Patents Assigned to Cipla Limited
  • Process for the Preparation of O-Desmethyl Venlafaxine and Intermediate for Use Therein
    Publication number: 20120157544
    Abstract: The present invention relates to a compound of formula A, wherein R is alkyl. Compound A may be used as an intermediate in the preparation of O-desmethyl venlafaxine or a salt thereof, and the present invention provides such a preparation, as well as a process for preparing the compound of formula A.
    Type: Application
    Filed: July 14, 2010
    Publication date: June 21, 2012
    Applicant: CIPLA LIMITED
    Inventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Manohar Raghunath Surve
  • Process for the synthesis of moxifloxacin hydrochloride
    Patent number: 8198451
    Abstract: A new polymorph of moxifloxacin hydrochloride is described, together with a method for making the polymorph.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: June 12, 2012
    Assignee: CIPLA Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Ravikumar Puppala, Manish Gangrade, Shashirekha Kanathala
  • Process for the preparation of rufinamide
    Patent number: 8183269
    Abstract: The present invention relates to a process for the preparation of rufinamide of formula I, which process comprises: (i) reacting a 2,6-difluorobenzylhalide of formula II, wherein X is chloride, bromide or iodide, with an azide to obtain 2-(azidomethyl)-1,3-difluorobenzene of formula III; (ii) reacting 2-(azidomethyl)-1,3-difluorobenzene of formula III with methyl propiolate to obtain methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate of formula IV; and (iii) reacting methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate of formula IV with ammonia to obtain rufinamide of formula I.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: May 22, 2012
    Assignee: CIPLA Limited
    Inventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Dilip Ramdas Birari
  • Rifaximin
    Publication number: 20120116071
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Application
    Filed: January 13, 2012
    Publication date: May 10, 2012
    Applicant: CIPLA LIMITED
    Inventors: Dharmaraj Ramachandra RAO, Rajendra Narayanrao KANKAN, Manjinder Singh PHULL, Maruti Ghagare
  • Combination of azelastine and steroids
    Patent number: 8168620
    Abstract: A pharmaceutical product or formulation, which comprises azelastine or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof, and a steroid, or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof, preferably the product or formulation being in a form suitable for nasal or ocular administration.
    Type: Grant
    Filed: June 13, 2003
    Date of Patent: May 1, 2012
    Assignee: CIPLA Limited
    Inventors: Amar Lulla, Geena Malhotra
  • Combination of azelastine and steroids
    Patent number: 8163723
    Abstract: A pharmaceutical product or formulation, which comprises azelastine or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof, and a steroid, or a pharmaceutical acceptable salt, solvate or physiologically functional derivative thereof, preferably the product or formulation being in a form suitable for nasal or ocular administration.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: April 24, 2012
    Assignee: CIPLA Limited
    Inventors: Amar Lulla, Geena Malhotra
  • Processes for the preparation of ciclesonide and its crystal modification
    Patent number: 8158780
    Abstract: Improved processes for the synthesis of ciclesonide, chemically termed as [11?,16?(R)]-16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione and its crystal modification.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: April 17, 2012
    Assignee: Cipla Limited
    Inventors: Manjinder Singh Phull, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Process for the preparation of ethyl-N-(2,3-dichloro-6-nitrobenzyl)glycine hydrochloride
    Patent number: 8133996
    Abstract: The invention relates to a process for the preparation of anagrelide, and for the preparation of intermediates for use in preparing anagrelide. The invention also relates to the intermediates per se, in particular compounds of Formula (V): where R constitutes a suitable leaving group, which may not be hydrogen. The R group may be selected from: (i) —SiR13, (ii) —CH2Ar, (iii) —COOR2, and (iv) sulfonates such as —SO2R3.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: March 13, 2012
    Assignee: CIPLA Limited
    Inventors: Srinivas Laxminarayan Pathi, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao
  • Process for the Preparation of Cinacalcet and Salts Thereof, and Intermediates for Use in the Process
    Publication number: 20120053362
    Abstract: There is provided a process for preparing a salt of the (R)- or (S)-isomer of 1-naphthylethylamine with mandelic acid or a derivative thereof, the process comprising reacting racemic 1-naphthylethylamine with mandelic acid or a derivative thereof to obtain the (R)- or (S)-isomer of 1-naphthylethylamine salt (III) with the acid. The salts also form an aspect of the present invention. There is also provided a salt of the (R)- or (S)-isomer of 1-naphthylethylamine with mandelic acid or a derivative thereof. There is also provided a process for preparing cinacalcet (I) or a salt thereof, the process comprising reacting an ester (II) with (R)-1-naphthylethylamine or a salt of (R)-1-naphthylethylamine and mandelic acid or a derivative thereof, to obtain cinacalcet, and optionally converting the cincalcet to a salt thereof.
    Type: Application
    Filed: March 4, 2010
    Publication date: March 1, 2012
    Applicant: CIPLA LIMITED
    Inventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Dilip Ramdas Birari
  • Process for the Preparation of Doxazosin and Salts Thereof
    Publication number: 20120041199
    Abstract: The present invention relates to a process for the preparation of doxazosin or salts thereof.
