Patents Assigned to Ciba-Geigy
  • Genes for the synthesis of antipathogenic substances
    Patent number: 5662898
    Abstract: The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: September 2, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: James M. Ligon, Thomas Schupp, James Joseph Beck, Dwight Steven Hill, John Andrew Ryals, Thomas Deane Gaffney, Stephen Ting Lam, Philip E. Hammer, Scott Joseph Uknes
  • Microbicides
    Patent number: 5663176
    Abstract: Mixtures of certain triazole fungicides (component I) and 4,6-dimethyl-N-phenyl-2-pyrimidinamine (component II) achieve synergistically enhanced activity against fungus infestation. Components I and II can also be applied to plant crops individually, one immediately after the other.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: September 2, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Adolf Hubele, Ronald Zeun
  • Resinated pigment compositions
    Patent number: 5660623
    Abstract: The present invention provides a method of reducing the tendency of a resinated pigment product to self-heat which comprises treating an aqueous slurry of the pigment with a compound of a multivalent metal or metalloid under conditions such as will precipitate an insoluble compound of the metal or metalloid on the pigment, and then isolating the treated pigment.
    Type: Grant
    Filed: February 28, 1995
    Date of Patent: August 26, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Ian Alexander Macpherson, John Aldred Nimmo, Brian Tuck
  • High molecular weight desulphatohirudin
    Patent number: 5661001
    Abstract: The invention pertains to the field of thrombin inhibitors and describes the production of modified desulphatohirudins, particularly desulphatohirudins, with the aid of genetic engineering. The present invention is also directed to a method for the denaturation and renaturation of a modified desulphatohirudin to a biologically active thrombin inhibitor and the combination of two or more of desulphatohirudins to form higher molecular weight thrombin inhibitors.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: August 26, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Hugo Grossenbacher, Jui Yoa Chang, Walter Marki
  • Preparation of 2,5-bis(1,1-dimethyl-4-hexyloxycarbonylbutyl)hydroquinone
    Patent number: 5659067
    Abstract: A description is given of a process for the preparation of 2,5-bis(1,1-dimethyl-4-hexyloxycarbonylbutyl)hydroquinone by reacting 5-methyl-4-hexenoic acid (m)ethyl ester, which is obtainable by reacting 2-hydroxy-2-methyl-3-butene with tri(m)ethyl orthoacetate in the presence of an acid catalyst, with hydroquinone according to Friedel-Crafts, and transesterifying the resulting 2,5-bis(1,1-dimethyl-4-(m)ethoxycarbonylbutyl)-hydroquinone product direct with hexanol in a one-pot process.
    Type: Grant
    Filed: September 12, 1996
    Date of Patent: August 19, 1997
    Assignee: Ciba-Geigy Corporation
    Inventor: Reinhard Sommerlade
  • Intravenous solutions for a derivative of staurosporine
    Patent number: 5658898
    Abstract: The invention relates to a novel advantageous dosage form for sparingly soluble staurosporin derivatives, especially N-benzoyl-staurosporin. The dosage form is administrable intravenously in the form of a nanoemulsion and comprises as solubilisers a combination of phospholipids, triglycerides and partial fatty acid esters of polyoxyethylene sorbitan.
    Type: Grant
    Filed: November 7, 1995
    Date of Patent: August 19, 1997
    Assignee: CIBA GEIGY Corporation
    Inventors: Hans Georg Weder, Ute Isele
  • (Meth)acrylates containing urethane groups
    Patent number: 5658712
    Abstract: Novel (meth)acrylates which also contain urethane groups and other polymerizable groups in one and the same molecule and can be polymerized either by means of free radicals and/or cationically are used for the production of coatings, adhesives, photoresists, solder masks or in stereolithography. The mouldings produced therefrom contain a coherent, homogeneous network and have high strength properties, in particular mechanical properties.
    Type: Grant
    Filed: November 3, 1995
    Date of Patent: August 19, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Bettina Steinmann, Jean-Pierre Wolf, Adrian Schulthess, Max Hunziker
  • Fluorescent whitening agents
    Patent number: 5656760
    Abstract: The present invention provides a compound having the formula: ##STR1## in which M is hydrogen, sodium, potassium, calcium, magnesium, ammonium, mono-, di-, tri- or tetra-C.sub.1 -C.sub.4 alkylammonium, mono-, di- or tri-C.sub.1 -C.sub.4 hydroxyalkylammonium or ammonium that is di- or tri-substituted by a mixture of C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 hydroxyalkyl groups; R.sub.1 is a group having the formula: ##STR2## in which M has its previous significance and n is 1 or 2; and R.sub.2 is O--C.sub.1 -C.sub.12 alkyl or N(R.sub.3)(R.sub.4) in which R.sub.3 and R.sub.4, independently, are hydrogen, C.sub.1 -C.sub.12 alkyl or C.sub.1 -C.sub.4 hydroxyalkyl, or R.sub.3 and R.sub.4, together with the nitrogen atom, are the atoms required to form a pyrrolidine, piperidine or morpholine group.
