Patents Assigned to College
  • Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
    Patent number: 9290501
    Abstract: The present invention discloses methods for treating bacterial infections in a subject comprising administering to the subject a sub-growth inhibiting amount of a 5?-methylthioinosine phosphorylase (MTIP) inhibitor, as well as assays for identifying such inhibitors, and compounds and pharmaceutical compositions comprising the inhibitors.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: March 22, 2016
    Assignees: Albert Einstein College of Medicine, Inc., Victoria Link Limited
    Inventors: Vern L. Schramm, Keith Clinch, Peter Charles Tyler, Gary Brian Evans, Richard Hubert Furneaux
  • Self-cleaning optical system
    Patent number: 9291818
    Abstract: A self-cleaning optical system for the transmission or reflection of light to and/or from a process region comprises a liquid bath and a transparent or reflective optical component continuously rotatable about a non-vertical axis so that a lower part of the component continuously rotates through the bath. When the component emerges from the bath, a coating of the liquid remains thereon which forms a substantially uniform film on at least a part of the component through which the light is transmitted or from which the light is reflected.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: March 22, 2016
    Assignee: University College Dublin, National University of Ireland, Dublin
    Inventors: Fergal O'Reilly, Kenneth Fahy, Paul Sheridan
  • Iron complexes and methods for polymerization
    Patent number: 9290591
    Abstract: Provided are methods of preparing polymers, such as polyisoprene, polybutadiene, polypiperylene, polycyclohexadiene, poly-?-farnesene, or poly-?-myrcene, using iron complexes. Also provided are novel iron complexes, pre-catalysts, intermediates, and ligands useful in the inventive polymerization system.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: March 22, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Tobias Ritter, Jean B. Raynaud, Jessica Yung Wu
  • CDDO-Me amino acid conjugates and methods of use
    Patent number: 9290455
    Abstract: 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid amino acid derivatives having antiinflammatory properties are provided. Pharmaceutical compositions and methods for preventing or treating inflammation or a disease or condition mediated by inflammation are described.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: March 22, 2016
    Assignee: Trustees of Dartmouth College
    Inventors: Michael B. Sporn, Karen T. Liby, Martine Cao, Evans O. Onyango, Liangfeng Fu, Gordon W. Gribble
  • Covalently immobilized protein gradients in three-dimensional porous scaffolds
    Patent number: 9290579
    Abstract: The invention provides a method for forming an immobilized agent gradient within a 3-dimensional porous scaffold. A 3-dimensional scaffold formed from a biocompatible material is provided. The surface of the scaffold and/or the agent is activated so as to allow binding of the agent to the scaffold. The activated scaffold is contacted with a solution containing the agent. Contact with the solution is maintained for a sufficient period of time to allow diffusion of the solution through a portion of the scaffold, thereby forming a desired gradient of the agent through the 3-dimensional scaffold.
    Type: Grant
    Filed: April 19, 2006
    Date of Patent: March 22, 2016
    Assignees: Trustees of Tufts College, Massachusetts Institute of Technology
    Inventors: Charu Vepari, David L. Kaplan, Gordana Vunjak-Novakovic
  • Foreign DNA Surveillance Protein
    Publication number: 20160076041
    Abstract: A method for augmenting expression of a heterologous nucleic acid in a eukaryotic cell or increasing the efficiency of gene expression using any gene expression system is carried out by decreasing expression or activity of an endogenous Interferon-induced protein-16 (IFI16).
    Type: Application
    Filed: May 5, 2014
    Publication date: March 17, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: David M. Knipe, Megan Horn Orzalli
  • IMMUNOGENIC COMPOSITIONS CONTAINING ESCHERICHIA COLI H7 FLAGELLA AND METHODS OF USE THEREOF
    Publication number: 20160074493
    Abstract: Immunogenic compositions containing Escherichia coli 0157:H7 flagella including fusion proteins and methods using the immunogenic compositions are disclosed. Inducing an immune response in an animal to Escherichia coli O157:H7 flagella will result in prevention of colonization by Escherichia coli O157:H7 in the animal or a reduction in the amount of Escherichia coli O157:H7 infecting the animal. The immune composition will prevent or reduce the attachment of Escherichia coli 0157:H7 to cells within the animal.
