Patents Assigned to Cleveland Biolabs, Inc.
  • Use of toll-like receptor agonist for treating cancer
    Patent number: 11628201
    Abstract: The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: April 18, 2023
    Assignee: Cleveland BioLabs, Inc.
    Inventors: Anatoli Gleiberman, Lyudmila Burdelya, Andrei Gudkov
  • Methods and compositions for the treatment of radiation-related disorders
    Patent number: 10857200
    Abstract: This invention relates, in part, to methods and compositions that are useful for the treatment and/or prevention of various disorders, including radiation-related disorders, such as acute radiation syndrome.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: December 8, 2020
    Assignee: Cleveland BioLabs, Inc.
    Inventors: Vadim Krivokrysenko, Elena Feinstein
  • Use of toll-like receptor agonist for treating cancer
    Patent number: 10780152
    Abstract: The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: September 22, 2020
    Assignee: Cleveland BioLabs, Inc.
    Inventors: Anatoli Gleiberman, Lyudmila Burdelya, Andrei Gudkov
  • Use of toll-like receptor agonist for treating cancer
    Patent number: 10265390
    Abstract: The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: April 23, 2019
    Assignee: CLEVELAND BIOLABS, INC.
    Inventors: Anatoli Gleiberman, Lyudmila Burdelya, Andrei Gudkov
  • Methods and compositions for the treatment of radiation-related disorders
    Patent number: 10183056
    Abstract: This invention relates, in part, to methods and compositions that are useful for the treatment and/or prevention of various disorders, including radiation-related disorders, such as acute radiation syndrome.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: January 22, 2019
    Assignee: CLEVELAND BIOLABS, INC.
    Inventors: Vadim Krivokrysenko, Elena Feinstein
  • FLAGELLIN COMPOSITIONS AND USES
    Publication number: 20180251498
    Abstract: The present invention relates to compositions comprising improved flagellin derived constructs and methods of using the same in the treatment of various diseases.
    Type: Application
    Filed: July 29, 2015
    Publication date: September 6, 2018
    Applicant: Cleveland BioLabs, Inc.
    Inventor: Vadim METT
  • Use of toll-like receptor agonist for treating cancer
    Patent number: 10034926
    Abstract: The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: July 31, 2018
    Assignee: Cleveland BioLabs, Inc.
    Inventors: Anatoli Gleiberman, Lyudmila Burdelya, Andrei Gudkov
  • Methods of protecting against apoptosis using lipopeptides
    Patent number: 9381225
    Abstract: The use of lipopeptides comprising variable groups defined as H or optionally substituted C6-C20 aliphatic and a peptide of one of the following amino acid sequences: GEESN (SEQ ID NO: 17), QGEESNDK (SEQ ID NO: 20), and VQGEESNDK (SEQ ID NO: 21). The use of the lipopeptides for activating Toll-like receptors (TLRs) in cells is described.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: July 5, 2016
    Assignees: CLEVELAND CLINIC FOUNDATION, CLEVELAND BIOLABS, INC.
    Inventors: Alexander Shakhov, Andrei Gudkov, Elena Feinstein
  • Use of Toll-Like Receptor agonist for treating cancer
    Patent number: 9376473
    Abstract: The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist.
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: June 28, 2016
    Assignee: Cleveland BioLabs, Inc.
    Inventors: Anatoli Gleiberman, Lyudmila Burdelya, Andrei Gudkov
  • Methods for treating tourniquet-induced injuries
    Patent number: 9006180
    Abstract: The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: April 14, 2015
    Assignees: Cleveland BioLabs, Inc., Cleveland Clinic Foundation
    Inventors: Andrei Gudkov, Robert Fairchild
  • Methods of protecting against apoptosis using lipopeptides
    Patent number: 9006183
    Abstract: The use of lipopeptides as inducers of NF-?B for the protection of mammals from the effects of apoptosis is described.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: April 14, 2015
    Assignees: Cleveland Clinic Foundation, Cleveland BioLabs, Inc.
