Patents Assigned to Ciba-Geigy Corporation
  • Patent number: 5650494
    Abstract: The process for the production of a dimeric, biologically active Transforming Growth Factor type .beta. (TGF-.beta.)-like protein or a salt thereof, comprising refolding the denatured monomeric form of the protein in the presence of a mild detergent that permits folding of the monomeric protein into a spatial conformation, which after dimerization, is the conformation associated with the biological activity, while retaining the monomeric protein in soluble form. Mild detergents include sulfobetaines, 3-(3-chlolamidopropyl)dimethylammonio-1-propanesulfonate, 3-(3-chlolamidopropyl)dimethylammonio-2-hydroxy-1-propane-sulfonate, digitonin, cholate and deoxycholate at a concentration of about 1 to 100 mM. Compositions containing a TGF-.beta.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 22, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Nico Cerletti, Gary Kent McMaster, David Cox, Albert Schmitz, Bernd Meyhack
  • Patent number: 5650517
    Abstract: 2,3-Difluoro-5-halopyridines of the formula I ##STR1## wherein X is Cl or Br are prepared by a process which comprises reacting a starting 2,3,5-trihalopyridine of the formula II ##STR2## wherein each X is individually Br or Cl and Y is F, Cl or Br with an effective amount of potassium fluoride in the presence of a mixture of sulfolane and a tetralkylurea and/or a dialkyl-alkyleneurea as diluent, at an effective temperature up to the boiling point of the diluent, optionally in the presence of a phase-transfer catalyst such as a crown ether or polyglycol ether. The compounds are useful as intermediates to prepare herbicides.
    Type: Grant
    Filed: November 1, 1994
    Date of Patent: July 22, 1997
    Assignee: Ciba-Geigy Corporation
    Inventor: Balakrishnan Venugopal
  • Patent number: 5650497
    Abstract: Azo dyes of the formula ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 independently of one another are hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or halogen,R.sub.6 is hydrogen or C.sub.1 -C.sub.4 Alkyl,X is --C.sub.1 -C.sub.4 alkylene-O--C.sub.1 -C.sub.4 alkyl andY is hydrogen; unsubstituted or hydroxy- or C.sub.1 -C.sub.4 alkoxy-substituted C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.4 -alkonoyl or C.sub.1 -C.sub.4 alkoxycarbonyl; a radical of the formula --CH.sub.2 --CH.dbd.CH.sub.2 ;C.sub.1 -C.sub.4 alkylsulfonyl; or unsubstituted or C.sub.1 -C.sub.4 alkyl-, C.sub.1 -C.sub.4 alkoxy- or halogen-substituted phenylsulfonyl, produce dyeings with good fastness properties on fibre materials containing nitrogen or containing hydroxyl groups.
    Type: Grant
    Filed: July 15, 1996
    Date of Patent: July 22, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Jean-Marie Adam, Peter Sutter
  • Patent number: 5650464
    Abstract: The invention relates to a process for the preparation of olefin polymers by polymerization using a transition metal catalyst with the addition of an aminoalkyl-1,1'-biphenyl-2,2'-diylphosphite or aminoalkyl-2,2'-alkylidene-bis(phenyl)phosphite, in conjunction with optional further modifiers. The polymers obtainable in this manner have excellent long-term stability.
    Type: Grant
    Filed: October 26, 1995
    Date of Patent: July 22, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Martin Brunner, Bruno Rotzinger, Thomas Schmutz, Werner Stauffer
  • Patent number: 5649980
    Abstract: A process is described for the photochemical and thermal stabilisation of undyed and dyed polyester fibre materials, which comprises treating said materials with a compound of formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently of the other C.sub.1 -C.sub.12 alkyl. Dyeings and prints of superior lightfastness and sublimation fastness on polyester and cellulose acetate are obtained by this process.
    Type: Grant
    Filed: October 2, 1995
    Date of Patent: July 22, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Dieter Reinehr, Gerhard Reinert, Manfred Rembold
  • Patent number: 5650513
    Abstract: Reacting the industrially readily available perylene-3,4,9,10-tetracarboxylic dianhydride (3) with specific primary amines in the presence of water gives perylene-3,4-dicarboxylic bisimides (2). Their hydrolysis affords the perylene-3,4-dicarboxylic anhydride on a preparative scale, and this anhydride is reacted with any primary amines to give likewise the corresponding imides 2. Condensation of the anhydride with diamines results in novel types of dyes, namely perylene-3,4-dicarboxamidines which have very good fastness properties. Also claimed are specific perylene-3,4-dicarboxylic diesters, perylene-3,4-dicarboxylic ester amides, perylene-3,4-dicarboxamidines and perylene-3,4-dicarbonyl derivatives, processes for preparing these compounds and their use.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: July 22, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Heinz Langhals, Leonhard Feiler
  • Patent number: 5650520
    Abstract: Diketopyrrolopyrrole of the formula ##STR1## in its .beta.-modification. The new .beta.-modification is likewise suitable as a pigment for coloring high-molecular weight organic material and, in comparison to the a-modification, shows a shift in shade towards yellowish-red.
