Abstract: Provided herein are compound of Formula (I) and (II), and pharmaceutically acceptable salts thereof. Also provided are methods of preparing the compounds, pharmaceutically acceptable compositions thereof, and methods of their use and treatment.

Abstract: Disclosed herein are compositions and methods for metabolically labeling cells using click chemistry reagents. The compositions and methods disclosed herein provide a specific and efficient means of localizing desired agents, such as anti-tumor cytokines, to a variety of cell types for adoptive cell therapy.

Abstract: Compositions of glycan strands and oligosaccharides derived from gram-positive bacteria and methods of use thereof are provided. The disclosed compositions have inhibitory activity toward both early and late stages of viral infection and transmission. The disclosed compositions may be used to treat and/or prevent infection and transmission of viruses, such as HIV, to upregulate one or both of AG3 and MX2, to enhance immune function, and/or to inhibit replication of a virus.

Abstract: The present disclosure relates generally to novel recombinant coronavirus-based fusion proteins (“RBDs-IgG Fc protein” and “RBDs protein”) and vaccine compositions using the same, in which the fusion proteins comprise tandemly arranged coronaviruses receptor binding domains (RBDs). The present disclosure further provides methods and kits for immunizing a subject using the compositions.

Abstract: Provided herein are small molecule compounds and methods inhibiting human sulfotransferase 1A3 (SULT1A3) using these small molecule compounds. Methods of manufacturing and treatment are also disclosed.

Abstract: A sensor device for detecting static modulus of elasticity in situ comprising: top and bottom frame end plates, the top and bottom frame end plates connected by frame side bars; a dry cavity connected to the top frame end plate and comprising a piston, precompression mechanism, and piston transfer plate; a displacement measurement gauge extending from the dry cavity along a longitudinal axis of the sensor device having a first end in contact with the piston transfer plate and a second end in contact with a bottom inner face of the bottom frame end plate; and a top inner face connected to the piston transfer plate wherein a portion of elastomeric material is positioned on the bottom and top inner faces, the elastomeric material positioned to prevent contact with either bottom or top inner faces except for a portion along the longitudinal axis of the displacement measurement gauge.

Abstract: The present invention generally relates to photon upconversion nanocapsules for 3D printing and other applications. For example, one aspect is generally related to nanocapsules that contain an upconversion material. Light, such as laser light, focused on a region of liquid containing nanocapsules may be upconverted by the upconversion material to produce wavelengths sufficient to cause polymerization of a polymerizable entity to occur. However, in contrast, although other regions may receive some light, that light may not be of sufficient focus or intensity to be upconverted, and thus, the polymerizable entity in those regions would generally not polymerize. In such a fashion, the extent of polymerization can be controlled, for example, by controlling where light is applied to the liquid. The light could be focused at arbitrary regions within the liquid, thus allowing true 3D-printing to occur.

Abstract: An isolated human NKT cell or a plurality of cells thereof, having reduced or no detectable expression of endogenous beta-2-microglobulin (B2M); endogenous MHC class II-associated invariant chain (Ii); or both. Methods to generate the cell or cells, and methods of treatment using the cell or cells are also provided.

Abstract: A system and method for vestibular and/or balance rehabilitation by monitoring and measuring head motion data of a user having vestibular impairment. The system as includes a user device, a head tracking device, and a remote server device. The user device receives therapeutical configuration data prescribed by a therapist using the remote server device. A visual and auditory and/or haptic stimuli is generated in the user interface according to the received therapeutic configuration data during a training session or initial assessment session. Head motion data from the head tracking device during the training session is received along with user inputted data pertaining to symptoms of the user. The remote server device receives and processes the head motion and positional data, the user inputted symptoms data and communicates a set of updated therapeutic configuration data to the user device based on the processed data for use in a next training session.

Abstract: A wearable sensor for monitoring an external bodily fluid includes a sensor thread, a wick, a substrate, and a communication interface all of which are disposed on a substrate. The wick wicks the external bodily fluid to a functionalized region of the thread. The communication interface transmits, to an external device, data indicative of what the sensor thread has measured in said external bodily fluid. The external device can then carry out real-time analysis or storage.

Abstract: Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: In one aspect, an entangled polymer composition includes an entangled polymer network including a plurality of entangled polymers; and a plurality of crosslinks crosslinking the polymers at a density of no more than one crosslink per 1,000 monomer units of the polymer; wherein the polymer composition has a toughness of at least about 100 Jm?2 and a stiffness of at least about 50 kPa.

