Patents Assigned to Clinical Micro Sensors, Inc.
  • AC methods for the detection of nucleic acids
    Patent number: 7056669
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: September 11, 2002
    Date of Patent: June 6, 2006
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor
  • Electronic transfer moieties attached to peptide nucleic acids
    Patent number: 7045285
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: April 21, 2000
    Date of Patent: May 16, 2006
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon F. Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
  • Detection of analytes using reorganization energy
    Patent number: 7018523
    Abstract: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Grant
    Filed: April 24, 2001
    Date of Patent: March 28, 2006
    Assignee: Clinical Micro Sensors, Inc.
    Inventor: Thomas J. Meade
  • Conductive oligomers attached to electrodes and nucleoside analogs
    Patent number: 7014992
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: March 21, 2006
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
  • Electrodes linked via conductive oligomers to nucleic acids
    Patent number: 6977151
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: December 20, 2005
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
  • Biochannel assay for hybridization with biomaterial
    Patent number: 6960467
    Abstract: The invention relates to a microfluidic device with microchannels that have separated regions which have a member of a specific binding pair member such as DNA or RNA bound to porous polymer, beads or structures fabricated into the microchannel. The microchannels of the invention are fabricated from plastic and are operatively associated with a fluid propelling component and detector.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: November 1, 2005
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Chan-Long Shieh, Barbara Foley, Huinan Yu, Vi-En Choong
  • Microfluidic systems in the electrochemical detection of target analytes
    Patent number: 6942771
    Abstract: The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.
    Type: Grant
    Filed: April 21, 1999
    Date of Patent: September 13, 2005
    Assignee: Clinical Micro Sensors, Inc.
    Inventor: Jon Faiz Kayyem
  • Tissue collection devices containing biosensors
    Patent number: 6833267
    Abstract: The present disclosure provides tissue collection devices comprising biosensors that can be used for the detection of target analytes, such as nucleic acids and proteins, including antibodies and enzymes.
    Type: Grant
    Filed: December 27, 1999
    Date of Patent: December 21, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventor: Jon Faiz Kayyem
  • Target analyte detection using asymmetrical self-assembled monolayers
    Patent number: 6753143
    Abstract: The present invention relates to the use asymmetric monolayer forming species and electroconduit forming species to detect target analytes.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: June 22, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Chunlin Tao, Changjun Yu
  • Signal detection techniques for the detection of analytes
    Patent number: 6740518
    Abstract: The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: May 25, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Hau H. Duong, Stephen D. O'Connor, Robert H. Terbrueggen, Jon Faiz Kayyem, Gary T. Olsen, Daniel A. Litvack, Javier Gonzalez
  • Amplification of nucleic acids with electronic detection
    Patent number: 6686150
    Abstract: The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the nucleic acid, either directly or indirectly, to allow electronic detection of the ETM using an electrode.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: February 3, 2004
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Gary Blackburn, Bruce D. Irvine, Jon Faiz Kayyem, Edward Lewis Sheldon, III, Robert H. Terbrueggen
  • Electronic methods for the detection of analytes utilizing monolayers
    Patent number: 6600026
    Abstract: The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: July 29, 2003
    Assignee: Clinical Micro Sensors, Inc.
    Inventor: Changjun Yu
  • Detection of target analytes using particles and electrodes
    Patent number: 6541617
    Abstract: The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte to be determined.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: April 1, 2003
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Cynthia C. Bamdad, Robert C. Mucic
  • Electrodes linked via conductive oligomers to nucleic acids
    Publication number: 20030003473
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Application
    Filed: February 20, 2002
    Publication date: January 2, 2003
    Applicant: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
  • AC methods for the detection of nucleic acids
    Patent number: 6495323
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: September 12, 2000
    Date of Patent: December 17, 2002
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor
  • Electrodes linked via conductive oligomers to nucleic acids
    Patent number: 6479240
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: May 22, 2000
    Date of Patent: November 12, 2002
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon F. Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu
  • Biosensors utilizing ligand induced conformation changes
    Patent number: 6432723
    Abstract: A method for detecting the presence of a target analyte comprising binding a target analyte to a binding ligand comprising at least a first electron donor moiety and a second electron acceptor moiety; and detecting the electron transfer between the donor and acceptor, wherein there is a change in the amount of electron transfer between the donor and acceptor as a result of altering the structured state of the donor and acceptor caused by a conformational change in the binding ligand upon binding of the target ligand.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: August 13, 2002
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Kevin W. Plaxco, Jon Faiz Kayyem
  • Detection of analytes using reorganization energy
    Publication number: 20020033345
    Abstract: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, &lgr;, of an electron transfer process
    Type: Application
    Filed: April 24, 2001
    Publication date: March 21, 2002
    Applicant: Clinical Micro Sensors, Inc.
    Inventor: Thomas J. Meade
  • Systems for electrophoretic transport and detection of analytes
    Patent number: 6290839
    Abstract: The invention relates to compositions and methods useful in the electrophoretic transport of target analytes to a detection electrode comprising a self-assembled monolayer (SAM). Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: September 18, 2001
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Gary Blackburn, Stephen D. O'Connor
  • Binding acceleration techniques for the detection of analytes
    Patent number: 6264825
    Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: July 24, 2001
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Gary Blackburn, Stephen E. Creager, Scott Fraser, Bruce D. Irvine, Thomas J. Meade, Stephen D. O'Connor, Robert H. Terbrueggen, Jost G. Vielmetter, Thomas W. Welch