Patents Assigned to CHR. Hansen
  • Publication number: 20230235307
    Abstract: The present invention relates to new improved peptide or dimeric peptides exhibiting betagalactosidase enzyme activity as well as improved methods for reducing the lactose content in compositions, such as dairy products.
    Type: Application
    Filed: November 14, 2022
    Publication date: July 27, 2023
    Applicant: Chr. Hansen A/S
    Inventors: Hans Raj, Pernille Smith, Thomas Eckhardt, Vojislav Vojinovic, Charlotte Elisabeth Grüner Schöller, Johannes Maarten van den Brink
  • Patent number: 11707070
    Abstract: The present invention provides a method of controlling growth of unwanted microorganisms by limiting their access to manganese. More specifically, the present invention provides a method of inhibiting or delaying growth of yeast and mold by reducing the manganese concentration in a product which is preferably a food product. The invention also provides manganese scavengers and uses thereof to inhibit or delay fungal growth.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: July 25, 2023
    Assignee: Chr. Hansen A/S
    Inventors: Solvej Siedler, Martin Holm Rau, Stina Dissing Aunsbjerg Nielsen
  • Publication number: 20230227507
    Abstract: The present invention provides a method of increasing nisin production in nisin-producing Lactococcus lactis by inactivating the phage infection protein Pip. The invention also provides nisin-producing Lactococcus lactis in which the phage infection protein is inactivated. The nisin-producing Lactococcus lactis can be used in starter culture for manufacturing food products or other industrial applications.
    Type: Application
    Filed: June 10, 2021
    Publication date: July 20, 2023
    Applicant: Chr. Hansen A/S
    Inventors: Thomas Janzen, Ditte Ellegaard Christiansen, Mia Vissing Mikkelsen, Thomas Eckhardt
  • Publication number: 20230210121
    Abstract: The present invention relates to new improved peptide or dimeric peptides exhibiting beta- galactosidase enzyme activity as well as improved methods for reducing the lactose content in compositions in particular at low temperatures.
    Type: Application
    Filed: April 11, 2018
    Publication date: July 6, 2023
    Applicant: Chr. Hansen A/S
    Inventors: Hans RAJ, Pernille SMITH, Thomas ECKHARDT, Vojislav VOJINOVIC, Charlotte Elisabeth Grüner SCHÖLLER, Johannes Maarten VAN DEN BRINK
  • Patent number: 11690384
    Abstract: Deposited Streptococcus thermophilus (ST) strains that e.g. are suitable to be used in an improved method for the manufacture of low browning mozzarella cheese.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: July 4, 2023
    Assignee: Chr. Hansen A/S
    Inventors: Thomas Janzen, Ditte Ellegaard Christiansen
  • Publication number: 20230200406
    Abstract: The invention relates to a composition for producing a fermented milk product comprising: (i) a starter culture comprising a glucose-fermenting Streptococcus thermophilus (St) strain and a glucose-fermenting Lactobacillus delbrueckii subsp. bulgaricus (Lb) strain; and (ii) a glucose-deficient Streptococcus thermophilus (St) strain, wherein said St strain is galactose-fermenting and carries a mutation in the DNA sequence of the glcK gene encoding a glucokinase protein, which mutation inactivates the glucokinase protein or has a negative effect on expression of the gene.
    Type: Application
    Filed: May 31, 2021
    Publication date: June 29, 2023
    Applicants: Chr. Hansen A/S, Compagnie Gervais Danone
    Inventors: Benoit Colson, Sonja Bloch, Gaelle Lettier Buchhorn, Nanna Christensen, Marie-Agnès Soucé, Laurent Marchal, Anne Depierris, Fanny Larrere
  • Patent number: 11685758
    Abstract: Provided is a method for the purification of lacto-N-neotetraose from other carbohydrates, characterized in that the method comprises the steps of subjecting an aqueous solution containing lacto-N-neotetraose to two membrane filtration steps using different membranes or of subjecting an aqueous solution containing lacto-N-neotetraose to a membrane filtration step and a continuous chromatography.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: June 27, 2023
    Assignee: Chr. Hansen HMO GmbH
    Inventors: Stefan Jennewein, Markus Helfrich
  • Patent number: 11684073
    Abstract: A method for producing a lactic acid bacteria fermented milk product comprising fermenting milk with both inoculated lactic acid bacteria (LAB) and inoculated Bacillus bacteria.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: June 27, 2023
    Assignee: Chr. Hansen A/S
    Inventors: Karin Bjerre, Mette Dines Cantor, Thomas Janzen, Patrick Derkx
  • Publication number: 20230189831
    Abstract: The present invention is in the field of dairy technology. It relates to methods for producing fermented milk products, characterized the bacterium Lactobacillus rhamnosus DSM 33515 or mutants obtainable therefrom is used. Lactobacillus rhamnosus bacteria DSM 33515 has low post-acidification in fermented milk products and can provide antimicrobial effects. The invention also provides Lactobacillus rhamnosus DSM 33515 or mutants obtainable therefrom as well as related compositions.
