Abstract: A process for the preparation of 3-hydroxyoxetanes of formula I ##STR1## wherein R.sub.9 and R.sub.10 are each independently of the other hydrogen or C.sub.1 -C.sub.4 alkyl, by(1) reaction of a carboxylic acid R--CO.sub.2 H, wherein R is branched alkyl, with an epichlorohydrin of formula II ##STR2## wherein R.sub.9 and R.sub.10 are as defined hereinbefore, to form an ester of formula III ##STR3## wherein R, R.sub.9 and R.sub.10 are as defined hereinbefore, (2) reaction of that ester with an ether of formula IVCHR.sub.1 .dbd.CH--O--R.sub.2 (IV),wherein R.sub.1 is hydrogen or methyl, R.sub.2 is C.sub.1 -C.sub.6 alkyl, or R.sub.1 and R.sub.2 together form a radical of formula --(CH.sub.2).sub.3 --, in the presence of a catalyst, to form an ester of formula V ##STR4## (3) hydrolysis and cyclization of that ester in the presence of a base to form a compound of formula VI ##STR5## wherein R.sub.1, R.sub.2, R.sub.9 and R.sub.
Type:
Grant
Filed:
June 28, 1996
Date of Patent:
September 2, 1997
Assignee:
Ciba-Geigy Corporation
Inventors:
Wolfgang Stutz, Rudolf Waditschatka, Klas Winter, Matthias von Frieling, Remy Gressly, Beat Jau, Sebastien Burki
Abstract: Mixtures of four .alpha.-alkoxy-substituted phthalocyanine isomers, predominantly ##STR1## or of four .beta.-alkoxy-substituted phthalocyanine isomers, whereMe is a divalent metal atom or a divalent oxo metal,R.sub.1 is a linear or branched C.sub.1 -C.sub.16 alkyl, C.sub.3 -C.sub.16 alkenyl or C.sub.3 -C.sub.16 alkynyl radical which is unsubstituted or substituted by C.sub.1 -C.sub.12 alkoxy, --CN, NO.sub.2, halogen, --OH, phenyl, cyanophenyl, nitrophenyl, halophenyl, hydroxyphenyl or (C.sub.1 -C.sub.12 alkoxy)phenyl,wherein two isomers of the formula II and of the formula III make up at least 80% of the total mixture and the two other isomers make up at most 20% of the total mixture, with the ratio between the compounds of the formula II and the compounds of the formula III being from 0.3 to 3.0:1.The isomer mixtures can be obtained by reacting .alpha.- or .beta.
Abstract: Compounds of the formula ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are as defined in claim 1 can be used as agrochemical active ingredients and can be prepared in a manner known per se.
Abstract: Di-, tri- and poly-perfluoroalkyl-substituted alcohols and acids and derivatives thereof are described which are prepared from perfluoroalkyl iodides and di-, tri- or polyallyl alcohols or acids. These compounds contain two or more perfluoroalkyl-iodoalkyl or perfluoroalkyl-alkenyl groups and one or two alcohol or acid groups or derivatized alcohol or acid functions. They can be reacted with isocyanates, epoxy compounds, anhydrides, acids or acid derivatives to prepare a great variety of oil- and water-repellent compositions which are useful for oil- and water-repellent treatment of textiles, glass, paper, leather and other substrates.
Type:
Grant
Filed:
May 31, 1995
Date of Patent:
September 2, 1997
Assignee:
Ciba-Geigy Corporation
Inventors:
Marlon Haniff, Robert Falk, Ted Deisenroth, Karl F. Mueller
Abstract: The invention relates to a novel formulation of per se known pesticides in the form of microcapsules, to a process for the preparation of microcapsules and to the use of said microcapsules for controlling weeds, plant diseases, insects and representatives of the order Acarina.
Type:
Grant
Filed:
May 26, 1995
Date of Patent:
September 2, 1997
Assignee:
Ciba-Geigy Corporation
Inventors:
Rudolf Nastke, Andreas Leonhardt, Ernst Neuenschwander
Abstract: A process for the synthesis of compounds of formula I ##STR1## wherein Ar.sub.1, Ar.sub.2, A.sub.1, A.sub.2, R and X are as defined in the description, exhibit valuable pharmaceutical properties and are effective especially against diseases responsive to the inhibition of protein kinases, for example tumors.
