Patents Assigned to CIRCUIT THERAPEUTICS, INC.
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Publication number: 20170319715Abstract: One embodiment is directed to a method for altering the function of the sensory unit that innervates a targeted tissue region in a mammal comprising the steps of identifying the targeted tissue region; cutaneously administering into the targeted tissue region an adeno-associated virus wherein the viral genome encodes at least one exogenous protein; expressing the exogenous protein in the targeted sensory unit; and altering the function of the targeted sensory unit to treat or restore the sensory response because of the exogenous protein expression while not impacting the function of nearby sensory units.Type: ApplicationFiled: February 8, 2017Publication date: November 9, 2017Applicant: Circuit Therapeutics, Inc.Inventors: Christopher L. Towne, Dan Andersen
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Publication number: 20170239488Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: March 28, 2017Publication date: August 24, 2017Applicant: Circuit Therapeutics, Inc.Inventors: Greg Stahler, Dan Andersen, Joyce Huang, David C. Lundmark, David Moore
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Publication number: 20170225008Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: March 29, 2017Publication date: August 10, 2017Applicant: Circuit Therapeutics, Inc.Inventors: Greg Stahler, Dan Andersen, Joyce Huang, David C. Lundmark, David Moore
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Publication number: 20170225009Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: April 24, 2017Publication date: August 10, 2017Applicant: Circuit Therapeutics, Inc.Inventors: Scott Delp, Karl Deisseroth, Dan Andersen
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Publication number: 20170225013Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: April 3, 2017Publication date: August 10, 2017Applicant: Circuit Therapeutics, Inc.Inventors: Scott Delp, Karl Deisseroth, Dan Andersen
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Publication number: 20170205595Abstract: Configurations are described for creating and using separable optical feedthroughs. These are especially useful in their at least semi-hermetic form when integrated with implantable photomedical devices. One embodiment is directed to a system for operatively coupling an optical output from a light source positioned inside of a sealed housing to an external optical fiber, comprising: a first optical fiber disposed adjacent to the light source and configured to receive at least a portion of the optical output; a second optical fiber operatively coupled to the first optical fiber and configured to capture at least a portion of an output from the first optical fiber; a primary seal operatively coupled to the housing between the light source and the second optical fiber that is at least partially transparent; and a secondary seal positioned between the second optical fiber and the environment.Type: ApplicationFiled: April 3, 2017Publication date: July 20, 2017Applicant: Circuit Therapeutics, Inc.Inventors: Greg Stahler, David Angeley, Brian Andrew Ellingwood
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Publication number: 20170182191Abstract: One embodiment is directed to a method for controllably managing pain in the afferent nervous system of a patient having a targeted tissue structure that has been genetically modified to have light sensitive protein, comprising: providing a light delivery element configured to direct radiation to at least a portion of a targeted tissue structure, a light source configured to provide light to the light delivery element, and a controller operatively coupled to light source, wherein the targeted tissue structure comprises a sensory neuron of the patient; and automatically operating the controller to illuminate the targeted tissue structure with radiation such that a membrane potential of cells comprising the targeted tissue structure is modulated at least in part due to exposure of the light sensitive protein to the radiation.Type: ApplicationFiled: July 29, 2015Publication date: June 29, 2017Applicant: Circuit Therapeutics, Inc.Inventors: Christopher L. Towne, Michael Kaplitt, Scott Delp, Karl Deisseroth, David Angeley, Greg Stahler, Dan Andersen, David C. Lundmark
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Patent number: 9662508Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: GrantFiled: July 29, 2014Date of Patent: May 30, 2017Assignee: Circuit Therapeutics, Inc.Inventors: Scott Delp, Karl Deisseroth, Dan Andersen
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Patent number: 9649503Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: GrantFiled: July 28, 2014Date of Patent: May 16, 2017Assignee: Circuit Therapeutic, Inc.Inventors: Scott Delp, Karl Deisseroth, Dan Andersen