    Type: Application
    Filed: November 23, 2015
    Publication date: March 17, 2016
    Applicants: The University Court of the University of Edinburg h, Moredun Research Institute, The Scottish Agricultural College
    Inventors: David GALLY, Tom Nathan MCNEILLY, David George Emslie SMITH, Chris LOW, Arvind Kumar MAHAJAN, Stuart W. NAYLOR
  • METHODS AND COMPOSITIONS FOR REJUVENATING SKELETAL MUSCLE STEM CELLS
    Publication number: 20160074477
    Abstract: Methods and compositions for rejuvenating skeletal muscle stem cells are disclosed.
    Type: Application
    Filed: April 8, 2014
    Publication date: March 17, 2016
    Applicants: President and Fellows of Harvard College, The Brigham and Women's Medical Center
    Inventors: Amy J. Wagers, Richard T. Lee
  • Compositions of toehold primer duplexes and methods of use
    Patent number: 9284602
    Abstract: Provided herein are primers and primer systems having improved specificity and kinetics over existing primers, and methods of use thereof.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: March 15, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: David Yu Zhang, Peng Yin
  • ADAM22 for use as a prognostic variable, and target for therapy, of a metastatic breast cancer disease
    Patent number: 9285370
    Abstract: A method of diagnosing metastatic potential of a breast cancer in an individual with breast cancer is described. The method comprises a step of assaying a breast cancer tumor sample from the patient for expression of A Disintegrin and Metalloproteinase 22, (ADAM22), wherein expression of ADAM22 correlates with increased potential for metastasis compared with a patient who is ADAM22 negative. The invention also describes an agent for use in the treatment of metastatic breast cancer in a patient, in which the agent is selected from leucine-rich, glioma-inactivated protein 1 (LGI1) protein (SEQ ID NO:1) and an LGI1 peptide mimic capable of mimicking the ADAM22 binding activity of LGI1 by binding to the LGI1 binding domain of ADAM22 (SEQ ID NO: 4) and which is capable of inhibiting migration of endocrine resistant breast cancer cells.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: March 15, 2016
    Assignee: Royal College of Surgeons in Ireland
    Inventors: Leonie Young, Damian McCartan, Christopher Byrne
  • Small molecule enhancer for dendritic cell cancer vaccines
    Patent number: 9284337
    Abstract: Disclosed is a method of treating cancer, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound that inhibits a plurality of mammalian dipeptidyl peptidase (DPP) IV activity and/or structural homologues thereof (DASH) serine proteases. Also disclosed is a method of (a) increasing antitumor immunity, (b) stimulating or enhancing an immune response, (c) treating a condition characterized by abnormal cell proliferation, (d) increasing cytokine and/or chemokine production, or (e) stimulating or enhancing production of T-cells, in a mammal, comprising administering to a mammal in need thereof an effective amount of a compound that inhibits a plurality of mammalian DASH serine proteases. For example, the compound that inhibits a plurality of mammalian DASH serine proteases may be t-butylGly-boroPro.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: March 15, 2016
    Assignee: Trustees of Tufts College
    Inventor: William W. Bachovchin
  • Halofuginone analogs for inhibition of tRNA synthetases and uses thereof
    Patent number: 9284297
    Abstract: The present invention provides novel analogs and derivatives of halofuginone. The invention also provides pharmaceutical and cosmetic compositions thereof and methods for using halofuginone analogs in treating chronic inflammatory diseases, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angiogenesis, viral infections, ischemic damage, transplant and implant rejection, neurodegenerative diseases, and cosmetic applications.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: March 15, 2016
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Tracy Keller, Ralph Mazitschek, Malcolm Whitman, Jinbo Lee, Mark S. Sundrud, Anjana Rao
  • Oil—water separator
    Patent number: 9284705
    Abstract: A separator is disclosed that may be used to separate oil from water in situ in the ocean or other water body. The difference in density between oil and water causes them to separate between two limbs of the apparatus, and to exit from different ports at different heights. The input may contain oil:water in essentially any ratio. The apparatus may be placed within a boat or ship, or it may be mounted on pontoons or other floatation gear and towed behind a boat or ship.
    Type: Grant
    Filed: May 25, 2011
    Date of Patent: March 15, 2016
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventor: Chandra S. Theegala
  • METHOD FOR TREATING NEUROENDOCRINE CANCER
    Publication number: 20160068599
    Abstract: Methods for decreasing proliferation and preventing or treating a neuroendocrine cancer using an N-methyl D-aspartate-associated (NMDA) glutamate receptor antagonists or binding agent, such as an antibody, antibody fragment or peptide aptamer specific for a NMDA glutamate receptor, are disclosed.