Abstract: A salt of formula ##STR1## where X denotes a group of formula ##STR2## Y denotes a group of formula ##STR3## and R denotes the residue of an aliphatic or cycloaliphatic sulphonic acid having at least 3 carbon atoms after removal of a --SO.sub.3 H group therefrom.
Type:
Grant
Filed:
March 11, 1996
Date of Patent:
September 2, 1997
Assignee:
CIBA-GEIGY Corporation
Inventors:
Nicholas Lowther, Ian Francis Hassan, Ian Timothy William Matthews
Abstract: The present invention provides a method of reducing the tendency of a resinated pigment product to self-heat which comprises treating an aqueous slurry of the pigment with a compound of a multivalent metal or metalloid under conditions such as will precipitate an insoluble compound of the metal or metalloid on the pigment, and then isolating the treated pigment.
Type:
Grant
Filed:
February 28, 1995
Date of Patent:
August 26, 1997
Assignee:
Ciba-Geigy Corporation
Inventors:
Ian Alexander Macpherson, John Aldred Nimmo, Brian Tuck
Abstract: The invention pertains to the field of thrombin inhibitors and describes the production of modified desulphatohirudins, particularly desulphatohirudins, with the aid of genetic engineering. The present invention is also directed to a method for the denaturation and renaturation of a modified desulphatohirudin to a biologically active thrombin inhibitor and the combination of two or more of desulphatohirudins to form higher molecular weight thrombin inhibitors.
Type:
Grant
Filed:
March 29, 1995
Date of Patent:
August 26, 1997
Assignee:
Ciba-Geigy Corporation
Inventors:
Hugo Grossenbacher, Jui Yoa Chang, Walter Marki
Abstract: The invention relates to a novel advantageous dosage form for sparingly soluble staurosporin derivatives, especially N-benzoyl-staurosporin. The dosage form is administrable intravenously in the form of a nanoemulsion and comprises as solubilisers a combination of phospholipids, triglycerides and partial fatty acid esters of polyoxyethylene sorbitan.
Abstract: Novel (meth)acrylates which also contain urethane groups and other polymerizable groups in one and the same molecule and can be polymerized either by means of free radicals and/or cationically are used for the production of coatings, adhesives, photoresists, solder masks or in stereolithography. The mouldings produced therefrom contain a coherent, homogeneous network and have high strength properties, in particular mechanical properties.
Type:
Grant
Filed:
November 3, 1995
Date of Patent:
August 19, 1997
Assignee:
Ciba-Geigy Corporation
Inventors:
Bettina Steinmann, Jean-Pierre Wolf, Adrian Schulthess, Max Hunziker
Abstract: A description is given of a process for the preparation of 2,5-bis(1,1-dimethyl-4-hexyloxycarbonylbutyl)hydroquinone by reacting 5-methyl-4-hexenoic acid (m)ethyl ester, which is obtainable by reacting 2-hydroxy-2-methyl-3-butene with tri(m)ethyl orthoacetate in the presence of an acid catalyst, with hydroquinone according to Friedel-Crafts, and transesterifying the resulting 2,5-bis(1,1-dimethyl-4-(m)ethoxycarbonylbutyl)-hydroquinone product direct with hexanol in a one-pot process.
Abstract: The present invention provides a compound having the formula: ##STR1## in which M is hydrogen, sodium, potassium, calcium, magnesium, ammonium, mono-, di-, tri- or tetra-C.sub.1 -C.sub.4 alkylammonium, mono-, di- or tri-C.sub.1 -C.sub.4 hydroxyalkylammonium or ammonium that is di- or tri-substituted by a mixture of C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 hydroxyalkyl groups; R.sub.1 is a group having the formula: ##STR2## in which M has its previous significance and n is 1 or 2; and R.sub.2 is O--C.sub.1 -C.sub.12 alkyl or N(R.sub.3)(R.sub.4) in which R.sub.3 and R.sub.4, independently, are hydrogen, C.sub.1 -C.sub.12 alkyl or C.sub.1 -C.sub.4 hydroxyalkyl, or R.sub.3 and R.sub.4, together with the nitrogen atom, are the atoms required to form a pyrrolidine, piperidine or morpholine group.