    Type: Application
    Filed: May 20, 2021
    Publication date: June 22, 2023
    Applicant: Chr. Hansen A/S
    Inventors: Cecilie Lykke Marvig Nielsen, Susanne Bidstrup, Vera Kuzina Poulsen, Solvej Siedler, Kim Ib Soerensen
  • Patent number: 11661435
    Abstract: The present application discloses a simple process for the purification of neutral human milk oligosaccharides (HMOs) produced by microbial fermentation. The process uses a combination of cationic ion exchanger treatment, an anionic ion exchanger treatment, and a nanofiltration and/or electrodialysis step, which allows efficient purification of large quantities of neutral HMOs at high purity. Contrary to the purification currently used in fermentative production of neutral HMOs, the presented process allows the provision of HMOs without the need of a chromatographic separation. The so purified HMOs may be obtained in solid form by spray drying, as crystalline material or as sterile filtered concentrate. The provided HMOs are free of proteins and recombinant material originating from the used recombinant microbial strains and thus very well-suited for use in food, medical food and feed (e.g. pet food) applications.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: May 30, 2023
    Assignee: Chr. Hansen HMO GmbH
    Inventor: Stefan Jennewein
  • Patent number: 11653659
    Abstract: Acidified milk product, which has a pH of between 3.0 and 5.0 and a content of lactose of at least 1.5 mg/ml, wherein the product contains a lactase, which retains its activity at a pH of 5.0 and a temperature of 37° C. at a level of at least 5% as compared to its activity at the optimum pH of the lactase.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: May 23, 2023
    Assignee: Chr. Hansen A/S
    Inventors: Soeren Ng Riis, Vojislav Vojinovic, Christian Gilleladen
  • Patent number: 11653689
    Abstract: The present invention relates to Bifidobacterium breve deposited as DSM 32356 and compositions comprising said strain. The composition may further comprise at least one other bacterial strain and/or at least one compound which may be an NSAID such as acetylsalicylic acid (aspirin). In a presently preferred embodiment the invention relates to Bifidobacterium breve deposited as DSM 32356 for use in the support of the defense against intestinal tissue damage such as intestinal mucosal breaks or lesions e.g. in connection with NSAID administration such as in connection with administration of acetylsalicylic acid (aspirin). The invention further provides a method of supporting the defense against intestinal tissue damage, the method comprising administering the Bifidobacterium breve strain deposited as DSM 32356 to a subject in need thereof, e.g. to a subject in need of NSAID treatment.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: May 23, 2023
    Assignee: Chr. Hansen A/S
    Inventors: Brynjulf Mortensen, Anders Damholt, Anja Wellejus, Vibeke Westphal Stennicke, Johan E. T. Van Hycklama Vlieg
  • Publication number: 20230148644
    Abstract: Disclosed is a method for the manufacture of a spray-dried powder consisting essentially of LNT and/or LNnT, the spray-dried powder, its use for the manufacture of nutritional compositions, and nutritional compositions containing the spray-dried powder.
    Type: Application
    Filed: November 22, 2022
    Publication date: May 18, 2023
    Applicant: Chr. Hansen HMO GmbH
    Inventor: Stefan Jennewein
  • Publication number: 20230149484
    Abstract: The present invention provides a pharmaceutical composition including a probiotic and a prebiotic for treatment of stunting in children. More particularly, the pharmaceutical composition includes at least one Lactobacillus specie(s) as a probiotic and at least one oligosaccharide as a prebiotic. The present invention further provides a method of treatment of stunting including administering an effective amount of a pharmaceutical composition including a probiotic and a prebiotic to children in need thereof.