    Type: Grant
    Filed: September 20, 1995
    Date of Patent: August 12, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Jean-Pierre Bacher, Claude Eckhardt, Dieter Reinehr
  • Heteroacetic acid derivatives
    Patent number: 5654468
    Abstract: Disclosed are compounds of formula ##STR1## wherein R is hydroxy, esterified hydroxy or etherified hydroxy;R.sub.1 is halogen, trifluoromethyl or lower alkyl;R.sub.2 is halogen, trifluoromethyl or lower alkyl;R.sub.1 is halogen, trifluoromethyl, lower alkyl, aryl, aryl-lower alkyl, cycloalokyl or cycloalkyl-lower alkyl; orR.sub.3 is the radical ##STR2## wherein R.sub.8 is hydrogen, lower alkyl, aryl, cycloalkyl, aryl-lower alkyl or cycloalkil-lower alkyl; R.sub.9 is hydroxy or acyloxy; R.sub.10 represents hydrogen or lower alkyl; or R.sub.9 and R.sub.10 together represent oxo;R.sub.4 is hydrogen, halogen, trifluoromethyl or lower alkyl;X is --NR.sub.7, S or O;W is O or S;R.sub.5 represents hydrogen, lower alkyl or aryl-lower alkyl; andR.sub.6 represents hydrogen; orR.sub.5 and R.sub.6 together represent oxo provided that X represents --NR.sub.7 ;R.sub.
    Type: Grant
    Filed: July 15, 1996
    Date of Patent: August 5, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Naokata Yokoyama, deceased, Gordon Northrop Walker, Alan Joseph Main
  • Oligomeric aliphatic HALS phosphites and HALS phosphonites as stabilizers
    Patent number: 5654430
    Abstract: The invention relates to novel oligomeric compounds of the formula I ##STR1## in which L is a group of the formula ##STR2## where the oxygen in the group L is in each case bonded to the phosphorus in the recurring structural units and the radical R.sub.2 or the carbon in the 4-position of the piperidinyl ring in the group L is in each case bonded to the oxygen in the recurring structural units; and the general symbols are as defined in claim 1, as stabilizers for organic materials against oxidative, thermal or light-induced degradation.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: August 5, 1997
    Assignee: Ciba-Geigy Corporation
    Inventor: Rita Pitteloud
  • Hydrogen peroxide oxidation of 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine
    Patent number: 5654434
    Abstract: An environmentally friendly process is described for the preparation of 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl by the direct hydrogen peroxide oxidation of 4-hydroxy-2,2,6,6-tetramethylpiperidine in the absence of any catalyst.
    Type: Grant
    Filed: November 9, 1995
    Date of Patent: August 5, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Stephen D. Pastor, Andrea R. Smith, Kurt M. Bessonen
  • Tris-phosphite ligands and their use in transitioin metal catalyzed processes
    Patent number: 5654455
    Abstract: Catalyst systems which comprise a transition metal and a tris(organophosphite) ligand are particularly effective as catalysts for hydrosilation reactions.
    Type: Grant
    Filed: December 21, 1995
    Date of Patent: August 5, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Stephen D. Pastor, Sai P. Shum
  • .delta.-amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acids
    Patent number: 5654445
    Abstract: .delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients.
    Type: Grant
    Filed: July 2, 1996
    Date of Patent: August 5, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Richard Goschke, Jurgen Klaus Maibaum, Walter Schilling, Stefan Stutz, Pascal Rigollier, Yasuchika Yamaguchi, Nissim Claude Cohen, Peter Herold
  • Process for the preparation of 2,2,6,6-tetramethyl-4-piperidyloxy-1,3,5-triazines with two or more triazine rings
    Patent number: 5652364
    Abstract: Novel process for the preparation of 2,2,6,6-tetramethyl-4-piperidyloxy-1,3,5-triazines, based on the reaction of cyanuric chloride with C.sub.1 -C.sub.4 alkanols or with sodium or potassium C.sub.1 -C.sub.4 alkoxides and subsequent reaction with 2,2,6,6-tetramethyl-4-piperidinols in the presence of a transesterification catalyst.The various reactions can be carried out in the same reactor, without isolation of the intermediates.
