Patents Assigned to CIRCUIT THERAPEUTICS, INC.
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Patent number: 10213617Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: GrantFiled: July 28, 2014Date of Patent: February 26, 2019Assignee: Circuit Therapeutics, Inc.Inventors: David C. Lundmark, Karl Deisseroth, Fred Moll, Dan Andersen, Alexander K. Arrow
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Publication number: 20190038908Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: October 19, 2018Publication date: February 7, 2019Applicant: Circuit Therapeutics, Inc.Inventors: David C. Lundmark, Karl Deisseroth, Fred Moll, Dan Andersen, Alexander K. Arrow
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Patent number: 10188870Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: GrantFiled: July 31, 2014Date of Patent: January 29, 2019Assignee: Circuit Therapeutics, Inc.Inventors: David C. Lundmark, Fred Moll, Alexander K. Arrow
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Publication number: 20190015677Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: September 18, 2018Publication date: January 17, 2019Applicant: Circuit Therapeutics, Inc.Inventors: Greg Stahler, Dan Andersen, Joyce Huang, David C. Lundmark, David Moore
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Publication number: 20180361169Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: March 5, 2018Publication date: December 20, 2018Applicant: Circuit Therapeutics, Inc.Inventors: Scott Delp, Karl Deisseroth, Dan Andersen
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Publication number: 20180345033Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: June 13, 2018Publication date: December 6, 2018Applicant: Circuit Therapeutics, Inc.Inventors: David C. Lundmark, Fred Moll, Alexander K. Arrow
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Publication number: 20180311508Abstract: One embodment is directed to a probe for illuminating a target tissue of a patient, comprising: a plurality of optical fibers; a probe body portion having proximal and distal ends, the probe body portion being moveably coupled to the plurality of fibers and configured to at least partially encapsulate the plurality of fibers; a distal end portion coupled to the distal end of the probe body portion, the distal end portion comprising at least one guiding feature configured to redirect a path of at least one of the optical fibers comprising the plurality of optical fibers as such at least portion of one of the optical fibers is extended through and past the distal end portion by moving the plurality of fibers relative to the probe body portion. The probe further may comprise an ejector portion configured to move the plurality of fibers relative to the probe body portion.Type: ApplicationFiled: March 2, 2018Publication date: November 1, 2018Applicant: Circuit Therapeutics, Inc.Inventors: Brian Andrew Ellingwood, Brian Beckey, Ethan Berry, Bruce Modesitt, Dan Andersen, David Angeley, Michael Drews, T.D. Barbara Nguyen-Vu, Laura Leung, Andrei T. Popescu
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Patent number: 10105550Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: GrantFiled: July 31, 2014Date of Patent: October 23, 2018Assignee: Circuit Therapeutics, Inc.Inventors: Greg Stahler, Ananya Mitra, Joyce Huang, Dan Andersen, Alexander Arrow, David Moore
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Publication number: 20180280716Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: March 28, 2018Publication date: October 4, 2018Applicant: Circuit Therapeutics, Inc.Inventors: Greg Stahler, Ananya Mitra, Joyce Huang, Dan Andersen, Alexander K. Arrow, David Moore
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Publication number: 20180214711Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: March 27, 2018Publication date: August 2, 2018Applicant: Circuit Therapeutics, Inc.Inventors: Greg Stahler, Ananya Mitra, Joyce Huang, Dan Andersen, Alexander K. Arrow, David Moore
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Patent number: 10022552Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: GrantFiled: July 31, 2014Date of Patent: July 17, 2018Assignee: Circuit Therapeutics, Inc.Inventors: Greg Stahler, Ananya Mitra, Joyce Huang, Dan Andersen, Alexander K. Arrow, David Moore
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Patent number: 10022553Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: GrantFiled: July 31, 2014Date of Patent: July 17, 2018Assignee: Circuit Therapeutics, Inc.Inventors: David C. Lundmark, Fred Moll, Alexander K. Arrow
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Publication number: 20180156994Abstract: Configurations are described for creating and using separable optical feedthroughs. These are especially useful in their at least semi-hermetic form when integrated with implantable photomedical devices. One embodiment is directed to a system for operatively coupling an optical output from a light source positioned inside of a sealed housing to an external optical fiber, comprising: a first optical fiber disposed adjacent to the light source and configured to receive at least a portion of the optical output; a second optical fiber operatively coupled to the first optical fiber and configured to capture at least a portion of an output from the first optical fiber; a primary seal operatively coupled to the housing between the light source and the second optical fiber that is at least partially transparent; and a secondary seal positioned between the second optical fiber and the environment.Type: ApplicationFiled: January 30, 2018Publication date: June 7, 2018Applicant: Circuit Therapeutics, Inc.Inventors: Greg Stahler, David Angeley, Brian Andrew Ellingwood
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Publication number: 20180140862Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: December 21, 2017Publication date: May 24, 2018Applicant: Circuit Therapeutics, Inc.Inventors: Greg Stahler, Dan Andersen, Joyce Huang, David C. Lundmark, David Moore
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Publication number: 20180133501Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: November 3, 2017Publication date: May 17, 2018Applicant: Circuit Therapeutics, Inc.Inventors: Greg Stahler, Dan Andersen, Joyce Huang, David C. Lundmark, David Moore
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Publication number: 20180056085Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: October 6, 2017Publication date: March 1, 2018Applicant: Circuit Therapeutics, Inc.Inventors: David C. Lundmark, Karl Deisseroth, Fred Moll, Dan Andersen, Alexander K. Arrow
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Publication number: 20180028832Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: October 10, 2017Publication date: February 1, 2018Applicant: Circuit Therapeutics, Inc.Inventors: David C. Lundmark, Karl Deisseroth, Fred Moll, Dan Andersen, Alexander K. Arrow
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Patent number: 9821170Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: GrantFiled: July 28, 2014Date of Patent: November 21, 2017Assignee: Circuit Therapeutics, Inc.Inventors: David C. Lundmark, Karl Deisseroth, Fred Moll, Dan Andersen, Alexander K. Arrow
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Patent number: 9814900Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: GrantFiled: July 28, 2014Date of Patent: November 14, 2017Assignee: Circuit Therapeutics, Inc.Inventors: David C. Lundmark, Karl Deisseroth, Fred Moll, Dan Andersen, Alexander K. Arrow
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Publication number: 20170319714Abstract: One embodiment is directed to a system for altering the function of a sensory unit that innervates a targeted tissue region in an animal, the sensory unit being configured to express a light-responsive protein, comprising a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure; and a light source configured to provide light to the light delivery element; wherein the targeted tissue structure is illuminated transcutaneously with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light-responsive protein to the radiation.Type: ApplicationFiled: February 8, 2017Publication date: November 9, 2017Applicant: Circuit Therapeutics, Inc.Inventors: Christopher L. Towne, Dan Andersen