Patents Assigned to Clinical Micro Sensors, Inc.
  • Publication number: 20210246491
    Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.
    Type: Application
    Filed: April 28, 2021
    Publication date: August 12, 2021
    Applicant: Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.)
    Inventors: Lisa Lynn Freeman-Cook, Christine J. Shaw, Milena Iacobelli Martinez, Anna Maria Al-Khouri, Bradley Adam Brown, John Jay Harvey, Michael Thomas Nguyen
  • Patent number: 11021759
    Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: June 1, 2021
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Lisa Lynn Freeman-Cook, Christine J. Shaw, Milena Iacobelli Martinez, Anna Maria Al-Khouri, Bradley Adam Brown, John Jay Harvey, Michael Thomas Nguyen
  • Publication number: 20200332346
    Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.
    Type: Application
    Filed: April 24, 2020
    Publication date: October 22, 2020
    Applicant: Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.)
    Inventors: Lisa Lynn Freeman-Cook, Christine J. Shaw, Milena Iacobelli Martinez, Anna Maria Al-Khouri, Bradley Adam Brown, John Jay Harvey
  • Patent number: 10669592
    Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: June 2, 2020
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Lisa Lynn Freeman-Cook, Christine J. Shaw, Milena Iacobelli Martinez, Anna Maria Al-Khouri, Bradley Adam Brown, John Jay Harvey
  • Publication number: 20190185915
    Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.
    Type: Application
    Filed: February 26, 2019
    Publication date: June 20, 2019
    Applicant: Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.)
    Inventors: Lisa Lynn Freeman-Cook, Christine J. Shaw, Milena Iacobelli Martinez, Anna Maria Al-Khouri, Bradley Adam Brown, John Jay Harvey
  • Patent number: 10273535
    Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: April 30, 2019
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Bradley Adam Brown, Milena Iacobelli Martinez, Lisa Lynn Freeman-Cook, John Jay Harvey, Christine J. Shaw, Anna Maria Al-Khouri
  • Publication number: 20190062809
    Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.
    Type: Application
    Filed: August 24, 2017
    Publication date: February 28, 2019
    Applicant: Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.)
    Inventors: Bradley Adam Brown, Milena Iacobelli Martinez, Lisa Lynn Freeman--Cook, John Jay Harvey, Christin J. Shaw, Anna Maria Al-Khouri
  • Publication number: 20190062803
    Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.
    Type: Application
    Filed: August 3, 2018
    Publication date: February 28, 2019
    Applicant: Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.)
    Inventors: Bradley Adam Brown, Milena Iacobelli Martinez, Lisa Lynn Freeman-Cook, John Jay Harvey, Christine J. Shaw, Anna Maria Al-Khouri
  • Patent number: 10106847
    Abstract: The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically relevant amplification and amplification from other sources such as from background contamination. The methods and devices further enable discrimination between gram-positive, gram-negative and fungal infections as wells as identify antimicrobial resistance genes. When applying the methods and devices of the invention, the species or genus of an infection(s), and genus of a fungal co-infection(s) or category of bacterial (gram-positive or negative) co-infection(s) are identified. Species identification of co-infections can also be achieved. Further, when applying the methods and devices of the invention, organisms which are likely to be contaminating organisms from a blood draw are identified.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: October 23, 2018
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Bradley Adam Brown, Milena Iacobelli Martinez, Lisa Lynn Freeman-Cook, John Jay Harvey, Christine J. Shaw, Anna Maria Al-Khouri
  • Patent number: 9874542
    Abstract: The invention relates to the use of signal processing methods in order to achieve higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: January 23, 2018
    Assignee: CLINICAL MICRO SENSORS, INC.
    Inventors: Robert M. Umek, Gary Blackburn, Bruce D. Irvine, Robert Terbrueggen, Changjun Yu, Jost G. Vielmetter
  • Patent number: 8741585
    Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: June 3, 2014
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Stephen D. O'Connor, Jon Faiz Kayyem, Thomas J. Meade
  • Publication number: 20120132527
    Abstract: The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.
    Type: Application
    Filed: October 30, 2007
    Publication date: May 31, 2012
    Applicant: Clinical Micro Sensors, Inc.
    Inventor: Jon Faiz Kayyem
  • Publication number: 20120135530
    Abstract: The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte to be determined.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 31, 2012
    Applicant: Clinical Micro Sensors, Inc.
    Inventors: Cynthia C. Bamdad, Robert C. Mucic
  • Publication number: 20110180425
    Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 28, 2011
    Applicant: Clinical Micro Sensors, Inc.
    Inventor: Jon Faiz Kayyem
  • Publication number: 20100285981
    Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.
    Type: Application
    Filed: October 31, 2007
    Publication date: November 11, 2010
    Applicant: Clinical Micro Sensors, Inc.
    Inventor: Jon Faiz Kayyem
  • Publication number: 20090173640
    Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 9, 2009
    Applicant: Clinical Micro Sensors, Inc.
    Inventors: Stephen D. O'Connor, Jon Faiz Kayyem, Thomas J. Meade
  • Publication number: 20090166196
    Abstract: The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 2, 2009
    Applicant: Clinical Micro Sensors, Inc.
    Inventor: Jon Faiz Kayyem
  • Patent number: 7514228
    Abstract: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: April 7, 2009
    Assignee: Clinical Micro Sensors, Inc.
    Inventor: Thomas J. Meade
  • Publication number: 20090057147
    Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.
    Type: Application
    Filed: October 31, 2007
    Publication date: March 5, 2009
    Applicant: Clinical Micro Sensors, Inc.
    Inventor: Jon Faiz Kayyem
  • Publication number: 20080254548
    Abstract: The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte to be determined.
    Type: Application
    Filed: October 31, 2007
    Publication date: October 16, 2008
    Applicant: Clinical Micro Sensors, Inc.
    Inventors: Cynthia C. Bamdad, Robert C. Mucic