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Patent number: 9645332Abstract: Configurations are described for creating and using separable optical feedthroughs. These are especially useful in their at least semi-hermetic form when integrated with implantable photomedical devices. One embodiment is directed to a system for operatively coupling an optical output from a light source positioned inside of a sealed housing to an external optical fiber, comprising: a first optical fiber disposed adjacent to the light source and configured to receive at least a portion of the optical output; a second optical fiber operatively coupled to the first optical fiber and configured to capture at least a portion of an output from the first optical fiber; a primary seal operatively coupled to the housing between the light source and the second optical fiber that is at least partially transparent; and a secondary seal positioned between the second optical fiber and the environment.Type: GrantFiled: July 29, 2015Date of Patent: May 9, 2017Assignee: Circuit Therapeutics, Inc.Inventors: Greg Stahler, David Angeley, Brian Andrew Ellin
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Publication number: 20160096035Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: July 28, 2014Publication date: April 7, 2016Applicant: Circuit Therapeutics, Inc.Inventors: David C. Lundmark, Karl Deisseroth, Fred Moll, Dan Andersen, Alexander Arrow
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Publication number: 20160096034Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: July 28, 2014Publication date: April 7, 2016Applicant: Circuit Therapeutics, Inc.Inventors: David C. Lundmark, Karl Deisseroth, Fred Moll, Dan Andersen, Alexander Arrow
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Publication number: 20160091680Abstract: Configurations are described for creating and using separable optical feedthroughs. These are especially useful in their at least semi-hermetic form when integrated with implantable photomedical devices. One embodiment is directed to a system for operatively coupling an optical output from a light source positioned inside of a sealed housing to an external optical fiber, comprising: a first optical fiber disposed adjacent to the light source and configured to receive at least a portion of the optical output; a second optical fiber operatively coupled to the first optical fiber and configured to capture at least a portion of an output from the first optical fiber; a primary seal operatively coupled to the housing between the light source and the second optical fiber that is at least partially transparent; and a secondary seal positioned between the second optical fiber and the environment.Type: ApplicationFiled: July 29, 2015Publication date: March 31, 2016Applicant: Circuit Therapeutics, Inc.Inventors: Greg Stahler, David Angeley, Brian Andrew Ellin
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Publication number: 20160082279Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: July 28, 2014Publication date: March 24, 2016Applicant: Circuit Therapeutics, Inc.Inventors: Dan Andersen, Joyce Huang, Greg Stahler, David C. Lundmark
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Publication number: 20160059030Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: July 31, 2014Publication date: March 3, 2016Applicant: Circuit Therapeutics, Inc.Inventors: Joyce Huang, Dan Andersen, David Angeley
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Publication number: 20160051830Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: July 31, 2014Publication date: February 25, 2016Applicant: Circuit Therapeutics, Inc.Inventors: Dan Andersen, Joyce Huang, Greg Stahler, David C. Lundmark, David Angeley, David Moore
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Publication number: 20160051838Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: July 31, 2014Publication date: February 25, 2016Applicant: Circuit Therapeutics, Inc.Inventors: Greg Stahler, Ananya Mitra, Joyce Huang, Dan Andersen, Alexander Arrow, David Moore
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Publication number: 20160051836Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: July 28, 2014Publication date: February 25, 2016Applicant: Circuit Therapeutics, Inc.Inventors: David C. Lundmark, Karl Deisseroth, Fred Moll, Dan Andersen, Alexander Arrow
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Publication number: 20160051828Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: July 31, 2014Publication date: February 25, 2016Applicant: Circuit Therapeutics, Inc.Inventors: Greg Stahler, Dan Andersen, Joyce Huang, David C. Lundmark, David Moore
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Publication number: 20160051831Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.Type: ApplicationFiled: July 31, 2014Publication date: February 25, 2016Applicant: Circuit Therapeutics, Inc.Inventors: David C. Lundmark, Fred Moll, Alexander Arrow