Abstract: An object can be moved via a robotic system with a combination of force and position control. The control system can include the object to be moved, the robotic system that moves the object, at least one force sensor, at least one position sensor, and a controller. A position control output, a force control output, and a hybrid weighting value can each be determined by the controller based on sensor data and then combined to determine an amount of position control and/or force control to be applied to move the object and/or modify an object in motion's trajectory.

Abstract: The present disclosure relates to compositions and methods for reducing virulence of microorganisms. In particular, the present invention provides HMGB1 and variants and mimetics thereof for use in reducing virulence of microorganisms (e.g., in disease).

Abstract: Compositions comprising an antigen, a carbohydrate, and a metabolizable oil, methods of administering such compositions to a subject, methods of making such compounds, and related compositions, methods, and uses.

Abstract: A temperature-regulating garment is provided for assisting a user with regulating body temperature. A garment body has first and second major garment body edges. The garment body has a neckline formed by a least a portion of the first major garment body edge. The garment body has a front right panel, a front left panel, and a back panel. At least one armhole is located laterally between the back panel and a selected one of the right front panel and the left front panel. First and second neck pockets are each configured to accept a temperature-regulating pack. The first neck pocket is disposed upon at least one of the right front panel and the back panel, spanning the first major garment body edge. The second neck pocket is disposed upon at least one of the left front panel and the back panel, spanning the first major garment body edge.

Abstract: Provided herein are compositions, systems, kits, and methods for expressing a peptide of interest, such as Apolipoprotein H (ApoH), also known as ?2-glycoprotein I (?2GPI), at increased levels using a non-ApoH signal peptide (e.g., a signal peptide that permits increased protein export from cells). Also provided herein are compositions, systems, kits, and methods for employing such recombinant ApoH with a non-ApoH signal peptide to detect subject Apolipoprotein H antibodies in a sample from a subject (e.g., to diagnose antiphospholipid syndrome in a subject).

Abstract: In embodiments of the invention, the invention provides a method for distinguishing between lymphoma types based on gene expression measurements. In embodiments, the invention distinguishes between PMBCL and DLBCL based on gene expression signatures, and can further distinguish between DLBCL subtypes. In embodiments of the invention, the distinctions are used in methods of treatment.

Abstract: Embodiments discussed herein facilitate segmentation of histological primitives from stained histology of renal biopsies via deep learning and/or training deep learning model(s) to perform such segmentation. One example embodiment is configured to access a first histological image of a renal biopsy comprising a first type of histological primitives, wherein the first histological image is stained with a first type of stain; provide the first histological image to a first deep learning model trained based on the first type of histological primitive and the first type of stain; and receive a first output image from the first deep learning model, wherein the first type of histological primitives is segmented in the first output image.

Abstract: A branched and fenestrated prosthesis may include a main tubular graft body including a proximal end opening, a distal end opening, a lumen, and a sidewall. A branch may extend from the sidewall and may include a first end opening, a second end opening, and a lumen. A fenestration may be disposed in the sidewall and positioned distal of the second end opening of the branch. The branched and fenestrated prosthesis may include a plurality of branches and a plurality of fenestrations.

Abstract: A method of treating a T-cell mediated disease in a subject by administering to the subject a therapeutically effective amount of an antibody or fragment thereof that specifically binds to CD6 is described. Humanized antibodies useful for the method are also described.

Abstract: This disclosure relates generally to systems and methods for characterizing a behavior of an anatomical structure. Tracking data can be generated by a tracking system to represent at least a location of at least one sensor in a three-dimensional tracking coordinate system over time. A motion model is generated to characterize the behavior of the anatomical structure over a plurality of time instances. For instance, the motion model includes at least one free parameter and a temporal parameter. Each free parameter estimating geometry of the anatomical structure derived from the tracking data, and the temporal parameter indexes the free parameter over the plurality of time instances. A visualization is generated to provide a sequence of graphical images based on the motion model to characterize behavior of the anatomical structure over time.

Abstract: A system for monitoring surgical objects is provided. An entry scanner captures a first set of image data from a surgical object identifier. A containment surface defines a target field of view. An exit scanner captures a second set of image data from a surgical object identifier within the target field of view. A monitoring system is electrically connected to at least one of the entry and exit scanners. The monitoring system has a surgical object recognition module having a database of pre-existing surgical object identifier data. The surgical recognition module identifies at least one of the number of surgical objects, the type of surgical objects, and the number of each type of surgical objects from the first and second sets of image data by comparing the first and second sets of image data with the pre-existing surgical object identifier data.