    Type: Grant
    Filed: June 22, 1995
    Date of Patent: July 22, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Zhimin Hao, Ingo Schloder, Abul Iqbal
  • Patent number: 5650509
    Abstract: Sterically hindered phenols of formula (1) are disclosed. These antioxidants are suitable for enhancing the thermal and photochemical stability of undyed and dyed polyamide fibre materials. They are distinguished by superior exhaustion which is almost independent of the pH.
    Type: Grant
    Filed: October 11, 1995
    Date of Patent: July 22, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Jean-Pierre Bacher, Manfred Rembold, Dieter Reinehr
  • Patent number: 5648383
    Abstract: When used in admixture with mancozeb, chlorothalonil, a copper salt, folpet, fluazinam or cymoxanil (it being possible for the latter to be used also together with one of the other five components), metalaxyl having a high R-enantiomer content of more than 70% by weight, or pure R-metalaxyl, exhibits a markedly increased fungicidal action against plant diseases as compared with a similar mixture in which metalaxyl is used in the form of the racemate.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 15, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Cosima Nuninger, John Edward Nicholas Goggin, Dino Sozzi
  • Patent number: 5648494
    Abstract: Compounds of the formula ##STR1## in which R.sub.1 is halogen, C.sub.1 -C.sub.3 alkyl, halo-C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, halo-C.sub.1 -C.sub.3 alkoxy or cyano and/or two substituents R.sub.1 which are bonded to adjacent C atoms of the phenyl ring together are --O--CH.sub.2 --O--; R.sub.2 is hydrogen, halogen or methyl;R.sub.3 is fluorine, chlorine, bromine or C.sub.1 -C.sub.3 alkyl; R.sub.4 is hydrogen or C.sub.1 -C.sub.3 alkyl; either R.sub.5 is hydrogen, C.sub.1 -C.sub.4 alkyl, ##STR2## --COCO--R.sub.8, --CO--R.sub.9 or S(O).sub.m --N(R.sub.10)--COO--R.sub.11 andR.sub.6 is C.sub.1 -C.sub.6 alkyl, halo-C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.6 alkenyl, halo-C.sub.3 -C.sub.4 alkenyl, C.sub.3 C.sub.5 alkynyl, halo-C.sub.3 -C.sub.5 alkynyl, C.sub.1 -C.sub.3 alkoxy-C.sub.1 -C.sub.3 alkyl, C.sub.3 -C.sub.6 cycloalkyl, unsubstituted or substituted phenyl; or R.sub.5 and R.sub.6 together are --(CH.sub.2).sub.4 -- or --(CH.sub.2).sub.5 --; R.sub.7 is hydrogen, halogen or C.sub.1 -C.sub.3 alkyl; R.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 15, 1997
    Assignee: Ciba-Geigy Corporation
    Inventor: Friedrich Karrer
  • Patent number: 5648509
    Abstract: The addition of acid diesters of phosphorous acid onto alpha,beta-unsaturated carboxylic acid derivatives under basic catalysis is achieved with good yields if it is carried out in the presence of alkali metal alcoholates or phenolates and in the presence of halides, oxides or hydroxides of divalent metals. Co-use of these metal compounds allows relatively small mounts of metal alcoholates or phenolates to be used. The resulting reaction mixtures do not contain relatively large amounts of troublesome by-products.
    Type: Grant
    Filed: July 27, 1995
    Date of Patent: July 15, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Salman Dermeik, Martina Wanner, Karl-Heinz Lemmer, Reinhold Braun
  • Patent number: 5648487
    Abstract: A process for the preparation of a compound of the formula ##STR1## where Z and R are defined herein. A compound of formula II ##STR2## where R.sub.1 defined herein, is reacted with hydrazine hydrate and then subjected to hydrolysis to form the compound of formula I ##STR3## and the compound of the formula I is reacted with the aldehyde of the formula ##STR4## into the resulting compound of the formula IV.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 15, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Ernst Beriger, Haukur Kristinsson
  • Patent number: 5648488
    Abstract: Tris-aryl-s-triazines of formula V ##STR1## which contain from one one to three resorcinol derived moieties with at least one of said moieties substituted in the 5-position with a group such as, for example, alkyl or phenylalkyl have UV spectra which are red-shifted to the near UV range and provide excellent stabilization to polymeric substrates against the deleterious effects of actinic light.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 15, 1997
    Assignee: Ciba-Geigy Corporation
    Inventor: Tyler Arthur Stevenson
  • Patent number: 5648408
    Abstract: The disclosure relates to the use of conditioned organic pigments as stir-in pigments in various applications. The conditioned pigments are prepared by wet-milling a pigment crude to a particle size of 0.1 to 9 .mu.m and a specific surface area in the range of from 6 to 35 m.sup.2 /g.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 15, 1997
    Assignee: Ciba-Geigy Corporation
    Inventor: Fridolin Babler
  • Patent number: 5646299
    Abstract: Diketopyrrolopyrrole of the formula ##STR1## in its .beta.-modification and in its .gamma.-modification. Both the .beta.-modification and the .gamma.-modification are suitable as pigments for coloring high-molecular weight organic material. In comparison to the .alpha.-modification, the .beta.-modification shows a shift in shade towards yellowish-red. The .gamma.-modification gives brilliant orange colorations.
