Abstract: A method of producing a low-lactose milk protein concentrate comprising the steps of providing a starting liquid milk protein concentrate, pre-treating the milk protein concentration by ultra-sonication, and treating the pre-treated milk protein concentration by diafiltration to provide a calcium depleted low-lactose milk protein concentrate. The process of the invention provides a milk protein concentrate with high levels of protein, less than 1% lactose, and a calcium level that is depleted by at least 20% compared with an untreated milk protein concentrate.

Abstract: A medicament with excellent JAK kinase (Janus Kinase) inhibitory activity can be used to prevent, treat and/or improve an autoimmune disease (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus and the like). The present invention also provides a pharmaceutically acceptable composition containing the compound and a method for preparing these compounds.

Abstract: Methods of evaluating viscous compositions are disclosed. These methods may be used to evaluate volumetric properties of fluids including peanut butter. The methods may include preparing a surface for testing by leveling and flattening a viscous composition, placing a drop of a liquid on the flattened leveled surface, evaluating the observed contact angle between the drop and the surface, and then comparing the observed contact angle to a reference contact angle.

Abstract: A first fluidic solution having a first ionic concentration is provided in a first fluidic reservoir in direct fluidic connection with a nanopore. A second fluidic solution, having a second ionic concentration, is provided in a second fluidic reservoir disposed in fluidic connection with the nanopore through a fluidic passage having at least one fluidic section in which the section length is greater than the section width. The electrical potential local to the fluidic passage is measured, and the resistance of both the fluidic passage the nanopore are determined based on the fluidic passage electrical potential. The fluidic passage resistance is compared with the nanopore resistance and at least one of the first and second ionic concentrations is adjusted based on the comparison. The measuring, determining, comparing, and adjusting steps are conducted until the fluidic passage resistance is between about 0.1 times and about 10 times the nanopore resistance.

Abstract: A method of controlling an electricity distribution network, wherein the electricity distribution network is a mesh network including a plurality of loads and there is a voltage-source converter connected to a point in the network. The method comprises, while using the voltage-source converter to try to hold the voltage magnitude constant at said point, establishing a record of how, at said point, the real power flowing between the network and the voltage-source converter varies with variation of the reactive power that the voltage-source converter causes to flow between itself and the network, using a reactive-power value, proportional to the sum of the reactive-power draws of the loads, in order to look up a real-power value from the record, and configuring the voltage-source converter to supply into the network at said point reactive and real power at said reactive- and real-power values, respectively.

Abstract: Disclosed are infrared (IR) light detectors. The detectors operate by generating hot electrons in a metallic absorber layer on photon absorption, the electrons being transported through an energy barrier of an insulating layer to a metal or semiconductor conductive layer. The energy barrier is set to bar response to wavelengths longer than a maximum wavelength. Particular embodiments also have a pattern of metallic shapes above the metallic absorber layer that act to increase photon absorption while reflecting photons of short wavelengths; these particular embodiments have a band-pass response.

Abstract: Embodiments of the present disclosure pertain to a composition with molecules that self-assemble to form a particle. Additional embodiments of the present disclosure pertain to methods of imaging a region of a subject by: (1) administering the compositions of the present disclosure to the subject to result in the accumulation of the molecules in the region of the subject; and (2) imaging the region of the subject. In some embodiments, the imaged region includes a tumor. In some embodiments, the imaged region includes a blood vessel.

Abstract: The present invention discloses a method for diagnosing congenital scoliosis of an individual, comprising: detecting whether a chromosome 16p11.2 region has a nucleotide sequence microdeletion of 0.6 Mb in length, or detecting whether a TBX6 gene has a frameshift mutation; and detecting a haplotype of two SNP sites of rs3809624-rs3809627 in the TBX6 gene located on another homologous chromosome. The diagnostic method of the present invention can be judged early in the congenital scoliosis and is suitable for clinical promotion. A method of treating congenital scoliosis is also provided.

Abstract: The invention relates to compounds of Formula (I): and related aspects.

Abstract: Disclosed are compositions and related methods of recapitulating bone marrow stroma using scaffold materials (e.g., a porous alginate hydrogel scaffold) containing one or more cellular differentiation factors, and one or more growth factors. Such methods and compositions promote the formation of an ectopic nodule or site that can improve transplanted cell engraftment and selectively drive the development of lymphocytes and the reconstitution of the adaptive immunity after hematopoietic stem cell transplant.

Abstract: Artificial cervical fluid is disclosed that contains a mucilaginous extract from the okra plant. The mucilaginous extract can be produced using a hot aqueous extractant or cold extraction process followed by separation of larger particles from the extract. The extract finds many uses, for example as a sperm storage medium, a sperm freezing medium, a sexual lubricant, an artificial insemination medium, and an in vitro fertilization medium.

