Abstract: A 1,2,4-triazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided: wherein, Ar represents naphthyl; 3,4-methylenedioxyphenyl: phenyl; or phenyl substituted with the group selected from C1-C6 alkyl, C1-C6 alkoxy, or halogen.

Abstract: Disclosed are a novel organic acid salt of amlodipine, its preparation method, and a pharmaceutical composition containing the same as a therapeutically active ingredient.

Abstract: A thiazolidine-4-one derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided: wherein: R1 and R2 each independently represent hydrogen, C1-C3 alkyl, halogen, methyl substituted with halogen, C1-C3 alkoxy substituted with halogen, cyano, or nitro.

Abstract: Disclosed are a novel organic acid salt of amlodipine with superb physicochemical properties, its preparation method, and a pharmaceutical composition containing the same as a therapeutically active ingredient.

Abstract: Disclosed is a toothbrush having soft and hard bristles together. The toothbrush having soft and hard bristles with 6-10 mm in tapered length and 0.01-0.08mm in diameter of end portions comprises: longer bristles(1) located at both edges; and shorter bristles(2) located at the central portion, wherein the bristles are generally in a semicircular form at their top portions when seen from a side, and a difference in length between the longer bristles(1) and the shorter bristles(2) is about 2-4mm. The toothbrush can increase brushing efficiency and effectively remove foreign matters between teeth and inside periodontal pockets.

Abstract: A 2-thioxothiazole derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided: wherein: R represents hydrogen or methyl; X represents hydrogen, methyl, halogen, nitro, or methanesulfonyl.

Abstract: The present invention relates to an isothiazole derivative of the following formula 1 or nontoxic salt thereof: 1

Abstract: Disclosed are a novel organic acid salt of amlodipine, its preparation method, and a pharmaceutical composition containing as a therapeutically active ingredient the same.

Abstract: Disclosed are a novel organic acid salt of amlodipine, its preparation method, and a pharmaceutical composition containing the same as a therapeutically active ingredient.

Abstract: A pyrazole-3-one derivative of formula 1 or a non-toxic salt thereof, a preparation method thereof, and a pharmaceutical composition containing the derivative or the salt as an active ingredient are provided: wherein: R1 and R2 each independently represent C1-C3 alkyl, aryl, or substituted aryl; R3 represents amino or methyl; R4 and R5 each independently represent hydrogen, C1-C3 alkyl, halogen, methyl substituted with halogen, C1-C3 alkoxy, cyano, or nitro; or a non-toxic salt thereof.

Abstract: The present invention relates to a processing method for preparing lovastatin and simvastatin which comprises the steps of (1) performing lactonization of mevinic acid and its homologous compounds in the presence of a mixed organic solvent without an acid catalyst through nitrogen sweep; and (2) making crystals. In the process of the present invention, lovastatin and simvastatin highly purified can be produced in a high yield and especially, heterodimers formed as a by-product can be reduced remarkably. Therefore, the processing method of the present invention can be convenient and economical.