    Inventors: Alexander Shakhov, Andrei Gudkov
  • USE OF TOLL-LIKE RECEPTOR AGONIST FOR TREATING CANCER
    Publication number: 20140248260
    Abstract: The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist.
    Type: Application
    Filed: January 10, 2012
    Publication date: September 4, 2014
    Applicant: CLEVELAND BIOLABS, INC.
    Inventors: Anatoli Gleiberman, Lyudmila Burdelya, Andrei Gudkov
  • METHODS FOR TREATING REPERFUSION INJURIES
    Publication number: 20140220037
    Abstract: The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin
    Type: Application
    Filed: November 22, 2013
    Publication date: August 7, 2014
    Applicants: Cleveland Clinic Foundation, Cleveland BioLabs, Inc.
    Inventors: Andrei Gudkov, Robert Fairchild
  • METHODS FOR INCREASING AND MOBILIZING HEMATOPOIETIC STEM CELLS
    Publication number: 20140045747
    Abstract: A method is provided for increasing the number of hematopoietic stem cells in the bone marrow, increasing the mobilization of these cells to migrate from the bone marrow to the bloodstream and elsewhere, and increasing the number of differentiating hematopoietic stem cells in the bloodstream.
    Type: Application
    Filed: July 2, 2013
    Publication date: February 13, 2014
    Applicant: Cleveland Biolabs, Inc.
    Inventors: Alexander Shakhov, Evguenia Strom
  • Methods for treating reperfusion injuries using flagellin
    Patent number: 8618059
    Abstract: The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: December 31, 2013
    Assignees: Cleveland BioLabs, Inc., Cleveland Clinic Foundation
    Inventors: Andrei Gudkov, Robert Fairchild
  • Methods of protecting against apoptosis using lipopeptides
    Patent number: 8524668
    Abstract: The use of lipopeptides as inducers of NF-?B for the protection of mammals from the effects of apoptosis is described.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: September 3, 2013
    Assignees: Cleveland Clinic Foundation, Cleveland Biolabs, Inc.
    Inventors: Alexander Shakhov, Andrei Gudkov
  • METHODS FOR TREATING REPERFUSION INJURIES
    Publication number: 20130004515
    Abstract: The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin
    Type: Application
    Filed: June 22, 2012
    Publication date: January 3, 2013
    Applicants: CLEVELAND CLINIC FOUNDATION, CLEVELAND BIOLABS, INC.
    Inventors: Andrei V. Gudkov, Robert Fairchild
  • Methods for treating reperfusion injuries using flagellin
    Patent number: 8324163
    Abstract: The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: December 4, 2012
    Assignees: Cleveland Biolabs, Inc., Cleveland Clinic Foundation
    Inventors: Andrei Gudkov, Robert Fairchild
  • Methods for identifying modulators of apoptosis
    Patent number: 8242057
    Abstract: Provided herein is a method for screening a modulator of apoptosis by contacting a cell comprising a FAS mediated apoptosis system, major vault protein and cytochrome b, with a candidate modulator, and measuring the level of apoptosis of the cell. The modulator of apoptosis is identified by a change in apoptosis in comparison to a control.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: August 14, 2012
    Assignee: Cleveland Biolabs, Inc.
    Inventor: Andrei V. Gudkov
  • METHODS OF PROTECTING AGAINST APOPTOSIS USING LIPOPEPTIDES
    Publication number: 20110237507
    Abstract: The use of lipopeptides as inducers of NF-?B for the protection of mammals from the effects of apoptosis is described.
    Type: Application
    Filed: March 18, 2011
    Publication date: September 29, 2011
    Applicants: CLEVELAND CLINIC FOUNDATION, CLEVELAND BIOLABS, INC.
    Inventors: Alexander Shakhov, Andrei Gudkov