Abstract: Disclosed are human G-CSF isoforms having a modified amino acid sequence containing a glycosylation sequence Asn-X-Ser/Thr (N-X-S/T) at one or more specific amino acid positions according to the present invention, genes encoding the human G-CSF isoforms, and expression vectors carrying the genes, eukaryotic cells transformed or transfected with the expression vectors. Also, the present invention discloses a method of preparing a glycosylated human G-CSF isoform, comprising the steps of culturing the transformant or transfectant and isolating a glycosylated human G-CSF isoform from the culture supernatant or cell lysates, a human G-CSF isoform prepared by the method, and a pharmaceutical composition comprising the human G-CSF isoform.
Type:
Grant
Filed:
August 29, 2003
Date of Patent:
March 18, 2008
Assignee:
CJ Corp
Inventors:
Eun Jung Lee, Hyun Seok Kim, Jong Sang Chung, Ki Wan Kim, Yeon Hyang Kim, Hyune Soo Lee, Hyung Kon Koh, Myung Suk Oh
Abstract: The present invention relates to a novel diaryl 1,2,4-triazole derivative of the following formula 1 as a highly selective cyclooxygenase-2 inhibitor: Wherein, R1, R2, R3, R4, R5, W and A is as defined in this specification.
Type:
Grant
Filed:
September 12, 2005
Date of Patent:
November 14, 2006
Assignee:
CJ Corp
Inventors:
Il-hwan Cho, Jee-woong Lim, Ji-young Noh, Jong-hoon Kim, Sang-wook Park, Hyung-chul Ryu, Je-hak Kim, Jong-ho Kim, So-young Wang, Dal-hyun Kim, Chun-seon Lyu
Abstract: Disclosed are a novel organic acid salt of amlodipine, its preparation method, and a pharmaceutical composition containing as a therapeutically active ingredient the same.
Type:
Grant
Filed:
July 29, 2003
Date of Patent:
June 7, 2005
Assignee:
CJ Corp
Inventors:
Seong Hwan Cho, Yong Sik Youn, Yun Taek Jung, Choong Sil Park, Hyuk Koo Lee, Kwang Hyeg Lee, Eun Ju Jeong, Young Hoon Kim, Hae Tak Jin, Jun Hee Cheon, Sung Hak Lee, Sung Hak Jung, Dong Kwon Lim, Kyu Jeong Yeon, Yun Cheul Kim, Kyung Mi Park, Hyun Suk Kang
Abstract: Disclosed are a novel organic acid salt of amlodipine, its preparation method, and a pharmaceutical composition containing the same as a therapeutically active ingredient.
Type:
Grant
Filed:
August 19, 2003
Date of Patent:
January 25, 2005
Assignee:
CJ Corp
Inventors:
Yong Sik Youn, Seong Hwan Cho, Choong Sil Park, Yun Cheul Kim, Dong Kwon Lim, Sung Hak Jung, Sung Hak Lee, Hyun Suk Kang, Kyung Mi Park, Yun Taek Jung, Young Hoon Kim, Kyu Jeong Yeon, Myeong Yun Chae, Hae Tak Jin, Hea Ran Suh, Kwang Hyeg Lee, Hyuk Koo Lee
Abstract: Disclosed are a novel organic acid salt of amlodipine, its preparation method, and a pharmaceutical composition containing as a therapeutically active ingredient the same.
Type:
Application
Filed:
July 29, 2003
Publication date:
February 12, 2004
Applicant:
CJ Corp
Inventors:
Seong Hwan Cho, Yong Sik Youn, Yun Taek Jung, Choong Sil Park, Hyuk Koo Lee, Kwang Hyeg Lee, Eun Ju Jeong, Young Hoon Kim, Hae Tak Jin, Jun Hee Cheon, Sung Hak Lee, Sung Hak Jung, Dong Kwon Lim, Kyu Jeong Yeon, Yun Cheul Kim, Kyung Mi Park, Hyun Suk Kang
Abstract: Disclosed are a novel organic acid salt of amlodipine, its preparation method, and a pharmaceutical composition containing the same as a therapeutically active ingredient.
Type:
Application
Filed:
July 29, 2003
Publication date:
February 12, 2004
Applicant:
CJ Corp
Inventors:
Seong Hwan Cho, Yong Sik Youn, Yun Taek Jung, Choong Sil Park, Hyuk Koo Lee, Kwang Hyeg Lee, Eun Ju Jeong, Young Hoon Kim, Hae Tak Jin, Jun Hee Cheon, Sung Hak Lee, Sung Hak Jung, Dong Kwon Lim, Kyu Jeong Yeon, Yun Cheul Kim, Kyung Mi Park, Hyun Suk Kang