Abstract: The invention relates to a composition for preparing a 3D scaffold for culturing cells and tissue, such as human cells and tissue. In particular embodiments, the present invention relates to a composition comprising a biocompatible polymer suitable for the preparation of a hydrogel, and a modified extracellular matrix (ECM) protein that is unreactive towards the biocompatible polymer, such that, after preparation of a hydrogel, the modified ECM protein is not covalently bound to the hydrogel. Compositions of the invention are suitable for use in 3D bioprinting, tissue engineering, drug screening, disease modelling and methods of treatment such as tissue regeneration.

Abstract: A vaccine platform using a Yersinia pestis mutant synthesizing an adjuvant form lipid A (monophosphoryl lipid A, MPLA) for the increased biogenesis of bacterial outer membrane vesicles (OMVs). To enhance the immunogenicity of the OMVs, an Asd-based balanced-lethal host-vector system was constructed to oversynthesize the LcrV antigen of Y. pestis, raise the amounts of LcrV enclosed in OMVs by Type II secretion system, and eliminate harmful factors like plasminogen activator (Pla) and murine toxin from the OMVs. Vaccination with OMVs containing MPLA and increased amounts of LcrV with diminished toxicity afforded complete protection in mice against subcutaneous challenge and intranasal challenge and was significantly superior to that resulting from vaccination with LcrV/alhydrogel. Additionally, the Yersinia OMV can be used as a platform to deliver the heterologous antigens of Bacillus anthraces.

Abstract: Aspects of the present disclosure describe techniques that involve an active stabilization of coherent controllers using nearby qubits. In an aspect, a quantum information processing (QIP) system for stabilizing phase damping in qubits is described that provides a first and a second qubit ion, measuring magnetic field fluctuations using the second qubit ion, and generates one or more magnetic fields based on the measured magnetic field fluctuations, the one or more magnetic fields being applied near the first qubit ion to cancel the magnetic field fluctuations to stabilize the phase damping of the first qubit ion. Another such QIP system performs provides a first and a second qubit ion, locks a local oscillator to a frequency reference associated with the second qubit ion, and tracks, using the local oscillator, a frequency of the first qubit ion based on the frequency reference. Methods associated with these QIP systems are also described.

Abstract: A machine-readable medium and methods of reading and writing same are disclosed. The machine-readable medium comprises a substrate having an array of addressable locations thereon, each addressable location adapted to be physically associated with a collection of non-polymeric molecules. The molecules in each collection are selected from a set of unambiguously identifiable molecules, each molecule uniquely associated with a predetermined position in a numerical value, wherein the presence of the molecule in the collection indicates a predetermined digit at the associated position and the absence of said molecule in the collection indicates a zero at said associated position.

Abstract: The present invention provides constructs comprising modified riboswitches to regulate expression of a transgene within a subject. Methods of treating a disease, specifically an eye disease, are also contemplated.

Abstract: Provided herein are methods and composition for trans-tympanic membrane delivery of therapeutic agents such as antimicrobial agents, anti-inflammatory agents, and anti-biofilm agents to the middle ear for rapid, localized treatment and prevention of diseases and conditions associated with a middle ear infection. In particular, provided herein are cationic, anionic, and polymer-based nanoparticles that provide a platform for delivery of therapeutic cargo, as well as cationic, anionic, and polymer-based nanoparticles compositions for rapid, localized delivery of therapeutic agents to the middle ear.

Abstract: A device is disclosed, including: a plate including a sample deposition tube adapted to receive a sample comprising one or more analytes, the sample deposition tube defining a vertical axis substantially perpendicular to a main surface of the plate; and a mirror positioned to project, substantially parallel to the main surface of the plate, an image of the sample deposition tube along its vertical axis, so as to allow determination of the vertical location of the one or more analytes inside the sample deposition tube. Methods for determining the density of one or more analytes using various embodiments of the device are also described.

Abstract: The disclosure relates, in certain aspects, to compounds that can be used to inhibit ?-lactamases, such as but not limited to OXA enzymes, such as but not limited to OXA-24, OXA-48, and/or OXA-58. In certain embodiments, these compounds can be used to inhibit activity of ?-lactamases in vitro and in vivo.