    Type: Grant
    Filed: June 22, 1995
    Date of Patent: July 8, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Zhimin Hao, Abul Iqbal, Fritz Herren
  • Patent number: 5645973
    Abstract: A process is described for the preparation of photopolymerizable compositions, wherein the photopolymerizable compositions can be photopolymerized by the irradiation of emission lines of differing wavelength from a UV/VIS laser light source, and contain a photopolymerizable compound and at least two photoinitiators, by adjusting the sensitivity to radiation. The ratio between the concentrations of the individual photoinitiators is so adjusted that the composition has virtually the same optical density for the radiation of the different emission lines at which the photoinitiators are effective.
    Type: Grant
    Filed: January 29, 1996
    Date of Patent: July 8, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Manfred Hofmann, Bernd Klingert, Max Hunziker, Rolf Wiesendanger, Adrian Schulthess, Paul Bernhard
  • Patent number: 5646145
    Abstract: The invention relates to a method of controlling insects in which compounds of the formula ##STR1## in free form or in agrochemically acceptable salt form, are used, wherein specific insects of the order Homoptera are controlled, to the corresponding use of those compounds, to corresponding insecticidal compositions, the active ingredient of which is selected from those compounds, and to a process for the preparation of and to the use of those compositions. The invention relates also to a method of protecting plant propagation material against attack by pests, wherein compounds of formula I, in free form or in agrochemically acceptable salt form, are used, to the corresponding use of those compounds, to corresponding pesticidal compositions, the active ingredient of which is selected from those compounds, to a process for the preparation of and to the use of those compositions, and to plant propagation material correspondingly protected against attack by pests.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: July 8, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Claude Fluckiger, Alfred Rindlisbacher, Robert Senn, Solang Uk
  • Patent number: 5646144
    Abstract: 1-Acylpiperidine compound of the formula I ##STR1## in which R.sub.1 is an optionally substituted aralkyl, aryloxyalkyl, heteroaralkyl, aroyl, heteroaroyl, cycloalkylcarbonyl, aralkanoyl, heteroarylalkanoyl, aralkoxycarbonyl or arylcarbamoyl radical or the acyl radical of an .alpha.-amino acid which is optionally N-substituted by lower alkanoyl or carbamoyl-lower-alkanoyl, R.sub.2 is cycloalkyl or an optionally substituted aryl or heteroaryl radical, R.sub.3 is hydrogen, alkyl, carbamoyl or an alkanoyl or alkenoyl radical which is optionally substituted by carboxyl or esterified or amidated carboxyl, R.sub.4 is an optionally substituted aryl or optionally partially hydrogenated heteroaryl radical, X.sub.1 is methylene, ethylene, a direct linkage, an optionally ketalized carbonyl group or an optionally etherified hydroxymethylene group, X.sub.2 is alkylene, carbonyl or a direct linkage, and X.sub.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 8, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Walter Schilling, Silvio Ofner, Siem J. Veenstra
  • Patent number: 5645169
    Abstract: A package containing water-soluble bags filled with agricultural chemicals in gel or liquid form facilitates the transport of the bags in a manner which prevents the breakage thereof. The package includes compartments for holding the bags. The walls and base of these compartments contain raised and unraised portions in a pattern such that a baffling effect is created to damper transport shock waves in the gel or liquid bag. These and other features result in the transmission of dynamic shock loads in the package in a manner which prevents such shock loads from breaking the fragile water-soluble bags during transport.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: July 8, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Lawrence Clifford Dull, Larry Arnold Simmons
  • Patent number: 5646167
    Abstract: Disclosed are compounds of formula I ##STR1## wherein R, R.sub.1, R.sub.2 and Ar have meanings as defined; pharmaceutically acceptable prodrug derivatives and pharmaceutically acceptable salts thereof; methods for preparation thereof; pharmaceutical compositions comprising said compounds; and methods of inhibiting matrix-degrading metalloproteinase and of treating matrix-degrading metalloproteinase dependent conditions in mammals using such compounds.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 8, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Lawrence J. MacPherson, David T. Parker