Type:
Grant
Filed:
September 20, 1995
Date of Patent:
August 12, 1997
Assignee:
Ciba-Geigy Corporation
Inventors:
Jean-Pierre Bacher, Claude Eckhardt, Dieter Reinehr
Abstract: .delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients.
Type:
Grant
Filed:
July 2, 1996
Date of Patent:
August 5, 1997
Assignee:
Ciba-Geigy Corporation
Inventors:
Richard Goschke, Jurgen Klaus Maibaum, Walter Schilling, Stefan Stutz, Pascal Rigollier, Yasuchika Yamaguchi, Nissim Claude Cohen, Peter Herold
Abstract: The invention relates to novel oligomeric compounds of the formula I ##STR1## in which L is a group of the formula ##STR2## where the oxygen in the group L is in each case bonded to the phosphorus in the recurring structural units and the radical R.sub.2 or the carbon in the 4-position of the piperidinyl ring in the group L is in each case bonded to the oxygen in the recurring structural units; and the general symbols are as defined in claim 1, as stabilizers for organic materials against oxidative, thermal or light-induced degradation.
Abstract: Catalyst systems which comprise a transition metal and a tris(organophosphite) ligand are particularly effective as catalysts for hydrosilation reactions.
Abstract: An environmentally friendly process is described for the preparation of 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl by the direct hydrogen peroxide oxidation of 4-hydroxy-2,2,6,6-tetramethylpiperidine in the absence of any catalyst.
Type:
Grant
Filed:
November 9, 1995
Date of Patent:
August 5, 1997
Assignee:
Ciba-Geigy Corporation
Inventors:
Stephen D. Pastor, Andrea R. Smith, Kurt M. Bessonen
Abstract: Disclosed are compounds of formula ##STR1## wherein R is hydroxy, esterified hydroxy or etherified hydroxy;R.sub.1 is halogen, trifluoromethyl or lower alkyl;R.sub.2 is halogen, trifluoromethyl or lower alkyl;R.sub.1 is halogen, trifluoromethyl, lower alkyl, aryl, aryl-lower alkyl, cycloalokyl or cycloalkyl-lower alkyl; orR.sub.3 is the radical ##STR2## wherein R.sub.8 is hydrogen, lower alkyl, aryl, cycloalkyl, aryl-lower alkyl or cycloalkil-lower alkyl; R.sub.9 is hydroxy or acyloxy; R.sub.10 represents hydrogen or lower alkyl; or R.sub.9 and R.sub.10 together represent oxo;R.sub.4 is hydrogen, halogen, trifluoromethyl or lower alkyl;X is --NR.sub.7, S or O;W is O or S;R.sub.5 represents hydrogen, lower alkyl or aryl-lower alkyl; andR.sub.6 represents hydrogen; orR.sub.5 and R.sub.6 together represent oxo provided that X represents --NR.sub.7 ;R.sub.
Type:
Grant
Filed:
July 15, 1996
Date of Patent:
August 5, 1997
Assignee:
Ciba-Geigy Corporation
Inventors:
Naokata Yokoyama, deceased, Gordon Northrop Walker, Alan Joseph Main
Abstract: Heat-curable epoxy resin systems comprising(a) at least one epoxy resin,(b) at least one polycarboxylic acid anhydride, and(c) 1,4-diazabicyclo(2,2,2)octane or a C.sub.1 -C.sub.4 alkyl-substituted derivative of 1,4-diazabicyclo(2,2,2)octane as curing accelerator, andwherein one portion of the curing accelerator (c) is replaced by(d) a complex of a boron halide with an amine,have good reactivity at elevated temperatures and comparatively high stability at temperatures below c. 80.degree. C.
Abstract: Novel process for the preparation of 2,2,6,6-tetramethyl-4-piperidyloxy-1,3,5-triazines, based on the reaction of cyanuric chloride with C.sub.1 -C.sub.4 alkanols or with sodium or potassium C.sub.1 -C.sub.4 alkoxides and subsequent reaction with 2,2,6,6-tetramethyl-4-piperidinols in the presence of a transesterification catalyst.The various reactions can be carried out in the same reactor, without isolation of the intermediates.