    Type: Application
    Filed: December 29, 2022
    Publication date: May 18, 2023
    Applicant: Chr. Hansen A/S
    Inventor: Pravas Ranjan Misra
  • Publication number: 20230118835
    Abstract: The present invention is directed to a method of producing a Streptococcus thermophilus strain comprising the steps of a) Providing a mother strain in the form of Streptococcus thermophilus DSM32502, b) Growing a culture of the mother strain in the presence of a bacteriophage, to which the mother strain is not resistant, to obtain a number of mutant strains, which are resistant to the said bacteriophage, c) Measuring the acidification time of the bacteriophage-resistant mutant strains and the mother strain in a milk base and selecting at least one mutant strain with a reduced acidification time as compared to the mother strain to obtain a fast-acidifying mutant strain.
    Type: Application
    Filed: December 22, 2022
    Publication date: April 20, 2023
    Applicant: Chr. Hansen A/S
    Inventors: Jeorgos Trihaas, Thomas Janzen, Patrick Derkx
  • Patent number: 11629343
    Abstract: Variants of chymosin with improved milk-clotting properties are disclosed.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: April 18, 2023
    Assignee: Chr. Hansen A/S
    Inventors: Johannes Maarten Van Den Brink, Jesper Langholm Jensen, Jonas Jacobsen, Martin Lund, Iben Jeppesen, Christian Jaeckel
  • Patent number: 11622566
    Abstract: The present invention relates to a glycerin- and protein-based candy product comprising probiotic bacteria, said product having a moisture content less than 9% and a water activity (aw) of less than 0.5 and comprising a) glycerin in an amount of at least 5% (w/w), b) at least one saccharide or at least one polyol which is not glycerin, or a mixture thereof, c) at least one protein which is not gelatin, and d) at least one species of a probiotic bacterium, and optionally e) at least one hydrocolloid. In a presently preferred embodiment the protein is a hydrolyzed protein. Further, the invention relates to processes for producing a glycerin- and protein-based candy product comprising probiotic bacteria.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: April 11, 2023
    Assignee: Chr. Hansen A/S
    Inventor: Mogens Dolmer
  • Patent number: 11606965
    Abstract: Process for producing an ambient storage food product comprising providing a food product with a pH of between 3.4 and 4.4, subjecting the food product to a heat treatment to obtain a heat treated food product, adding aseptically to the heat treated food product one or more of ambient storage lactic acid bacteria strains to obtain an ambient storage food product, and storing the ambient storage food product at ambient temperature for a period of time, wherein the ambient storage lactic acid bacteria strain is selected from the group consisting of strains, (i) wherein the strain is capable of retaining viability at the end of 150 days at a temperature of 25#C, and (ii) wherein the pH at most decreases 0.8 units during the storage period, and (iii) wherein the strain is selected from the group consisting of Lactobacillus paracasei, Lactobacillus rhamnosus, Lactobacillus fermentum and Lactobacillus delbrueckii subsp. bulgaricus, and mutants and variants thereof.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: March 21, 2023
    Assignee: Chr. Hansen A/S
    Inventors: Christian Gilleladen, Jeorgos Trihaas, Thomas Janzen, Mette Oehrstroem Runge
  • Publication number: 20230076578
    Abstract: The present invention relates to new improved peptide or dimeric peptides exhibiting beta-galactosidase enzyme activity as well as improved methods for reducing the lactose content in compositions optionally at elevated temperatures.
    Type: Application
    Filed: April 11, 2018
    Publication date: March 9, 2023
    Applicant: Chr. Hansen A/S
    Inventors: Hans RAJ, Pernille SMITH, Thomas ECKHARDT, Vojislav VOJINOVIC, Charlotte Elisabeth Grüner SCHÖLLER, Johannes Maarten VAN DEN BRINK
  • Patent number: 11597740
    Abstract: The present application discloses a simple process for the purification of neutral human milk oligosaccharides (HMOs) produced by microbial fermentation. The process uses a combination of cationic ion exchanger treatment, an anionic ion exchanger treatment, and a nanofiltration and/or electrodialysis step, which allows efficient purification of large quantities of neutral HMOs at high purity. Contrary to the purification currently used in fermentative production of neutral HMOs, the presented process allows the provision of HMOs without the need of a chromatographic separation. The so purified HMOs may be obtained in solid form by spray drying, as crystalline material or as sterile filtered concentrate. The provided HMOs are free of proteins and recombinant material originating from the used recombinant microbial strains and thus very well-suited for use in food, medical food and feed (e.g. pet food) applications.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: March 7, 2023
    Assignee: Chr. Hansen HMO GmbH
    Inventor: Stefan Jennewein