Patents Assigned to Cipla Limited
  • Low Dose Pharmaceutical Composition Comprising Zanamivir
    Publication number: 20130251790
    Abstract: The present invention provides a pharmaceutical composition comprising a low dose of zanamivir and a process for preparing the pharmaceutical composition comprising a low dose of zanamivir. The pharmaceutical composition comprising a low dose zanamivir may be used in the treatment and/or prophylaxis of influenza. The present invention also provides a method of treatment and/or prophylaxis of influenza which comprises administering a dry powder inhaler composition comprising a low dose zanamivir. The pharmaceutical composition of the present invention comprises zanamivir and one or more pharmaceutically acceptable excipients, wherein the total daily dose of the zanamivir is less than 10 mg, preferably for administration at least once a day, and preferably wherein the composition delivers from 3 mg to 8 mg of zanamivir per administered dose.
    Type: Application
    Filed: September 26, 2011
    Publication date: September 26, 2013
    Applicant: CIPLA LIMITED
    Inventors: Geena Malhotra, Shrinivas Madhukar Purandare
  • Dry powder inhaler
    Patent number: 8522775
    Abstract: An inhaler (1) device for inhalation of a medicament from a pierceable capsule (10) comprises a housing (2) for receiving a medicament, capsule, closure means (3) for closing the housing, said closure means being moveable relative to the housing; piercing means (7) suitable for piercing a medicament capsule; wherein movement of the closure means relative to the housing causes movement of the piercing means, and wherein the device comprises an air inlet (71) and an air outlet (72) defining an inhalation passage therebetween, the passage comprising one or more vents (70).
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: September 3, 2013
    Assignee: CIPLA Limited
    Inventors: Geena Malhotra, Amar Lulla
  • Crystalline form of tenofovir disoproxil and a process for its preparation
    Patent number: 8519126
    Abstract: Crystalline Form C of tenofovir disoproxil, salts thereof and a process for its preparation. The process involves adding a solution comprising tenofovir disoproxil and an organic solvent to salt-saturated water, whereby the crystalline Form C of tenofovir disoproxil precipitates. The crystalline Form C of tenofovir disoproxil may be converted to a salt thereof. There is also provided a process for purifying a crude product comprising tenofovir monoisoproxil and tenofovir disoproxil.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: August 27, 2013
    Assignee: Cipla Limited
    Inventors: Manjinder Singh Phull, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao
  • Topical Foam Composition
    Publication number: 20130202654
    Abstract: A topical foam pharmaceutical composition for rectal administration comprising rifaximin in the form of nanosized particles is described. Also described is a method of making the composition and the use of the composition to as a medicament.
    Type: Application
    Filed: November 23, 2010
    Publication date: August 8, 2013
    Applicant: CIPLA LIMITED
    Inventors: Amar Lulla, Geena Malhotra, Shrinivas Madhukar Purandare
  • Method of synthesis of Bosentan, its polymorphic forms and its salts
    Patent number: 8481730
    Abstract: The present invention relates to alkaline earth metal salts of bosentan, anyhdrous bosentan, polymorphic forms thereof, amorphous bosentan and processes for preparing them. The present invention further relates to a process for the preparation of bosentan and its pharmaceutically acceptable salts.
    Type: Grant
    Filed: January 2, 2009
    Date of Patent: July 9, 2013
    Assignee: CIPLA Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Ashwini Amol Sawant
  • Process for the Preparation of Nateglinide
    Publication number: 20130165686
    Abstract: The present invention relates to a process for the preparation of substantially pure nateglinide of formula (I), substantially free from the cis-isomer and L-enantiomer and preparation of enantiomerically pure nateglinide form B, directly from the hydrolysis of a (?)-N-(trans-4-isopropylcyclohexyl-1-carbonyl)-D-phenylalanine alkyl ester in a ketonic solvent or water or mixture thereof.
    Type: Application
    Filed: June 14, 2011
    Publication date: June 27, 2013
    Applicant: CIPLA LIMITED
    Inventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Dilip Ramdas Birari
  • Pharmaceutical Aerosol Composition
    Publication number: 20130160761
    Abstract: A pharmaceutical aerosol composition comprising at least one hydrofluoroalkane propellant; at least one active agent complexed with an adjuvant; and, optionally, at least one pharmaceutically acceptable excipient.
    Type: Application
    Filed: November 27, 2012
    Publication date: June 27, 2013
    Applicant: CIPLA LIMITED
    Inventors: CIPLA LIMITED, Mustafa Khwaja Hamieel
  • Valve for an aerosol device
    Patent number: 8464914
    Abstract: A valve for an aerosol device includes a valve assembly receivable in an opening provided in a container of the aerosol device to close the opening and includes a seal between the valve assembly and the container.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: June 18, 2013
    Assignee: CIPLA Limited
    Inventors: Amar Lulla, Xerxes Rao
  • Process for the Preparation of Esomeprazole Magnesium Dihydrate
    Publication number: 20130150587
    Abstract: A process for preparing Form A of (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole magnesium dihydrate, processes for preparing various intermediates useful in the preparation of Form A of (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole magnesium dihydrate and a novel polymorphic Form II of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]thio]-1H-benzimidazole.
    Type: Application
    Filed: February 5, 2013
    Publication date: June 13, 2013
    Applicant: CIPLA LIMITED
    Inventor: CIPLA LIMITED
  • Salts and Polymorphs of Dexrabeprazole
    Publication number: 20130150588
    Abstract: The present invention provides dexrabeprazole magnesium hydrate and a process for its preparation. The present invention also provides a magnesium, calcium or potassium salt of dexrabeprazole, optionally in amorphous form, and processes for its preparation.