    Type: Grant
    Filed: August 10, 1995
    Date of Patent: July 29, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Graziano Vignali, Fabrizio Guizzardi, Graziano Zagnoni, Roberto Scrima
  • Heat-curable epoxy resin systems having a good reactivity/stability ratio
    Patent number: 5652322
    Abstract: Heat-curable epoxy resin systems comprising(a) at least one epoxy resin,(b) at least one polycarboxylic acid anhydride, and(c) 1,4-diazabicyclo(2,2,2)octane or a C.sub.1 -C.sub.4 alkyl-substituted derivative of 1,4-diazabicyclo(2,2,2)octane as curing accelerator, andwherein one portion of the curing accelerator (c) is replaced by(d) a complex of a boron halide with an amine,have good reactivity at elevated temperatures and comparatively high stability at temperatures below c. 80.degree. C.
    Type: Grant
    Filed: September 17, 1996
    Date of Patent: July 29, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Roland Moser, Daniel Bar
  • Crystal modification of a diketopyrrolopyrrole pigment
    Patent number: 5650520
    Abstract: Diketopyrrolopyrrole of the formula ##STR1## in its .beta.-modification. The new .beta.-modification is likewise suitable as a pigment for coloring high-molecular weight organic material and, in comparison to the a-modification, shows a shift in shade towards yellowish-red.
    Type: Grant
    Filed: June 22, 1995
    Date of Patent: July 22, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Zhimin Hao, Ingo Schloder, Abul Iqbal
  • Process for the photochemical and thermal stabilization of undyed and dyed polyester fibre materials
    Patent number: 5649980
    Abstract: A process is described for the photochemical and thermal stabilisation of undyed and dyed polyester fibre materials, which comprises treating said materials with a compound of formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently of the other C.sub.1 -C.sub.12 alkyl. Dyeings and prints of superior lightfastness and sublimation fastness on polyester and cellulose acetate are obtained by this process.
    Type: Grant
    Filed: October 2, 1995
    Date of Patent: July 22, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Dieter Reinehr, Gerhard Reinert, Manfred Rembold
  • Process for the preparation of stabilized olefin polymers
    Patent number: 5650464
    Abstract: The invention relates to a process for the preparation of olefin polymers by polymerization using a transition metal catalyst with the addition of an aminoalkyl-1,1'-biphenyl-2,2'-diylphosphite or aminoalkyl-2,2'-alkylidene-bis(phenyl)phosphite, in conjunction with optional further modifiers. The polymers obtainable in this manner have excellent long-term stability.
    Type: Grant
    Filed: October 26, 1995
    Date of Patent: July 22, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Martin Brunner, Bruno Rotzinger, Thomas Schmutz, Werner Stauffer
  • Azo dyes, processes for their preparation and their use
    Patent number: 5650497
    Abstract: Azo dyes of the formula ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 independently of one another are hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or halogen,R.sub.6 is hydrogen or C.sub.1 -C.sub.4 Alkyl,X is --C.sub.1 -C.sub.4 alkylene-O--C.sub.1 -C.sub.4 alkyl andY is hydrogen; unsubstituted or hydroxy- or C.sub.1 -C.sub.4 alkoxy-substituted C.sub.1 -C.sub.8 alkyl, C.sub.2 -C.sub.4 -alkonoyl or C.sub.1 -C.sub.4 alkoxycarbonyl; a radical of the formula --CH.sub.2 --CH.dbd.CH.sub.2 ;C.sub.1 -C.sub.4 alkylsulfonyl; or unsubstituted or C.sub.1 -C.sub.4 alkyl-, C.sub.1 -C.sub.4 alkoxy- or halogen-substituted phenylsulfonyl, produce dyeings with good fastness properties on fibre materials containing nitrogen or containing hydroxyl groups.
    Type: Grant
    Filed: July 15, 1996
    Date of Patent: July 22, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Jean-Marie Adam, Peter Sutter
  • Process for the preparation of 2,3-difluoro-5-halopyridines
    Patent number: 5650517
    Abstract: 2,3-Difluoro-5-halopyridines of the formula I ##STR1## wherein X is Cl or Br are prepared by a process which comprises reacting a starting 2,3,5-trihalopyridine of the formula II ##STR2## wherein each X is individually Br or Cl and Y is F, Cl or Br with an effective amount of potassium fluoride in the presence of a mixture of sulfolane and a tetralkylurea and/or a dialkyl-alkyleneurea as diluent, at an effective temperature up to the boiling point of the diluent, optionally in the presence of a phase-transfer catalyst such as a crown ether or polyglycol ether. The compounds are useful as intermediates to prepare herbicides.
    Type: Grant
    Filed: November 1, 1994
    Date of Patent: July 22, 1997
    Assignee: Ciba-Geigy Corporation
    Inventor: Balakrishnan Venugopal