Abstract: Demand response methodologies for primary frequency response (PFR) for under or over frequency events. Aspects of the present disclosure include methods for controlling a fleet of distributed energy resources equipped for PFR and quantifying in real time an amount of primary frequency control capacity available in the fleet. In some examples, the DERs may be configured to consume and discharge electrical energy in discrete energy packets and be equipped with a frequency response local control law that causes each DER to independently and instantaneously interrupt an energy packet in response to local frequency measurements indicating a grid disturbance event has occurred.

Abstract: In an embodiment, the present disclosure pertains to a method of changing the glass transition temperature of a polymer. In some embodiments, the polymer includes at least one hydrazone-containing compound. In general, the methods of the present disclosure include one or more of the following steps of: (1) applying light to the polymer; and (2) thereby changing the glass transition temperature of the polymer. In another embodiment, the present disclosure pertains to a polymer having a light-adjustable glass transition temperature. In some embodiments, the polymer includes at least one hydrazone-containing compound.

Abstract: Described herein is a method of making a reduced metal nanoparticle, the method including mixing a reactive reducing agent with a metal salt in a solution at a temperature of 4-100° C., and forming the reduced metal nanoparticles in the solution. Also described is a kit including a reactive reducing agent that is sensitive to ßgalactosidase, a metal salt, and optionally a modifying agent/functionalizing agent for reduced metal nanoparticles. A 3,4-cyclohexeneoesculetin-B-D-galacto pyranoside (SGNP) gold nanoparticle and its use for measuring ßgalactosidase enzyme activity, comprising by detecting a structural change in the SGNPs caused by the ßgalactosidase are described. Further described are a point of care device, a chip, a biosensor, a laboratory animal, a gene delivery agent, a drug delivery agent, a diagnostic agent, or a disease targeting agent including SGNPs.

Abstract: Embodiments are disclosed for generating continuous curve textures based on an input exemplar. A method of generating continuous curve textures may include receiving an input exemplar which represents a repetitive pattern as a plurality of vector curves, generating an input graph representation of the input exemplar which represents a geometry and a topology of the input exemplar, synthesizing an output graph based on the input graph representation, and reconstructing output vector curves from the output graph.

Abstract: A genetically modified mammalian cell and genetically modified mammalian cell line comprise a recombination sequence inserted in a target locus on a chromosome of the mammalian cell genome, wherein the recombination sequence comprises Bxb1attB sequence from Mycobacterium smegmatis. A transgenic mammalian cell and transgenic mammalian cell line comprise a heterologous nucleic acid stably integrated in a target locus on a chromosome of the mammalian genome, wherein the heterologous nucleic comprises a heterologous gene configured for expression by the transgenic mammalian cell.

Abstract: Storage media are provided. A substrate has an array of addressable locations thereon, each addressable location adapted to be physically associated with a collection of molecules, each collection comprising at least a first subcollection of molecules and a second subcollection of molecules. The molecules in the collection are selected from a set of unambiguously identifiable molecules, the set comprising at least a first subset of molecules and a second subset of molecules. Each molecule in the first subset is identifiable by a first physical property, and each molecule in the second subset is identifiable by a second physical property, different from the first physical property. Each molecule in the set is uniquely associated with a predetermined position in a numerical value, wherein the presence of the molecule in the collection indicates a predetermined digit at the associated position and the absence of said molecule in the collection indicates a zero at said associated position.

Abstract: A filling level monitoring device for monitoring a filling level of a fluid in a container includes exciter(s), sensor(s), a signal source connected to the exciter(s), a processor, at least one spatial orientation and acceleration sensor, and a filling level indicator. The device uses the signal source and the exciter(s) to couple vibrational loads having multiple frequency components into the container. Sensors measure vibrations in the container after the exciters transmit the vibrational loads into the container. The processor performs spectral analysis of the input signal and of vibration signals from the sensors, comparing these respective spectral functions to extract resonance frequencies of the container, which are based on the spatial orientation of the container.

Abstract: This disclosure is generally directed to methods for obtaining sequence information at nucleotide resolution with spatial information directly from chromosome(s) in situ.

Abstract: A compression device is used to increase intra-luminal pressure within the upper esophageal sphincter of a patient in order relieve an impact of an abnormal or defective upper esophageal sphincter anatomy, physiology, or functionality. In one implementation, the compression device is used in conjunction with an external pressure sensing device to determine the external pressure that is to be applied to the cricoid for a specific patient. The compression device can be a means for the management and/or treatment of abnormal upper esophageal sphincter functionality, or a means for strengthening an esophageal sphincter of a subject, or a means for curing esophageal reflux disease of a subject, or a means for improving vocal function in a subject, or a means for managing lung aspiration, or a means for applying cricoid pressure during anesthesia intubation, or a means for stabilizing body structures such as during medical imaging or radiation treatment.