    Type: Application
    Filed: November 19, 2015
    Publication date: March 10, 2016
    Applicant: Trustees of Dartmouth College
    Inventor: William G. North
  • SYSTEMS, METHODS, AND WORKFLOWS FOR OPTOGENETICS ANALYSIS
    Publication number: 20160069876
    Abstract: The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and actuator may be based on genetically-encoded rhodopsins incorporated into the cell. The invention provides all optical methods that may be used instead of, or as a complement to, traditional patch clamp technologies and that can provide rapid, accurate, and flexible assays of cellular physiology.
    Type: Application
    Filed: November 16, 2015
    Publication date: March 10, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Adam E. Cohen, Joel Kralj, Adam D. Douglass, Daniel Hochbaum
  • DEVICE AND METHOD FOR CORRECTING A SPINAL DEFORMITY
    Publication number: 20160066964
    Abstract: A method for correcting a spinal deformity is provided. A spinal implant for correcting a spinal deformity includes a multipoint connector that connects to at least one vertebra of a spine at a plurality of locations and a force directing device that applies a force to the vertebra through the multipoint connector. The force directing device may include a rod which extends generally along an axis of the spine and a force directing member which is adjustably coupled to both the rod and the multipoint connector and which applies a corrective force to the at least one vertebra.
    Type: Application
    Filed: March 20, 2015
    Publication date: March 10, 2016
    Applicant: Albany Medical College
    Inventors: Allen L. Carl, Dan Sachs
  • Antimicrobial Monomers and Polymers, and Their Use in Dental Devices
    Publication number: 20160068536
    Abstract: Antimicrobial compounds are provided that are polymerizable. The compounds include monomers with antimicrobial properties. The compounds have cross-linking properties and are hydrolytically stable. The compounds may be utilized in dental and/or medical applications, including dental composites, dentures, bonding agents, sealants, resins and medical devices.
    Type: Application
    Filed: April 8, 2014
    Publication date: March 10, 2016
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Xiaoming XU, Stephen A. COSTIN
  • Selective Sensitization of Cancer Cells to, and Selective Protection of Non-Cancer Cells from Genotoxic Therapies
    Publication number: 20160067316
    Abstract: Compositions and methods are disclosed that employ Tousled-like kinase to selectively protect normal tissues from the adverse effects of radiation therapy, genotoxic chemotherapy and the like without protecting cancer tissues; or to sensitize cancer cells to such cancer therapies without similarly sensitizing normal tissues; or both protect normal cells and sensitize cancer cells. The compositions and methods may be used as a complementary therapy to selectively reduce adverse effects of the principal therapy (radiation therapy or chemotherapy) in normal tissues, with minimal impact on the antitumor effects of the principal therapy.
    Type: Application
    Filed: September 9, 2015
    Publication date: March 10, 2016
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventor: Gulshan N. Sunavala-Dossabhoy
  • Manipulation of fluids in three-dimensional porous photonic structures with patterned surface properties
    Patent number: 9279771
    Abstract: A three-dimensional porous photonic structure, whose internal pore surfaces can be provided with desired surface properties in a spatially selective manner with arbitrary patterns, and methods for making the same are described. When exposed to a fluid (e.g., via immersion or wicking), the fluid can selectively penetrate the regions of the structure with compatible surface properties. Broad applications, for example in security, encryption and document authentication, as well as in areas such as simple microfluidics and diagnostics, are anticipated.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: March 8, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Joanna Aizenberg, Ian B. Burgess, Lidiya Mishchenko, Benjamin Hatton, Marko Loncar
  • Enrichment of stem cells from adult tissues
    Patent number: 9279105
    Abstract: Subjecting a heterogeneous cell population (one with both stem cells and non-stem cells) to extreme stress selectively eliminated the non-stem cells and resulted in the enrichment of stem cells in the population. The stress can take many forms, including without limitation, cell toxins, high temperature, high salt, and low oxygen (hypoxic) conditions. The number of stem cells remaining after stress were increased, and showed increased expression of traditional stem cell markers. The stem cells were shown to be capable of proliferation and differentiation into multiple types of cells. This method allows purification of stem cells from adult heterogeneous cell populations on a large scale basis without requirement of expensive equipment, and without requiring the presence of cell surface markers. Stem cells produced by the above method can be used for clinical applications, including tissue engineering.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: March 8, 2016
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventors: Gary E. Wise, Shaomian Yao