    Type: Application
    Filed: June 24, 2011
    Publication date: June 13, 2013
    Applicant: CIPLA LIMITED
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Dilip Ramdas Birari
  • Process for the synthesis of propargylated aminoindan derivatives
    Patent number: 8461388
    Abstract: A process for preparing a compound of formula (V) or its enantiomer, which comprises: (a) reacting racemic aminoindan of formula (II) or its enantiomer with allylhalide in presence of a base and an organic solvent at a temperature ranging from 25 C to the reflux temperature of the solvent to give compound of formula (III); Where R is H or (b) reacting the compound (III) with halogenating agent in a suitable organic solvent to give a dihalo compound of formula (IV). (c) treating the dihalo compound (IV) with a suitable base to give compound (V).
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: June 11, 2013
    Assignee: CIPLA Limited
    Inventors: Manjinder Singh Phull, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Process for resolving zopiclone
    Patent number: 8461334
    Abstract: The present invention provides a process for the preparation of the dextrorotatory isomer of zopiclone (eszopiclone). The present invention also provides eszopiclone di-p-anisolyl-L-tartrate and eszopiclone diacetyl-L-tartrate, which are useful as intermediates in a process for preparing eszopiclone.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: June 11, 2013
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Maruti Ganpati Ghagare, Sunilkumar Parasnath Saroj
  • Process for the preparation of a RAF kinase inhibitor and intermediates for use in the process
    Patent number: 8445687
    Abstract: There is provided a process for preparing sorafenib or a salt thereof comprising the use of a compound of formula (A) wherein R? is selected from the group consisting of hydrogen, —C(O)OA, —C(O)CX3, —C(O)NH2, —C(O)—NHOH or There is also provided intermediate compounds of general formula (A), N-methyl-4-(4-ureidophenoxy)picolinamide, 4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate derivative and N-methyl-4-(4-(2,2,2-trihaloacetamido)phenoxy)picolinamide, processes for their preparation and their use in the preparation of sorafenib.
    Type: Grant
    Filed: September 10, 2008
    Date of Patent: May 21, 2013
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Maruti Ghagare, Sandip Chikhalikar
  • Process for the preparation of doxazosin and salts thereof
    Patent number: 8426590
    Abstract: The present invention relates to a process for the preparation of doxazosin or salts thereof.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: April 23, 2013
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Dilip Ramdas Birari
  • Pharmaceutical Combinations
    Publication number: 20130074834
    Abstract: A pharmaceutical combination comprising (a) a combination of two or more bronchodilators; or (b) a combination of at least one bronchodilator in combination with at least one corticosteroid.
    Type: Application
    Filed: November 21, 2012
    Publication date: March 28, 2013
    Applicant: CIPLA LIMITED
    Inventor: Cipla Limited
  • Process for the preparation of esomeprazole magnesium dihydrate
    Patent number: 8394963
    Abstract: A process for preparing Form A of (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl) -methyl]sulfinyl]-1H-benzimidazole magnesium dihydrate, processes for preparing various intermediates useful in the preparation of Form A of (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole magnesium dihydrate and a novel polymorphic Form II of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]thio]-1H-benzimidazole.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: March 12, 2013
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Gopalakrishna Sumana Bangalore
  • Crystalline polymorph of doxazosin mesylate (form IV) and process for preparation thereof
    Patent number: 8383627
    Abstract: Crystalline Form IV of doxazosin mesylate, a process for its preparation and uses thereof.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: February 26, 2013
    Assignee: CIPLA Limited
    Inventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Manish Gopaldas Gangrade, Shrikant Suresh Mudgal
  • Darunavir Polymorph and Process for Preparation Thereof
    Publication number: 20130029945
    Abstract: There is disclosed crystalline darunavir hydrate substantially free of any non-aqueous solvent.
    Type: Application
    Filed: October 6, 2010
    Publication date: January 31, 2013
    Applicant: CIPLA LIMITED
    Inventors: Manjinder Singh Phull, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Combination of Azelastine and Mometasone for Nasal Administration
    Publication number: 20130029952
    Abstract: A pharmaceutical product or formulation, which comprises azelastine or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof, and a steroid, or a pharmaceutical acceptable salt, solvate or physiologically functional derivative thereof, preferably the product or formulation being in a form suitable for nasal or ocular administration.
    Type: Application
    Filed: October 3, 2012
    Publication date: January 31, 2013
    Applicant: CIPLA LIMITED
    Inventor: CIPLA Limited
  • Process for preparing isomers of salbutamol
    Patent number: RE43984
    Abstract: A process for making optically Optically pure (R) and (S) salbutamol comprises obtaining the (R) or (S) isomer of either salbutamol or a salbutamol precursor in substantially optically pure form is obtained by resolving a racemic or optically impure mixture of enantiomers of salbutamol or of said a salbutamol precursor with either (L) or (D) tartaric acid, and where necessary converting said isomer of said precursor into either (R) or (S) salbutamol respectively; then optionally converting said optically pure (R) and/or (S) salbutamol into a pharmaceutically acceptable salt.
    Type: Grant
    Filed: December 10, 2001
    Date of Patent: February 5, 2013
    Assignee: Cipla Limited
    Inventors: Yusuf Khwaja Hamied, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao