Patents Assigned to College
  • Treatment of disease
    Patent number: 9249463
    Abstract: The invention relates to the use of angiogenin, or a fragment or variant thereof, to treat diseases or conditions characterised by neuronal injury or death, or axonal degeneration, especially neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS). The invention also describes a plurality of mutations of the human angiogenin gene which are associated with a neurodegenerative disease phenotype, and particularly a ALS phenotype. Also described is a method of assessing whether an individual is afflicted with, or generically predisposed to develop, a disease or condition characterised by neuronal injury or death, or axonal degeneration.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: February 2, 2016
    Assignee: Royal College of Surgeons in Ireland
    Inventors: Matt Greenway, Orla Hardiman
  • Multicapacitor force/moment sensor arrays
    Patent number: 9250143
    Abstract: A multicapacitor sensor system facilitates the measurement of applied shear and moment forces. In one disclosed configuration, moments may be detectable in x, y and z directions, resulting in a full, 3-axis load cell with 6 degrees of freedom. The system may further include electrical circuitry to generate electrical drive pulses, sense amplify and buffer the voltages induced on the sense plates, and compute applied forces. An array of multicapacitor sensors that can be addressed individually without cross-talk and globally produce a map of forces and moments applied to the whole array. A MEMS implementation enables in vivo application.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: February 2, 2016
    Assignee: College Park Industries, Inc.
    Inventors: Richard H. Harrington, Michael G. Leydet
  • Polymer solid electrolyte for flexible batteries
    Patent number: 9252456
    Abstract: A flexible polymer solid electrolyte material useful in battery technology is described. The flexible solid electrolyte comprises a first block that has the ability to solvate alkali metal salts. The flexible solid electrolyte comprises a second block that has the ability to incorporate lithium ions within microphase separated spherical domains, wherein the lithium ions are from a secondary lithium source. The flexible solid electrolyte further comprises a second lithium salt.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: February 2, 2016
    Assignee: University of Maryland, College Park
    Inventors: Peter Kofinas, Ayan Ghosh
  • Methods of increasing satellite cell proliferation
    Patent number: 9248185
    Abstract: The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided is a method for repairing or regenerating a damaged muscle tissue of a subject.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: February 2, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Lee L. Rubin, Amanda Gee, Amy J. Wagers
  • Method for predicting the athletic performance potential of a subject
    Patent number: 9249470
    Abstract: A method for predicting the athletic performance potential of a subject comprising the step of assaying a biological sample from a subject for a genetic variant in linkage disequilibrium with MSTN-66493737 (T/C) SNP. The invention also provides an assay for determining the athletic performance potential of a subject.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: February 2, 2016
    Assignee: University College Dublin-National University of Ireland
    Inventors: Emmeline Hill, David MacHugh, JingJing Gu, Beatrice McGivney
  • Fabrication of Nanopores in Atomically-Thin Membranes By Ultra-Short Electrical Pulsing
    Publication number: 20160023239
    Abstract: In a method for forming nanopores, two opposing surfaces of a membrane are exposed to an electrically conducting liquid environment. A nanopore nucleation voltage pulse, having a first nucleation pulse amplitude and duration, is applied between the two membrane surfaces, through the liquid environment. After applying the nanopore nucleation voltage pulse, the electrical conductance of the membrane is measured and compared to a first prespecified electrical conductance. Then at least one additional nanopore nucleation voltage pulse is applied between the two membrane surfaces, through the liquid environment, if the measured electrical conductance is no greater than the first prespecified electrical conductance.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Jene A. Golovchenko, Bo Lu, Aaron T. Kuan
  • METHOD FOR IDENTIFYING A BACTERIAL INFECTION
    Publication number: 20160025725
    Abstract: Method for identifying a bacterial infection The present application concerns a method for identifying the nature of a bacterial infection from a peritoneal sample, in particular, whether it is a Gram-negative or Gram-positive infection, based upon the determination of one or more cellular and/or humoral markers in a sample.
    Type: Application
    Filed: March 11, 2014
    Publication date: January 28, 2016
    Applicant: University College Cardiff Consultants Limited
    Inventors: Matthias EBERL, Nicholas TOPLEY, Chan-Yu LIN
  • OSTEOSARCOMA-ASSOCIATED RISK MARKERS AND USES THEREOF
    Publication number: 20160024588
    Abstract: Provided herein are methods and compositions for identifying subjects, including canine subjects, as having an elevated risk of developing cancer or having an undiagnosed osteosarcoma. These subjects are identified based on the presence of germ-line risk markers.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicants: The Broad Institute, Inc., President and Fellows of Harvard College
    Inventors: Elinor Karlsson, Kerstin Lindblad-Toh, Snaevar Sigurdsson, Emma Ivansson
  • STAPLED AND STITCHED POLYPEPTIDES AND USES THEREOF
    Publication number: 20160024153
    Abstract: The present invention provides stapled polypeptides of the Formulae (I) and (VI): (I) (VI) and salts thereof; wherein the groups =====; R1a, R1b, R1c, R2a, R3a, R2b, R3b, R4a, R4b, RA, RZ, L1a, L1b, L2, L3, XAA, v, w, p, m, s, n, t, and q are as defined herein. The present invention further provides methods of preparing the inventive stapled polypeptides from unstapled polypeptide precursors. The present invention further provides pharmaceutical compositions comprising a stapled polypeptide of Formula (I) or (VI), and methods of using the stapled peptides. The present invention also provides modifications of the staples post ring closing metathesis.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 28, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Gregory L. VERDINE, Gerard HILINSKI
  • COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE DISEASES
    Publication number: 20160022788
    Abstract: The present invention provides compositions comprising immunologically effective amounts of one or more autoimmune disease associated antigens or antigenic fragments or derivatives thereof and one or more Th2 promoting adjuvants. The compositions may optionally comprise one or more Th2 promoting TLR2 ligands. The invention further provides methods of treating or preventing an autoimmune disease, such as multiple sclerosis, comprising administering to a subject in need thereof an immunologically-effective amount of an autoimmune disease associated antigen, a Th2 promoting adjuvant and optionally one or more Th2 promoting TLR2 ligands which overall causes re-routing of the harming immune cells to places where they can be of no harm.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 28, 2016
    Applicant: Albany Medical College
    Inventor: Dorina AVRAM
  • SPRAY DRYING TECHNIQUES
    Publication number: 20160023126
    Abstract: The present invention generally relates to microfluidics, and to spray drying and other drying techniques. In some aspects, an article containing one or more channels or microfluidic channels is used to mix one or more fluids prior to spray drying. The mixing may occur immediately before the fluids are expelled through a nozzle or other opening into a drying region of the spray dryer. In one set of embodiments, for example, a first fluid is exposed to a second fluid, then the fluids are exposed to air or other gases before being expelled through a nozzle. In certain instances, the first fluid may contain a dissolved species that may precipitate upon exposure to the second fluid; such precipitation may occur immediately before expulsion through a nozzle or other opening, thereby resulting in controlled precipitation as part of the spray drying process.
    Type: Application
    Filed: August 25, 2015
    Publication date: January 28, 2016
    Applicants: President and Fellows of Harvard College, BASF SE
    Inventors: Adam R. Abate, Julian W.P. Thiele, David A. Weitz, Christian Holtze, Maike Windbergs
  • Fracture fatigue entropy determination
    Patent number: 9243985
    Abstract: A method and apparatus are disclosed for approximating in real time the fracture fatigue entropy (FFE) of a metallic object subjected to cyclic loading. Such objects experience fatigue, which can lead to failure after a number of loading cycles. The disclosed invention allows for real time monitoring of the entropy increase in a metallic object under cyclic loading, and allows for removing the object from service before fatigue fracture occurs. Through use of the present invention, users may keep metallic objects in service for longer periods, because such objects may be safely taken closer to the fatigue fracture point. The invention therefore can effectively extend the useful life of many critical components and reduce downtime resulting from repair or premature replacement.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: January 26, 2016
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventors: Michael M. Khonsari, Mehdi Naderi Abadi, Mehdi Amiri Darehbidi
  • Methods for quantitative assessment of volumetric image from a subject and uses therof
    Patent number: 9245334
    Abstract: Methods and systems are disclosed for assessing a quantitative image volume from an individual subject comprising comparing the image from the subject to images from a control group of subjects using voxel-wise comparison. The methods allow detection of pathologies or lesions in the individual subject being assessed.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: January 26, 2016
    Assignee: Albert Einstein College of Medicine, Inc.
    Inventors: Michael L. Lipton, Namhee Kim
  • Gramicidin a mutants that function as antibiotics with improved solubility and reduced toxicity
    Patent number: 9243037
    Abstract: Described herein are antimicrobial peptides for use in pharmaceutical antibiotic compositions and methods of use thereof. These antimicrobial peptides are Gramicidin A (gA) peptide analogs that, in addition to having potent anti-microbial activity, have greatly increased solubility and significantly reduced toxicity in comparison to the wild-type Gramicidin A peptide.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: January 26, 2016
    Assignee: Trustees of Boston College
    Inventors: Jianmin Gao, Fang Wang
  • Wavelength beam combining of quantum cascade laser arrays
    Patent number: 9246310
    Abstract: A laser source based on a quantum cascade laser array (QCL), wherein the outputs of at least two elements in the array are collimated and overlapped in the far field using an external diffraction grating and a transform lens.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: January 26, 2016
    Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology
    Inventors: Anish Goyal, Benjamin G. Lee, Christian Pfluegl, Laurent Diehl, Mikhail Belkin, Antonio Sanchez-Rubio, Federico Capasso
  • Cognitive performance with sirtuin activators
    Patent number: 9241916
    Abstract: Provided herein are methods and compositions for enhancing the cognitive performance of a subject in need thereof. A method may include administering to a subject an agent that increases the level of protein or activity of a sirtuin, such as SIRT1.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: January 26, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: David A. Sinclair, Li-Huei Tsai, Andre Fischer
  • vaccine and antibody for prevention and treatment of human, animal and cell culture infection
    Patent number: 9241983
    Abstract: The present invention encompasses methods and compositions for Ureaplasma infection prevention and/or treatment. In specific cases, the invention concerns vaccines for Ureaplasma, including DNA vaccines. In certain embodiments, the invention regards vaccines directed towards the multiple-banded antigen(s) of Ureaplasma.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: January 26, 2016
    Assignee: Baylor College of Medicine
    Inventors: Leonard Weisman, Lingkun Kong
  • Genetically encoded initiator for polymer growth from proteins
    Patent number: 9243274
    Abstract: This invention pertains to methods for producing homogeneous recombinant proteins that contain polymer initiators at defined sites. The unnatural amino acid, 4-(2?-bromoisobutyramido)phenylalanine of formula 1, was designed and synthesized as a molecule comprising a functional group further comprising an initiator for an atom-transfer radical polymerization (‘ATRP”) that additionally would provide a stable linkage between the protein and growing polymer. We evolved a Methanococcus jannaschii (Mj) tyrosyl-tRNA synthetase/tRNACUA pair to genetically encode this unnatural amino acid in response to an amber codon. To demonstrate the utility of this functional amino acid, we produced Green Fluorescent Protein with the unnatural amino acid initiator of formula 1 site-specifically incorporated on its surface (GFP-1).
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: January 26, 2016
    Assignee: Franklin and Marshall College
    Inventors: Ryan A. Mehl, Krzysztof Matyjaszewski, Saadyah Averick
  • Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof
    Patent number: 9243038
    Abstract: Macrocyclic compounds that specifically inhibit insulin degrading enzyme (IDE) are provided. Pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, polymorphs, tautomers, isotopically enriched forms, and prodrugs of the macrocyclic IDE inhibitors are also described. Pharmaceutical compositions are also provided. In vivo and in vitro methods of using the IDE inhibitor, and pharmaceutical compositions comprising the IDE inhibitor, for example, for the inhibition of IDE in a subject exhibiting aberrant IDE activity, impaired insulin signaling, or insulin resistance, for example, a subject having diabetes, are also provided.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: January 26, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: David R. Liu, Juan Pablo Maianti, Alan Saghatelian, Ralph E. Kleiner
  • MULTICALORIC MnNiSi ALLOYS
    Publication number: 20160017462
    Abstract: A multicaloric alloy material combines two isostructural compounds, the first compound being MnNiSi and the second compound being either MnFeGe or CoFeGe, each such compound having extremely different magnetic and thermo-structural properties. The resulting alloy material (MnNiSi)1-x(MnFeGe)x or (MnNiSi)1-x(CoFeGe)x possesses extraordinary magnetocaloric and/or barocaloric properties with an acute sensitivity to applied pressure and no appreciable magnetic hysteresis losses.
    Type: Application
    Filed: July 17, 2015
    Publication date: January 21, 2016
    Applicants: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY
    Inventors: Tapas Samanta, Shane Stadler, Naushad Ali