    Type: Application
    Filed: March 23, 2010
    Publication date: February 16, 2012
    Applicant: CIPLA LIMITED
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Dilip Ramdas Birari
  • Process for preparing trityl olmesartan medoxomil and olmesartan medoxomil
    Patent number: 8076492
    Abstract: A process for the preparation of trityl olmesartan comprising (a) condensing 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazol-5-carboxylic acid alkyl ester with trityl biphenyl bromide in the presence of a polar aprotic solvent and a base selected from the group consisting of alkali metal carbonates, alkali metal hydroxides, alkali metal alkoxides, and tertiary amines to obtain a compound of formula V, b) deesterifying the compound of formula (V) with a base; and c) reacting the product of step (b) with 4-halomethyl-5-methyl-2-oxo-1,3-dioxolene of formula (IV), wherein X is halogen selected from F or Cl or Br or I, to obtain trityl olmesartan medoxomil of formula. The trityl olmesartan medoxomil may be deprotected to produce olmesartan medoxomil.
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: December 13, 2011
    Assignee: Cipla Limited
    Inventors: Srinivas Laxminarayan Pathi, Ravikumar Puppala, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao
  • Rifaximin Complexes
    Publication number: 20110262378
    Abstract: There is provided a complex comprising rifaximin and a complexing agent, wherein the complexing agent is a polyvinyl pyrrolidone (PVP) or a cyclodextrin. There is also provided a process for preparing the complex, a pharmaceutical composition including the complex, and therapeutic uses of the complex.
    Type: Application
    Filed: December 9, 2009
    Publication date: October 27, 2011
    Applicant: CIPLA LIMITED
    Inventors: Maruti Ganpati Ghagare, Sunilkumar Parasnath Saroj, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Process for Preparing Zanamivir and Intermediates for Use in the Process
    Publication number: 20110257418
    Abstract: The present invention provides a process for preparing methyl 5-acetamido-4-amino-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (V), which process comprises reducing methyl 5-acetamido-4-azido-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (IV) in the presence of a reducing agent selected from the group consisting of lithium aluminium hydride, sodium borohydride, zinc/ammonium chloride, zinc-ferric chloride and ferric chloride/sodium iodide. The present invention also provides compounds of formula (VIII) and (IX) which may be used in the synthesis of zanamivir. The present invention also provides processes for preparing compounds (VIII) and (IX) and processes involving their use, including in the synthesis of zanamivir.
    Type: Application
    Filed: November 24, 2009
    Publication date: October 20, 2011
    Applicant: CIPLA LIMITED
    Inventors: Manjinder Singh Phull, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Ashwini Amol Sawant, Sanoj Thoppil
  • Tiotropium Bromide Having a Low Degree of Crystallinity
    Publication number: 20110250149
    Abstract: The present invention provides tiotropium bromide having a low degree of crystallinity. The present invention also provides a complex of tiotropium bromide and polyvinylpyrrolidone, processes for preparing it and pharmaceutical formulations including it.
    Type: Application
    Filed: October 29, 2009
    Publication date: October 13, 2011
    Applicant: CIPLA LIMITED
    Inventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Maruti Ghagare
  • Process for Resolving Zopiclone
    Publication number: 20110245499
    Abstract: The present invention provides a process for the preparation of the dextrorotatory isomer of zopiclone (eszopiclone). The present invention also provides eszopiclone di-p-anisolyl-L-tartrate and eszopiclone diacetyl-L-tartrate, which are useful as intermediates in a process for preparing eszopiclone.
    Type: Application
    Filed: November 6, 2009
    Publication date: October 6, 2011
    Applicant: CIPLA LIMITED
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Maruti Ganpati Ghagare, Sunilkumar Parasnath Saroj
  • Process and intermediate for preparation of donepezil
    Patent number: 8030491
    Abstract: The invention relates to new compounds of formula (III): wherein R is a C1-C4 linear or branched alkyl group. The invention also relates to new compounds of formula (IV) wherein M is a metal. The invention also relates to methods of making compounds of formulas (III) and (IV) and to methods of making donepezil and pharmaceutically acceptable salts thereof, such as donepezil hydrochloride, using the compounds.
    Type: Grant
    Filed: January 3, 2007
    Date of Patent: October 4, 2011
    Assignee: Cipla Limited
    Inventors: Srinivas Laxminarayan Pathi, Vinod Acharya, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Cartridge for a multidose inhaler
    Patent number: D646383
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: October 4, 2011
    Assignee: CIPLA Limited
    Inventors: Amar Lulla, Xerxes Rao
  • Inhaler device
    Patent number: D646780
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: October 11, 2011
    Assignee: Cipla Limited
    Inventors: Amar Lulla, Geena Malhotra
  • Cam strip
    Patent number: D656605
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: March 27, 2012
    Assignee: Cipla Limited
    Inventors: Amar Lulla, Xerxes Rao
  • Dose counter
    Patent number: D657043
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: April 3, 2012
    Assignee: cipla limited
    Inventors: Amar Lulla, Xerxes Rao