Abstract: A trackable guidewire apparatus and method for use are described. Longitudinally spaced proximal and distal guidewire ends are separated by a guidewire body. A plurality of longitudinally spaced position sensors are configured to provide signals corresponding to a three-dimensional position of at least one position sensor in a coordinate system of an associated tracking system in response to an electromagnetic field/stimulus. At least one retention mechanism is provided for maintaining the medical device in a predetermined retention position longitudinally along the guidewire body. At least one stop structure is provided in a predetermined stop position longitudinally along the guidewire body.

Abstract: Systems and methods for performing psychological assessment are provided. An initial visual stimulus is selected and a series of steps are iteratively performed until associated confidence values for each of a plurality of indices meet a threshold value. The selected visual stimulus is provided at the display. Gaze tracking data is received from a remote eye tracking device in response to the selected stimulus being displayed to a patient. A deviation of the gaze tracking data from a standard response is determined. A score and the associated confidence value for at least one of the plurality of indices are adjusted based on the determined deviation of the gaze tracking data from the standard response. A new visual stimulus is selected based on the confidence values of the plurality of indices. Respective scores for the plurality of indices are provided to a user.

Abstract: Embodiments discussed herein facilitate determination of risk of recurrence of atrial fibrillation (AF) after ablation based on fractal features. One example embodiment is configured to generate a binary mask of at least a portion of a CT scan of a heart of a patient with AF; compute one or more radiomic fractal-based features from at least one of the binary mask or the portion of the CT scan; provide the one or more radiomic fractal-based features to a trained machine learning (ML) classifier; and receive a prediction from the trained ML classifier of whether or not the AF will recur after AF ablation, wherein the prediction is based at least in part on the one or more radiomic fractal-based features.

Abstract: Systems and methods provide for detection and controlled interaction with one or more objects. The system can include an imaging subsystem (20), a tool subsystem (26) containing one or more tools, a stage subsystem (16) and a control system (40). The control system (40) can integrate controls for each of the other subsystems, which controls can be implement desired functions over a variety of process parameters to perform the controlled interaction.

Abstract: Embodiments include controlling a processor to perform operations, the operations comprising accessing a digitized image of a region of tissue (ROT) demonstrating cancerous pathology; extracting a set of radiomic features from the digitized image, where the set of radiomic features are positively correlated with programmed death-ligand 1 (PD-L1) expression; providing the set of radiomic features to a machine learning classifier; receiving, from the machine learning classifier, a probability that the region of tissue will experience cancer recurrence, where the machine learning classifier computes the probability based, at least in part, on the set of radiomic features; generating a classification of the region of tissue as likely to experience recurrence or non-recurrence based, at least in part, on the probability; and displaying the classification and at least one of the probability, the set of radiomic features, or the digitized image.

Abstract: Provided herein are compositions, systems, kits, and methods for treating a subject with cancer by administering a BACE1 inhibitor, such as MK-8931. In particular embodiments, the subject is treated with radiation (e.g., low dose radiation) first, and then administered a BACE1 inhibitor within a certain time window (e.g., about 3 hours to 6 days after the radiation treatment).

Abstract: Described herein is a system for remote monitoring of non-critically ill hospitalized patients. The system can include a graphical user interface displaying a representation of the patient census. Each patient is represented by a graphic showing a clinical status, with an underlying expanded view of various parameters. The system can also include a non-transitory memory storing computer executable instructions and a processor configured to execute the computer executable instructions. Upon execution, the computer executable instructions can at least: receive a data stream associated with a non-critically ill hospitalized patient; determine a risk score associated with the non-critically ill hospitalized patient based on data associated with the alarm notification, wherein the risk score represents a probability of the non-critically ill hospitalized patient developing an actionable clinical event; and rearrange the plurality of graphical representations on the GUI based on the risk score.

Abstract: Compositions and methods for immunization against human breast cancer are disclosed. A breast cancer vaccine comprises an immunogenic polypeptide comprising human ?-lactalbumin.