grant
Filed:
June 29, 2000
Date of Patent:
November 26, 2002
Assignee:
Choongwae Pharma Corporation
Inventors:
Jae-Young Jung, Kye-Hyun Kim, Sang-Heon Lee, Ji-Woong Hong, Jong-Woo Park, Kyu-Hyun Lee
Abstract: The present invention relates to novel genipin derivatives which have an excellent liver protection activity with little cytotoxicity, and these compounds are so stable in vivo that they do not induce any side effects.